LOCUS       NM_010009               2440 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus cytochrome P450, family 27, subfamily b, polypeptide 1
            (Cyp27b1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_010009 XM_125908
VERSION     NM_010009.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2440)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2440)
  AUTHORS   Yadav,P.S., Kobelski,M.M., Martins,J.S., Tao,T., Liu,E.S. and
            Demay,M.B.
  TITLE     Impaired Growth Plate Maturation in XLH Is due to Both Excess FGF23
            and Decreased 1,25-Dihydroxyvitamin D Signaling
  JOURNAL   Endocrinology 165 (1) (2023)
   PUBMED   38066669
REFERENCE   3  (bases 1 to 2440)
  AUTHORS   Xie,H., Bastepe,I., Zhou,W., Ay,B., Ceraj,Z.,
            Portales-Castillo,I.A., Liu,E.S., Burnett-Bowie,S.M., Juppner,H.,
            Rhee,E.P., Bastepe,M. and Simic,P.
  TITLE     1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage
  JOURNAL   JCI Insight 8 (17), e168957 (2023)
   PUBMED   37681408
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2440)
  AUTHORS   Rana,R., Baker,J.T., Sorsby,M., Jagga,S., Venkat,S., Almardini,S.
            and Liu,E.S.
  TITLE     Impaired 1,25-dihydroxyvitamin D3 action underlies enthesopathy
            development in the Hyp mouse model of X-linked hypophosphatemia
  JOURNAL   JCI Insight 8 (17), e163259 (2023)
   PUBMED   37490334
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2440)
  AUTHORS   Chen,J., Zhang,J., Li,J., Qin,R., Lu,N., Goltzman,D., Miao,D. and
            Yang,R.
  TITLE     1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related
            Osteoarthritis via Downregulation of Sirt1 in Mice
  JOURNAL   Int J Biol Sci 19 (2), 610-624 (2023)
   PUBMED   36632467
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2440)
  AUTHORS   St-Arnaud,R.
  TITLE     Targeted inactivation of vitamin D hydroxylases in mice
  JOURNAL   Bone 25 (1), 127-129 (1999)
   PUBMED   10423037
  REMARK    Review article
REFERENCE   7  (bases 1 to 2440)
  AUTHORS   Kato,S., Takeyama,K., Kitanaka,S., Murayama,A., Sekine,K. and
            Yoshizawa,T.
  TITLE     In vivo function of VDR in gene expression-VDR knock-out mice
  JOURNAL   J Steroid Biochem Mol Biol 69 (1-6), 247-251 (1999)
   PUBMED   10418998
  REMARK    Review article
REFERENCE   8  (bases 1 to 2440)
  AUTHORS   Brenza,H.L., Kimmel-Jehan,C., Jehan,F., Shinki,T., Wakino,S.,
            Anazawa,H., Suda,T. and DeLuca,H.F.
  TITLE     Parathyroid hormone activation of the 25-hydroxyvitamin
            D3-1alpha-hydroxylase gene promoter
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1387-1391 (1998)
   PUBMED   9465024
REFERENCE   9  (bases 1 to 2440)
  AUTHORS   Nguyen,T.M., Pavlovitch,J., Papiernik,M., Guillozo,H.,
            Walrant-Debray,O., Pontoux,C. and Garabedian,M.
  TITLE     Changes in 1,25-(OH)2D3 synthesis and its receptor expression in
            spleen cell subpopulations of mice infected with LPBM5 retrovirus
  JOURNAL   Endocrinology 138 (12), 5505-5510 (1997)
   PUBMED   9389537
REFERENCE   10 (bases 1 to 2440)
  AUTHORS   Takeyama,K., Kitanaka,S., Sato,T., Kobori,M., Yanagisawa,J. and
            Kato,S.
  TITLE     25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis
  JOURNAL   Science 277 (5333), 1827-1830 (1997)
   PUBMED   9295274
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF168641.1, AB006034.1, BC080697.1 and BM119774.2.
            
            On Apr 25, 2009 this sequence version replaced NM_010009.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                CF168641.1         1-14
            15-1965             AB006034.1         9-1959
            1966-2342           BC080697.1         2001-2377
            2343-2417           BM119774.2         1-75                c
            2418-2440           BC080697.1         2453-2475
FEATURES             Location/Qualifiers
     source          1..2440
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..2440
                     /gene="Cyp27b1"
                     /gene_synonym="Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr;
                     Vdd1; Vddr; VddrI; Vdr"
                     /note="cytochrome P450, family 27, subfamily b,
                     polypeptide 1"
                     /db_xref="GeneID:13115"
                     /db_xref="MGI:MGI:1098274"
     exon            1..230
                     /gene="Cyp27b1"
                     /gene_synonym="Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr;
                     Vdd1; Vddr; VddrI; Vdr"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1559
                     /gene="Cyp27b1"
                     /gene_synonym="Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr;
                     Vdd1; Vddr; VddrI; Vdr"
                     /EC_number="1.14.15.18"
                     /note="cytochrome P450, 27b1; VD3 1A hydroxylase;
                     cytochrome p450 27B1; cytochrome P450C1 alpha; cytochrome
                     P450VD1-alpha; calcidiol 1-monooxygenase; 25-OHD-1
                     alpha-hydroxylase; 25-hydroxyvitamin D(3)
                     1-alpha-hydroxylase; cytochrome P450 subfamily XXVIIB
                     polypeptide 1; cytochrome P450, 40 (25-hydroxyvitamin D3 1
                     alpha-hydroxylase); P450VD1alpha; 1alpha(OH)ase; 25(OH)D
                     1alpha-hydroxylase; 25-hydroxyvitamin D3
                     1alpha-hydroxylase; 25-hydroxyvitamin D-1 alpha
                     hydroxylase, mitochondrial precursor (25-OHD-1
                     alpha-hydroxylase) (25-hydroxyvitamin D3
                     1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha)
                     (P450VD1-alpha)"
                     /codon_start=1
                     /product="25-hydroxyvitamin D-1 alpha hydroxylase,
                     mitochondrial"
                     /protein_id="NP_034139.2"
                     /db_xref="CCDS:CCDS24224.2"
                     /db_xref="GeneID:13115"
                     /db_xref="MGI:MGI:1098274"
                     /translation="MTQAVKLASRVFHRIHLPLQLDASLGSRGSESVLRSLSDIPGPS
                     TLSFLAELFCKGGLSRLHELQVHGAARYGPIWSGSFGTLRTVYVADPTLVEQLLRQES
                     HCPERCSFSSWAEHRRRHQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDN
                     VVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDT
                     ETFIHAVGSVFVSTLLTMAMPNWLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAA
                     MRNQGKPEEDMPSGHHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELS
                     RHPDVQTALHSEITAGTRGSCAHPHGTALSQLPLLKAVIKEVLRLYPVVPGNSRVPDR
                     DIRVGNYVIPQDTLVSLCHYATSRDPTQFPDPNSFNPARWLGEGPTPHPFASLPFGFG
                     KRSCIGRRLAELELQMALSQILTHFEVLPEPGALPIKPMTRTVLVPERSINLQFVDR"
     exon            231..421
                     /gene="Cyp27b1"
                     /gene_synonym="Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr;
                     Vdd1; Vddr; VddrI; Vdr"
                     /inference="alignment:Splign:2.1.0"
     exon            422..624
                     /gene="Cyp27b1"
                     /gene_synonym="Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr;
                     Vdd1; Vddr; VddrI; Vdr"
                     /inference="alignment:Splign:2.1.0"
     exon            625..825
                     /gene="Cyp27b1"
                     /gene_synonym="Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr;
                     Vdd1; Vddr; VddrI; Vdr"
                     /inference="alignment:Splign:2.1.0"
     exon            826..998
                     /gene="Cyp27b1"
                     /gene_synonym="Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr;
                     Vdd1; Vddr; VddrI; Vdr"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1168
                     /gene="Cyp27b1"
                     /gene_synonym="Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr;
                     Vdd1; Vddr; VddrI; Vdr"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1247
                     /gene="Cyp27b1"
                     /gene_synonym="Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr;
                     Vdd1; Vddr; VddrI; Vdr"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1445
                     /gene="Cyp27b1"
                     /gene_synonym="Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr;
                     Vdd1; Vddr; VddrI; Vdr"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..2421
                     /gene="Cyp27b1"
                     /gene_synonym="Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr;
                     Vdd1; Vddr; VddrI; Vdr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2400..2405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp27b1"
                     /gene_synonym="Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr;
                     Vdd1; Vddr; VddrI; Vdr"
                     /note="hexamer: ATTAAA"
     polyA_site      2421
                     /gene="Cyp27b1"
                     /gene_synonym="Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr;
                     Vdd1; Vddr; VddrI; Vdr"
                     /note="major polyA site"
ORIGIN      
        1 aaaagtgctc tcgagcagac tccccaaaca cagacatgac ccaggcagtc aagctcgcct
       61 ccagagtttt tcaccgaatc cacctgcctc tgcagctgga tgcctcgctg ggctccagag
      121 gcagtgagtc ggttctccgg agcttgtctg acatccctgg gccctctaca ctcagcttcc
      181 tggctgaact cttctgcaaa ggggggctgt ccaggctgca tgaactgcag gtgcatggcg
      241 ctgcgcggta cgggccaata tggtctggca gctttgggac acttcgcaca gtttacgttg
      301 ccgaccctac acttgtggag cagctcctgc gacaagaaag tcactgtcca gagcgctgta
      361 gtttctcatc atgggcagag caccgtcgcc gccaccagcg tgcttgcgga ttgctaacgg
      421 cggatggtga agaatggcag aggctccgaa gtcttctggc cccgctcctc ctccggccac
      481 aagcagccgc gggctatgct ggaactctgg acaacgtggt ccgtgacctt gtgcgacgac
      541 taaggcgcca gcggggacgt ggctctgggc tacccggcct agttctggac gtggcaggag
      601 agttttacaa atttggccta gaaagtatag gcgcggtgct gctgggatcg cgcctgggct
      661 gcctagaggc tgaagtccct cctgacacag aaaccttcat acatgcagtg ggctcagtgt
      721 ttgtgtctac actcttgacc atggcgatgc ccaactggtt gcaccacctt atacctggac
      781 cctgggcccg cctctgccga gactgggatc agatgtttgc ctttgcccag aggcacgtgg
      841 agctgcgaga aggtgaagct gcgatgagga accagggaaa gcctgaggag gatatgccgt
      901 ctgggcatca cttaacccac ttcctttttc gggaaaaggt gtctgtccag tccatagtgg
      961 ggaatgtgac agagctacta ctggctggag tggacacggt atccaatacg ctctcctgga
     1021 cactctatga gctttcccgg caccccgatg tccagactgc actccactct gagatcacag
     1081 ctgggacccg tggctcctgt gcccaccccc atggcactgc tctgtcccag ctgcccctgt
     1141 taaaggctgt gatcaaagaa gtgttgagat tgtaccctgt ggtacctggg aattcccgtg
     1201 tcccagacag agacatccgt gtaggaaact atgtaattcc ccaagatacg ctagtctccc
     1261 tatgtcacta tgccacttca agggacccca cacagtttcc agaccccaac tcttttaatc
     1321 cagctcgctg gctgggggag ggtccgaccc cccacccatt tgcatctctt cccttcggct
     1381 ttggcaaacg gagctgcatc gggagacgct tggcagagct tgagctacaa atggctttgt
     1441 cccagatctt gacccatttt gaagtgctac ctgagccagg tgctcttcct atcaagccca
     1501 tgacccggac tgtcctggtc cctgagagga gcatcaatct acagtttgta gatagataac
     1561 cattcggaag acagccaaca tcgtctctct caagacagga tggggtcttt gttatacaca
     1621 agaggcacac tctccttgga ggcctgtctg accgagcaaa ctccaggaag caggtcctga
     1681 cctatgtgta cttggcctga ctcagcaggc atcgcagaac caccatcttt ctccttcctg
     1741 ctcagtgcct ctcctgatca ttcctcagga tccaatgcct tcagatttta acacatcctt
     1801 aaagtgccaa cgcaggggtt aactaccaac tccaggcagc ctggggaggg attcgcccct
     1861 gatcctgtag tgttcgttga tgctctgtct aagcatttat cacggcacaa gctaagtgat
     1921 tgcatctggt ctgcacctgg ctgcatctct acctgaccat gtgtgccttc tgagaagagt
     1981 aatgactagt ctactgggct tttagctctt tttctttttg agacagagtc ttgctatgta
     2041 ttccatgctg tccttgaact cacaacctcc ttgcctcacc ttcccaagta ttgggttaca
     2101 gacttgagct accacttcca gctgtatcag tctttctatc tcctgccaga gtctatccct
     2161 ggctattcag caccatacat tctcagactg aacctggacc atgtggcagg atcgtccact
     2221 caccaggctc tgcccaccct tttctctctt aatctttcct ctagggaagt aaatctgccc
     2281 ttgcctaatt tacagcgttt ttaagcctcc gctaccttgg ttcttcagcc actctcaagt
     2341 ggatccactt cttatcatcc atcttttggc ctgcccctcc tccagcctgt cttttttata
     2401 ttaaaaattt tatatatatt aaaaaaaaaa aaaaaaaaaa
//
