LOCUS       NM_010006               1651 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily d, polypeptide 9
            (Cyp2d9), mRNA.
ACCESSION   NM_010006
VERSION     NM_010006.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1651)
  AUTHORS   Chikada,H., Ida,K., Ando,E., Inagaki,Y., Sakamoto,A. and Kamiya,A.
  TITLE     Establishment and analysis of a mouse model that regulates
            sex-related differences in liver drug metabolism
  JOURNAL   Lab Invest 98 (11), 1500-1511 (2018)
   PUBMED   29968852
REFERENCE   2  (bases 1 to 1651)
  AUTHORS   Creasy,K.T., Jiang,J., Ren,H., Peterson,M.L. and Spear,B.T.
  TITLE     Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic
            Cyp Gene Expression in the Adult Mouse Liver
  JOURNAL   Gene Expr 17 (1), 7-17 (2016)
   PUBMED   27197076
REFERENCE   3  (bases 1 to 1651)
  AUTHORS   Krebs,C.J., Larkins,L.K., Price,R., Tullis,K.M., Miller,R.D. and
            Robins,D.M.
  TITLE     Regulator of sex-limitation (Rsl) encodes a pair of KRAB
            zinc-finger genes that control sexually dimorphic liver gene
            expression
  JOURNAL   Genes Dev 17 (21), 2664-2674 (2003)
   PUBMED   14563677
REFERENCE   4  (bases 1 to 1651)
  AUTHORS   Choudhary,D., Jansson,I., Schenkman,J.B., Sarfarazi,M. and
            Stoilov,I.
  TITLE     Comparative expression profiling of 40 mouse cytochrome P450 genes
            in embryonic and adult tissues
  JOURNAL   Arch Biochem Biophys 414 (1), 91-100 (2003)
   PUBMED   12745259
REFERENCE   5  (bases 1 to 1651)
  AUTHORS   Jones,B.C., Tarantino,L.M., Rodriguez,L.A., Reed,C.L.,
            McClearn,G.E., Plomin,R. and Erwin,V.G.
  TITLE     Quantitative-trait loci analysis of cocaine-related behaviours and
            neurochemistry
  JOURNAL   Pharmacogenetics 9 (5), 607-617 (1999)
   PUBMED   10591541
REFERENCE   6  (bases 1 to 1651)
  AUTHORS   Gumley,T.P., McKenzie,I.F., Kozak,C.A. and Sandrin,M.S.
  TITLE     Isolation and characterization of cDNA clones for the mouse
            thymocyte B cell antigen (ThB)
  JOURNAL   J Immunol 149 (8), 2615-2618 (1992)
   PUBMED   1401899
REFERENCE   7  (bases 1 to 1651)
  AUTHORS   Ichikawa,T., Itakura,T. and Negishi,M.
  TITLE     Functional characterization of two cytochrome P-450s within the
            mouse, male-specific steroid 16 alpha-hydroxylase gene family:
            expression in mammalian cells and chimeric proteins
  JOURNAL   Biochemistry 28 (11), 4779-4784 (1989)
   PUBMED   2788458
REFERENCE   8  (bases 1 to 1651)
  AUTHORS   Wong,G., Itakura,T., Kawajiri,K., Skow,L. and Negishi,M.
  TITLE     Gene family of male-specific testosterone 16 alpha-hydroxylase
            (C-P-450(16 alpha)) in mice. Organization, differential regulation,
            and chromosome localization
  JOURNAL   J Biol Chem 264 (5), 2920-2927 (1989)
   PUBMED   2914938
REFERENCE   9  (bases 1 to 1651)
  AUTHORS   Wong,G., Kawajiri,K. and Negishi,M.
  TITLE     Gene family of male-specific testosterone 16 alpha-hydroxylase
            (C-P-450(16) alpha) in mouse liver: cDNA sequences, neonatal
            imprinting, and reversible regulation by androgen
  JOURNAL   Biochemistry 26 (26), 8683-8690 (1987)
   PUBMED   2831949
REFERENCE   10 (bases 1 to 1651)
  AUTHORS   Gonzalez,F.J., Matsunaga,T., Nagata,K., Meyer,U.A., Nebert,D.W.,
            Pastewka,J., Kozak,C.A., Gillette,J., Gelboin,H.V. and
            Hardwick,J.P.
  TITLE     Debrisoquine 4-hydroxylase: characterization of a new P450 gene
            subfamily, regulation, chromosomal mapping, and molecular analysis
            of the DA rat polymorphism
  JOURNAL   DNA 6 (2), 149-161 (1987)
   PUBMED   3582092
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143963.1 and M23998.1.
            
            On Nov 22, 2007 this sequence version replaced NM_010006.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143963.1, BC010593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1038              AK143963.1         1-1038
            1039-1651           M23998.1           1035-1647
FEATURES             Location/Qualifiers
     source          1..1651
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.6 cM"
     gene            1..1651
                     /gene="Cyp2d9"
                     /gene_synonym="Cyp2d; P450-2D"
                     /note="cytochrome P450, family 2, subfamily d, polypeptide
                     9"
                     /db_xref="GeneID:13105"
                     /db_xref="MGI:MGI:88606"
     exon            1..264
                     /gene="Cyp2d9"
                     /gene_synonym="Cyp2d; P450-2D"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1590
                     /gene="Cyp2d9"
                     /gene_synonym="Cyp2d; P450-2D"
                     /EC_number="1.14.14.1"
                     /note="CYPIID9; cytochrome P450CA; cytochrome
                     P450-16-alpha; testosterone 16-alpha hydroxylase;
                     cytochrome P450, 2d9; testosterone 16alpha-hydroxylase"
                     /codon_start=1
                     /product="cytochrome P450 2D9"
                     /protein_id="NP_034136.2"
                     /db_xref="CCDS:CCDS27691.1"
                     /db_xref="GeneID:13105"
                     /db_xref="MGI:MGI:88606"
                     /translation="MELLTGTDLWPVAIFTVIFILLVDLTHQRQRWTSRYPPGPVPWP
                     VLGNLLQVDLGNMPYSLYKLQNRYGDVFSLQMAWKPMVVINGLKAMKEMLLTCGEDTA
                     DRPPVPIFEYLGVKPGSQGVVLAPYGPEWREQRRFSVSTLRNFGLGKKSLEDWVTKEA
                     NHLCDAFTAQAGQPINPNPMLNKSTCNVIASLIFARRFEYEDPFLIRMLKVLEQSLTE
                     VSGLIPEVLNAFPILLRIPRLADKALQGQKSFIAILDNLLTENRTTWDPVQAPRNLTD
                     AFLAEIEKAKGNPESSFNDENLLMVVRDLFGAGMLTTSTTLSWALMLMILHPDVQRRV
                     QQEIDEVIGQVRHPEMADQAHMPYTNAVIHEVQRFGDIVPVNLPRITSHDIEVQDFLI
                     PKGTILLPNMSSMLKDESVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSAGRRSCLGEA
                     LARMELFLFFTCLLQRFSFSVPDGQPQPSNSGVYGILVAPSPYQLCAVVRDQGH"
     exon            265..436
                     /gene="Cyp2d9"
                     /gene_synonym="Cyp2d; P450-2D"
                     /inference="alignment:Splign:2.1.0"
     exon            437..589
                     /gene="Cyp2d9"
                     /gene_synonym="Cyp2d; P450-2D"
                     /inference="alignment:Splign:2.1.0"
     exon            590..750
                     /gene="Cyp2d9"
                     /gene_synonym="Cyp2d; P450-2D"
                     /inference="alignment:Splign:2.1.0"
     exon            751..927
                     /gene="Cyp2d9"
                     /gene_synonym="Cyp2d; P450-2D"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1069
                     /gene="Cyp2d9"
                     /gene_synonym="Cyp2d; P450-2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1257
                     /gene="Cyp2d9"
                     /gene_synonym="Cyp2d; P450-2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1399
                     /gene="Cyp2d9"
                     /gene_synonym="Cyp2d; P450-2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1651
                     /gene="Cyp2d9"
                     /gene_synonym="Cyp2d; P450-2D"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttcctga tcctaggtgt tgtattgagt gttgttcatt ggtctctggg aagcctgggc
       61 agtagtgggg cagccatgga gctgctgact gggactgacc tgtggcctgt ggccatattc
      121 acagtcatct tcatattact ggtggacctg acccaccagc gccagcgctg gacttctcgt
      181 tacccaccag gccctgtgcc atggcctgta ctgggtaact tgctgcaggt ggacctaggt
      241 aacatgccat acagcttgta caagcttcaa aaccgctatg gtgacgtgtt cagcctacag
      301 atggcctgga agcctatggt tgtgatcaat ggactgaagg caatgaagga aatgctgttg
      361 acctgtggag aggacactgc tgaccgccct ccagtgccca tctttgagta cctgggtgtg
      421 aagcctggat cccaaggtgt ggtccttgca ccctacgggc ccgagtggcg agagcagagg
      481 cgattctctg tgtctaccct gcgcaacttt ggcctgggca agaaatcact ggaggactgg
      541 gtgaccaagg aggccaatca cctctgtgat gccttcaccg cccaggctgg gcagcccatc
      601 aatcccaacc ccatgctgaa caaatccacg tgcaatgtga ttgcatctct catttttgcc
      661 cgtcgctttg aatatgaaga ccctttcctc atcaggatgc tgaaagtact ggaacaaagt
      721 ttgacagaag tctctggctt aattcctgag gttcttaatg cattcccgat actcttgcgt
      781 atcccaaggc tggctgacaa ggccctccaa ggtcagaagt ccttcatcgc catactggat
      841 aacctgttga ctgagaatag gaccacctgg gaccctgtcc aagcaccccg aaatttgact
      901 gatgccttcc tggcagagat agagaaggcc aaagggaatc ctgagagcag cttcaatgat
      961 gagaacctgc tcatggtggt gcgtgacctg tttggtgcag ggatgctgac cacctcaacc
     1021 acattgtcct gggccctgat gctcatgatc ctgcatccag atgtgcagcg cagagtccaa
     1081 caagaaatcg atgaggtcat agggcaggtg aggcatccag agatggcaga ccaggcccac
     1141 atgccctaca ccaatgctgt cattcatgag gtgcagcgct ttggggacat tgttccagtg
     1201 aatttgccac gcatcacaag tcatgacatt gaagtgcagg acttcctcat ccccaagggg
     1261 acgatcctcc tccccaacat gtcctccatg ctgaaagatg agtctgtctg ggagaagccc
     1321 ctccgcttcc atcctgaaca cttcctggat gcccagggcc actttgtgaa gcctgaggcc
     1381 ttcatgccat tctcagcagg ccgcagatca tgcctggggg aggccctggc ccgcatggag
     1441 cttttcctct tcttcacctg cctcctgcag cgctttagct tctcagtgcc tgatggacag
     1501 ccccagccca gcaactctgg agtctatggt attcttgttg ccccctctcc ctaccagctc
     1561 tgtgctgtgg tacgagacca aggacactaa ttccagacat gctctgtagg gcagtttcct
     1621 gccatgtata ataaactagt cttgtgtctt c
//
