LOCUS       NM_007813               1876 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily b, polypeptide 13
            (Cyp2b13), mRNA.
ACCESSION   NM_007813 XM_990772 XM_993629 XM_993651
VERSION     NM_007813.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1876)
  AUTHORS   AlOgayil,N., Bauermeister,K., Galvez,J.H., Venkatesh,V.S.,
            Zhuang,Q.K., Chang,M.L., Davey,R.A., Zajac,J.D., Ida,K., Kamiya,A.,
            Taketo,T., Bourque,G. and Naumova,A.K.
  TITLE     Distinct roles of androgen receptor, estrogen receptor alpha, and
            BCL6 in the establishment of sex-biased DNA methylation in mouse
            liver
  JOURNAL   Sci Rep 11 (1), 13766 (2021)
   PUBMED   34215813
  REMARK    Erratum:[Sci Rep. 2021 Nov 22;11(1):22975. PMID: 34811454]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1876)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1876)
  AUTHORS   Chikada,H., Ida,K., Ando,E., Inagaki,Y., Sakamoto,A. and Kamiya,A.
  TITLE     Establishment and analysis of a mouse model that regulates
            sex-related differences in liver drug metabolism
  JOURNAL   Lab Invest 98 (11), 1500-1511 (2018)
   PUBMED   29968852
REFERENCE   5  (bases 1 to 1876)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   6  (bases 1 to 1876)
  AUTHORS   Damiri,B., Holle,E., Yu,X. and Baldwin,W.S.
  TITLE     Lentiviral-mediated RNAi knockdown yields a novel mouse model for
            studying Cyp2b function
  JOURNAL   Toxicol Sci 125 (2), 368-381 (2012)
   PUBMED   22083726
  REMARK    GeneRIF: Report lentiviral-mediated RNAi knockdown of multiple
            mouse Cyp2b enzymes.
REFERENCE   7  (bases 1 to 1876)
  AUTHORS   Lundgren,M., Darnerud,P.O., Molin,Y., Lilienthal,H., Blomberg,J.
            and Ilback,N.G.
  TITLE     Viral infection and PBDE exposure interact on CYP gene expression
            and enzyme activities in the mouse liver
  JOURNAL   Toxicology 242 (1-3), 100-108 (2007)
   PUBMED   17964055
REFERENCE   8  (bases 1 to 1876)
  AUTHORS   Wang,H., Donley,K.M., Keeney,D.S. and Hoffman,S.M.
  TITLE     Organization and evolution of the Cyp2 gene cluster on mouse
            chromosome 7, and comparison with the syntenic human cluster
  JOURNAL   Environ Health Perspect 111 (15), 1835-1842 (2003)
   PUBMED   14630516
REFERENCE   9  (bases 1 to 1876)
  AUTHORS   Lakso,M., Masaki,R., Noshiro,M. and Negishi,M.
  TITLE     Structures and characterization of sex-specific mouse cytochrome
            P-450 genes as members within a large family. Duplication boundary
            and evolution
  JOURNAL   Eur J Biochem 195 (2), 477-486 (1991)
   PUBMED   1997326
REFERENCE   10 (bases 1 to 1876)
  AUTHORS   Stupans,I., Ikeda,T., Kessler,D.J. and Nebert,D.W.
  TITLE     Characterization of a cDNA clone for mouse phenobarbital-inducible
            cytochrome P-450b
  JOURNAL   DNA 3 (2), 129-137 (1984)
   PUBMED   6547088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167357.6, BC145895.1 and AC171401.8.
            
            On Nov 22, 2007 this sequence version replaced NM_007813.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC167357.6         184755-184756
            3-1668              BC145895.1         1-1666
            1669-1876           AC171401.8         143140-143347
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 14.11 cM"
     gene            1..1876
                     /gene="Cyp2b13"
                     /note="cytochrome P450, family 2, subfamily b, polypeptide
                     13"
                     /db_xref="GeneID:13089"
                     /db_xref="MGI:MGI:88599"
     exon            1..196
                     /gene="Cyp2b13"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1501
                     /gene="Cyp2b13"
                     /note="phenobarbital inducible, type c; cytochrome P450,
                     2b13, phenobarbitol inducible, type c"
                     /codon_start=1
                     /product="cytochrome P450, family 2, subfamily b,
                     polypeptide 13 precursor"
                     /protein_id="NP_031839.2"
                     /db_xref="CCDS:CCDS21000.2"
                     /db_xref="GeneID:13089"
                     /db_xref="MGI:MGI:88599"
                     /translation="MDPSVLLLLAVLLSLFLLLVRGHAKIHGHLPPGPRPLPLLGNLL
                     QMDRGGLLKCFIHLQEKHGDVFTVHLGPRPVVVLCGTQTIREALVNNAEAFSGRGTIA
                     AAQLVMQDYGIFFSSGERWKTLRRFSLATMKEFGMGKRSVEERIKEEAQCLVEELKKY
                     QGAPLDPTFFFQCVTANIICSIVFGERFDYTDEQFLRLLNLMYQIYSLLRSFSCQMFE
                     LFSGLLKYFPGVHRQIAKNQQEILNFITHRVEKHRATLDPSEPRDFIDTYLLRMEKEK
                     SNHNTEFHHQNLMMSVLSLFFAGTETTSTTLCCGFLLMLMYPHVAEKVQKEIDQVIGS
                     HRLPTLDDRTKMPYTDAVIHEIQRFSDIVPTGAPHRVTKDTMFRGYLLPKNTEVYPIL
                     SSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESIARNELFLFF
                     TSILQNFSVASPVASKDIDLTPKESGIGKIPPTYQICFLAR"
     exon            197..359
                     /gene="Cyp2b13"
                     /inference="alignment:Splign:2.1.0"
     exon            360..509
                     /gene="Cyp2b13"
                     /inference="alignment:Splign:2.1.0"
     exon            510..670
                     /gene="Cyp2b13"
                     /inference="alignment:Splign:2.1.0"
     exon            671..847
                     /gene="Cyp2b13"
                     /inference="alignment:Splign:2.1.0"
     exon            848..989
                     /gene="Cyp2b13"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1177
                     /gene="Cyp2b13"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1319
                     /gene="Cyp2b13"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1876
                     /gene="Cyp2b13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcagactc ttgttagacc ggaccatgga tcctagtgtc ctgctcctcc ttgctgtcct
       61 tctgagctta tttctactcc tggtcagggg ccatgcaaag atccatggtc atcttccacc
      121 aggaccccgt cctctacccc tcttggggaa cctcttgcag atggatagag gaggccttct
      181 taagtgtttc attcatcttc aagaaaaaca tggagatgtg ttcacagtgc acttgggacc
      241 gaggcccgtg gttgtgttgt gtgggacaca gacgataagg gaggctctgg tgaacaacgc
      301 tgaggctttt tctggccggg ggaccattgc tgcagctcag ctagttatgc aggactatgg
      361 catatttttt tctagtgggg aacgctggaa gacccttcgg cgattctctc tggccaccat
      421 gaaagagttt ggaatgggaa agcggagtgt ggaggagagg ataaaggagg aggcccaatg
      481 tttggtggag gaactgaaga aataccaggg agcccccctg gatccaacct ttttcttcca
      541 gtgtgttaca gccaatatca tctgctccat tgtctttgga gagcgctttg actacacaga
      601 tgaacagttc ctgcgtttgc tgaatctgat gtatcagata tattcactct taaggtcatt
      661 ctcctgccag atgtttgagc tcttctctgg tctcttgaag tactttcctg gtgtacacag
      721 acaaattgct aaaaaccagc aggaaatcct caacttcatt acccatcgtg tggaaaagca
      781 cagggcaacc ttggacccca gtgagccacg agacttcatc gatacctatc tgctgaggat
      841 ggagaaggag aagtcaaacc acaacacgga gttccatcac cagaacctca tgatgtctgt
      901 gctctctctc ttctttgctg gaactgagac taccagcacc actctctgct gtggtttcct
      961 gctcatgctc atgtaccccc atgttgcaga gaaagtccaa aaggagattg atcaggtgat
     1021 cggctcacac cggctaccaa cccttgatga tcgcaccaaa atgccataca ctgatgcagt
     1081 cattcacgaa attcagagat tttcagatat tgtccctact ggagcaccac acagagtgac
     1141 caaagatacc atgttccgag ggtacctgct ccccaagaac actgaggtgt accccatcct
     1201 gagttcagct ctccatgacc cacagtactt tgaacaacca gacagtttca atcctgacca
     1261 cttcctggat gccaatgggg cactgaagaa aagtgaagct tttctaccct tctccacagg
     1321 aaagcgcatt tgtcttggtg aaagcattgc ccgcaacgaa ttgttccttt tcttcacgtc
     1381 catcctccag aacttctctg tggcaagccc tgttgcttct aaggacattg acctcactcc
     1441 caaggagagt ggtattggaa aaatacctcc aacgtaccag atctgcttct tggcccgctg
     1501 actgggctga ggcagccagg tggccccact tttgttgaga atggctctat ttttgtgcct
     1561 ctgagagagc tgctggaaac tagactgtat gttgctgctc acatctttcc tcctattgtg
     1621 gttctccaca gctggaaggt gtgttcttcc ctgtgaatgg cactggagaa aacaatcaac
     1681 tatcatactt gatttgtgaa cagagacttc tggagtccac atctcatgct gagtcacttc
     1741 cctcttcctc ccaacttcac actctgtggt ctgtgctaat gggccctgta caaggtctga
     1801 attctatgtc tacagacttg cctagtatgt caacatacta ggtatgtttc aggtaaacag
     1861 aatcacatag tgtgtg
//
