LOCUS       NM_010001               1824 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus cytochrome P450, family 2. subfamily c, polypeptide 37
            (Cyp2c37), mRNA.
ACCESSION   NM_010001 XM_975170 XM_975210 XM_975240 XM_975274 XM_975309
            XM_975342
VERSION     NM_010001.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1824)
  AUTHORS   Kawamura,T., Ichikawa,M., Hatogai,J., Koyama,Y., Tachibana,M.,
            Kuwahara,M., Negishi,K., Matsumoto,M., Miyazaki,M. and Ochiai,W.
  TITLE     Mouse Cyp2c expression and zonation structure in the liver begins
            in the early neonatal stage
  JOURNAL   Biopharm Drug Dispos 43 (4), 130-139 (2022)
   PUBMED   35748067
REFERENCE   2  (bases 1 to 1824)
  AUTHORS   Kasai,F., Yoshihara,M., Matsukuma,S., O'Brien,P. and
            Ferguson-Smith,M.A.
  TITLE     Emergence of complex rearrangements at translocation breakpoints in
            a transgenic mouse; implications for mechanisms involved in the
            formation of chromosome rearrangements
  JOURNAL   Cytogenet Genome Res 119 (1-2), 83-90 (2007)
   PUBMED   18160786
REFERENCE   3  (bases 1 to 1824)
  AUTHORS   Ghazalpour,A., Doss,S., Zhang,B., Wang,S., Plaisier,C.,
            Castellanos,R., Brozell,A., Schadt,E.E., Drake,T.A., Lusis,A.J. and
            Horvath,S.
  TITLE     Integrating genetic and network analysis to characterize genes
            related to mouse weight
  JOURNAL   PLoS Genet 2 (8), e130 (2006)
   PUBMED   16934000
REFERENCE   4  (bases 1 to 1824)
  AUTHORS   Choudhary,D., Jansson,I., Schenkman,J.B., Sarfarazi,M. and
            Stoilov,I.
  TITLE     Comparative expression profiling of 40 mouse cytochrome P450 genes
            in embryonic and adult tissues
  JOURNAL   Arch Biochem Biophys 414 (1), 91-100 (2003)
   PUBMED   12745259
REFERENCE   5  (bases 1 to 1824)
  AUTHORS   Luo,G., Zeldin,D.C., Blaisdell,J.A., Hodgson,E. and Goldstein,J.A.
  TITLE     Cloning and expression of murine CYP2Cs and their ability to
            metabolize arachidonic acid
  JOURNAL   Arch Biochem Biophys 357 (1), 45-57 (1998)
   PUBMED   9721182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005017.1 and AC148014.3.
            
            On Nov 22, 2007 this sequence version replaced NM_010001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005017.1, BC057912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-820               AK005017.1         2-821
            821-824             AC148014.3         62688-62691
            825-1824            AK005017.1         826-1825
FEATURES             Location/Qualifiers
     source          1..1824
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.24 cM"
     gene            1..1824
                     /gene="Cyp2c37"
                     /note="cytochrome P450, family 2. subfamily c, polypeptide
                     37"
                     /db_xref="GeneID:13096"
                     /db_xref="MGI:MGI:1306806"
     exon            1..184
                     /gene="Cyp2c37"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1489
                     /gene="Cyp2c37"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450 2C37; CYPIIC37; cytochrome P450,
                     2c37"
                     /codon_start=1
                     /product="cytochrome P450 2C37 precursor"
                     /protein_id="NP_034131.2"
                     /db_xref="CCDS:CCDS29799.1"
                     /db_xref="GeneID:13096"
                     /db_xref="MGI:MGI:1306806"
                     /translation="MDPILVLVLTLSCLFLLSLWRQSSERGKLPPGPTPLPIIGNILQ
                     IDVKDICQSFTNLSKVYGPVYTLYLGRKPTVVLHGYEAVKEALVDHGEEFAGRGRFPV
                     FDKATNGMGLAFSKGNVWKNTRRFSLMTLRNLGMGKRSIEDRVQEEARCLVEELRKTN
                     GSPCDPTFILGCAPCNVICSIIFQDRFDYKDRDFLNLMEKLNEITKILSSPWLQICNT
                     YPALLDYCPGSHKQFFKNYASIKNFLLEKIKEHEESLDVTIPRDFIDYFLINGGQEDG
                     NQPLQNRLEHLAITVTDLFSAGTETTSTTLRYAILLLLKYPHVTAKVQEEIEHVIGKH
                     RSPCMQDRSRMPYTDAMIHEVQRFIDLIPNSLPHEVTSDIKFRNYFIPKGTTVITSLS
                     SVLHDSTEFPNPEKFDPGHFLDENGKFKKSDYFIPFSTGKRICAGEGLARMELFLFLT
                     SILQNFNLKPLVHPKDIDVTPMLIGLASVPPAFQLCFIPS"
     exon            185..347
                     /gene="Cyp2c37"
                     /inference="alignment:Splign:2.1.0"
     exon            348..497
                     /gene="Cyp2c37"
                     /inference="alignment:Splign:2.1.0"
     exon            498..658
                     /gene="Cyp2c37"
                     /inference="alignment:Splign:2.1.0"
     exon            659..835
                     /gene="Cyp2c37"
                     /inference="alignment:Splign:2.1.0"
     exon            836..977
                     /gene="Cyp2c37"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1165
                     /gene="Cyp2c37"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1307
                     /gene="Cyp2c37"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1824
                     /gene="Cyp2c37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1803..1808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2c37"
                     /note="putative"
     polyA_site      1824
                     /gene="Cyp2c37"
                     /note="putative"
ORIGIN      
        1 agtaagaaga atctccatgg atccaatcct ggtcctggtg ctcactctct cctgtctgtt
       61 tctcctctca ctctggagac agagctctga aagggggaag ctccctcctg gccccactcc
      121 tcttccaatt attggaaaca tccttcagat agatgtgaag gacatctgcc aatccttcac
      181 caatttatca aaagtttatg gccctgtgta tactctatat ttgggcagga agcccactgt
      241 ggtgttgcat ggatatgagg cagtgaagga agctctggtt gaccatgggg aggagtttgc
      301 tggaagggga aggttcccag tttttgataa agctactaat ggaatgggcc ttgcatttag
      361 taaaggaaat gtatggaaaa acacgaggcg tttctcactc atgacgctgc ggaatttagg
      421 catgggaaaa aggagcattg aggaccgcgt tcaagaggaa gcacgttgcc ttgtggagga
      481 acttaggaaa accaatggct caccctgtga tcccaccttc atcctgggct gtgctccttg
      541 caatgtcatc tgctcaatta ttttccagga tcgttttgat tataaagatc gggattttct
      601 taacttgatg gaaaaactga atgaaataac aaagattctg agcagccctt ggttgcagat
      661 ttgcaataca tatcctgctc tgcttgatta ttgtccagga agtcataaac aattttttaa
      721 aaattatgct tctattaaaa atttcctttt ggagaaaata aaagaacatg aagaatcatt
      781 ggatgttaca attcctcgtg actttattga ttatttccta attaatggag gccaggaaga
      841 tggcaatcaa ccattgcaaa ataggcttga acacctggca ataacagtga ctgatctttt
      901 ttctgctggg acagagacaa caagcacaac actgagatat gctatcctac tcctcttgaa
      961 gtacccacat gtcacagcta aagtccagga agaaattgag catgtgatcg gcaagcaccg
     1021 aagcccatgc atgcaggaca ggagccgcat gccctatact gatgccatga ttcatgaggt
     1081 ccagagattc attgacctca tccccaacag ccttccccat gaagtgacca gtgacattaa
     1141 attcaggaac tacttcatcc ccaagggaac aactgtaata acatcactgt catcagtgct
     1201 gcatgacagc acggagttcc ccaacccaga gaaatttgac cctggccact ttctagatga
     1261 gaatggaaag tttaagaaaa gtgactactt cattcccttc tcaacaggga aacggatatg
     1321 tgcaggagag ggcctggcac gcatggagct gttcctgttc ctaaccagca ttttacagaa
     1381 cttcaacctg aaacctctgg ttcacccaaa ggacatagat gtaaccccaa tgctcattgg
     1441 attggcctcg gtgcctcctg ctttccagct ctgcttcatt ccttcctgaa aatcaaatgc
     1501 ctggctccag ctgggacatc ttctgtgatc accctgaggc tttaattcac tgctttccac
     1561 actggaaaca ctgactttta tccagttctt ttgcctcctc ataatttcat aaggttctat
     1621 gaacaaacat ttaccaattt gcagattctg cacaaatatt tctgacagtt cctattttct
     1681 aaaacactgt taccatatgc tgtggtgata tgtacctgat cccaagttaa atatactctc
     1741 ataaaattga aattactatt gcaggataat tcactgtcac ttctcttctg cattttctta
     1801 ataataaatt gttttggtat acct
//
