LOCUS       NM_007814               2765 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily b, polypeptide 19
            (Cyp2b19), mRNA.
ACCESSION   NM_007814
VERSION     NM_007814.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2765)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   2  (bases 1 to 2765)
  AUTHORS   Damiri,B., Holle,E., Yu,X. and Baldwin,W.S.
  TITLE     Lentiviral-mediated RNAi knockdown yields a novel mouse model for
            studying Cyp2b function
  JOURNAL   Toxicol Sci 125 (2), 368-381 (2012)
   PUBMED   22083726
  REMARK    GeneRIF: Report lentiviral-mediated RNAi knockdown of multiple
            mouse Cyp2b enzymes.
REFERENCE   3  (bases 1 to 2765)
  AUTHORS   Lundgren,M., Darnerud,P.O., Molin,Y., Lilienthal,H., Blomberg,J.
            and Ilback,N.G.
  TITLE     Viral infection and PBDE exposure interact on CYP gene expression
            and enzyme activities in the mouse liver
  JOURNAL   Toxicology 242 (1-3), 100-108 (2007)
   PUBMED   17964055
REFERENCE   4  (bases 1 to 2765)
  AUTHORS   Du,L., Yermalitsky,V., Ladd,P.A., Capdevila,J.H., Mernaugh,R. and
            Keeney,D.S.
  TITLE     Evidence that cytochrome P450 CYP2B19 is the major source of
            epoxyeicosatrienoic acids in mouse skin
  JOURNAL   Arch Biochem Biophys 435 (1), 125-133 (2005)
   PUBMED   15680914
  REMARK    GeneRIF: We conclude that while mouse epidermis likely expresses
            multiple cytochrome P450 enzymes, existing evidence supports native
            CYP2B19 as being the major source of epidermal EET formation
REFERENCE   5  (bases 1 to 2765)
  AUTHORS   Wang,H., Donley,K.M., Keeney,D.S. and Hoffman,S.M.
  TITLE     Organization and evolution of the Cyp2 gene cluster on mouse
            chromosome 7, and comparison with the syntenic human cluster
  JOURNAL   Environ Health Perspect 111 (15), 1835-1842 (2003)
   PUBMED   14630516
REFERENCE   6  (bases 1 to 2765)
  AUTHORS   Ladd,P.A., Du,L., Capdevila,J.H., Mernaugh,R. and Keeney,D.S.
  TITLE     Epoxyeicosatrienoic acids activate transglutaminases in situ and
            induce cornification of epidermal keratinocytes
  JOURNAL   J Biol Chem 278 (37), 35184-35192 (2003)
   PUBMED   12840027
  REMARK    GeneRIF: This enzyme is a keratinocyte-specific arachidonic acid
            epoxygenase expressed in the granular cell layer of mouse
            epidermis.
REFERENCE   7  (bases 1 to 2765)
  AUTHORS   Keeney,D.S., Skinner,C., Travers,J.B., Capdevila,J.H., Nanney,L.B.,
            King,L.E. Jr. and Waterman,M.R.
  TITLE     Differentiating keratinocytes express a novel cytochrome P450
            enzyme, CYP2B19, having arachidonate monooxygenase activity
  JOURNAL   J Biol Chem 273 (48), 32071-32079 (1998)
   PUBMED   9822682
REFERENCE   8  (bases 1 to 2765)
  AUTHORS   Keeney,D.S.
  TITLE     The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal
            chromosome 7 in the mouse, near a cluster of Cyp2 family genes
  JOURNAL   Genomics 53 (3), 417-419 (1998)
   PUBMED   9799616
REFERENCE   9  (bases 1 to 2765)
  AUTHORS   Jaradat,S.A., Ko,M.S. and Grossman,L.I.
  TITLE     Tissue-specific expression and mapping of the Cox7ah gene in mouse
  JOURNAL   Genomics 49 (3), 363-370 (1998)
   PUBMED   9615220
  REMARK    Erratum:[Genomics 1998 Dec 15;54(3):583-4]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138334.11 and AF047529.1.
            
            On Feb 11, 2015 this sequence version replaced NM_007814.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF047529.1, BC137965.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC138334.11        114611-114655
            46-2765             AF047529.1         1-2720
FEATURES             Location/Qualifiers
     source          1..2765
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.44 cM"
     gene            1..2765
                     /gene="Cyp2b19"
                     /gene_synonym="CYPIIB19"
                     /note="cytochrome P450, family 2, subfamily b, polypeptide
                     19"
                     /db_xref="GeneID:13090"
                     /db_xref="MGI:MGI:107303"
     exon            1..219
                     /gene="Cyp2b19"
                     /gene_synonym="CYPIIB19"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1524
                     /gene="Cyp2b19"
                     /gene_synonym="CYPIIB19"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, 2b19"
                     /codon_start=1
                     /product="cytochrome P450 2B19"
                     /protein_id="NP_031840.1"
                     /db_xref="CCDS:CCDS21006.1"
                     /db_xref="GeneID:13090"
                     /db_xref="MGI:MGI:107303"
                     /translation="MEFSVLLLLALTTGFLIFLVSQSQPKTHGHFPPGPRPLPFLGNL
                     LQMDRRGLLSSFIQLQEKYGDVFTVHLGPRPVVMLCGTDTIREALVNQAEAFSGRGTV
                     AVLDPIVQGYGVIFSSGERWKTLRRFSLATMRDFGMGKRSVEERIKEEAQCLVEELKK
                     YKGAPLNPTFYFQCIVANIICSIVFGERFDYKDHQFLHLLNLIYQTFSLMSSLSSQVF
                     ELFSAILKYFPGAHRQISKNLQEILDYIGHSVEKHRATLDPSAPRDFIDTYLLRMEKE
                     KSNHHTEFHHQNLVISVLSLFFAGTETTSTTLRYSFLIMLKYPHVAEKVQKEIDQVIG
                     SHRLPTLDDRTKMPYTDAVIHEIQRFTDLAPIGLPHKVTKDTLFRGYLIPKNTEVYPI
                     LSSALHDPRYFEQPDSFNPEHFLDANGALKTNEAFMPFSTGKRICLGEGIARNELFLF
                     FTTILQNFSLASPVAPENIDLIPNNSGATKTPPQYQIHFLSR"
     exon            220..382
                     /gene="Cyp2b19"
                     /gene_synonym="CYPIIB19"
                     /inference="alignment:Splign:2.1.0"
     exon            383..532
                     /gene="Cyp2b19"
                     /gene_synonym="CYPIIB19"
                     /inference="alignment:Splign:2.1.0"
     exon            533..693
                     /gene="Cyp2b19"
                     /gene_synonym="CYPIIB19"
                     /inference="alignment:Splign:2.1.0"
     exon            694..870
                     /gene="Cyp2b19"
                     /gene_synonym="CYPIIB19"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1012
                     /gene="Cyp2b19"
                     /gene_synonym="CYPIIB19"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1200
                     /gene="Cyp2b19"
                     /gene_synonym="CYPIIB19"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1342
                     /gene="Cyp2b19"
                     /gene_synonym="CYPIIB19"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..2740
                     /gene="Cyp2b19"
                     /gene_synonym="CYPIIB19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgctggag tgtgcactga agtcagaagt gattagacca ggaccatgga attcagtgtg
       61 ctgctccttc tcgctctcac cacaggcttc ttgatattct tagtcagcca aagtcagcca
      121 aagacccatg gccacttccc accaggacct cgtcccctgc ccttcttggg taacctcttg
      181 cagatggaca gacggggcct tctgagctct ttcatacagc ttcaagaaaa atatggagat
      241 gtgttcacag tacacctggg accgaggccc gtggtcatgt tgtgcgggac agacaccata
      301 agggaagctc tggtgaacca agctgaggct ttctctggcc gagggacagt tgctgtgctt
      361 gatccaattg ttcagggata tggtgtgatc ttttccagtg gggaacgttg gaaaaccctt
      421 cggcgattct ctctggccac catgagagac tttgggatgg gaaagcggag tgtggaggag
      481 cggataaagg aagaggccca atgtttggtg gaggaactga agaaatacaa gggagcccct
      541 ctgaacccca ccttctactt ccagtgcatc gtagcaaata tcatctgctc cattgtcttt
      601 ggagagcgct ttgactacaa agaccaccaa ttcctgcatc tgctaaatct gatctaccag
      661 acattttccc tcatgagctc attgtccagc caggtgtttg agctcttctc tgccatcctg
      721 aagtactttc ctggtgccca cagacaaatc tccaaaaacc tgcaggaaat ccttgactac
      781 attggccata gtgtggagaa gcacagggcc accttggacc ccagtgctcc acgagacttc
      841 attgatacct accttctgcg catggagaag gagaagtcca accaccatac agagttccat
      901 caccagaacc tcgtgatctc tgtgctctct ctgttctttg ctggcaccga gaccaccagc
      961 accacgctcc gttacagctt cctgatcatg ctcaagtacc cccatgtcgc agagaaagtc
     1021 caaaaggaga ttgatcaggt gatcggctca caccggctac cgactcttga tgatagaacc
     1081 aaaatgccat acactgatgc agtcatccat gagattcaga gatttacaga tcttgctccg
     1141 attggtctac cacacaaagt caccaaagac acactgttcc gaggatacct gatccccaag
     1201 aacactgagg tgtaccccat cctgagttca gctcttcatg acccacggta ctttgaacaa
     1261 ccagacagct tcaatcctga gcacttcctg gatgccaatg gggcactgaa gacaaatgaa
     1321 gctttcatgc ccttctccac aggaaagcgc atttgtcttg gagaaggcat tgcccgcaat
     1381 gaattgttcc ttttcttcac caccatcctc cagaacttct ctttggccag ccctgtagct
     1441 cctgagaaca ttgacctcat tcccaataac agtggtgcaa ccaaaacacc cccacagtac
     1501 cagattcact tcttgtcccg ttgaatgggc caagagagga gagtcagtgg acttcaggtt
     1561 cgcatgtgtc cccatttccg tcccttgtga atggaatggg aaaacccagt gaagcacctt
     1621 tcttgatgtc tggacagaga gacttctgga ggccatggct tgttctgagt cacctctctc
     1681 atgcttgtta acagtcatag tccctacttg ccagagcaat ctagactcca tgatcagtgc
     1741 tagcggacta gagatgctct ctcttgagtt ggctccatca tgctcccacg tgttgtgttg
     1801 gagggtcatg tttgagaatc ccctttatag atgagtgaca ggccacatga tgacatcaca
     1861 ctgctagtga gtagcggggg acaagatcac actgtgagtc tagaaaagca cctcccctcc
     1921 ccttccctac ttgtgcttaa attgagatga aattcataaa atgaagctga caaaattttt
     1981 cagttacgta ttctgagaca gagtctcatg tagctcagac caacctcaaa atcctatata
     2041 catccaaaga tgtcttgaat tctggatctg ttttccacta ctggcatcat aggcacatgg
     2101 acctacaccc agattttaaa ctgactatat cttaatgttt agattataat gtcttttaat
     2161 ttattcacaa tgctgtatga tttcactacc taattccagg tattttgtca catttaacca
     2221 acaccacccc aaaccctgac ctattaaaag atcagtccct cgtccctctc tccataacct
     2281 cccccacatc taccacctac cctgccacac acagtctgac ttctgtgtca atggactgac
     2341 ctgactccat gtgtcttgta gaaaaagcaa caatgtgatc ttttgtcagc tgtccctgct
     2401 tctcaggtcc ctgtactgtg cgggccacag tcacacacct tcacagactt tcccattctc
     2461 tttcttagac aaggatctcc tcagccctca ggccctgaac tgaatgactc tgcttagatt
     2521 ctcccacatt cccctgtaag tcctccacgg atctcataaa tacacaaagc cttcctcacc
     2581 gatcaagaaa gaacccttgc tgtgattttg tttgagtgtg ggttgcttgc ttgtttgttg
     2641 agacaggatc tcactatgta gacctggttg gtcttgagct cactaaaacc catctgcctc
     2701 gacctcctga gtgctgagat taaaggtttg tgctgccaca aaaaaaaaaa aaaaaaaaaa
     2761 aaaaa
//
