LOCUS       NM_021282               1762 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily e, polypeptide 1
            (Cyp2e1), mRNA.
ACCESSION   NM_021282
VERSION     NM_021282.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1762)
  AUTHORS   Chen,H., Luo,S., Deng,X., Li,S., Mao,Y., Yan,J., Cheng,Y., Liu,X.,
            Pan,J. and Huang,H.
  TITLE     Pre-eclamptic foetal programming predisposes offspring to hepatic
            steatosis via DNA methylation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167189 (2024)
   PUBMED   38648899
REFERENCE   2  (bases 1 to 1762)
  AUTHORS   Bai,W., Su,H., Xu,S., Gao,Z., Chang,Z., Sun,X. and Liu,T.
  TITLE     Cyp2e1 protects against OVA-induced allergic rhinitis through the
            inhibition of Th2 cell activation and differentiation: Mediated by
            MAFB
  JOURNAL   Int Immunopharmacol 132, 112003 (2024)
   PUBMED   38603858
  REMARK    GeneRIF: Cyp2e1 protects against OVA-induced allergic rhinitis
            through the inhibition of Th2 cell activation and differentiation:
            Mediated by MAFB.
REFERENCE   3  (bases 1 to 1762)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1762)
  AUTHORS   Oguro,A., Fujiyama,T., Ishihara,Y., Kataoka,C., Yamamoto,M.,
            Eto,K., Komohara,Y., Imaoka,S., Sakuragi,T., Tsuji,M., Shibata,E.,
            Kotake,Y. and Yamazaki,T.
  TITLE     Maternal DHA intake in mice increased DHA metabolites in the pup
            brain and ameliorated MeHg-induced behavioral disorder
  JOURNAL   J Lipid Res 64 (11), 100458 (2023)
   PUBMED   37838304
REFERENCE   5  (bases 1 to 1762)
  AUTHORS   Wei,D., Tian,X., Zhu,L., Wang,H. and Sun,C.
  TITLE     USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease
            through deubiquitination and stabilization of HSP90AA1
  JOURNAL   Cell Death Dis 14 (8), 566 (2023)
   PUBMED   37633951
  REMARK    GeneRIF: USP14 governs CYP2E1 to promote nonalcoholic fatty liver
            disease through deubiquitination and stabilization of HSP90AA1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1762)
  AUTHORS   Pan,J., Hong,J.Y. and Yang,C.S.
  TITLE     Post-transcriptional regulation of mouse renal cytochrome P450 2E1
            by testosterone
  JOURNAL   Arch Biochem Biophys 299 (1), 110-115 (1992)
   PUBMED   1444443
REFERENCE   7  (bases 1 to 1762)
  AUTHORS   Freeman,J.E., Stirling,D., Russell,A.L. and Wolf,C.R.
  TITLE     cDNA sequence, deduced amino acid sequence, predicted gene
            structure and chemical regulation of mouse Cyp2e1
  JOURNAL   Biochem J 281 (Pt 3) (Pt 3), 689-695 (1992)
   PUBMED   1536649
REFERENCE   8  (bases 1 to 1762)
  AUTHORS   Ramesh,V., Cheng,S.V., Kozak,C.A., Herron,B.J., Shih,V.E.,
            Taylor,B.A. and Gusella,J.F.
  TITLE     Mapping of ornithine aminotransferase gene sequences to mouse
            chromosomes 7, X, and 3
  JOURNAL   Mamm Genome 3 (1), 17-22 (1992)
   PUBMED   1349842
REFERENCE   9  (bases 1 to 1762)
  AUTHORS   Forkert,P.G., Massey,T.E., Jones,A.B., Park,S.S., Gelboin,H.V. and
            Anderson,L.M.
  TITLE     Distribution of cytochrome CYP2E1 in murine liver after ethanol and
            acetone administration
  JOURNAL   Carcinogenesis 12 (12), 2259-2268 (1991)
   PUBMED   1747925
REFERENCE   10 (bases 1 to 1762)
  AUTHORS   Voliva,C.F. and Paigen,K.
  TITLE     Isolation of the mouse cytochrome P450J (CYP2E1) cDNA and its
            reciprocal testosterone regulation in kidney and liver
  JOURNAL   J Mol Endocrinol 7 (2), 155-166 (1991)
   PUBMED   1930627
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107815.11.
            
            On Jun 3, 2018 this sequence version replaced NM_021282.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013451.1, X62595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC107815.11        160845-161053       c
            210-369             AC107815.11        159913-160072       c
            370-519             AC107815.11        155627-155776       c
            520-680             AC107815.11        155148-155308       c
            681-857             AC107815.11        154644-154820       c
            858-999             AC107815.11        153789-153930       c
            1000-1187           AC107815.11        151666-151853       c
            1188-1329           AC107815.11        151101-151242       c
            1330-1762           AC107815.11        149882-150314       c
FEATURES             Location/Qualifiers
     source          1..1762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 85.94 cM"
     gene            1..1762
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e; CYPIIE1"
                     /note="cytochrome P450, family 2, subfamily e, polypeptide
                     1"
                     /db_xref="GeneID:13106"
                     /db_xref="MGI:MGI:88607"
     exon            1..209
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e; CYPIIE1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..369
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e; CYPIIE1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..519
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e; CYPIIE1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..680
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e; CYPIIE1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..857
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e; CYPIIE1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..999
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e; CYPIIE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1187
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e; CYPIIE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1329
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e; CYPIIE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1762
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e; CYPIIE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1737..1742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e; CYPIIE1"
                     /note="hexamer: AATAAG"
     polyA_site      1759
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e; CYPIIE1"
                     /note="major polyA site"
ORIGIN      
        1 ctacaaattt agagtggagc cccatcggca ccatggcggt tcttggcatc accgttgcct
       61 tgcttgtctg gatcgccacc ctcctcctcg tatccatctg gaaacagatc tatagaagtt
      121 ggaacctgcc cccaggacct ttcccaattc ctttctttgg aaacattttt cagctggatt
      181 tgaaggatat tcccaagtct ttaaccaagt tggcaaagcg cttcgggcca gtgttcacac
      241 tgcacctggg tcagaggcgc atcgtggtcc tgcatggcta caaggctgtc aaggaggtgc
      301 tactgaacca caagaatgag ttctctggcc gaggggacat tcctgtgttc caggagtaca
      361 agaacaaggg gattattttc aataatggac ccacatggaa ggacgtgcgg aggttttccc
      421 taagtatcct ccgtgactgg ggaatgggga aacagggtaa tgaggcccgc atccaaagag
      481 aggcacactt cctggtggag gagctcaaaa agaccaaagg ccagcctttt gaccctacct
      541 ttctgattgg ctgtgcaccc tgcaatgtca ttgcggatat tctcttcaac aaacgcttcg
      601 attacgatga caagaagtgt ctggagctca tgagtttgtt caatgaaaac ttctacctgc
      661 tgagtactcc ctggatccag gcttacaatt acttttcgga ttatctacaa tatctacctg
      721 gaagccacag aaaagtcatg aaaaatgtgt ctgaaataag acagtacaca cttggaaaag
      781 ccaaggaaca ccttaagtca ctggacatca actgcccccg ggatgtgact gactgtctcc
      841 tcatagagat ggagaaggaa aaacacagcc aagaacccat gtacacaatg gaaaatattt
      901 ctgtgacttt ggccgacctg ttctttgcag gaacagagac caccagcaca actctgagat
      961 atgggctcct gattctcatg aaatacccag aaattgaaga gaaacttcat gaagaaattg
     1021 acagggttat tgggccaagc cgtgcccctg cagtccgaga caggatgaat atgccctaca
     1081 tggacgctgt agtgcatgag attcagagat tcatcaacct cgtcccttcc aacctgcccc
     1141 acgaagcaac ccgagacacc gtgttccgag gatatgtcat ccccaagggt acagttgtaa
     1201 ttccaactct ggactccctt ttatttgaca actatgagtt tccagatcca gagacattta
     1261 aacctgagca ttttctgaat gaaaatggga agttcaagta cagtgactat ttcaaggcgt
     1321 tttctgcagg aaagcgcgtg tgtgttggag aaggcctggc ccgcatggaa ctgtttctgc
     1381 ttttgtctgc tattctgcag cattttaatc tgaagtctct ggttgaccct aaggatatcg
     1441 acctcagccc tgttacaatt ggctttggca gtatcccacg cgaatttaaa ctctgtgtca
     1501 ttcctcgttc atgagacctg ctgcccatca ttatccctta caaaatgact gtttaaaaaa
     1561 atgccaagcg ggctggtgag atggctcagt gggtaagagc acccgactgc tcttccgaag
     1621 gtccggagtt caaatcccag caaccacatg gtggctcaca accatctgta tcgagatctg
     1681 actctgtctt ctggagtgtc tgaagacagc tacagtgtac ttacatataa taaataaata
     1741 agtctttaaa aaatgccaag ca
//
