LOCUS       NM_010004               1801 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily c, polypeptide 40
            (Cyp2c40), mRNA.
ACCESSION   NM_010004 NM_134143 XM_917497 XM_924979 XM_924980 XM_924982
            XM_924983
VERSION     NM_010004.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1801)
  AUTHORS   Creasy,K.T., Jiang,J., Ren,H., Peterson,M.L. and Spear,B.T.
  TITLE     Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic
            Cyp Gene Expression in the Adult Mouse Liver
  JOURNAL   Gene Expr 17 (1), 7-17 (2016)
   PUBMED   27197076
REFERENCE   2  (bases 1 to 1801)
  AUTHORS   Kasai,F., Yoshihara,M., Matsukuma,S., O'Brien,P. and
            Ferguson-Smith,M.A.
  TITLE     Emergence of complex rearrangements at translocation breakpoints in
            a transgenic mouse; implications for mechanisms involved in the
            formation of chromosome rearrangements
  JOURNAL   Cytogenet Genome Res 119 (1-2), 83-90 (2007)
   PUBMED   18160786
REFERENCE   3  (bases 1 to 1801)
  AUTHORS   Ghazalpour,A., Doss,S., Zhang,B., Wang,S., Plaisier,C.,
            Castellanos,R., Brozell,A., Schadt,E.E., Drake,T.A., Lusis,A.J. and
            Horvath,S.
  TITLE     Integrating genetic and network analysis to characterize genes
            related to mouse weight
  JOURNAL   PLoS Genet 2 (8), e130 (2006)
   PUBMED   16934000
REFERENCE   4  (bases 1 to 1801)
  AUTHORS   Wang,S., Yehya,N., Schadt,E.E., Wang,H., Drake,T.A. and Lusis,A.J.
  TITLE     Genetic and genomic analysis of a fat mass trait with complex
            inheritance reveals marked sex specificity
  JOURNAL   PLoS Genet 2 (2), e15 (2006)
   PUBMED   16462940
REFERENCE   5  (bases 1 to 1801)
  AUTHORS   Choudhary,D., Jansson,I., Schenkman,J.B., Sarfarazi,M. and
            Stoilov,I.
  TITLE     Comparative expression profiling of 40 mouse cytochrome P450 genes
            in embryonic and adult tissues
  JOURNAL   Arch Biochem Biophys 414 (1), 91-100 (2003)
   PUBMED   12745259
REFERENCE   6  (bases 1 to 1801)
  AUTHORS   Tsao,C.C., Foley,J., Coulter,S.J., Maronpot,R., Zeldin,D.C. and
            Goldstein,J.A.
  TITLE     CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major
            CYP2C in murine intestinal tract
  JOURNAL   Mol Pharmacol 58 (2), 279-287 (2000)
   PUBMED   10908295
REFERENCE   7  (bases 1 to 1801)
  AUTHORS   Luo,G., Zeldin,D.C., Blaisdell,J.A., Hodgson,E. and Goldstein,J.A.
  TITLE     Cloning and expression of murine CYP2Cs and their ability to
            metabolize arachidonic acid
  JOURNAL   Arch Biochem Biophys 357 (1), 45-57 (1998)
   PUBMED   9721182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121935.3.
            
            On Mar 8, 2019 this sequence version replaced NM_010004.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF047727.1, BC139471.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AC121935.3         11899-12158
            261-423             AC121935.3         17036-17198
            424-573             AC121935.3         17398-17547
            574-734             AC121935.3         20783-20943
            735-911             AC121935.3         22057-22233
            912-1053            AC121935.3         37813-37954
            1054-1241           AC121935.3         46612-46799
            1242-1383           AC121935.3         50748-50889
            1384-1801           AC121935.3         57223-57640
FEATURES             Location/Qualifiers
     source          1..1801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.24 cM"
     gene            1..1801
                     /gene="Cyp2c40"
                     /note="cytochrome P450, family 2, subfamily c, polypeptide
                     40"
                     /db_xref="GeneID:13099"
                     /db_xref="MGI:MGI:1306815"
     exon            1..260
                     /gene="Cyp2c40"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1568
                     /gene="Cyp2c40"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450 2C40; CYPIIC40; cytochrome P450,
                     2c40"
                     /codon_start=1
                     /product="cytochrome P450 2C40 precursor"
                     /protein_id="NP_034134.3"
                     /db_xref="CCDS:CCDS29798.3"
                     /db_xref="GeneID:13099"
                     /db_xref="MGI:MGI:1306815"
                     /translation="MDPFVVLVLCLSFLLVLSLWRQRSARGNLPPGPTPLPIIGNYHL
                     IDMKDIGQCLTNFSKTYGPVFTLYFGSQPIVVLHGYEAIKEALIDHGEEFSGRGRIPV
                     FDKVSTGKGIGFSHGNVWKATRVFTVNTLRNLGMGKRTIENKVQEEAQWLMKELKKTN
                     GSPCDPQFIIGCAPCNVICSIVFQNRFDYKDKDFLSLIGKVNECTEILSSPGCQIFNA
                     VPILIDYCPGSHNKLFKNHTWIKSYLLGKIKEHEESLDVTNPRDFIDYFLIQRRQKNG
                     IEHMDYTIEHLATLVTDLVFGGTETLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRH
                     RSPCMQDRNHMPYTNAMVHEVQRYIDLGPNGVVHEVTCDTKFRNYFIPKGTQVMTSLT
                     SVLHDSTEFPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGKRICVGESLARMELFLFLT
                     TILQNFKLKPLVDPKDIDMTPKHSGFSKIPPNFQMCFIPVE"
     exon            261..423
                     /gene="Cyp2c40"
                     /inference="alignment:Splign:2.1.0"
     exon            424..573
                     /gene="Cyp2c40"
                     /inference="alignment:Splign:2.1.0"
     exon            574..734
                     /gene="Cyp2c40"
                     /inference="alignment:Splign:2.1.0"
     exon            735..911
                     /gene="Cyp2c40"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1053
                     /gene="Cyp2c40"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1241
                     /gene="Cyp2c40"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1383
                     /gene="Cyp2c40"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1801
                     /gene="Cyp2c40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1782..1787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2c40"
                     /note="hexamer: ATTAAA"
     polyA_site      1801
                     /gene="Cyp2c40"
                     /note="major polyA site"
ORIGIN      
        1 caaagatgcc caaacgcaaa atattgattt gcgaatgctg tataaagtgt ctggagtgcc
       61 tgatcatacc agtgtcagta agaagggtct ccatggatcc atttgtagtc ttggtgcttt
      121 gtctgtcctt tctgcttgtc ctgtcattgt ggagacagag atctgcaaga gggaacctcc
      181 ctcctggccc tactcctctc ccaattattg gaaattacca cctgatagat atgaaggaca
      241 ttgggcagtg ccttaccaat ttttctaaaa catatggccc tgtgttcact ctgtattttg
      301 gctcacagcc tattgtggta ttacatggtt atgaggcaat taaagaagcc ctcattgacc
      361 atggagaaga gttctctgga agaggaagga ttccggtttt tgacaaggtt tctacaggaa
      421 agggcattgg ttttagccat ggaaatgtat ggaaagccac aagggtcttc acagtgaata
      481 ccttgaggaa cttgggcatg ggaaaaagga ccattgagaa caaagtgcaa gaggaagcac
      541 agtggctcat gaaggaactg aagaaaacaa atggctcacc ctgtgatccc caattcatca
      601 taggatgtgc tccctgcaat gtcatctgct ccattgtttt ccagaatcgt ttcgattata
      661 aggataagga ttttcttagc ttgataggaa aagtgaatga atgcactgaa attttgagct
      721 ctcctgggtg tcagattttc aatgcagtcc ctattcttat tgattattgt ccaggaagtc
      781 ataataaact ttttaaaaat catacatgga ttaagagcta tcttttgggg aaaataaaag
      841 aacatgaaga atcattggat gttacaaatc ctcgggactt cattgattac ttcctaattc
      901 aaagacgtca gaaaaatggc attgagcaca tggactatac cattgaacac ctggcaacat
      961 tggtgactga tctggttttt ggtgggacag agaccttaag ctcaacgatg agatttgctc
     1021 tcctgctctt gatgaagcac acacacatca cagctaaagt ccaggaagag attgacaatg
     1081 tgattgggag acaccgcagc ccctgtatgc aggacaggaa ccacatgcct tacacaaatg
     1141 ccatggtgca tgaggtccag cggtacattg accttggccc aaatggtgtg gtgcatgaag
     1201 taacctgtga cactaagttc agaaactact tcatccccaa gggaacacag gtaatgacat
     1261 cactgacatc agtgctgcat gacagcacgg agttccccaa cccagaggtg tttgaccctg
     1321 gccactttct agatgacaat ggaaacttta agaaaagtga ctacttcgtg cctttctcag
     1381 caggaaaacg gatttgtgtg ggagagagcc ttgcccgcat ggagctgttt ctattcctga
     1441 ccaccatttt acagaatttc aaactgaaac ctctggttga tccaaaggac atcgatatga
     1501 cccccaaaca ttctggattt tctaaaattc ctcccaattt ccagatgtgc tttatccctg
     1561 tggaatgaag atgataaaat agaagtgaag atgatgaaag cttctgctat gctgtttttc
     1621 tcaatcaccc acggaagccc tcatttaacc cagtcccaga aattccatct atattccttc
     1681 ttatcccagc ttctgttctc taattgccca aggctaacag ttctctatta tatagtttct
     1741 gaagtcaatg taaaaaatcc tgaaggataa aatcattgca aattaaagga ttcaactatg
     1801 a
//
