LOCUS       NM_009999               1878 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily b, polypeptide 10
            (Cyp2b10), mRNA.
ACCESSION   NM_009999 NM_009998
VERSION     NM_009999.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1878)
  AUTHORS   Mackowiak,B., Xu,M., Lin,Y., Guan,Y., Seo,W., Ren,R., Feng,D.,
            Jones,J.W., Wang,H. and Gao,B.
  TITLE     Hepatic CYP2B10 is highly induced by binge ethanol and contributes
            to acute-on-chronic alcohol-induced liver injury
  JOURNAL   Alcohol Clin Exp Res 46 (12), 2163-2176 (2022)
   PUBMED   36224745
  REMARK    GeneRIF: Hepatic CYP2B10 is highly induced by binge ethanol and
            contributes to acute-on-chronic alcohol-induced liver injury.
REFERENCE   2  (bases 1 to 1878)
  AUTHORS   Kawase,A., Mukai,H., Tateishi,S., Kuroda,S., Kazaoka,A., Satoh,R.,
            Shimada,H., Sugiura,R. and Iwaki,M.
  TITLE     Protein Kinase N Family Negatively Regulates Constitutive
            Androstane Receptor-Mediated Transcriptional Induction of
            Cytochrome P450 2b10 in the Livers of Mice
  JOURNAL   J Pharmacol Exp Ther 379 (1), 53-63 (2021)
   PUBMED   34312179
  REMARK    GeneRIF: Protein Kinase N Family Negatively Regulates Constitutive
            Androstane Receptor-Mediated Transcriptional Induction of
            Cytochrome P450 2b10 in the Livers of Mice.
REFERENCE   3  (bases 1 to 1878)
  AUTHORS   Heintz,M.M., Kumar,R., Rutledge,M.M. and Baldwin,W.S.
  TITLE     Cyp2b-null male mice are susceptible to diet-induced obesity and
            perturbations in lipid homeostasis
  JOURNAL   J Nutr Biochem 70, 125-137 (2019)
   PUBMED   31202118
  REMARK    GeneRIF: Cyp2b-null male mice are susceptible to diet-induced
            obesity and perturbations in lipid homeostasis.
REFERENCE   4  (bases 1 to 1878)
  AUTHORS   Chikada,H., Ida,K., Ando,E., Inagaki,Y., Sakamoto,A. and Kamiya,A.
  TITLE     Establishment and analysis of a mouse model that regulates
            sex-related differences in liver drug metabolism
  JOURNAL   Lab Invest 98 (11), 1500-1511 (2018)
   PUBMED   29968852
REFERENCE   5  (bases 1 to 1878)
  AUTHORS   Koga,T., Yao,P.L., Goudarzi,M., Murray,I.A., Balandaram,G.,
            Gonzalez,F.J., Perdew,G.H., Fornace,A.J. Jr. and Peters,J.M.
  TITLE     Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by
            Peroxisome Proliferator-activated Receptor-beta/delta Modulation of
            SP1 Promoter Occupancy
  JOURNAL   J Biol Chem 291 (48), 25255-25263 (2016)
   PUBMED   27765815
  REMARK    GeneRIF: results from the present study demonstrate a novel
            regulatory role of PPARbeta/delta in modulating CYP2B10 that may
            contribute to the etiology of alcoholic liver disease.
REFERENCE   6  (bases 1 to 1878)
  AUTHORS   Honkakoski,P., Kojo,A. and Lang,M.A.
  TITLE     Regulation of the mouse liver cytochrome P450 2B subfamily by sex
            hormones and phenobarbital
  JOURNAL   Biochem J 285 (Pt 3) (Pt 3), 979-983 (1992)
   PUBMED   1497633
REFERENCE   7  (bases 1 to 1878)
  AUTHORS   Kipling,D., Ackford,H.E., Taylor,B.A. and Cooke,H.J.
  TITLE     Mouse minor satellite DNA genetically maps to the centromere and is
            physically linked to the proximal telomere
  JOURNAL   Genomics 11 (2), 235-241 (1991)
   PUBMED   1685135
REFERENCE   8  (bases 1 to 1878)
  AUTHORS   Miles,J.S., Moss,J.E., Meehan,R.R. and Wolf,C.R.
  TITLE     Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to
            Cyp2b and Coh on mouse chromosome 7
  JOURNAL   Genomics 7 (3), 445-448 (1990)
   PUBMED   1973143
REFERENCE   9  (bases 1 to 1878)
  AUTHORS   Burkhart,B.A., Skow,L.C. and Negishi,M.
  TITLE     Two steroid 15 alpha-hydroxylase genes and a homologous gene family
            in mice
  JOURNAL   Gene 87 (2), 205-211 (1990)
   PUBMED   1970547
REFERENCE   10 (bases 1 to 1878)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     The syntenic relationship of proximal mouse chromosome 7 and the
            myotonic dystrophy gene region on human chromosome 19q
  JOURNAL   Genomics 6 (2), 324-332 (1990)
   PUBMED   2307474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028103.1, AI304065.1 and AC160471.10.
            
            On Jan 18, 2014 this sequence version replaced NM_009999.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028103.1, BC060973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AK028103.1         1-137
            138-138             AI304065.1         92-92
            139-1865            AK028103.1         139-1865
            1866-1878           AC160471.10        117497-117509       c
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 14.11 cM"
     gene            1..1878
                     /gene="Cyp2b10"
                     /gene_synonym="Cyp2b; Cyp2b20; p16"
                     /note="cytochrome P450, family 2, subfamily b, polypeptide
                     10"
                     /db_xref="GeneID:13088"
                     /db_xref="MGI:MGI:88598"
     exon            1..198
                     /gene="Cyp2b10"
                     /gene_synonym="Cyp2b; Cyp2b20; p16"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1503
                     /gene="Cyp2b10"
                     /gene_synonym="Cyp2b; Cyp2b20; p16"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, family 2, subfamily b, polypeptide
                     20; cytochrome P450, 2b20; cytochrome P450 2B10; P24;
                     CYPIIB10; CYPIIB20; cytochrome P450 2B20; cytochrome
                     P450-16-alpha; cytochrome P450 clone PF3/46; testosterone
                     16-alpha hydroxylase; phenobarbitol inducible, type b;
                     cytochrome P450, 2b10, phenobarbitol inducible, type b"
                     /codon_start=1
                     /product="cytochrome P450 2B10 precursor"
                     /protein_id="NP_034129.1"
                     /db_xref="CCDS:CCDS20999.1"
                     /db_xref="GeneID:13088"
                     /db_xref="MGI:MGI:88598"
                     /translation="MEPSVLLLLALLVGFLLLLARGHPKSRGNFPPGPRPLPLLGNLL
                     QMDRGGLLKSFIQLREKYGDVFTVHLGPRPVVMLCGTDTIREALVGQAEAFSGRGTVA
                     VVEPTFKEYGVIFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKS
                     QGAPLDPTFLFQCITANIICSIVFGERFEYTDRQFLRLLELFYQTFSLISSFSSQMFE
                     LFSGFLKYFPGAHRQISKNLQELLDYIGHSVEKHRATLDPSVPRDFIDIYLLRMEKEK
                     SNQHTEFHHQNLMMSVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGS
                     HRLPTLDDRTKMPYTDAVIHEIQRFSDLIPIGVPHRVTKDTMFRGYLLPKNTEVYPIL
                     SSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESIARNELFLFF
                     TSILQNFSVASHVAPKDIDLTPKESGIGKIPPTYQICFLAR"
     exon            199..361
                     /gene="Cyp2b10"
                     /gene_synonym="Cyp2b; Cyp2b20; p16"
                     /inference="alignment:Splign:2.1.0"
     exon            362..511
                     /gene="Cyp2b10"
                     /gene_synonym="Cyp2b; Cyp2b20; p16"
                     /inference="alignment:Splign:2.1.0"
     exon            512..672
                     /gene="Cyp2b10"
                     /gene_synonym="Cyp2b; Cyp2b20; p16"
                     /inference="alignment:Splign:2.1.0"
     exon            673..849
                     /gene="Cyp2b10"
                     /gene_synonym="Cyp2b; Cyp2b20; p16"
                     /inference="alignment:Splign:2.1.0"
     exon            850..991
                     /gene="Cyp2b10"
                     /gene_synonym="Cyp2b; Cyp2b20; p16"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1179
                     /gene="Cyp2b10"
                     /gene_synonym="Cyp2b; Cyp2b20; p16"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1321
                     /gene="Cyp2b10"
                     /gene_synonym="Cyp2b; Cyp2b20; p16"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1878
                     /gene="Cyp2b10"
                     /gene_synonym="Cyp2b; Cyp2b20; p16"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1878
                     /gene="Cyp2b10"
                     /gene_synonym="Cyp2b; Cyp2b20; p16"
                     /note="major polyA site"
ORIGIN      
        1 gaagtcaaca ttggttagac caggaccatg gagcccagtg tcctgctcct ccttgctctc
       61 cttgtgggct tcttgttact cttagccagg ggacacccaa agtcccgtgg caacttccca
      121 ccaggacccc gtcccctgcc cctcttgggg aacctcttgc agatggacag aggaggcctc
      181 ctcaagtctt ttattcagct tcgagaaaaa tatggagatg tgttcacagt gcacctggga
      241 ccaaggcctg tggttatgct gtgtggaaca gacaccataa gggaggctct ggtgggccaa
      301 gccgaggctt tctctggccg ggggacagtt gctgtcgttg agccaacctt caaggaatat
      361 ggtgtgatct ttgccaatgg ggaacgttgg aagacccttc gtagattctc tctggccacc
      421 atgagagact ttgggatggg aaagaggagt gtggaggagc ggattcagga ggaagcccaa
      481 tgtttagtgg aggaactgcg gaaatcccag ggagcccccc tggaccccac gttcctcttc
      541 cagtgcatca cggccaatat tatctgctcc attgtgtttg gagagcgctt tgagtacaca
      601 gaccgtcagt tcttgcgcct gctggagctg ttctatcaga ccttttcact cataagctca
      661 ttctccagcc agatgtttga gctcttctct ggcttcctga agtactttcc tggtgcccac
      721 agacaaatct ccaaaaacct gcaggaactc ctcgactaca ttggccatag tgtggagaag
      781 cacagggcca ccttggaccc cagtgttcca cgagacttca ttgatattta ccttctgcgc
      841 atggagaagg agaagtccaa ccagcacacg gagttccatc accagaacct catgatgtct
      901 gtgctctctc tcttctttgc tggcaccgag accagcagca ccacgctccg ctatggcttc
      961 ctgctcatgc tcaagtaccc ccatgttgca gagaaagtcc aaaaggagat tgatcaggtg
     1021 atcggctcac accggctacc aacccttgat gaccgcacca aaatgccata cactgatgca
     1081 gtcatccacg agattcagag attttcagat cttataccta ttggagtgcc acacagagtg
     1141 accaaagata ccatgttccg agggtacctg ctccccaaga acactgaggt gtaccccatc
     1201 ctgagttcag ctctacatga tccacagtac tttgaacaac cagacagttt caatcctgac
     1261 cacttcctgg atgccaatgg ggcactgaag aaaagtgaag cttttctgcc cttctcaaca
     1321 ggaaagcgca tttgtcttgg tgaaagcatt gcccgcaacg agttgttcct tttcttcacg
     1381 tccatcctcc agaacttctc tgtggcaagc catgttgctc ctaaggacat tgacctcact
     1441 cccaaggaga gtggtattgg aaaaatacct ccaacgtacc agatctgctt cttggcccgc
     1501 tgattgggct gaggcagaca ggtggcccca gtactgttga gaatgactct atctttgagc
     1561 ctctgagaga cctgctggaa atcagtactc ctattgcatg tctccaaatc tccagggctc
     1621 caaggcatgt tcttcttccc tgtgaatggc actggagaaa tcaatcaact gtctttcttg
     1681 acatgtgaaa agagacttct ggagtccaca tctcatgttg agtcacttcc cttttcctcc
     1741 caatagccca agtccgcact tatcagctct ccatgatctg ggatctgtgc taatggactc
     1801 tgtataaggt ctgaattcta tgtctacaga tttgcctagt atgtatggtt caggtaaaca
     1861 gaatcacata gtgtgtga
//
