LOCUS       NM_010000               1877 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily b, polypeptide 9
            (Cyp2b9), mRNA.
ACCESSION   NM_010000 XM_907209
VERSION     NM_010000.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1877)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1877)
  AUTHORS   AlOgayil,N., Bauermeister,K., Galvez,J.H., Venkatesh,V.S.,
            Zhuang,Q.K., Chang,M.L., Davey,R.A., Zajac,J.D., Ida,K., Kamiya,A.,
            Taketo,T., Bourque,G. and Naumova,A.K.
  TITLE     Distinct roles of androgen receptor, estrogen receptor alpha, and
            BCL6 in the establishment of sex-biased DNA methylation in mouse
            liver
  JOURNAL   Sci Rep 11 (1), 13766 (2021)
   PUBMED   34215813
  REMARK    Erratum:[Sci Rep. 2021 Nov 22;11(1):22975. doi:
            10.1038/s41598-021-02512-8.. PMID: 34811454]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1877)
  AUTHORS   Chikada,H., Ida,K., Ando,E., Inagaki,Y., Sakamoto,A. and Kamiya,A.
  TITLE     Establishment and analysis of a mouse model that regulates
            sex-related differences in liver drug metabolism
  JOURNAL   Lab Invest 98 (11), 1500-1511 (2018)
   PUBMED   29968852
REFERENCE   4  (bases 1 to 1877)
  AUTHORS   Creasy,K.T., Jiang,J., Ren,H., Peterson,M.L. and Spear,B.T.
  TITLE     Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic
            Cyp Gene Expression in the Adult Mouse Liver
  JOURNAL   Gene Expr 17 (1), 7-17 (2016)
   PUBMED   27197076
REFERENCE   5  (bases 1 to 1877)
  AUTHORS   Xie,X., Miao,L., Yao,J., Feng,C., Li,C., Gao,M., Liu,M., Gong,L.,
            Wang,Y., Qi,X. and Ren,J.
  TITLE     Role of multiple microRNAs in the sexually dimorphic expression of
            Cyp2b9 in mouse liver
  JOURNAL   Drug Metab Dispos 41 (10), 1732-1737 (2013)
   PUBMED   23704697
  REMARK    GeneRIF: Multiple microRNAs participated in the regulation of
            Cyp2b9 expression.
REFERENCE   6  (bases 1 to 1877)
  AUTHORS   Honkakoski,P., Kojo,A. and Lang,M.A.
  TITLE     Regulation of the mouse liver cytochrome P450 2B subfamily by sex
            hormones and phenobarbital
  JOURNAL   Biochem J 285 (Pt 3) (Pt 3), 979-983 (1992)
   PUBMED   1497633
REFERENCE   7  (bases 1 to 1877)
  AUTHORS   Rudert,F., Saunders,A.M., Rebstock,S., Thompson,J.A. and
            Zimmermann,W.
  TITLE     Characterization of murine carcinoembryonic antigen gene family
            members
  JOURNAL   Mamm Genome 3 (5), 262-273 (1992)
   PUBMED   1638085
REFERENCE   8  (bases 1 to 1877)
  AUTHORS   Lakso,M., Masaki,R., Noshiro,M. and Negishi,M.
  TITLE     Structures and characterization of sex-specific mouse cytochrome
            P-450 genes as members within a large family. Duplication boundary
            and evolution
  JOURNAL   Eur J Biochem 195 (2), 477-486 (1991)
   PUBMED   1997326
REFERENCE   9  (bases 1 to 1877)
  AUTHORS   Miles,J.S., Moss,J.E., Meehan,R.R. and Wolf,C.R.
  TITLE     Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to
            Cyp2b and Coh on mouse chromosome 7
  JOURNAL   Genomics 7 (3), 445-448 (1990)
   PUBMED   1973143
REFERENCE   10 (bases 1 to 1877)
  AUTHORS   Noshiro,M., Lakso,M., Kawajiri,K. and Negishi,M.
  TITLE     Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha)
            of testosterone 16 alpha-hydroxylase in mouse liver, chromosome
            localization, and cloning of P-450 cDNA
  JOURNAL   Biochemistry 27 (17), 6434-6443 (1988)
   PUBMED   3219345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157782.7.
            
            On Nov 17, 2006 this sequence version replaced NM_010000.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M21855.1, BC120527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC157782.7         104196-104391       c
            197-359             AC157782.7         91057-91219         c
            360-509             AC157782.7         90765-90914         c
            510-670             AC157782.7         89988-90148         c
            671-847             AC157782.7         79206-79382         c
            848-989             AC157782.7         78615-78756         c
            990-1177            AC157782.7         76880-77067         c
            1178-1319           AC157782.7         76568-76709         c
            1320-1877           AC157782.7         67140-67697         c
FEATURES             Location/Qualifiers
     source          1..1877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 14.11 cM"
     gene            1..1877
                     /gene="Cyp2b9"
                     /gene_synonym="Cyp2b"
                     /note="cytochrome P450, family 2, subfamily b, polypeptide
                     9"
                     /db_xref="GeneID:13094"
                     /db_xref="MGI:MGI:88600"
     exon            1..196
                     /gene="Cyp2b9"
                     /gene_synonym="Cyp2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1501
                     /gene="Cyp2b9"
                     /gene_synonym="Cyp2b"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450 2B9; 16alphaoh-a; CYPIIB9;
                     cytochrome P450-16-alpha; cytochrome P450 clone PF26;
                     testosterone 16-alpha hydroxylase; phenobarbitol
                     inducible, type a; cytochrome P450, 2b9, phenobarbitol
                     inducible, type a"
                     /codon_start=1
                     /product="cytochrome P450 2B9 precursor"
                     /protein_id="NP_034130.1"
                     /db_xref="CCDS:CCDS21001.1"
                     /db_xref="GeneID:13094"
                     /db_xref="MGI:MGI:88600"
                     /translation="MDPSVLLLLAVLLSLFLLLVRGHAKIHGHLPPGPHPLPLLGNLL
                     QMDRGGLLKCFIQLQEKHGDVFTVHLGPRPVVVLCGTQTIREALVDHAEAFSGRGTIA
                     AAQLVMQDYGIFFASGQRWKTLRRFSLATMKEFGMGKRSVEERIKEEAQCLVEELKKY
                     QGVPLDPTFLFQCITANIICSIVFGERFDYTDDQFLHLLNLMYKIFSLLSSFSGQMFE
                     LFSGFLKYFPGVHRQIVKKQQELLDYIAHSVEKHKATLDPSAPRDYIDTYLLRMEKEK
                     SNHNTEFHHQNLMMSVLSLFFAGTETTSATLHYGVLLMLKYPHVTEKVQKEIDQVIGS
                     HRLPTLDDRTKMPYTDAVIHEIQRFSDLVPIGLPHKVIKDTLFRGYLLPKNTEVYPVL
                     SSALHDPQYFEQPDKFNPEHFLDANGALKKCEAFLPFSTGKRICLGESIARNELFIFF
                     TTILQNFSVASPVAPKDIDLTPKESGIGKIPPAHQIYFLAR"
     exon            197..359
                     /gene="Cyp2b9"
                     /gene_synonym="Cyp2b"
                     /inference="alignment:Splign:2.1.0"
     exon            360..509
                     /gene="Cyp2b9"
                     /gene_synonym="Cyp2b"
                     /inference="alignment:Splign:2.1.0"
     exon            510..670
                     /gene="Cyp2b9"
                     /gene_synonym="Cyp2b"
                     /inference="alignment:Splign:2.1.0"
     exon            671..847
                     /gene="Cyp2b9"
                     /gene_synonym="Cyp2b"
                     /inference="alignment:Splign:2.1.0"
     exon            848..989
                     /gene="Cyp2b9"
                     /gene_synonym="Cyp2b"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1177
                     /gene="Cyp2b9"
                     /gene_synonym="Cyp2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1319
                     /gene="Cyp2b9"
                     /gene_synonym="Cyp2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1877
                     /gene="Cyp2b9"
                     /gene_synonym="Cyp2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcagactc ttgttagacc ggaccatgga tcctagtgtc ctgctcctcc ttgctgtcct
       61 tctgagctta tttctactcc tggtcagggg ccatgcaaag atccatggcc atcttccacc
      121 aggaccccat cctctacccc tcttggggaa cctgttgcag atggatagag gaggccttct
      181 taagtgtttc attcagcttc aagaaaaaca tggagatgtg ttcacagtgc acttgggacc
      241 gaggcccgtg gttgtgttgt gtgggacaca gacgataagg gaggctctgg tggaccacgc
      301 tgaggctttt tctggccgag ggaccattgc tgcagctcag ctagttatgc aggactatgg
      361 tatatttttt gccagtgggc aacgctggaa gacccttcgg cgattctctc tggccaccat
      421 gaaagagttt ggaatgggaa agcggagtgt ggaggagagg ataaaggagg aggcccaatg
      481 tttggtggag gaattgaaga aataccaggg agtgcccctg gatcccacct ttctcttcca
      541 gtgcatcaca gccaacatca tctgctccat tgtctttgga gagcgttttg actacacaga
      601 tgaccagttc cttcatctgc tgaatctgat gtataagatc ttttcactct taagctcatt
      661 ctctggtcag atgtttgagc tcttctctgg attcctgaag tactttcctg gtgtacacag
      721 acaaattgtc aaaaaacagc aggaactcct cgactacatt gcccatagtg tggagaagca
      781 caaggccacc ttggacccca gtgctccacg agactacatt gatacctacc ttctgaggat
      841 ggagaaggag aagtcaaacc acaacacaga gttccatcac cagaacctca tgatgtctgt
      901 gctctctctc ttctttgctg gaactgagac cacaagcgcc accctccact atggagtcct
      961 gctcatgctc aagtaccccc atgtcacaga gaaagtccaa aaggagattg atcaggtgat
     1021 cggctcacac cggctaccaa ctcttgatga ccgcaccaaa atgccataca cagatgcagt
     1081 catccatgag attcagagat tttcagatct tgtcccaatt ggtctaccac ataaagtcat
     1141 caaagacaca ctgttccgag ggtacctgct ccccaagaac actgaggtgt accccgtcct
     1201 tagttcagct ctacatgatc cacagtactt tgaacaacca gacaagttca atcctgagca
     1261 ctttctagat gccaatgggg cactgaagaa atgtgaagct tttctgccct tctccacagg
     1321 aaagcgcatt tgtcttggtg aaagcattgc ccgcaacgaa ttgttcattt tcttcacaac
     1381 cattctccag aacttctctg tggcaagccc tgttgctcca aaggacattg acctcactcc
     1441 caaagagagt ggtattggaa aaatacctcc agcacaccag atctacttct tagcccgcta
     1501 attggggtga gggagccagg tgtcaccact tatgttgaga atggctctat ctttgtgcct
     1561 ctaagagagc tgctggaaac caggccattg gtagctgctc acacccttcc ttctactgtt
     1621 gttctccaaa gctccaaggc atgttcttct tccctgggaa tggcgctgga gaaagcaatc
     1681 aactgtctgt tttgatttct ggagtccaca actcatgctg agtcacttcc ctcttcctcc
     1741 caacagtcca agtctccact tatcagctct ccatgatctg tgatctgtgc tagtggactc
     1801 tatataaggt ctgatttcta tgtctacaga cttgcctagt atgtatggct caggtaaaca
     1861 gaatcacata gtgtgtg
//
