LOCUS       NM_010007               2345 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily j, polypeptide 5
            (Cyp2j5), transcript variant 1, mRNA.
ACCESSION   NM_010007
VERSION     NM_010007.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2345)
  AUTHORS   Kong,C., Yan,X., Zhu,Y., Zhu,H., Luo,Y., Liu,P., Ferrandon,S.,
            Kalady,M.F., Gao,R., He,J., Yin,F., Qu,X., Zheng,J., Gao,Y.,
            Wei,Q., Ma,Y., Liu,J.Y. and Qin,H.
  TITLE     Fusobacterium Nucleatum Promotes the Development of Colorectal
            Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis
            via TLR4/Keap1/NRF2 Signaling
  JOURNAL   Cancer Res 81 (17), 4485-4498 (2021)
   PUBMED   34162680
REFERENCE   2  (bases 1 to 2345)
  AUTHORS   Agba,S., Hanif,A., Edin,M.L., Zeldin,D.C. and Nayeem,M.A.
  TITLE     Cyp2j5-Gene Deletion Affects on Acetylcholine and Adenosine-Induced
            Relaxation in Mice: Role of Angiotensin-II and CYP-Epoxygenase
            Inhibitor
  JOURNAL   Front Pharmacol 11, 27 (2020)
   PUBMED   32116704
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2345)
  AUTHORS   Orjuela Leon,A.C., Marwosky,A. and Arand,M.
  TITLE     Evidence for a complex formation between CYP2J5 and mEH in living
            cells by FRET analysis of membrane protein interaction in the
            endoplasmic reticulum (FAMPIR)
  JOURNAL   Arch Toxicol 91 (11), 3561-3570 (2017)
   PUBMED   29030652
  REMARK    GeneRIF: Microsomal epoxide hydrolase forms complex with CYP2J5 in
            the endoplasmic reticulum.
REFERENCE   4  (bases 1 to 2345)
  AUTHORS   Ma,B., Xiong,X., Chen,C., Li,H., Xu,X., Li,X., Li,R., Chen,G.,
            Dackor,R.T., Zeldin,D.C. and Wang,D.W.
  TITLE     Cardiac-specific overexpression of CYP2J2 attenuates diabetic
            cardiomyopathy in male streptozotocin-induced diabetic mice
  JOURNAL   Endocrinology 154 (8), 2843-2856 (2013)
   PUBMED   23696562
  REMARK    GeneRIF: Data indicate that cardiac-specific overexpression of
            arachidonate epoxygenase (CYP2J5) significantly protects against
            diabetic cardiomyopathy, which may be due to improved cardiac
            insulin resistance, glucose uptake, and reversal of cardiac
            hypertrophy.
REFERENCE   5  (bases 1 to 2345)
  AUTHORS   Li,R., Xu,X., Chen,C., Yu,X., Edin,M.L., Degraff,L.M., Lee,C.R.,
            Zeldin,D.C. and Wang,D.W.
  TITLE     Cytochrome P450 2J2 is protective against global cerebral ischemia
            in transgenic mice
  JOURNAL   Prostaglandins Other Lipid Mediat 99 (3-4), 68-78 (2012)
   PUBMED   23041291
  REMARK    GeneRIF: Cytochrome P450 2J2 is protective against global cerebral
            ischemia in transgenic mice.
REFERENCE   6  (bases 1 to 2345)
  AUTHORS   Athirakul,K., Bradbury,J.A., Graves,J.P., DeGraff,L.M., Ma,J.,
            Zhao,Y., Couse,J.F., Quigley,R., Harder,D.R., Zhao,X., Imig,J.D.,
            Pedersen,T.L., Newman,J.W., Hammock,B.D., Conley,A.J., Korach,K.S.,
            Coffman,T.M. and Zeldin,D.C.
  TITLE     Increased blood pressure in mice lacking cytochrome P450 2J5
  JOURNAL   FASEB J 22 (12), 4096-4108 (2008)
   PUBMED   18716027
  REMARK    GeneRIF: our findings illustrate a sex-specific role for CYP2J5 in
            regulation of blood pressure, proximal tubular transport, and
            afferent arteriolar responsiveness via an estrogen-dependent
            mechanism.
REFERENCE   7  (bases 1 to 2345)
  AUTHORS   Korstanje,R., Eriksson,P., Samnegard,A., Olsson,P.G.,
            Forsman-Semb,K., Sen,S., Churchill,G.A., Rollins,J., Harris,S.,
            Hamsten,A. and Paigen,B.
  TITLE     Locating Ath8, a locus for murine atherosclerosis susceptibility
            and testing several of its candidate genes in mice and humans
  JOURNAL   Atherosclerosis 177 (2), 443-450 (2004)
   PUBMED   15530921
REFERENCE   8  (bases 1 to 2345)
  AUTHORS   Choudhary,D., Jansson,I., Schenkman,J.B., Sarfarazi,M. and
            Stoilov,I.
  TITLE     Comparative expression profiling of 40 mouse cytochrome P450 genes
            in embryonic and adult tissues
  JOURNAL   Arch Biochem Biophys 414 (1), 91-100 (2003)
   PUBMED   12745259
REFERENCE   9  (bases 1 to 2345)
  AUTHORS   Ma,J., Qu,W., Scarborough,P.E., Tomer,K.B., Moomaw,C.R.,
            Maronpot,R., Davis,L.S., Breyer,M.D. and Zeldin,D.C.
  TITLE     Molecular cloning, enzymatic characterization, developmental
            expression, and cellular localization of a mouse cytochrome P450
            highly expressed in kidney
  JOURNAL   J Biol Chem 274 (25), 17777-17788 (1999)
   PUBMED   10364221
REFERENCE   10 (bases 1 to 2345)
  AUTHORS   Ma,J., Ramachandran,S., Fiedorek,F.T. Jr. and Zeldin,D.C.
  TITLE     Mapping of the CYP2J cytochrome P450 genes to human chromosome 1
            and mouse chromosome 4
  JOURNAL   Genomics 49 (1), 152-155 (1998)
   PUBMED   9570962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL683816.6.
            
            On Mar 21, 2023 this sequence version replaced NM_010007.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021624.1, AK143932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               AL683816.6         154810-155163       c
            355-517             AL683816.6         154121-154283       c
            518-667             AL683816.6         150490-150639       c
            668-828             AL683816.6         149601-149761       c
            829-1005            AL683816.6         132281-132457       c
            1006-1144           AL683816.6         126803-126941       c
            1145-1332           AL683816.6         125157-125344       c
            1333-1471           AL683816.6         121720-121858       c
            1472-2345           AL683816.6         119782-120655       c
FEATURES             Location/Qualifiers
     source          1..2345
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 44.71 cM"
     gene            1..2345
                     /gene="Cyp2j5"
                     /note="cytochrome P450, family 2, subfamily j, polypeptide
                     5"
                     /db_xref="GeneID:13109"
                     /db_xref="MGI:MGI:1270149"
     exon            1..354
                     /gene="Cyp2j5"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1650
                     /gene="Cyp2j5"
                     /EC_number="1.14.14.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytochrome P450 2J5; CYPIIJ5; arachidonic acid
                     epoxygenase; cytochrome P450, 2j5"
                     /codon_start=1
                     /product="cytochrome P450 2J5 isoform 1"
                     /protein_id="NP_034137.1"
                     /db_xref="CCDS:CCDS18371.1"
                     /db_xref="GeneID:13109"
                     /db_xref="MGI:MGI:1270149"
                     /translation="MIMFLSSLVTTFWEALHLKTLVLAVVTFLFLINILRSRHPKNYP
                     PGPWRLPFVGNFFQIDTKQTHLVLQQFVKKYGNVFSLELGQSPVVVVSGLPLIKEMFT
                     HLDQNFVNRFMTPVRERITGKNGLVVSNGQTWKEQRRLALMALRNFGLGKKSLEERIQ
                     EETHHLVEAIREEGGQPFNPHLKLINAVSNIICSVTFGERFDYEDCQFQELLQLLDET
                     MHLMGSSAGQLYNGFPCIMKYLPGPHQKIFRNWGKLKLFVSHIVKKHEKDWNPDEPRD
                     FIDAFLIEMQKDPDRTTSFNEENLISTTLDLFLGGTETTSSTLRWALLYMSSYPEIQE
                     NVQAEIDRVIGHKRQVSLSDRESMPYTNAVIHEVQRMGNIVPLNSSREVTVDTKFNGF
                     HLPKGTMILTNLTALHRDPKEWATPEVFNPEHFLENGQFKKRESFLPFSMGKRACLGE
                     QLAKSELFIFFSALMQKFTFKPPINEKLSLKFRMGLILSPASYRICAIPRV"
     exon            355..517
                     /gene="Cyp2j5"
                     /inference="alignment:Splign:2.1.0"
     exon            518..667
                     /gene="Cyp2j5"
                     /inference="alignment:Splign:2.1.0"
     exon            668..828
                     /gene="Cyp2j5"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1005
                     /gene="Cyp2j5"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1144
                     /gene="Cyp2j5"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1332
                     /gene="Cyp2j5"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1471
                     /gene="Cyp2j5"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..2345
                     /gene="Cyp2j5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1954..1959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2j5"
                     /note="hexamer: AATAAA"
     polyA_site      1972
                     /gene="Cyp2j5"
     polyA_site      2345
                     /gene="Cyp2j5"
                     /note="major polyA site"
ORIGIN      
        1 gggtaatcca agccacagca gggcttgtac ttggaagatc atcaaggggc aggaaggggt
       61 gagaatgtcc actgtaaccc tgtcatagag agcctactgt tccccatttt cttttctaca
      121 gaggagtgtg caaggatccc aaatatgatt atgtttttga gctccctggt gaccaccttc
      181 tgggaagcac tccatctcaa gactctggta ctggctgttg tcactttcct gttcctgatt
      241 aacatcctca gaagccgtca ccccaaaaac tacccaccag ggccatggcg tctgcccttt
      301 gtgggcaact tctttcaaat agacactaag caaacccact tggtgcttca gcagtttgtg
      361 aagaaatatg ggaatgtatt tagtctggag ttgggccaat caccagtggt ggttgtatca
      421 ggactgcctt taatcaaaga aatgtttacc cacctggacc aaaattttgt gaatcgcttt
      481 atgacaccgg ttagagaacg aatcacaggt aaaaatggat tagtcgtatc taatggccag
      541 acatggaagg agcaaaggag gcttgccctg atggcactga ggaactttgg attaggaaag
      601 aagagcttgg aggagcgcat tcaggaggag acccatcacc tggtggaagc cataagagag
      661 gagggaggtc aaccttttaa tcctcatttg aagctcatca atgccgtttc caatatcatt
      721 tgctctgtca cctttgggga gcgctttgat tatgaggact gccagtttca ggagctgctg
      781 cagttactag atgagaccat gcatttgatg ggttcatcag caggccaact ctacaatggc
      841 ttcccatgta taatgaaata tcttcctgga ccacatcaga aaatattcag aaattgggga
      901 aaactgaaat tgtttgtttc tcatattgtc aagaaacacg agaaagattg gaacccagat
      961 gagccaagag atttcattga tgctttccta atagaaatgc aaaaggaccc tgatagaact
     1021 acaagtttca atgaagaaaa ccttatcagc accactctgg acctcttttt gggtggaaca
     1081 gagacaacat cctcaacact gcgatgggct ttgctctaca tgagtagcta tccagaaatc
     1141 caagaaaatg tacaggcgga gattgacaga gttattggcc acaagaggca ggtgagcttg
     1201 tctgaccgag agtccatgcc ctacaccaat gctgtcatcc atgaggtcca gaggatgggc
     1261 aacatcgtcc ctttgaattc ttccagggaa gttacagttg acaccaagtt taatggattc
     1321 cacctgccaa agggaaccat gatcctgacc aatttgactg cactacacag agaccccaaa
     1381 gagtgggcca ctccagaagt gttcaatcca gagcattttt tggagaatgg acagtttaag
     1441 aagagagaat cctttctgcc attctcaatg ggaaaaagag cttgtcttgg agaacagttg
     1501 gctaaatctg agctgttcat ttttttctct gcccttatgc aaaaatttac cttcaagccc
     1561 ccaatcaatg agaagctgag cctgaagttc agaatgggcc tcatcctttc tccagccagc
     1621 taccgaattt gtgctatccc tagagtgtga tatcagagaa gcgaaaagaa tgtagaagtg
     1681 gaagagctga catgtgctat tgagtcactg gggcctgctc acatgagaag tgataggatg
     1741 aatgtgactg gggaaatatg agaggacaga aactaaaaaa ttggatccag ttccaagaca
     1801 actattatct tgatgctgtc tctggacaaa tcacctatgt gtccagtgac ataccttatc
     1861 atctaaaggg tacagaaaaa tgatgattct ttgcataaac aaagttctta tatgagtcag
     1921 aatcagagga aatggtaaac taaaaaacgt atcaataaat aattagaaca tagtcatatc
     1981 ttcactttct ctctttcagt gggtcacaag tgtgtacttg cttctggcct attaaattta
     2041 aattcagaaa ggagcttata gttcttagaa catagaagga caaagagtgt ttacaaagta
     2101 tgtttaccat gggtatatgg ggtttctgct gtttttgtca ttattgaata ccagccttag
     2161 gccatggtga tctgatagtg tgcatgggat tattttattc ttcttgtatc atttttggct
     2221 tgttttgtga ctgattatat ggtcaatttg gagaaggtac tatgaggtgc tgagaaggta
     2281 cattattttg ttttagggtg aaatgttctg tagatatctg ttaaatccat ctgattcaga
     2341 acctc
//
