LOCUS       NP_076112                338 aa            linear   ROD 04-AUG-2023
DEFINITION  cytochrome P450, family 2, subfamily d, polypeptide 40 [Mus
            musculus].
ACCESSION   NP_076112 XP_001001912 XP_283309 XP_899740 XP_914900 XP_926530
VERSION     NP_076112.2
DBSOURCE    REFSEQ: accession NM_023623.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 338)
  AUTHORS   Ning M, Koh KH, Pan X and Jeong H.
  TITLE     Hepatocyte nuclear factor (HNF) 4alpha transactivation of
            cytochrome P450 (Cyp) 2d40 promoter is enhanced during pregnancy in
            mice
  JOURNAL   Biochem Pharmacol 94 (1), 46-52 (2015)
   PUBMED   25598084
  REMARK    GeneRIF: Cyp2d40 is induced during pregnancy through enhanced
            transactivation by HNF4alpha.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061152.1.
            
            On or before Jan 29, 2007 this sequence version replaced
            XP_899740.1, XP_283309.2, XP_914900.1, XP_926530.1, XP_001001912.1,
            NP_076112.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061152.1, BC087906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.71 cM"
     Protein         1..338
                     /product="cytochrome P450, family 2, subfamily d,
                     polypeptide 40"
                     /calculated_mol_wt=38349
     Region          <63..333
                     /region_name="cytochrome_P450"
                     /note="cytochrome P450 (CYP) superfamily; cl41757"
                     /db_xref="CDD:477761"
     Site            order(142..143,146..147,150..151,154,205,215,217,240,
                     276..278,282..286,289..290)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:410651"
     Site            order(142,145..146,150,213..216)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:410651"
     CDS             1..338
                     /gene="Cyp2d40"
                     /gene_synonym="1300013D18Rik; CYPIID3; P450-DB3"
                     /coded_by="NM_023623.2:13..1029"
                     /db_xref="CCDS:CCDS37162.1"
                     /db_xref="GeneID:71754"
                     /db_xref="MGI:MGI:1919004"
ORIGIN      
        1 melltgtdlw pvaiftvifi llvdllhrrq rwtsryppgp vpwpvlgnll qvdldnmpys
       61 fykvvkmfpi vlripgladk ifpgqktflt mvdklvtehk rtwdpdqppr dltdafmaem
      121 etakgnpess fneanlrlvv ldlfgggivt tsatltwall lmilhpdvqr rvqeeidevi
      181 gqarrpemad qarmpytnav ihevqrfadi apmtlphrts cdievqgfli pkgttlicnl
      241 ssvlkdetvw ekplrfypeh fldaqghfvk peafmpfsag rraclgeplv rmelflfftc
      301 llqrfsfsvp dgqplpsdyg iysmvvspap yqlcavvr
//
