LOCUS       NM_013809               1853 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily g, polypeptide 1
            (Cyp2g1), mRNA.
ACCESSION   NM_013809 XM_991009
VERSION     NM_013809.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1853)
  AUTHORS   Chen M, Reed RR and Lane AP.
  TITLE     Chronic Inflammation Directs an Olfactory Stem Cell Functional
            Switch from Neuroregeneration to Immune Defense
  JOURNAL   Cell Stem Cell 25 (4), 501-513 (2019)
   PUBMED   31523027
REFERENCE   2  (bases 1 to 1853)
  AUTHORS   Herrick DB, Lin B, Peterson J, Schnittke N and Schwob JE.
  TITLE     Notch1 maintains dormancy of olfactory horizontal basal cells, a
            reserve neural stem cell
  JOURNAL   Proc Natl Acad Sci U S A 114 (28), E5589-E5598 (2017)
   PUBMED   28637720
REFERENCE   3  (bases 1 to 1853)
  AUTHORS   Roby YA, Bushey MA, Cheng LE, Kulaga HM, Lee SJ and Reed RR.
  TITLE     Zfp423/OAZ mutation reveals the importance of Olf/EBF transcription
            activity in olfactory neuronal maturation
  JOURNAL   J Neurosci 32 (40), 13679-1388a (2012)
   PUBMED   23035080
REFERENCE   4  (bases 1 to 1853)
  AUTHORS   Zhou X, Wei Y, Xie F, Laukaitis CM, Karn RC, Kluetzman K, Gu J,
            Zhang QY, Roberts DW and Ding X.
  TITLE     A novel defensive mechanism against acetaminophen toxicity in the
            mouse lateral nasal gland: role of CYP2A5-mediated regulation of
            testosterone homeostasis and salivary androgen-binding protein
            expression
  JOURNAL   Mol Pharmacol 79 (4), 710-723 (2011)
   PUBMED   21252290
REFERENCE   5  (bases 1 to 1853)
  AUTHORS   Lane AP, Turner J, May L and Reed R.
  TITLE     A genetic model of chronic rhinosinusitis-associated olfactory
            inflammation reveals reversible functional impairment and dramatic
            neuroepithelial reorganization
  JOURNAL   J Neurosci 30 (6), 2324-2329 (2010)
   PUBMED   20147558
REFERENCE   6  (bases 1 to 1853)
  AUTHORS   Zhuo X, Gu J, Behr MJ, Swiatek PJ, Cui H, Zhang QY, Xie Y, Collins
            DN and Ding X.
  TITLE     Targeted disruption of the olfactory mucosa-specific Cyp2g1 gene:
            impact on acetaminophen toxicity in the lateral nasal gland, and
            tissue-selective effects on Cyp2a5 expression
  JOURNAL   J Pharmacol Exp Ther 308 (2), 719-728 (2004)
   PUBMED   14610229
REFERENCE   7  (bases 1 to 1853)
  AUTHORS   Choudhary D, Jansson I, Schenkman JB, Sarfarazi M and Stoilov I.
  TITLE     Comparative expression profiling of 40 mouse cytochrome P450 genes
            in embryonic and adult tissues
  JOURNAL   Arch Biochem Biophys 414 (1), 91-100 (2003)
   PUBMED   12745259
REFERENCE   8  (bases 1 to 1853)
  AUTHORS   Taru H, Iijima K, Hase M, Kirino Y, Yagi Y and Suzuki T.
  TITLE     Interaction of Alzheimer's beta -amyloid precursor family proteins
            with scaffold proteins of the JNK signaling cascade
  JOURNAL   J Biol Chem 277 (22), 20070-20078 (2002)
   PUBMED   11912189
REFERENCE   9  (bases 1 to 1853)
  AUTHORS   Verhey KJ, Meyer D, Deehan R, Blenis J, Schnapp BJ, Rapoport TA and
            Margolis B.
  TITLE     Cargo of kinesin identified as JIP scaffolding proteins and
            associated signaling molecules
  JOURNAL   J Cell Biol 152 (5), 959-970 (2001)
   PUBMED   11238452
REFERENCE   10 (bases 1 to 1853)
  AUTHORS   Hua Z, Zhang QY, Su T, Lipinskas TW and Ding X.
  TITLE     cDNA cloning, heterologous expression, and characterization of
            mouse CYP2G1, an olfactory-specific steroid hydroxylase
  JOURNAL   Arch Biochem Biophys 340 (2), 208-214 (1997)
   PUBMED   9143323
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L81171.1.
            
            On May 4, 2006 this sequence version replaced XM_991009.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L81171.1, BC046321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.5 cM"
     gene            1..1853
                     /gene="Cyp2g1"
                     /note="cytochrome P450, family 2, subfamily g, polypeptide
                     1"
                     /db_xref="GeneID:13108"
                     /db_xref="MGI:MGI:109612"
     CDS             1..1485
                     /gene="Cyp2g1"
                     /note="cytochrome P450, 2g1"
                     /codon_start=1
                     /product="cytochrome P450, family 2, subfamily g,
                     polypeptide 1 precursor"
                     /protein_id="NP_038837.1"
                     /db_xref="CCDS:CCDS21007.1"
                     /db_xref="GeneID:13108"
                     /db_xref="MGI:MGI:109612"
                     /translation="MMLGGAFSIFMALCLSCLLILIAWKRTSKGGKLPPGPTPIPFLG
                     NFLQVRTDATFQSFQKLQKKYGSVFTVYFGPRPVVVLCGHEAVKEALVDQADDFSGRG
                     EMPTLEKNFQGYGLALSNGERWKILRRFSLTVLRNFGMGKRSIEERIQEEAGYLLEEL
                     HKVKGAPIDPTLYLSRTVSNVICSVVFGKRFDYQDQRFQSLMRMINESFVEMSKPWAQ
                     LYDMYWKVMQYFPGRHNYLYNLIEDLKDFIASRVKINEASFDPSNPRDFIDCFLIKMH
                     QDKSDPHTEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLLKYPEVEAKIHEEINQV
                     IGTHRTPRVDDRAKMPYTDAVIHEIQRLTDIVPLGVPHNVTRDTHFRGYLLPKGTDVY
                     PLFGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNDAFVVFSSGKRICVGEALARMELF
                     LYFTSILQRFSLRSLVPPADIDIAHKISGFGNIPPVYELCFMAR"
     exon            1..180
                     /gene="Cyp2g1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..343
                     /gene="Cyp2g1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..493
                     /gene="Cyp2g1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..654
                     /gene="Cyp2g1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..831
                     /gene="Cyp2g1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..973
                     /gene="Cyp2g1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1161
                     /gene="Cyp2g1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1303
                     /gene="Cyp2g1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1853
                     /gene="Cyp2g1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1853
                     /gene="Cyp2g1"
                     /note="putative"
ORIGIN      
        1 atgatgctgg gaggagcctt cagcatcttt atggcacttt gtttgtcttg cctgctcatc
       61 ctgattgctt ggaagaggac cagtaaggga ggaaagctgc cccccggccc cacaccaata
      121 ccgtttttgg gaaacttctt acaagtccgc actgatgcca catttcagtc cttccagaag
      181 ctccagaaaa aatatggctc tgtgttcact gtgtacttcg gtccaaggcc agtggttgtc
      241 ttatgtggac atgaggcagt gaaggaggcc ctggtggacc aggcagatga cttcagtggc
      301 cgtggtgaaa tgcctacact agagaagaac ttccaaggtt atggtttagc tctgtccaat
      361 ggagaacgat ggaagattct tcggcgtttt tccctgaccg tccttcgaaa ctttgggatg
      421 gggaagcgga gcattgagga gcggatccag gaggaggctg gctacctact ggaggagctc
      481 cataaggtca agggagctcc catagatccc accttatacc tgagccgcac tgtgtccaac
      541 gtcatctgtt ccgtggtctt cggaaaacgc ttcgactatc aggaccagcg tttccagagc
      601 ctcatgagga tgatcaatga gagctttgtg gagatgagca agccctgggc acagttatat
      661 gatatgtact ggaaagtcat gcagtatttt ccaggaagac acaactacct ctacaacttg
      721 atagaagacc ttaaggactt cattgcatcc agggtcaaaa tcaatgaagc atcctttgac
      781 ccctcaaacc ctagggactt catagattgc tttctcatca agatgcacca ggataaaagt
      841 gacccgcaca cagaattcaa cctcaagaac ttggttctca ccaccctcaa cctcttcttt
      901 gctggcacag aaactgtgag ttccacgtta cggtatggat tcttgctgct gctgaagtac
      961 cccgaggtgg aggccaagat ccacgaggag attaaccagg tgatcggaac acaccgtacc
     1021 ccaagagtgg atgaccgggc caagatgccc tacactgacg ctgtcatcca tgagatacag
     1081 agattgacag acattgtgcc cctgggtgtc ccccataatg tcacacggga cactcatttc
     1141 cgaggctacc ttctacctaa gggtacagat gtgtatcccc tgtttggctc agtcctcaaa
     1201 gatcccaaat acttccgcta cccagatgct ttttatcctc aacacttcct ggatgaacag
     1261 gggcgcttca agaagaatga tgcctttgtg gtcttttcct ctggaaagcg catctgcgtt
     1321 ggggaggccc tggcccgcat ggaactcttc ctttacttca catccattct tcagaggttc
     1381 tccttacgtt ctctggtgcc tcctgctgac attgacatcg ctcacaaaat ctcaggcttt
     1441 ggcaacatcc ccccagttta tgagctctgc ttcatggccc gctgagtgcc cactgcaaga
     1501 ccagccaaga gtcatctgag agctgagctc tgctgaagtt cacacacaca caccatctgc
     1561 cttcaatcct ccatactcct tgaagagagg tcactctcac tgttgttctg agaccatggg
     1621 tcaagagagg tgtctggata tataaactag ggttctagtc acaatctggg ggaaaagcct
     1681 gagggtttca ttaaatttcc tgaatttttc aacctcagtc tcagtgggca ccaaatttac
     1741 agatgctgtc agcttacata atctttgtct ttgccctgat attgaccaga atataccttg
     1801 caattctttc ctgtttgctt ttatttctcc tccccaataa aaaactcaaa act
//
