LOCUS       NM_007817               1842 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily f, polypeptide 2
            (Cyp2f2), mRNA.
ACCESSION   NM_007817
VERSION     NM_007817.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1842)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1842)
  AUTHORS   Stupnikov,M.R., Yang,Y., Mori,M., Lu,J. and Cardoso,W.V.
  TITLE     Jagged and Delta-like ligands control distinct events during airway
            progenitor cell differentiation
  JOURNAL   Elife 8, e50487 (2019)
   PUBMED   31631837
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1842)
  AUTHORS   Cruzan,G., Bus,J.S., Banton,M.I., Sarang,S.S., Waites,R.,
            Layko,D.B., Raymond,J., Dodd,D. and Andersen,M.E.
  TITLE     Editor's Highlight: Complete Attenuation of Mouse Lung Cell
            Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1
            Humanized Mice Exposed to Inhaled Styrene for up to 2 Years
            Supports a Lack of Human Relevance
  JOURNAL   Toxicol Sci 159 (2), 413-421 (2017)
   PUBMED   28962520
REFERENCE   4  (bases 1 to 1842)
  AUTHORS   Strupp,C., Bomann,W., Cohen,S.M. and Weber,K.
  TITLE     Relationship of Metabolism and Cell Proliferation to the Mode of
            Action of Fluensulfone-Induced Mouse Lung Tumors. II: Additional
            Mechanistic Studies
  JOURNAL   Toxicol Sci 154 (2), 296-308 (2016)
   PUBMED   27605420
REFERENCE   5  (bases 1 to 1842)
  AUTHORS   Lopez,I.P., Pineiro-Hermida,S., Pais,R.S., Torrens,R., Hoeflich,A.
            and Pichel,J.G.
  TITLE     Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role
            during Repair Kinetics after Selective Club Cell Ablation
  JOURNAL   PLoS One 11 (11), e0166388 (2016)
   PUBMED   27861515
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1842)
  AUTHORS   Chen,N., Whitehead,S.E., Caillat,A.W., Gavit,K., Isphording,D.R.,
            Kovacevic,D., McCreary,M.B. and Hoffman,S.M.
  TITLE     Identification and cross-species comparisons of CYP2F subfamily
            genes in mammals
  JOURNAL   Mutat Res 499 (2), 155-161 (2002)
   PUBMED   11827709
REFERENCE   7  (bases 1 to 1842)
  AUTHORS   Ye,X., Lu,L. and Gill,S.S.
  TITLE     Suppression of cytochrome P450 Cyp2f2 mRNA levels in mice by the
            peroxisome proliferator diethylhexylphthalate
  JOURNAL   Biochem Biophys Res Commun 239 (3), 660-665 (1997)
   PUBMED   9367824
REFERENCE   8  (bases 1 to 1842)
  AUTHORS   Ritter,J.K., Owens,I.S., Negishi,M., Nagata,K., Sheen,Y.Y.,
            Gillette,J.R. and Sasame,H.A.
  TITLE     Mouse pulmonary cytochrome P-450 naphthalene hydroxylase: cDNA
            cloning, sequence, and expression in Saccharomyces cerevisiae
  JOURNAL   Biochemistry 30 (48), 11430-11437 (1991)
   PUBMED   1742282
REFERENCE   9  (bases 1 to 1842)
  AUTHORS   Nagata,K., Martin,B.M., Gillette,J.R. and Sasame,H.A.
  TITLE     Isozymes of cytochrome P-450 that metabolize naphthalene in liver
            and lung of untreated mice
  JOURNAL   Drug Metab Dispos 18 (5), 557-564 (1990)
   PUBMED   1981702
REFERENCE   10 (bases 1 to 1842)
  AUTHORS   Nhamburo,P.T., Kimura,S., McBride,O.W., Kozak,C.A., Gelboin,H.V.
            and Gonzalez,F.J.
  TITLE     The human CYP2F gene subfamily: identification of a cDNA encoding a
            new cytochrome P450, cDNA-directed expression, and chromosome
            mapping
  JOURNAL   Biochemistry 29 (23), 5491-5499 (1990)
   PUBMED   1974816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157553.10, BU148924.1, CB595035.1 and CK626215.1.
            
            [WARNING] On Aug 15, 2024 this sequence was replaced by
            NM_007817.3.
            
            On Jan 23, 2007 this sequence version replaced NM_007817.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M77497.1, BC011089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC157553.10        70036-70071         c
            37-766              BU148924.1         1-730
            767-1376            CB595035.1         22-631
            1377-1842           CK626215.1         1-466               c
FEATURES             Location/Qualifiers
     source          1..1842
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.82 cM"
     gene            1..1842
                     /gene="Cyp2f2"
                     /gene_synonym="Cyp2f"
                     /note="cytochrome P450, family 2, subfamily f, polypeptide
                     2"
                     /db_xref="GeneID:13107"
                     /db_xref="MGI:MGI:88608"
     exon            1..61
                     /gene="Cyp2f2"
                     /gene_synonym="Cyp2f"
                     /inference="alignment:Splign:2.1.0"
     exon            62..252
                     /gene="Cyp2f2"
                     /gene_synonym="Cyp2f"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1557
                     /gene="Cyp2f2"
                     /gene_synonym="Cyp2f"
                     /note="CYPIIF2; cytochrome P450-NAH-2; naphthalene
                     hydroxylase; naphthalene dehydrogenase; cytochrome P450,
                     2f2"
                     /codon_start=1
                     /product="cytochrome P450 2F2"
                     /protein_id="NP_031843.2"
                     /db_xref="CCDS:CCDS21010.1"
                     /db_xref="GeneID:13107"
                     /db_xref="MGI:MGI:88608"
                     /translation="MDGVSTAILLLLLAVISLSLTFSSRGKGQLPPGPKPLPILGNLL
                     QLRSQDLLTSLTKLSKEYGSVFTVYLGSRPVIVLSGYQTVKEALVDKGEEFSGRGAYP
                     VFFNFTRGNGIAFSDGERWKILRRFSVQILRNFGMGKRSIEERILEEGSFLLEVLRKM
                     EGKPFDPVFILSRSVSNIICSVVFGSRFDYDDERLLTIIHFINDNFKIMSSPWGEMYN
                     IFPSVLDWIPGPHKRLFRNFGGMKDLIARSVREHQDSLDPNSPRDFIDCFLTKMAQEK
                     QDPLSHFNMDTLLMTTHNLLFGGTETVGTTLRHAFLILMKYPKVQARVQEEIDRVVGR
                     SRMPTLEDRTSMPYTDAVIHEVQRFADVIPMNLPHRVTRDTPFRGFLIPKGTDVITLL
                     NTVHYDSDQFKTPQEFNPEHFLDDNHSFKKSPAFMPFSAGRRLCLGEPLARMELFIYF
                     TSILQNFTLQPLVDPEDIDLTPLSSGLGNLPRPFQLCMHIR"
     exon            253..415
                     /gene="Cyp2f2"
                     /gene_synonym="Cyp2f"
                     /inference="alignment:Splign:2.1.0"
     exon            416..565
                     /gene="Cyp2f2"
                     /gene_synonym="Cyp2f"
                     /inference="alignment:Splign:2.1.0"
     exon            566..726
                     /gene="Cyp2f2"
                     /gene_synonym="Cyp2f"
                     /inference="alignment:Splign:2.1.0"
     exon            727..903
                     /gene="Cyp2f2"
                     /gene_synonym="Cyp2f"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1045
                     /gene="Cyp2f2"
                     /gene_synonym="Cyp2f"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1233
                     /gene="Cyp2f2"
                     /gene_synonym="Cyp2f"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1375
                     /gene="Cyp2f2"
                     /gene_synonym="Cyp2f"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1820
                     /gene="Cyp2f2"
                     /gene_synonym="Cyp2f"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacacatac actgcagcac acacaagaac ttcagaacat tgctgcagaa tactgataca
       61 ggcgctgcag ctgccttcac tatggatggt gtgagcacag ccatcttgct tctcctcctg
      121 gctgtcatct ctctgtccct gaccttcagc tcacggggca agggccagct gcctccagga
      181 cccaaacctc tcccaatcct gggaaacctg ctgcagcttc gctcccaaga cttgctgacc
      241 tccctcacca agcttagcaa ggagtatggg tcggtgttca cggtgtacct ggggtccagg
      301 cctgtgatag tcctcagcgg ataccaaact gtgaaggagg ctcttgtgga caaaggggag
      361 gagttcagtg gccgaggcgc ataccccgtc tttttcaact tcaccagggg caacggcatc
      421 gccttctccg atggagagcg ctggaagatc ctcagaaggt tctctgtcca aatcctgcgg
      481 aactttggca tgggaaaaag aagcatcgag gagcggatcc tggaagaagg cagcttcctg
      541 ctggaggtgc tgaggaaaat ggaaggcaag ccctttgacc ccgtgtttat cctgagccgc
      601 tctgtgtcca acattatctg ctctgtcgtc ttcggaagtc gcttcgacta tgacgatgag
      661 cgtctgctca ccatcatcca ctttatcaat gacaacttca agattatgag cagcccttgg
      721 ggcgagatgt acaacatctt cccaagtgtc cttgattgga tacctgggcc acacaaacgc
      781 ttgttccgga actttggagg catgaaagat ctcattgccc gcagcgtccg cgaacaccag
      841 gattccctgg accccaactc tccccgggac ttcatcgact gcttcctcac aaagatggca
      901 caggagaagc aagacccact gagccacttc aatatggata ccctgctgat gaccacacac
      961 aacctgctct tcggtggcac agaaaccgtg ggcaccacac tgcgtcacgc cttccttatt
     1021 cttatgaaat accccaaagt gcaagcccgc gtgcaggaag agattgaccg tgtggtgggg
     1081 cgctcgcgga tgccgacgct ggaagaccgt acatccatgc cttacacaga tgcagtgatc
     1141 cacgaagtgc aacgctttgc tgacgtcatc cccatgaacc tgcctcaccg tgtcactcgg
     1201 gacacacctt tccggggctt cctgataccc aagggcacag atgtcatcac actccttaac
     1261 actgtgcact acgactcgga ccagttcaag acgcctcagg agttcaatcc tgaacatttt
     1321 ctggacgaca atcattcttt caaaaagagc cccgccttca tgccattttc ggctggacgt
     1381 cgactgtgtc tgggagagcc actggcgcgc atggagctct tcatatactt cacctccatt
     1441 ctgcagaact tcacattgca gccgctggtg gatcctgagg acatcgacct gaccccgctc
     1501 agctcagggc tgggcaattt gccaaggcct ttccagctgt gtatgcacat tcgctgagta
     1561 ctgcgcccag ggacccctgt ccttcttcca gttggggttc actgtcatag gcctccattg
     1621 atatctctct cacatgatct tcccttaacc ctgggcctgc cacgtatcag tactttaccc
     1681 cgcctatctt aagcccatct tcatggaaag aatgacgtga caaaggtgaa atacccgtct
     1741 tatacgcaca gaacctattc tatgatgcac ccttttcctg tctgtttgta tcatttccta
     1801 gtaaatatct taataactga aaaaaaaaaa aaaaaaaaaa aa
//
