LOCUS       NM_010002               1760 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily c, polypeptide 38
            (Cyp2c38), transcript variant 1, mRNA.
ACCESSION   NM_010002 XM_911996
VERSION     NM_010002.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1760)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1760)
  AUTHORS   Kawamura,T., Ichikawa,M., Hatogai,J., Koyama,Y., Tachibana,M.,
            Kuwahara,M., Negishi,K., Matsumoto,M., Miyazaki,M. and Ochiai,W.
  TITLE     Mouse Cyp2c expression and zonation structure in the liver begins
            in the early neonatal stage
  JOURNAL   Biopharm Drug Dispos 43 (4), 130-139 (2022)
   PUBMED   35748067
REFERENCE   3  (bases 1 to 1760)
  AUTHORS   Meng,X.Y., Zheng,Q.C. and Zhang,H.X.
  TITLE     A comparative analysis of binding sites between mouse CYP2C38 and
            CYP2C39 based on homology modeling, molecular dynamics simulation
            and docking studies
  JOURNAL   Biochim Biophys Acta 1794 (7), 1066-1072 (2009)
   PUBMED   19358898
  REMARK    GeneRIF: By comparison of active site architectures between CYP2C38
            and CYP2C39, the possible reasons affecting their substrate binding
            were proposed
REFERENCE   4  (bases 1 to 1760)
  AUTHORS   Kasai,F., Yoshihara,M., Matsukuma,S., O'Brien,P. and
            Ferguson-Smith,M.A.
  TITLE     Emergence of complex rearrangements at translocation breakpoints in
            a transgenic mouse; implications for mechanisms involved in the
            formation of chromosome rearrangements
  JOURNAL   Cytogenet Genome Res 119 (1-2), 83-90 (2007)
   PUBMED   18160786
REFERENCE   5  (bases 1 to 1760)
  AUTHORS   Luo,G., Zeldin,D.C., Blaisdell,J.A., Hodgson,E. and Goldstein,J.A.
  TITLE     Cloning and expression of murine CYP2Cs and their ability to
            metabolize arachidonic acid
  JOURNAL   Arch Biochem Biophys 357 (1), 45-57 (1998)
   PUBMED   9721182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139233.10.
            
            On Jul 29, 2022 this sequence version replaced NM_010002.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050051.1, AF047725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC139233.10        49463-49651
            190-352             AC139233.10        51799-51961
            353-502             AC139233.10        52126-52275
            503-663             AC139233.10        74164-74324
            664-840             AC139233.10        76308-76484
            841-982             AC139233.10        107736-107877
            983-1170            AC139233.10        110745-110932
            1171-1312           AC139233.10        120248-120389
            1313-1760           AC139233.10        121426-121873
FEATURES             Location/Qualifiers
     source          1..1760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.03 cM"
     gene            1..1760
                     /gene="Cyp2c38"
                     /note="cytochrome P450, family 2, subfamily c, polypeptide
                     38"
                     /db_xref="GeneID:13097"
                     /db_xref="MGI:MGI:1306819"
     exon            1..189
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1494
                     /gene="Cyp2c38"
                     /EC_number="1.14.14.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cytochrome P450 2C38; CYPIIC38; cytochrome
                     P450, 2c38"
                     /codon_start=1
                     /product="cytochrome P450 2C38 isoform 1 precursor"
                     /protein_id="NP_034132.2"
                     /db_xref="CCDS:CCDS29794.1"
                     /db_xref="GeneID:13097"
                     /db_xref="MGI:MGI:1306819"
                     /translation="MDLVTFLVLTLSSLILLSLWRQRSRRGRLPPGPTPFPIIGNFLQ
                     IDVKNFNQSLTNFSKTYGPVFTLYLGSRPIVVLHGYEAVKEALIDHGEEFSGRENIPM
                     SEKINNGLGITFSNGNSWKETRRFTLMTLRNLGMGKRNIEDRVREEAQCLVEELRKTK
                     GSPCDPTFILSCAPCNVICSIIFQDRFDYKDKDFLMLMKKLNENVKILSSPWLQVCNN
                     FPLLIDYCPGSHHKVLKNFKYIRSYLLEKVKEHQESLDVTNPRDFIDYFLIKQKQANH
                     IEQAEYSLENLVCTINNLFAAGTETTSTTLRYALLLLMKYPDVTAKVQEEIDHVVGRH
                     RSPCMQDRSRMPYTDAMIHEVQRFINLVPNNLPHAVTCDIKFRNYIIPKGTTVVTSLT
                     SVLHDSKEFPNPEMFDPGHFLDANGNFKKSDYFMTFSAGKRVCAGEGLARMELFLILT
                     TILQNFKLKSLVHPKDIDMIPFVNGLITLPPHYQLCFIPL"
     exon            190..352
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            353..502
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            503..663
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            664..840
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            841..982
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1170
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1312
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1760
                     /gene="Cyp2c38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1736..1741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2c38"
                     /note="hexamer: AATAAA"
     polyA_site      1748
                     /gene="Cyp2c38"
                     /note="major polyA site"
     polyA_site      1760
                     /gene="Cyp2c38"
ORIGIN      
        1 gtatgaataa ggagggtttc tatggatctt gtcacattcc tggtgctcac tctctcctct
       61 ctcattctcc tctcactatg gagacagagg tctagaagag ggaggctccc tcctggcccc
      121 actcctttcc cgattattgg taatttcctt cagattgatg tgaagaactt caaccaatcc
      181 ttaaccaatt tctcaaaaac ctatggcccc gttttcactc tgtatttggg ctcacggccc
      241 attgttgtat tgcatgggta tgaagcagtg aaggaagctc tgattgatca tggggaggag
      301 ttttctggta gagaaaacat cccaatgtct gaaaagatta ataatggcct tggcattact
      361 tttagcaatg gaaacagttg gaaagagaca agacgtttca cactcatgac cctaaggaat
      421 ttgggcatgg ggaaaaggaa cattgaggat cgtgttcgag aagaagcaca gtgtcttgtg
      481 gaagaactaa ggaaaaccaa gggctcacct tgtgacccca cattcattct gagctgtgct
      541 ccatgcaatg tcatctgctc aattattttt caagatcgtt ttgattacaa ggataaagat
      601 tttcttatgc tcatgaaaaa actaaatgag aatgtcaaga ttctgagctc cccatggttg
      661 caggtctgca ataatttccc cttgctcatt gactattgtc cgggaagtca tcacaaagta
      721 ctaaaaaact tcaaatatat tagaagttac ctgttggaga aagtaaaaga acaccaagaa
      781 tcactggatg ttacaaaccc tcgtgacttt atcgattatt tcctgattaa acaaaaacag
      841 gcaaaccaca tcgaacaagc agaatattca cttgaaaatc tggtctgcac tatcaataat
      901 ctctttgctg caggaacaga gacaacaagc acaacactga gatatgctct cctactcctg
      961 atgaagtacc cagatgtcac agctaaagtc caagaagaga ttgaccatgt ggttggtaga
     1021 caccgtagcc cctgcatgca ggacaggagc cgcatgccct atactgatgc catgattcat
     1081 gaggtccaga gattcatcaa ccttgtccct aacaacctac cccatgcagt gacctgtgac
     1141 attaaattca gaaactacat catccccaag ggaacaacag tagtaacgtc actgacatca
     1201 gttctgcatg acagcaagga gttccccaac ccagagatgt ttgaccctgg ccactttcta
     1261 gacgctaatg gaaactttaa gaaaagtgac tacttcatga ctttctcagc aggaaaacgg
     1321 gtttgtgctg gagagggcct ggcccgcatg gagctgtttc taatcctgac caccatttta
     1381 cagaacttta aactgaaatc tctggttcac ccaaaagaca ttgatatgat cccatttgtg
     1441 aatggattaa tcactctgcc accccattac cagctctgct tcattcctct ctaaagagat
     1501 cacacattct gaaccctcct ctgttgcctt ctgcaatccc ccccccaggg ttttattcac
     1561 ctctttcctt atcagggata aggcatcttc catcctggct cacagaaccc ccttttctga
     1621 agacctagca aacacatgcg gtttctggag ttatagcaca aatgcacttg tattatctct
     1681 tttatataac agttgtctga gcccttatgc ttatgtttat ccattcctgc gttagaataa
     1741 aacttcactg gcaaataata
//
