LOCUS       NM_007812               1746 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily a, polypeptide 5
            (Cyp2a5), mRNA.
ACCESSION   NM_007812 XM_907444
VERSION     NM_007812.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Oguro,A., Fujiyama,T., Ishihara,Y., Kataoka,C., Yamamoto,M.,
            Eto,K., Komohara,Y., Imaoka,S., Sakuragi,T., Tsuji,M., Shibata,E.,
            Kotake,Y. and Yamazaki,T.
  TITLE     Maternal DHA intake in mice increased DHA metabolites in the pup
            brain and ameliorated MeHg-induced behavioral disorder
  JOURNAL   J Lipid Res 64 (11), 100458 (2023)
   PUBMED   37838304
REFERENCE   2  (bases 1 to 1746)
  AUTHORS   Lin,L., Huang,Y., Wang,J., Guo,X., Yu,F., He,D., Wu,C., Guo,L. and
            Wu,B.
  TITLE     CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression
            of E4BP4
  JOURNAL   Biochem Pharmacol 217, 115843 (2023)
   PUBMED   37797722
  REMARK    GeneRIF: CRY1/2 regulate rhythmic CYP2A5 in mouse liver through
            repression of E4BP4.
REFERENCE   3  (bases 1 to 1746)
  AUTHORS   Nail,A.N., Spear,B.T. and Peterson,M.L.
  TITLE     Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially
            expressed in the liver and both express long non-coding antisense
            RNAs
  JOURNAL   Gene 767, 145162 (2021)
   PUBMED   32987105
REFERENCE   4  (bases 1 to 1746)
  AUTHORS   Chen,X., Acquaah-Mensah,G.K., Denning,K.L., Peterson,J.M., Wang,K.,
            Denvir,J., Hong,F., Cederbaum,A.I. and Lu,Y.
  TITLE     High-fat diet induces fibrosis in mice lacking CYP2A5 and
            PPARalpha: a new model for steatohepatitis-associated fibrosis
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 319 (5), G626-G635 (2020)
   PUBMED   32877213
REFERENCE   5  (bases 1 to 1746)
  AUTHORS   Chen,X., Wang,K., Cederbaum,A.I. and Lu,Y.
  TITLE     Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is
            associated with nicotine- and cotinine-enhanced alcoholic fatty
            liver in mice
  JOURNAL   Biochem Biophys Res Commun 512 (1), 119-124 (2019)
   PUBMED   30876690
REFERENCE   6  (bases 1 to 1746)
  AUTHORS   Salonpaa,P., Iscan,M., Pasanen,M., Arvela,P., Pelkonen,O. and
            Raunio,H.
  TITLE     Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome
            P4502a-4/5) expression in the liver and kidneys of inbred mice
  JOURNAL   Biochem Pharmacol 44 (7), 1269-1274 (1992)
   PUBMED   1417950
REFERENCE   7  (bases 1 to 1746)
  AUTHORS   Lindberg,R.L., Juvonen,R. and Negishi,M.
  TITLE     Molecular characterization of the murine Coh locus: an amino acid
            difference at position 117 confers high and low coumarin
            7-hydroxylase activity in P450coh
  JOURNAL   Pharmacogenetics 2 (1), 32-37 (1992)
   PUBMED   1302041
REFERENCE   8  (bases 1 to 1746)
  AUTHORS   Wood,A.W. and Taylor,B.A.
  TITLE     Genetic regulation of coumarin hydroxylase activity in mice.
            Evidence for single locus control on chromosome
  JOURNAL   J Biol Chem 254 (13), 5647-5651 (1979)
   PUBMED   447675
REFERENCE   9  (bases 1 to 1746)
  AUTHORS   Endell,W. and Seidel,G.
  TITLE     Coumarin toxicity in different strains of mice
  JOURNAL   Agents Actions 8 (3), 299-302 (1978)
   PUBMED   665441
REFERENCE   10 (bases 1 to 1746)
  AUTHORS   Lush,I.E. and Andrews,K.M.
  TITLE     Genetic variation between mice in their metabolism of coumarin and
            its derivatives
  JOURNAL   Genet Res 31 (2), 177-186 (1978)
   PUBMED   566237
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149439.1, AK132617.1 and BC046605.1.
            
            On May 22, 2007 this sequence version replaced NM_007812.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046605.1, AK149439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK149439.1         2-3
            3-1328              AK132617.1         2-1327
            1329-1746           BC046605.1         1303-1720
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.54 cM"
     gene            1..1746
                     /gene="Cyp2a5"
                     /gene_synonym="Coh; Cyp15a2; CYPIIA5"
                     /note="cytochrome P450, family 2, subfamily a, polypeptide
                     5"
                     /db_xref="GeneID:13087"
                     /db_xref="MGI:MGI:88597"
     exon            1..205
                     /gene="Cyp2a5"
                     /gene_synonym="Coh; Cyp15a2; CYPIIA5"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1510
                     /gene="Cyp2a5"
                     /gene_synonym="Coh; Cyp15a2; CYPIIA5"
                     /EC_number="1.14.14.1"
                     /note="coumarin 7-hydroxylase; cytochrome P450-15-COH;
                     cytochrome P450-IIA3.2; cytochrome P450, 2a5"
                     /codon_start=1
                     /product="cytochrome P450 2A5"
                     /protein_id="NP_031838.2"
                     /db_xref="CCDS:CCDS21008.1"
                     /db_xref="GeneID:13087"
                     /db_xref="MGI:MGI:88597"
                     /translation="MLTSGLLLVAAVAFLSVLVLMSVWKQRKLSGKLPPGPTPLPFIG
                     NFLQLNTEQMYNSLMKISQRYGPVFTIYLGPRRIVVLCGQEAVKEALVDQAEEFSGRG
                     EQATFDWLFKGYGVAFSSGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDSF
                     RKTNGAFIDPTFYLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSMGQ
                     LYEMFSSVMKHLPGPQQQAFKELQGLEDFITKKVEHNQRTLDPNSPRDFIDSFLIRML
                     EEKKNPNTEFYMKNLVLTTLNLFFAGTETVSTTLRYGFLLLMKHPDIEAKVHEEIDRV
                     IGRNRQPKYEDRMKMPYTEAVIHEIQRFADMIPMGLARRVTKDTKFRDFLLPKGTEVF
                     PMLGSVLKDPKFFSNPKDFNPKHFLDDKGQFKKNDAFVPFSIGKRYCFGEGLARMELF
                     LFLTNIMQNFHFKSTQAPQDIDVSPRLVGFATIPPTYTMSFLSR"
     exon            206..368
                     /gene="Cyp2a5"
                     /gene_synonym="Coh; Cyp15a2; CYPIIA5"
                     /inference="alignment:Splign:2.1.0"
     exon            369..518
                     /gene="Cyp2a5"
                     /gene_synonym="Coh; Cyp15a2; CYPIIA5"
                     /inference="alignment:Splign:2.1.0"
     exon            519..679
                     /gene="Cyp2a5"
                     /gene_synonym="Coh; Cyp15a2; CYPIIA5"
                     /inference="alignment:Splign:2.1.0"
     exon            680..856
                     /gene="Cyp2a5"
                     /gene_synonym="Coh; Cyp15a2; CYPIIA5"
                     /inference="alignment:Splign:2.1.0"
     exon            857..998
                     /gene="Cyp2a5"
                     /gene_synonym="Coh; Cyp15a2; CYPIIA5"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1186
                     /gene="Cyp2a5"
                     /gene_synonym="Coh; Cyp15a2; CYPIIA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1328
                     /gene="Cyp2a5"
                     /gene_synonym="Coh; Cyp15a2; CYPIIA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1715
                     /gene="Cyp2a5"
                     /gene_synonym="Coh; Cyp15a2; CYPIIA5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1690..1695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2a5"
                     /gene_synonym="Coh; Cyp15a2; CYPIIA5"
                     /note="hexamer: AATAAA"
     polyA_site      1715
                     /gene="Cyp2a5"
                     /gene_synonym="Coh; Cyp15a2; CYPIIA5"
                     /note="major polyA site"
ORIGIN      
        1 gtctgtctat caccccaccg ccaccatgct gacctcagga ctcctcctgg tggctgcagt
       61 ggccttcctc agcgtcctgg tcttgatgtc tgtctggaag cagagaaagc tctcaggaaa
      121 gctgcctcca ggacccaccc cactgccctt cattgggaac ttccttcagc tgaacacaga
      181 gcaaatgtac aactctctca tgaagatcag ccaacgttat ggtcctgtat tcaccatcta
      241 cctgggacct cgccgaattg tggtgctgtg cggacaggag gcagtcaagg aagctctggt
      301 ggaccaagct gaggaattca gcgggcgggg cgagcaagct accttcgact ggcttttcaa
      361 aggctatggc gtagccttca gcagcgggga gcgagccaaa cagctaaggc gcttctccat
      421 cgccacgctg cgggacttcg gcgtggggaa gcgtggcatc gaggagcgca tccaagagga
      481 ggcgggcttt ctcatcgatt catttcggaa gacgaacggt gcttttattg accccacctt
      541 ctaccttagc cgaacagtct ccaatgtcat tagctcaatt gtcttcgggg accgctttga
      601 ctatgaggac aaagagttcc tgtcactgct tcgaatgatg ctgggaagct tccagttcac
      661 tgctacctcc atggggcagc tctatgagat gttctcttct gtgatgaaac acctgccagg
      721 gccccagcaa caggccttta aggagctgca gggcctggag gacttcataa ccaagaaagt
      781 ggaacacaat cagcgcacgc tggatcccaa ttccccaagg gacttcatcg actccttcct
      841 catccgaatg ctggaggaga agaagaaccc caatactgag ttctacatga agaacttggt
      901 gctgactaca ctaaatctct tctttgctgg cacagagacc gtcagcacca ccctgcgcta
      961 tggctttctg ttgctcatga agcacccaga tattgaggcc aaggtccatg aggagattga
     1021 tcgggtgatt ggcaggaacc ggcagcccaa gtatgaggac cgaatgaaga tgccctatac
     1081 ggaggctgta atccatgaga tccagagatt tgcagacatg atccccatgg gcctggctcg
     1141 aagggtcacc aaggacacca agtttcgaga tttcctcctc cccaagggta ctgaagtgtt
     1201 tcctatgctg ggctctgtgc tgaaagaccc caagttcttc tccaacccca aagacttcaa
     1261 cccaaagcac ttcctagatg acaagggaca gtttaagaag aatgatgcct ttgtgccctt
     1321 ttccattgga aaacggtatt gtttcggaga aggactggct aggatggaac tcttcctctt
     1381 cctcacaaac atcatgcaga acttccactt caaatccaca caggcacccc aggacatcga
     1441 tgtgtctcct agactcgtgg gctttgccac gatcccacca acctacacta tgagtttctt
     1501 gtcccgttga gcctgggctg catgaggtta aagggaatga ttgagaccag acaagtcagg
     1561 ggttgaaact tagaaaaggt caaaggtaca gaagaaacag aggacacaga gtagacttgc
     1621 agaggatatt tcaaaggtag ccaaagaaga gggaaattta tactatgttg tcaataggaa
     1681 taataaaata ataaaagtag atattattta tggcaaaaaa aaaaaaaaaa aaaaaaaaaa
     1741 aaaaaa
//
