LOCUS       NM_019823               2782 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily d, polypeptide 22
            (Cyp2d22), transcript variant 2, mRNA.
ACCESSION   NM_019823
VERSION     NM_019823.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2782)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2782)
  AUTHORS   Long,N., Tang,H., Lin,L., Li,J., Guo,L., Sun,F. and Dai,M.
  TITLE     Effects of infection of MRSA on the expression and activity of
            renal cytochrome P450s in mice
  JOURNAL   J Toxicol Sci 44 (4), 299-307 (2019)
   PUBMED   30944282
  REMARK    GeneRIF: Its mRNA expression is decreased by the high level of
            MRSA, but the low level of MRSA increased its expression.
REFERENCE   3  (bases 1 to 2782)
  AUTHORS   Yasukochi,Y. and Satta,Y.
  TITLE     Molecular evolution of the CYP2D subfamily in primates: purifying
            selection on substrate recognition sites without the frequent or
            long-tract gene conversion
  JOURNAL   Genome Biol Evol 7 (4), 1053-1067 (2015)
   PUBMED   25808902
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2782)
  AUTHORS   Singh,S., Singh,K., Patel,D.K., Singh,C., Nath,C., Singh,V.K.,
            Singh,R.K. and Singh,M.P.
  TITLE     The expression of CYP2D22, an ortholog of human CYP2D6, in mouse
            striatum and its modulation in 1-methyl
            4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease
            phenotype and nicotine-mediated neuroprotection
  JOURNAL   Rejuvenation Res 12 (3), 185-197 (2009)
   PUBMED   19594327
  REMARK    GeneRIF: CYP2D22 is expressed in mouse striatum and has a possible
            role in the MPTP-induced Parkinson's disease phenotype and
            nicotine-mediated neuroprotection
REFERENCE   5  (bases 1 to 2782)
  AUTHORS   Choudhary,D., Jansson,I., Schenkman,J.B., Sarfarazi,M. and
            Stoilov,I.
  TITLE     Comparative expression profiling of 40 mouse cytochrome P450 genes
            in embryonic and adult tissues
  JOURNAL   Arch Biochem Biophys 414 (1), 91-100 (2003)
   PUBMED   12745259
REFERENCE   6  (bases 1 to 2782)
  AUTHORS   Blume,N., Leonard,J., Xu,Z.J., Watanabe,O., Remotti,H. and
            Fishman,J.
  TITLE     Characterization of Cyp2d22, a novel cytochrome P450 expressed in
            mouse mammary cells
  JOURNAL   Arch Biochem Biophys 381 (2), 191-204 (2000)
   PUBMED   11032406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113593.14, BY297294.1, BX520002.1, AK090296.1, AC104325.28 and
            AW494268.1.
            
            On Jul 31, 2009 this sequence version replaced NM_019823.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR.
            Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.21048.1,
                                           SRR1660821.57630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC113593.14        75806-75810         c
            6-316               BY297294.1         1-311
            317-604             BX520002.1         284-571
            605-1052            AK090296.1         271-718
            1053-1054           AC104325.28        222068-222069       c
            1055-2765           AK090296.1         719-2429
            2766-2782           AW494268.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2782
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.57 cM"
     gene            1..2782
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /note="cytochrome P450, family 2, subfamily d, polypeptide
                     22"
                     /db_xref="GeneID:56448"
                     /db_xref="MGI:MGI:1929474"
     exon            1..183
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /inference="alignment:Splign:2.1.0"
     exon            184..432
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1746
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /note="cytochrome P450, 2d22"
                     /codon_start=1
                     /product="cytochrome P450, family 2, subfamily d,
                     polypeptide 22"
                     /protein_id="NP_062797.3"
                     /db_xref="CCDS:CCDS37159.1"
                     /db_xref="GeneID:56448"
                     /db_xref="MGI:MGI:1929474"
                     /translation="MRLPTGAELWPIAIFTVIFLILVNLMHWRQRWTAHYPPGPMPWP
                     VLGNLLHMDFQNMPAGFQKLRGRYGDLFSLQLASESVVVLNGLTALREALVKHSEDTA
                     DRPPLHFNDLLGFGPRSQGIVLARYGPAWRQQRRFSVSTMHHFGLGKKSLEQWVTEEA
                     RCLCAAFADHTGHPFSPNTLLDKAVCNVIASLLYACRFEYDDPRFIRLLGLLKETLKE
                     EAGFLPMFLNVFPMLLRIPGLVGKVFPGKRAFVTMLDELLAEHKTTWDPTQPPRDLTD
                     AFLAEVEKAKGNPESSFNDENLRTVVGDLFSAGMVTTSTTLSWALMLMILHPDVQRRV
                     QQEIDEVIGQVQCPEMADQARMPYTNAVIHEVQRFADILPLGVPHKTSRDIELQGFLI
                     PKGTTLITNLSSALKDETVWEKPLCFHPEHFLDAQGHFVKPEAFMPFSAGRRSCLGEP
                     LARMELFLFFTCLLQRFSISVPDGQPQPSDHGVFRALTTPCPYQLCALPR"
     exon            433..604
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /inference="alignment:Splign:2.1.0"
     exon            605..757
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /inference="alignment:Splign:2.1.0"
     exon            758..918
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1095
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1237
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1425
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1567
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..2766
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1796..1801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /note="hexamer: AATAAA"
     polyA_site      1821
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /note="major polyA site"
     regulatory      2740..2745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /note="hexamer: AATAAA"
     polyA_site      2766
                     /gene="Cyp2d22"
                     /gene_synonym="2D22"
                     /note="major polyA site"
ORIGIN      
        1 tcctcttcct cctccccgtc agaacgtgcc ctcctcttca gagttgctgc tcctcacaac
       61 tccccctcca cctcagagtg aatcctcctg agttgccctt tttcctcgag ctcctactcc
      121 tcctgttcct gcgaggctcc agacacctct tgcctctcct cggctgagtt tcagaacgca
      181 ccggtagctg gagttaggat tgagaagtgt ttccaaagaa acccaaagag cagccgggca
      241 gccatgagac tgccgaccgg ggctgaactg tggcccatag ccatattcac ggtcatcttc
      301 ctgattctgg tgaacctgat gcactggcgc cagcgctgga ctgcccacta ccctccaggc
      361 cctatgccgt ggcctgtgct tgggaacctg ctgcacatgg acttccagaa tatgccagca
      421 ggcttccaaa agctgcgggg tcgctatggg gacctgttca gcctacagct ggcctctgag
      481 tcagtggttg tactaaatgg gctgacggcc ctgcgagagg cactggtgaa acacagcgag
      541 gacactgctg accggccacc gctgcatttc aatgacctgc tgggctttgg accacgctct
      601 caaggtatag tcctagcacg gtatgggcct gcctggcgtc agcagcggcg cttctctgtg
      661 tctaccatgc accactttgg cctgggcaag aagtcactgg agcagtgggt gactgaggag
      721 gccagatgcc tctgtgccgc cttcgctgac catactggac accctttcag ccctaacacc
      781 ctattggaca aagcagtgtg taacgtgatc gcgtccctcc tctatgcctg ccgctttgag
      841 tacgatgacc cacgcttcat caggctactg ggcttgttga aggaaactct taaggaggaa
      901 gctggattcc tacccatgtt cctgaatgtg ttcccgatgc tcctgcgcat cccggggctg
      961 gttggcaagg tcttccctgg gaaaagggcc tttgttacca tgttggatga gctgctggct
     1021 gaacacaaga cgacctggga ccctacccag ccaccccgag atttgactga tgccttcctg
     1081 gctgaggtgg agaaggccaa ggggaatcct gagagcagct tcaatgatga gaacctgcgc
     1141 acggtagtgg gtgacctgtt ctctgcaggg atggtgacca cctcaaccac actgtcctgg
     1201 gccctgatgc tcatgatcct gcatccagat gtgcagcgcc gagtacaaca ggaaatcgat
     1261 gaagtcatag ggcaggtgca gtgtccagag atggcagacc aggctcgcat gccctacacc
     1321 aatgctgtca ttcatgaggt gcagcgcttt gcagacattc tccctcttgg tgtacctcac
     1381 aagacttctc gtgacattga actacagggc ttccttatcc ctaaggggac gaccctcatc
     1441 accaacctgt cctccgcgct aaaagatgag actgtctggg agaagcccct ctgcttccat
     1501 cctgaacact tcctggatgc ccagggccac tttgtgaagc ctgaggcctt catgccattc
     1561 tcagcaggcc gcagatcatg cctgggggag cccctggccc gcatggagct cttcctcttc
     1621 ttcacctgcc tcctgcagcg ctttagcatc tcagtgcccg atggacagcc ccagcccagc
     1681 gaccatggcg tctttagggc tctgacaacc ccatgcccct accagctctg tgctttgccc
     1741 cgctaagagg atgtatgaca tctcactcac tgtgcttgct ggggtcctaa tgtgcaataa
     1801 agcattttac tctaaactaa atcatcccta tgagatctcc tggctgtaag ggacctaggc
     1861 agccttccca tgagcatcca ctttccctgc ttattctgac ttgactattt gaccccagta
     1921 gaaggactgc cctgtcagaa atgataccat tcttgccttt acccttcccc cactttttcc
     1981 ctcaaattga taatgtttat acatagatgc caacgtctgg aaggatggcc agaagggact
     2041 gctaagatgt gacagtgtaa gttacataga tgaaggaagg gcaggacctc tctctcctag
     2101 atgcccccat ttcagaccta ccacacaacc aagactagct gcttagccag catcatcaca
     2161 acgtcttata tggcatcccc aaagatgtag agaagtccgg gaagctggaa atgatatgca
     2221 ggttaagtgc ctaaggtttc ctgttgggta ccacatgctt ctctaaaagg ctttaaggga
     2281 gtccagaagc aggggtttac ctcctaagct tctttgtcaa cactaactcc atgacccaac
     2341 agggatactg ttgtccaggc ccatgcccag taagaaagtg cctctgtaac cagggttggt
     2401 aggacctgca agcttgatgt tgaaacaggc tcccagacct tagaaagtcc tcagacctta
     2461 gcacagctga gtccatgatg gaagtaccat aaaactctgc acatagacag cagttcctgt
     2521 cataatgaaa acaaagacct aatccatcaa attccatagt tctgggaaag tccctaaaag
     2581 tagtaatctt gctttttgac ttcgatagtt cttctagcta actgttcttg ctaactgaag
     2641 tgtgtcaata catgatatag ttgttggtaa aagctcaccc tgagtacagc tcaggactat
     2701 actgggattc tgagcaccca gtgttgtcac cagccagcta ataaagcttc tattggctta
     2761 aatctaaaaa aaaaaaaaaa aa
//
