LOCUS       NM_134144               1834 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily c, polypeptide 50
            (Cyp2c50), transcript variant 1, mRNA.
ACCESSION   NM_134144
VERSION     NM_134144.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1834)
  AUTHORS   Zhang,D., Zhao,Y., Zhang,G., Lank,D., Cooke,S., Wang,S.,
            Nuotio-Antar,A., Tong,X. and Yin,L.
  TITLE     Suppression of hepatic ChREBP-CYP2C50 axis-driven fatty acid
            oxidation sensitizes mice to diet-induced MASLD/MASH
  JOURNAL   Mol Metab 85, 101957 (2024)
   PUBMED   38740087
  REMARK    GeneRIF: Suppression of hepatic ChREBP-CYP2C50 axis-driven fatty
            acid oxidation sensitizes mice to diet-induced MASLD/MASH.
REFERENCE   2  (bases 1 to 1834)
  AUTHORS   Kasai,F., Yoshihara,M., Matsukuma,S., O'Brien,P. and
            Ferguson-Smith,M.A.
  TITLE     Emergence of complex rearrangements at translocation breakpoints in
            a transgenic mouse; implications for mechanisms involved in the
            formation of chromosome rearrangements
  JOURNAL   Cytogenet Genome Res 119 (1-2), 83-90 (2007)
   PUBMED   18160786
REFERENCE   3  (bases 1 to 1834)
  AUTHORS   Wang,H., Zhao,Y., Bradbury,J.A., Graves,J.P., Foley,J.,
            Blaisdell,J.A., Goldstein,J.A. and Zeldin,D.C.
  TITLE     Cloning, expression, and characterization of three new mouse
            cytochrome p450 enzymes and partial characterization of their fatty
            acid oxidation activities
  JOURNAL   Mol Pharmacol 65 (5), 1148-1158 (2004)
   PUBMED   15102943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY086770.1, AY206873.1, AC148014.3 and AW111073.1.
            
            On Nov 18, 2009 this sequence version replaced NM_134144.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011222.1, AY206873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BY086770.1         4-24
            22-1163             AY206873.1         1-1142
            1164-1164           AC148014.3         164950-164950
            1165-1393           AY206873.1         1144-1372
            1394-1834           AW111073.1         1-441               c
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.24 cM"
     gene            1..1834
                     /gene="Cyp2c50"
                     /note="cytochrome P450, family 2, subfamily c, polypeptide
                     50"
                     /db_xref="GeneID:107141"
                     /db_xref="MGI:MGI:2147497"
     exon            1..189
                     /gene="Cyp2c50"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1494
                     /gene="Cyp2c50"
                     /EC_number="1.14.14.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytochrome P450, 2c50; cytochrome P450 2C50; CYPIIC50"
                     /codon_start=1
                     /product="cytochrome P450 2C50 isoform 1"
                     /protein_id="NP_598905.2"
                     /db_xref="CCDS:CCDS29801.1"
                     /db_xref="GeneID:107141"
                     /db_xref="MGI:MGI:2147497"
                     /translation="MDPILVLVFTLSCLFLLSLWRQSSERGKLPPGPTPLPIIGNILQ
                     INVKDICQSFTNLSKVYGPVYTLYLGRKPTVVLHGYEAVKEALVDHGEEFAGRGRLPV
                     FDKATNGMGIIFSKGNVWKNTRRFSLTTLRNLGMGKRSIEDRVQEEARCLVEELRKTN
                     GSPCDPTFILGCAPCNVICSIIFQDRFDYKDRDFLNLMEKLNEITKIMSTPWLQVCNT
                     FPVLLDYCPGSHNKVFKNYACIKNFLLEKIKEHEESLDVTIPRDFIDYFLINGGQENG
                     NYPLKNRLEHLAITVTDLFSAGTETTSTTLRYALLLLLKYPHVTAKVQEEIEHVIGKH
                     RRPCMQDRSHMPYTDAMIHEVQRFIDLVPNSLPHEVTCDIKFRNYFIPKGTNVITSLS
                     SVLRDSKEFPNPEKFDPGHFLDENGKFKKSDYFMPFSTGKRICAGEGLARMELFLFLT
                     SILQNFNLKPLVHPKDIDVTPMLIGLASVPPAFQLCFIPS"
     exon            190..352
                     /gene="Cyp2c50"
                     /inference="alignment:Splign:2.1.0"
     exon            353..502
                     /gene="Cyp2c50"
                     /inference="alignment:Splign:2.1.0"
     exon            503..663
                     /gene="Cyp2c50"
                     /inference="alignment:Splign:2.1.0"
     exon            664..840
                     /gene="Cyp2c50"
                     /inference="alignment:Splign:2.1.0"
     exon            841..982
                     /gene="Cyp2c50"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1170
                     /gene="Cyp2c50"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1312
                     /gene="Cyp2c50"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1834
                     /gene="Cyp2c50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1808..1813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2c50"
                     /note="hexamer: AATAAA"
     polyA_site      1830
                     /gene="Cyp2c50"
                     /note="major polyA site"
ORIGIN      
        1 gtgtcagtaa gaagaatctc catggatcca atcctggtcc tggtgttcac cctctcctgt
       61 ctgtttctcc tctcactctg gagacagagc tctgaaaggg ggaagctccc tcctggcccc
      121 actcctcttc caattattgg aaatatcctt cagatcaatg tgaaggacat ctgccaatcc
      181 ttcaccaatt tatcaaaagt ttatggccct gtgtatactc tatatttggg caggaagccc
      241 actgtggtgt tgcatggata tgaggcagtg aaggaagctc tggttgacca tggggaggag
      301 tttgctggaa gaggaaggct cccagttttt gataaagcta ctaatggaat gggcattata
      361 tttagtaaag gaaatgtatg gaaaaacaca aggcgcttct cactcacgac tctgcggaat
      421 ttaggcatgg gaaaaaggag cattgaggac cgtgttcaag aggaagcacg ttgccttgtg
      481 gaggaactta ggaaaaccaa tggctcaccc tgtgatccca ccttcatcct gggctgtgct
      541 ccctgcaatg tcatctgctc aattattttc caggatcgtt ttgattataa agatcgggat
      601 tttcttaatt tgatggaaaa actgaatgaa ataaccaaga taatgagcac cccttggttg
      661 caggtttgca atacatttcc tgttctgctt gattattgtc caggaagtca taacaaagtt
      721 tttaaaaatt atgcttgtat taaaaatttc cttttggaga aaataaaaga acatgaagaa
      781 tcattggatg ttacaattcc tcgggacttt attgattatt tcctaattaa tggaggccag
      841 gaaaacggca actatccatt gaaaaatagg cttgaacacc tggcaataac agtgactgat
      901 cttttttctg ctgggacaga gacaacaagc acaacactga gatatgctct cctactcctg
      961 ttgaagtacc cacatgtcac agctaaagtc caggaagaaa ttgagcatgt gatcggcaag
     1021 caccgaagac catgcatgca ggacaggagc cacatgccct atactgatgc catgattcat
     1081 gaggtccaga gattcattga ccttgtcccc aacagcctgc cccatgaagt gacctgtgac
     1141 attaaattca ggaactactt catccccaag gggacaaatg taataacatc actgtcatca
     1201 gtgctgcgtg atagcaaaga gttccccaac ccagagaagt ttgaccctgg gcactttcta
     1261 gatgagaacg gaaagtttaa gaaaagtgac tacttcatgc ccttctcaac aggaaaacgg
     1321 atatgtgcag gagaaggcct ggcacgcatg gagctgttcc tattcctaac cagcatttta
     1381 cagaacttca acctgaaacc tctggttcac ccaaaggaca tagatgtaac cccaatgctc
     1441 attggattgg cctcagtgcc tcctgctttc cagctctgct tcattccttc ctgaaaatca
     1501 aatgcctggc tccagctggg acatcttctg tgatcaccct gaggctttaa ttcactactt
     1561 tccacactgg acacactgct ttttatccat ttcttttgcc tgctcataat ttcataaggt
     1621 tctatgaaca tacatttacc aatttgcaga tcctgcacaa atatttctga ctggtcctat
     1681 tttctgaaac actgttacca tatgctgtga tgatatggac ctgattccaa gttaaatata
     1741 ctctcataaa attgaaatta ctattgtaag ataattcact gtcgcttctc ttctgcattt
     1801 tcttaataat aaattctttt ggtataacta ttct
//
