LOCUS       NM_007815               1774 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily c, polypeptide 29
            (Cyp2c29), transcript variant 1, mRNA.
ACCESSION   NM_007815 XM_003946029 XM_003946030
VERSION     NM_007815.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1774)
  AUTHORS   Oguro,A., Fujiyama,T., Ishihara,Y., Kataoka,C., Yamamoto,M.,
            Eto,K., Komohara,Y., Imaoka,S., Sakuragi,T., Tsuji,M., Shibata,E.,
            Kotake,Y. and Yamazaki,T.
  TITLE     Maternal DHA intake in mice increased DHA metabolites in the pup
            brain and ameliorated MeHg-induced behavioral disorder
  JOURNAL   J Lipid Res 64 (11), 100458 (2023)
   PUBMED   37838304
REFERENCE   2  (bases 1 to 1774)
  AUTHORS   Kawamura,T., Ichikawa,M., Hatogai,J., Koyama,Y., Tachibana,M.,
            Kuwahara,M., Negishi,K., Matsumoto,M., Miyazaki,M. and Ochiai,W.
  TITLE     Mouse Cyp2c expression and zonation structure in the liver begins
            in the early neonatal stage
  JOURNAL   Biopharm Drug Dispos 43 (4), 130-139 (2022)
   PUBMED   35748067
  REMARK    GeneRIF: Mouse Cyp2c expression and zonation structure in the liver
            begins in the early neonatal stage.
REFERENCE   3  (bases 1 to 1774)
  AUTHORS   Oteng,A.B., Higuchi,S., Banks,A.S. and Haeusler,R.A.
  TITLE     Cyp2c-deficiency depletes muricholic acids and protects against
            high-fat diet-induced obesity in male mice but promotes liver
            damage
  JOURNAL   Mol Metab 53, 101326 (2021)
   PUBMED   34438105
  REMARK    GeneRIF: Cyp2c-deficiency depletes muricholic acids and protects
            against high-fat diet-induced obesity in male mice but promotes
            liver damage.
REFERENCE   4  (bases 1 to 1774)
  AUTHORS   Wang,Q., Tang,Q., Zhao,L., Zhang,Q., Wu,Y., Hu,H., Liu,L., Liu,X.,
            Zhu,Y., Guo,A. and Yang,X.
  TITLE     Time serial transcriptome reveals Cyp2c29 as a key gene in
            hepatocellular carcinoma development
  JOURNAL   Cancer Biol Med 17 (2), 401-417 (2020)
   PUBMED   32587777
  REMARK    GeneRIF: Time serial transcriptome reveals Cyp2c29 as a key gene in
            hepatocellular carcinoma development.
REFERENCE   5  (bases 1 to 1774)
  AUTHORS   Chang,Q., Berdyshev,E., Cao,D., Bogaard,J.D., White,J.J., Chen,S.,
            Shah,R., Mu,W., Grantner,R., Bettis,S. and Grassi,M.A.
  TITLE     Cytochrome P450 2C epoxygenases mediate photochemical
            stress-induced death of photoreceptors
  JOURNAL   J Biol Chem 289 (12), 8337-8352 (2014)
   PUBMED   24519941
  REMARK    GeneRIF: Gene-targeted knockdown of CYP2C55, the homologous gene of
            CYP2C9, demonstrated viability rescue to light-induced cell death,
            whereas stable expression of functional CYP2C9-GFP fusion protein
            further exacerbated light-induced cell death.
REFERENCE   6  (bases 1 to 1774)
  AUTHORS   Rochelle,J.M., Watson,M.L., Oakey,R.J. and Seldin,M.F.
  TITLE     A linkage map of mouse chromosome 19: definition of comparative
            mapping relationships with human chromosomes 10 and 11 including
            the MEN1 locus
  JOURNAL   Genomics 14 (1), 26-31 (1992)
   PUBMED   1358795
REFERENCE   7  (bases 1 to 1774)
  AUTHORS   Johnson,K.R., Cook,S.A., Bustin,M. and Davisson,M.T.
  TITLE     Genetic mapping of the murine gene and 14 related sequences
            encoding chromosomal protein HMG-14
  JOURNAL   Mamm Genome 3 (11), 625-632 (1992)
   PUBMED   1360278
REFERENCE   8  (bases 1 to 1774)
  AUTHORS   Oakey,R.J., Caron,M.G., Lefkowitz,R.J. and Seldin,M.F.
  TITLE     Genomic organization of adrenergic and serotonin receptors in the
            mouse: linkage mapping of sequence-related genes provides a method
            for examining mammalian chromosome evolution
  JOURNAL   Genomics 10 (2), 338-344 (1991)
   PUBMED   1676978
REFERENCE   9  (bases 1 to 1774)
  AUTHORS   Hutton,J.J., Meier,J. and Hackney,C.
  TITLE     Comparison of the in vitro mutagenicity and metabolism of
            dimethylnitrosamine and benzo[a]pyrene in tissues from inbred mice
            treated with phenobarbital, 3-methylcholanthrene or polychlorinated
            biphenyls
  JOURNAL   Mutat Res 66 (1), 75-94 (1979)
   PUBMED   106274
REFERENCE   10 (bases 1 to 1774)
  AUTHORS   Niwa,A., Kumaki,K., Nebert,D.W. and Poland,A.P.
  TITLE     Genetic expression of aryl hydrocarbon hydroxylase activity in the
            mouse. Distinction between the 'responsive' homozygote and
            heterozygote at the Ah locus
  JOURNAL   Arch Biochem Biophys 166 (2), 559-564 (1975)
   PUBMED   1119809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120840.32 and AC139233.10.
            
            On Jul 28, 2022 this sequence version replaced NM_007815.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D17674.1, BC019908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC120840.32        35001-35189         c
            190-352             AC120840.32        31395-31557         c
            353-502             AC120840.32        31080-31229         c
            503-663             AC120840.32        14518-14678         c
            664-840             AC120840.32        12455-12631         c
            841-982             AC120840.32        594-735             c
            983-1170            AC139233.10        187445-187632       c
            1171-1312           AC139233.10        183293-183434       c
            1313-1774           AC139233.10        181825-182286       c
FEATURES             Location/Qualifiers
     source          1..1774
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 33.91 cM"
     gene            1..1774
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /note="cytochrome P450, family 2, subfamily c, polypeptide
                     29"
                     /db_xref="GeneID:13095"
                     /db_xref="MGI:MGI:103238"
     exon            1..189
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1494
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /EC_number="1.14.14.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cytochrome P450 2C29; CYPIIC29; aldehyde
                     oxygenase; cytochrome P-450 MUT-2; cytochrome P450, 2c29"
                     /codon_start=1
                     /product="cytochrome P450 2C29 isoform 1 precursor"
                     /protein_id="NP_031841.3"
                     /db_xref="CCDS:CCDS29793.1"
                     /db_xref="GeneID:13095"
                     /db_xref="MGI:MGI:103238"
                     /translation="MDLVVFLALTLSCLILLSLWRQSSGRGKLPPGPTPLPIIGNFLQ
                     IDVKNISQSFTNFSKAYGPVFTLYLGSKPTVILHGYEAVKEALIDRGEEFAGRGSFPM
                     AEKIIKGFGVVFSNGNRWKEMRRFTLMTLRNLGMGKRNIEDRVQEEAQCLVEELRKTK
                     GSPCDPTFILSCAPCNVICSIIFQNRFDYKDKEFLILMDKINENVKILSSPWLQVCNS
                     FPSLIDYCPGSHHKIVKNFNYLKSYLLEKIKEHKESLDVTNPRDFIDYYLIKQKQVNH
                     IEQSEFSLENLASTINDLFGAGTETTSTTLRYALLLLLKYPDVTAKVQEEIDRVVGRH
                     RSPCMQDRSHMPYTDAMIHEVQRFIDLLPTSLPHAVTCDIKFRKYLIPKGTTVITSLS
                     SVLHDSKEFPNPEMFDPGHFLNGNGNFKKSDYFMPFSTGKRICAGEGLARMELFLILT
                     TILQNFKLKSLVHPKEIDITPVMNGFASLPPPYQLCFIPL"
     exon            190..352
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /inference="alignment:Splign:2.1.0"
     exon            353..502
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /inference="alignment:Splign:2.1.0"
     exon            503..663
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /inference="alignment:Splign:2.1.0"
     exon            664..840
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /inference="alignment:Splign:2.1.0"
     exon            841..982
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1170
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1312
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1774
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1733..1738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /note="hexamer: AATAAA"
     regulatory      1750..1755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /note="hexamer: AAGAAA"
     polyA_site      1760
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
                     /note="major polyA site"
     polyA_site      1774
                     /gene="Cyp2c29"
                     /gene_synonym="Ah-2; Ahh-1; AHOH; AHOHase; Cyp2c; P450-2C"
ORIGIN      
        1 gtgtcagtaa ggaggttcgc tatggatctg gtcgtgttcc tagcgctcac tctatcctgt
       61 cttattctcc tctcactatg gagacagagc tctgggagag ggaagctccc tcctggcccc
      121 acgcctctcc caattattgg taacttcctc cagatagatg tgaagaacat cagccaatcc
      181 ttcaccaact tctcaaaagc ttatggccct gtgttcactc tgtatttggg ctcaaagcct
      241 actgtcatat tgcatgggta tgaagcagtg aaggaagctc tgattgatcg tggggaggag
      301 tttgctggta gaggaagctt tccaatggct gaaaaaatta ttaaaggttt tggcgttgtt
      361 tttagcaatg gaaacagatg gaaagagatg agacgattta cactcatgac cctgcgaaat
      421 ttgggcatgg ggaaaaggaa cattgaggac cgtgttcaag aggaagcaca gtgtcttgtg
      481 gaagaactga ggaaaaccaa aggctcaccc tgtgacccca ccttcatcct gagctgtgct
      541 ccatgcaatg tcatctgctc aattattttc cagaatcgtt ttgattataa ggataaggaa
      601 tttcttatcc tcatggataa aataaatgag aatgtcaaga ttctgagctc cccatggttg
      661 caggtctgca atagtttccc ttcactcatt gactattgtc ctggaagtca tcacaaaata
      721 gtaaaaaatt ttaattatct aaaaagttat ttgttggaga aaataaaaga acacaaggaa
      781 tcactggatg ttacaaaccc ccgtgacttt attgattatt acctaattaa acaaaaacag
      841 gtaaaccaca ttgaacaatc agagttttca cttgaaaatc tggcaagcac tatcaatgac
      901 ctctttggtg cagggacaga gaccacaagc acaacactga gatatgctct cctactcctg
      961 ctgaagtacc cagatgtcac agctaaagtc caggaagaga ttgaccgtgt ggttggcagg
     1021 caccgcagcc cctgcatgca agacaggagc cacatgccct atacagacgc catgattcat
     1081 gaggtccaga gattcatcga cctcctcccc actagcctgc ctcatgcagt gacctgtgac
     1141 attaaattca ggaaatacct catccccaag ggaactacag taataacatc actgtcatca
     1201 gtgctgcatg acagcaagga gtttcccaac ccagagatgt ttgaccctgg gcactttcta
     1261 aatgggaatg gaaactttaa gaaaagtgac tacttcatgc ctttttcaac aggaaaacgg
     1321 atttgtgctg gagagggcct ggcccgcatg gagctgtttc taatcctgac aaccatttta
     1381 cagaacttca aactgaaatc tctggtccac ccaaaagaaa ttgatattac cccagtgatg
     1441 aatggatttg cctctctgcc acccccttac cagctctgct tcattcctct ctaaagagat
     1501 cagactttct ggcccctgct gtgatgcctt ctacaattgt ctcaggtctt tatccacatc
     1561 cctccctatc agggatatgg tatctttcat cctggcttac agaaccctct tctctcaaga
     1621 cccagcaaac acatacagtt tctggagtta tagtacaaat gcacttgtat tttctctttt
     1681 atataacagt tttctgattc cttgtgttta tgtgtatcca ttcttgagta aaaataaagc
     1741 ttcactgtaa agaaaaataa ctatcataag ataa
//
