LOCUS       NM_010003               1857 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily c, polypeptide 39
            (Cyp2c39), transcript variant 1, mRNA.
ACCESSION   NM_010003
VERSION     NM_010003.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1857)
  AUTHORS   Kawamura,T., Ichikawa,M., Hatogai,J., Koyama,Y., Tachibana,M.,
            Kuwahara,M., Negishi,K., Matsumoto,M., Miyazaki,M. and Ochiai,W.
  TITLE     Mouse Cyp2c expression and zonation structure in the liver begins
            in the early neonatal stage
  JOURNAL   Biopharm Drug Dispos 43 (4), 130-139 (2022)
   PUBMED   35748067
REFERENCE   2  (bases 1 to 1857)
  AUTHORS   Boj,S.F., van Es,J.H., Huch,M., Li,V.S., Jose,A., Hatzis,P.,
            Mokry,M., Haegebarth,A., van den Born,M., Chambon,P., Voshol,P.,
            Dor,Y., Cuppen,E., Fillat,C. and Clevers,H.
  TITLE     Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic
            response to perinatal and adult metabolic demand
  JOURNAL   Cell 151 (7), 1595-1607 (2012)
   PUBMED   23260145
REFERENCE   3  (bases 1 to 1857)
  AUTHORS   Meng,X.Y., Zheng,Q.C. and Zhang,H.X.
  TITLE     A comparative analysis of binding sites between mouse CYP2C38 and
            CYP2C39 based on homology modeling, molecular dynamics simulation
            and docking studies
  JOURNAL   Biochim Biophys Acta 1794 (7), 1066-1072 (2009)
   PUBMED   19358898
  REMARK    GeneRIF: By comparison of active site architectures between CYP2C38
            and CYP2C39, the possible reasons affecting their substrate binding
            were proposed
REFERENCE   4  (bases 1 to 1857)
  AUTHORS   Zhang,M., Hu,P., Krois,C.R., Kane,M.A. and Napoli,J.L.
  TITLE     Altered vitamin A homeostasis and increased size and adiposity in
            the rdh1-null mouse
  JOURNAL   FASEB J 21 (11), 2886-2896 (2007)
   PUBMED   17435174
REFERENCE   5  (bases 1 to 1857)
  AUTHORS   Kasai,F., Yoshihara,M., Matsukuma,S., O'Brien,P. and
            Ferguson-Smith,M.A.
  TITLE     Emergence of complex rearrangements at translocation breakpoints in
            a transgenic mouse; implications for mechanisms involved in the
            formation of chromosome rearrangements
  JOURNAL   Cytogenet Genome Res 119 (1-2), 83-90 (2007)
   PUBMED   18160786
REFERENCE   6  (bases 1 to 1857)
  AUTHORS   Andreola,F., Hayhurst,G.P., Luo,G., Ferguson,S.S., Gonzalez,F.J.,
            Goldstein,J.A. and De Luca,L.M.
  TITLE     Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its
            down-regulation offers a molecular basis for liver retinoid
            accumulation and fibrosis in aryl hydrocarbon receptor-null mice
  JOURNAL   J Biol Chem 279 (5), 3434-3438 (2004)
   PUBMED   14623888
  REMARK    GeneRIF: CYP2C39 is a novel retinoic acid 4-hydroxylase
REFERENCE   7  (bases 1 to 1857)
  AUTHORS   Luo,G., Zeldin,D.C., Blaisdell,J.A., Hodgson,E. and Goldstein,J.A.
  TITLE     Cloning and expression of murine CYP2Cs and their ability to
            metabolize arachidonic acid
  JOURNAL   Arch Biochem Biophys 357 (1), 45-57 (1998)
   PUBMED   9721182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139233.10 and AC117790.23.
            
            On Jun 30, 2009 this sequence version replaced NM_010003.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF047726.1, BC139291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC139233.10        1500-1716           c
            218-380             AC117790.23        108069-108231       c
            381-530             AC117790.23        107755-107904       c
            531-691             AC117790.23        84508-84668         c
            692-868             AC117790.23        82374-82550         c
            869-1010            AC117790.23        60404-60545         c
            1011-1198           AC117790.23        57391-57578         c
            1199-1340           AC117790.23        54376-54517         c
            1341-1857           AC117790.23        52875-53391         c
FEATURES             Location/Qualifiers
     source          1..1857
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.15 cM"
     gene            1..1857
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /note="cytochrome P450, family 2, subfamily c, polypeptide
                     39"
                     /db_xref="GeneID:13098"
                     /db_xref="MGI:MGI:1306818"
     exon            1..217
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1522
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /EC_number="1.14.14.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cytochrome P450 2C39; cytochrome P450, 2c39"
                     /codon_start=1
                     /product="cytochrome P450 2C39 isoform 1 precursor"
                     /protein_id="NP_034133.2"
                     /db_xref="CCDS:CCDS29795.1"
                     /db_xref="GeneID:13098"
                     /db_xref="MGI:MGI:1306818"
                     /translation="MDLVTFLVLTLSSLILLSLWRQSCGRGSLPPGPTPFPIIGNFLQ
                     IDIKNVSQSLTNFSKAYGPVFTLYLGSRPTVVLHGYEAVKEALIDHGEEFSDRGSIPM
                     VEKINNGLGIVFSNGNRWKEIRRFTLTTLRNLGMGKRNIEDRVQEEAQCLVEELRKTK
                     GSPCDPTFILSCAPCNVICSIIFQDRFDYKDKDFLMLMEKLNENVKILSSPWLQVCNN
                     FPLLIDYCPGSHHKVLKNVKYIRSYLLEKIKEHQESLDVTNPRDFIDYYLIKQKQANH
                     IQQAEFSLENLACTINNLFAAGTETTSTTLRYALLLLMKYPDVTAKVQEEIDHVIGRH
                     RSPCMQDRNHMPYTDAMIHEVQRFINLVPNNIPRAVTCDIKFRNYLIPKGTTVVTSLT
                     SVLHDSKEFPNPELFDPGHFLDANGNFKKSDHFMPFSAGKRVCAGEGLARMELFLFLT
                     TILQNFKLKSLVHPKDIDMIPFVNGLIALPPHYQVCIIPR"
     exon            218..380
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /inference="alignment:Splign:2.1.0"
     exon            381..530
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /inference="alignment:Splign:2.1.0"
     exon            531..691
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /inference="alignment:Splign:2.1.0"
     exon            692..868
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1010
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1198
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1340
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1857
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1763..1768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /note="hexamer: AATAAA"
     regulatory      1781..1786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /note="hexamer: AATAAT"
     polyA_site      1787
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /note="major polyA site"
     polyA_site      1802
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /note="major polyA site"
     regulatory      1834..1839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
                     /note="hexamer: AATAAT"
     polyA_site      1857
                     /gene="Cyp2c39"
                     /gene_synonym="CYPIIC39"
ORIGIN      
        1 aaaaggccag tgatgcctga tcacaattgt gtgaataaaa agggtttcca tggaccttgt
       61 cacattccta gtgctcactc tctcttctct cattctcctc tcactatgga gacagagctg
      121 tggcagaggg agcctccctc ctggccccac tcctttcccg attattggta atttccttca
      181 gatagatata aaaaacgtca gccaatcctt aaccaatttc tcaaaagcct atggccctgt
      241 gttcactctg tatttgggct cacggcccac tgttgtatta catgggtatg aagcagtgaa
      301 ggaagctctg attgatcatg gggaggagtt ttctgataga ggaagcattc caatggtaga
      361 aaagattaat aacggccttg gcattgtttt tagcaatgga aacagatgga aagagattag
      421 gcgcttcaca ctcacgaccc tgcgaaattt gggaatggga aaaaggaaca ttgaggaccg
      481 tgttcaagag gaagcacagt gtcttgtgga agaactaagg aaaaccaagg gctcaccttg
      541 tgaccccaca ttcattctga gctgtgctcc atgcaatgtc atctgctcca ttattttcca
      601 ggatcgtttt gattataagg ataaagattt tcttatgctc atggaaaaac taaatgagaa
      661 tgtcaagatt ctgagctccc catggttgca ggtctgcaat aatttcccct tgctcattga
      721 ctattgtcca ggaagtcatc acaaagtact aaaaaacgtc aaatatatta gaagttacct
      781 gttggagaaa ataaaagaac accaagaatc actggatgtt acaaaccctc gtgattttat
      841 tgattattac ttgattaaac aaaaacaggc aaatcacatc caacaagcag aattttcact
      901 tgaaaatctg gcctgcacta tcaataacct ctttgctgca gggacagaga caacaagcac
      961 aacactgaga tatgctctcc tactcctgat gaagtaccca gatgtcacag ctaaagtcca
     1021 ggaagagatt gaccatgtga ttggtagaca ccgcagcccc tgcatgcagg acaggaacca
     1081 catgccctat accgatgcca tgattcatga ggtccagaga ttcatcaacc ttgtccctaa
     1141 caacataccc cgtgcagtga cttgtgacat taaatttagg aactacctca tccccaaggg
     1201 aacaacagta gtaacgtcac tgacatcagt tctgcatgac agcaaggagt tcccaaaccc
     1261 agagttgttt gaccctggcc actttctaga tgctaatgga aactttaaga aaagtgacca
     1321 cttcatgcct ttctcagcag gaaaacgtgt ttgtgctgga gagggcctgg cccgcatgga
     1381 gctgtttcta ttcctgacca ccattttaca gaactttaaa ctgaaatctc tggttcaccc
     1441 aaaagacatt gatatgatcc catttgtgaa tggattaata gctctgccac cccattacca
     1501 ggtctgcatc attcctcgct aaagagatca catattctga ccccctcctt tattgccttc
     1561 tgcaatcctg tccaggtctt tatttacctc tttacttatc aggaataagg catcttccat
     1621 cctggctcac aaaacccctt tttataaaga cctagcaaac acatctggtt tctggagtta
     1681 tagcacaaat gcacttgtat tatctctttt atataacagt tgtctgagcc tttatgctta
     1741 tgtttatcca ttcctgagtt agaataaaac ttcactggta aataatagtt attataagat
     1801 aatccctagt ccttttttct tttgaatgtt ttcaataata cttgattttg atttgtg
//
