LOCUS       NM_028089               1989 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily c, polypeptide 55
            (Cyp2c55), mRNA.
ACCESSION   NM_028089
VERSION     NM_028089.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1989)
  AUTHORS   Hilman,A., Sato,T., Wijatniko,B.D., Fujimura,S., Nakamura,K.,
            Miura,H., Iwatsuki,K., Inoue,R. and Suzuki,T.
  TITLE     The expression of intestinal Cyp2c55 is regulated by the microbiota
            and inflammation
  JOURNAL   FASEB J 38 (20), e70117 (2024)
   PUBMED   39432326
  REMARK    GeneRIF: The expression of intestinal Cyp2c55 is regulated by the
            microbiota and inflammation.
REFERENCE   2  (bases 1 to 1989)
  AUTHORS   Wei,L., Zheng,Y.Y., Sun,J., Wang,P., Tao,T., Li,Y., Chen,X.,
            Sang,Y., Chong,D., Zhao,W., Zhou,Y., Wang,Y., Jiang,Z., Qiu,T.,
            Li,C.J., Zhu,M.S. and Zhang,X.
  TITLE     GGPP depletion initiates metaflammation through disequilibrating
            CYB5R3-dependent eicosanoid metabolism
  JOURNAL   J Biol Chem 295 (47), 15988-16001 (2020)
   PUBMED   32913122
REFERENCE   3  (bases 1 to 1989)
  AUTHORS   Chen,S., Lu,W., Yueh,M.F., Rettenmeier,E., Liu,M., Paszek,M.,
            Auwerx,J., Yu,R.T., Evans,R.M., Wang,K., Karin,M. and Tukey,R.H.
  TITLE     Intestinal NCoR1, a regulator of epithelial cell maturation,
            controls neonatal hyperbilirubinemia
  JOURNAL   Proc Natl Acad Sci U S A 114 (8), E1432-E1440 (2017)
   PUBMED   28167773
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4115. doi:
            10.1073/pnas.1705671114.. Paszek, Miles [added]. PMID: 28484028]
REFERENCE   4  (bases 1 to 1989)
  AUTHORS   Scheer,N., Kapelyukh,Y., Chatham,L., Rode,A., Buechel,S. and
            Wolf,C.R.
  TITLE     Generation and characterization of novel cytochrome P450 Cyp2c gene
            cluster knockout and CYP2C9 humanized mouse lines
  JOURNAL   Mol Pharmacol 82 (6), 1022-1029 (2012)
   PUBMED   22918969
REFERENCE   5  (bases 1 to 1989)
  AUTHORS   van Waterschoot,R.A., Rooswinkel,R.W., Wagenaar,E., van der
            Kruijssen,C.M., van Herwaarden,A.E. and Schinkel,A.H.
  TITLE     Intestinal cytochrome P450 3A plays an important role in the
            regulation of detoxifying systems in the liver
  JOURNAL   FASEB J 23 (1), 224-231 (2009)
   PUBMED   18794335
  REMARK    GeneRIF: The mechanism of regulation of CYP2C55 and other
            detoxifying systems in Cyp3a(-/-) mice is reported.
REFERENCE   6  (bases 1 to 1989)
  AUTHORS   Wang,H., Zhao,Y., Bradbury,J.A., Graves,J.P., Foley,J.,
            Blaisdell,J.A., Goldstein,J.A. and Zeldin,D.C.
  TITLE     Cloning, expression, and characterization of three new mouse
            cytochrome p450 enzymes and partial characterization of their fatty
            acid oxidation activities
  JOURNAL   Mol Pharmacol 65 (5), 1148-1158 (2004)
   PUBMED   15102943
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC100729.21.
            
            On Apr 30, 2007 this sequence version replaced NM_028089.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008580.1, BC010824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC100729.21        50096-50290
            196-358             AC100729.21        54097-54259
            359-508             AC100729.21        54767-54916
            509-669             AC100729.21        61720-61880
            670-846             AC100729.21        74339-74515
            847-988             AC100729.21        77316-77457
            989-1176            AC100729.21        78522-78709
            1177-1318           AC100729.21        81177-81318
            1319-1989           AC100729.21        85094-85764
FEATURES             Location/Qualifiers
     source          1..1989
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 33.64 cM"
     gene            1..1989
                     /gene="Cyp2c55"
                     /gene_synonym="2010318C06Rik; CYPIIC55"
                     /note="cytochrome P450, family 2, subfamily c, polypeptide
                     55"
                     /db_xref="GeneID:72082"
                     /db_xref="MGI:MGI:1919332"
     exon            1..195
                     /gene="Cyp2c55"
                     /gene_synonym="2010318C06Rik; CYPIIC55"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1500
                     /gene="Cyp2c55"
                     /gene_synonym="2010318C06Rik; CYPIIC55"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, 2c55"
                     /codon_start=1
                     /product="cytochrome P450 2C55"
                     /protein_id="NP_082365.1"
                     /db_xref="CCDS:CCDS29790.1"
                     /db_xref="GeneID:72082"
                     /db_xref="MGI:MGI:1919332"
                     /translation="MDPVLVLVLTLSCLLLLSLWRQNSGRGKLPPGPTPFPIIGNILQ
                     IDIKNISKSFNYFSKVYGPVFTLYFGSKPTVVVHGYEAVKEALDDLGEEFSGRGSFQI
                     FERINNDLGVIFSNGTKWKELRRFSIMTLRSFGMGKRSIEDRIQEEASCLVEELRKAN
                     GSLCDPTFILSCAPSNVICSVIFHNRFDYKDEKFLNLMERLNENFKILNSPWMQVYNA
                     LPTLINYLPGSHNKVIKNFTEIKSYILGRVKEHQETLDMDNPRDFIDCFLIKMEQEKH
                     NPHSEFTIESLMATVTDIFVAGTETTNITLRYGLLLLLKHTEVTAKVQAEIDHVIGRH
                     RSPCMQDRTRMPYTDAMVHEIQRYIDLIPNNVPHAATCNVRFRSYFIPKGTELVTSLT
                     SVLHDDKEFPNPEVFDPGHFLDENGNFKKSDYFMPFSIGKRMCVGEALARTELFLILT
                     TILQNFNLKSLVDTKDIDTTPVANTFGRVPPSYQLYFIPR"
     exon            196..358
                     /gene="Cyp2c55"
                     /gene_synonym="2010318C06Rik; CYPIIC55"
                     /inference="alignment:Splign:2.1.0"
     exon            359..508
                     /gene="Cyp2c55"
                     /gene_synonym="2010318C06Rik; CYPIIC55"
                     /inference="alignment:Splign:2.1.0"
     exon            509..669
                     /gene="Cyp2c55"
                     /gene_synonym="2010318C06Rik; CYPIIC55"
                     /inference="alignment:Splign:2.1.0"
     exon            670..846
                     /gene="Cyp2c55"
                     /gene_synonym="2010318C06Rik; CYPIIC55"
                     /inference="alignment:Splign:2.1.0"
     exon            847..988
                     /gene="Cyp2c55"
                     /gene_synonym="2010318C06Rik; CYPIIC55"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1176
                     /gene="Cyp2c55"
                     /gene_synonym="2010318C06Rik; CYPIIC55"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1318
                     /gene="Cyp2c55"
                     /gene_synonym="2010318C06Rik; CYPIIC55"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1989
                     /gene="Cyp2c55"
                     /gene_synonym="2010318C06Rik; CYPIIC55"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtctccct gagaagagaa agctgccatg gatccagtcc tggtcctggt gctcactctc
       61 tcctgtctgc ttctcctctc cctctggaga caaaactctg ggagagggaa gctccctcct
      121 ggccccaccc ctttcccaat tattggaaac atccttcaga tagatataaa gaacatcagc
      181 aaatccttca actatttctc aaaagtctat ggccccgtgt tcactctgta ctttggttca
      241 aagcctactg tggtggtaca tggatatgaa gcagtaaagg aagctctgga tgaccttgga
      301 gaggagtttt ctgggagggg tagttttcaa atttttgaaa gaataaataa tgatctgggg
      361 gtgattttca gcaatggaac aaaatggaag gagcttcggc gcttctcaat catgaccttg
      421 aggagttttg ggatggggaa gaggagcatc gaggatcgca ttcaagagga agcatcctgt
      481 cttgtggaag agctaagaaa agcaaatggt tcactctgtg atcccacatt catcctgagc
      541 tgtgctccct ccaatgtgat ctgttcagtt attttccaca atcgttttga ttataaagat
      601 gagaagtttc ttaacttgat ggagagactc aatgaaaact ttaaaatctt gaactcccca
      661 tggatgcagg tctacaatgc tctgcctacc ctcatcaatt atctcccagg gagtcataac
      721 aaagtaatta aaaattttac tgaaataaaa agttacattt tggggcgagt gaaagaacac
      781 caggaaacac tggacatgga caatcctcgg gacttcattg actgcttcct gatcaaaatg
      841 gaacaggaaa aacacaatcc ccattcggag tttactattg aaagcttgat ggccactgta
      901 accgacatat ttgtagctgg aacagaaacc acaaacatta ctctaagata tggactcttg
      961 ctcctactga aacacacaga ggtcacagct aaagtccagg cagagatcga tcacgtgatt
     1021 ggcagacaca ggagcccctg catgcaggac agaacccgca tgccctacac agatgccatg
     1081 gtacatgaga ttcagagata cattgacctc atccccaaca atgtgcccca tgcagctacc
     1141 tgtaatgtta gattcagaag ttacttcatc cccaagggca cagagttagt aacatcactg
     1201 acttctgtgc tgcatgatga caaagaattt cccaacccag aagtatttga ccctggccat
     1261 tttctggatg agaatgggaa ctttaagaag agtgactact ttatgccttt ctcaatagga
     1321 aagcgaatgt gcgtgggaga ggccctggct cgcacggagc tgtttttgat tctgaccacc
     1381 attttacaga attttaacct gaaatctttg gttgatacaa aggacattga cactactcca
     1441 gtggccaata cttttggccg tgtaccacct tcataccagc tgtacttcat tcctcgttaa
     1501 agcagaacac actggctgtt gctatgctgg tatctctgac ttctcaggga gcagtctcca
     1561 tatcctgtca actattaggg acatctctct cactactcct ctcacatctt ttcattctcc
     1621 cacaatccag tcatcatcca tctttgttta agaagatttt ccagagttac catgcagatc
     1681 catcctctgt cctcttcagt ctacaacact tatatcgaca gtactaagac atgtactgtg
     1741 tcactaatat gttaaaagtg taatacagac gaggtcaact gagagccatc tatgctttgc
     1801 ttgactcaaa gtaaaaggag ttattaactg aagagtcatt tttcaggttt cttttttaac
     1861 acataattcg tataaagagt gaaaaagtaa ggttagtatt gaaatgcata atatgatatc
     1921 atcttttacc tatttgaatg tggatttgta aattaaaatg aaactgaaaa taaaagaatt
     1981 ggtaataag
//
