LOCUS       NM_001105201            1557 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cytochrome P450, family 26, subfamily c, polypeptide 1
            (Cyp26c1), mRNA.
ACCESSION   NM_001105201 XM_621503
VERSION     NM_001105201.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1557)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1557)
  AUTHORS   Daniel,E., Barlow,H.R., Sutton,G.I., Gu,X., Htike,Y., Cowdin,M.A.
            and Cleaver,O.
  TITLE     Cyp26b1 is an essential regulator of distal airway epithelial
            differentiation during lung development
  JOURNAL   Development 147 (4) (2020)
   PUBMED   32001436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1557)
  AUTHORS   El Shahawy,M., Reibring,C.G., Hallberg,K., Neben,C.L.,
            Marangoni,P., Harfe,B.D., Klein,O.D., Linde,A. and Gritli-Linde,A.
  TITLE     Sonic Hedgehog Signaling Is Required for Cyp26 Expression during
            Embryonic Development
  JOURNAL   Int J Mol Sci 20 (9), 2275 (2019)
   PUBMED   31072004
  REMARK    GeneRIF: We found that developing teeth from K14-CRE/Shhf/f mutant
            mice exhibit severe downregulation of Cyp26a1 and Cyp26c1
            expression levels in the inner dental epithelium
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1557)
  AUTHORS   Hong,S.H., Fang,S., Lu,B.C., Nofsinger,R., Kawakami,Y.,
            Castro,G.L., Yin,Y., Lin,C., Yu,R.T., Downes,M., Izpisua
            Belmonte,J.C., Shilatifard,A. and Evans,R.M.
  TITLE     Corepressor SMRT is required to maintain Hox transcriptional memory
            during somitogenesis
  JOURNAL   Proc Natl Acad Sci U S A 115 (41), 10381-10386 (2018)
   PUBMED   30254164
REFERENCE   5  (bases 1 to 1557)
  AUTHORS   Metzler,M.A., Raja,S., Elliott,K.H., Friedl,R.M., Tran,N.Q.H.,
            Brugmann,S.A., Larsen,M. and Sandell,L.L.
  TITLE     Correction: RDH10-mediated retinol metabolism and RARalpha-mediated
            retinoic acid signaling are required for submandibular salivary
            gland initiation (doi: 10.1242/dev.164822)
  JOURNAL   Development 145 (17) (2018)
   PUBMED   30166332
  REMARK    Correction to:[Development. 2018 Aug 2;145(15):dev164822. doi:
            10.1242/dev.164822.. PMID: 29986869]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1557)
  AUTHORS   Sirbu,I.O., Gresh,L., Barra,J. and Duester,G.
  TITLE     Shifting boundaries of retinoic acid activity control hindbrain
            segmental gene expression
  JOURNAL   Development 132 (11), 2611-2622 (2005)
   PUBMED   15872003
  REMARK    GeneRIF: Raldh2 and Cyp26 generate shifting boundaries of retionic
            acid activity, controlling hindbrain segmental gene expression.
REFERENCE   7  (bases 1 to 1557)
  AUTHORS   Matt,N., Schmidt,C.K., Dupe,V., Dennefeld,C., Nau,H., Chambon,P.,
            Mark,M. and Ghyselinck,N.B.
  TITLE     Contribution of cellular retinol-binding protein type 1 to retinol
            metabolism during mouse development
  JOURNAL   Dev Dyn 233 (1), 167-176 (2005)
   PUBMED   15765518
REFERENCE   8  (bases 1 to 1557)
  AUTHORS   Makita,T., Duncan,S.A. and Sucov,H.M.
  TITLE     Retinoic acid, hypoxia, and GATA factors cooperatively control the
            onset of fetal liver erythropoietin expression and erythropoietic
            differentiation
  JOURNAL   Dev Biol 280 (1), 59-72 (2005)
   PUBMED   15766748
REFERENCE   9  (bases 1 to 1557)
  AUTHORS   Sakai,Y., Luo,T., McCaffery,P., Hamada,H. and Drager,U.C.
  TITLE     CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the
            equatorial retina during later eye development
  JOURNAL   Dev Biol 276 (1), 143-157 (2004)
   PUBMED   15531370
  REMARK    GeneRIF: Cyp26c1 degrades retinoic acid within the equatorial
            retina during later eye development.
REFERENCE   10 (bases 1 to 1557)
  AUTHORS   Tahayato,A., Dolle,P. and Petkovich,M.
  TITLE     Cyp26C1 encodes a novel retinoic acid-metabolizing enzyme expressed
            in the hindbrain, inner ear, first branchial arch and tooth buds
            during murine development
  JOURNAL   Gene Expr Patterns 3 (4), 449-454 (2003)
   PUBMED   12915310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110212.12.
            
            On Sep 20, 2007 this sequence version replaced XM_621503.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151106.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142, SAMN02146467
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AC110212.12        100278-100481       c
            205-429             AC110212.12        99500-99724         c
            430-705             AC110212.12        98767-99042         c
            706-861             AC110212.12        97176-97331         c
            862-1179            AC110212.12        95134-95451         c
            1180-1557           AC110212.12        92854-93231         c
FEATURES             Location/Qualifiers
     source          1..1557
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 32.36 cM"
     gene            1..1557
                     /gene="Cyp26c1"
                     /gene_synonym="EG546726"
                     /note="cytochrome P450, family 26, subfamily c,
                     polypeptide 1"
                     /db_xref="GeneID:546726"
                     /db_xref="MGI:MGI:2679699"
     CDS             1..1557
                     /gene="Cyp26c1"
                     /gene_synonym="EG546726"
                     /EC_number="1.14.14.1"
                     /codon_start=1
                     /product="cytochrome P450 26C1"
                     /protein_id="NP_001098671.1"
                     /db_xref="CCDS:CCDS50428.1"
                     /db_xref="GeneID:546726"
                     /db_xref="MGI:MGI:2679699"
                     /translation="MISWGLSCLSVLGAAGTTLLCAGLLLGLAQQLWTLRWTLSRDWA
                     STLPLPKGSMGWPFFGETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENV
                     RTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGEPHRQRRKVLARVFSRSSLEQFVPR
                     LQGALRREVRSWCAAQRPVAVYQAAKALTFRMAARILLGLQLDEARCTELAHTFEQLV
                     ENLFSLPLDVPFSGLRKGIRARDQLYEHLDEAVAEKLQEKQTAEPGDALLLIINSARE
                     LGHEPSVQELKELAVELLFAAFFTTASASTSLILLLLQHPAAITKIQQELSAQGLGRA
                     CTCTPRASGSPPDCGCEPDLSLAMLGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFEL
                     DGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGVESGDARGSGGRFHYIPFGG
                     GARSCLGQELAQAVLQLLAVELVRTARWELATPAFPVMQTVPIVHPVDGLLLFFHPLP
                     TSGAGDGLPF"
     exon            1..204
                     /gene="Cyp26c1"
                     /gene_synonym="EG546726"
                     /inference="alignment:Splign:2.1.0"
     exon            205..429
                     /gene="Cyp26c1"
                     /gene_synonym="EG546726"
                     /inference="alignment:Splign:2.1.0"
     exon            430..705
                     /gene="Cyp26c1"
                     /gene_synonym="EG546726"
                     /inference="alignment:Splign:2.1.0"
     exon            706..861
                     /gene="Cyp26c1"
                     /gene_synonym="EG546726"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1179
                     /gene="Cyp26c1"
                     /gene_synonym="EG546726"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1557
                     /gene="Cyp26c1"
                     /gene_synonym="EG546726"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatttcct gggggctgag ctgtttgtcc gtgctggggg ctgccggcac cactctcctg
       61 tgtgcgggtc tgctgctcgg cctggcccaa caactctgga ccctccgctg gactctgagc
      121 cgggattggg cctccacctt gcccctaccc aagggctcca tgggctggcc attcttcggt
      181 gaaacgctgc actggttggt acagggctct cgtttccaca gttcccgccg cgagcgctac
      241 gggacagtgt ttaagacgca ccttctgggc aggccagtga tccgggtgag cggcgctgag
      301 aacgtgcgca ccatcctgct gggcgagcac cgcctggtgc gtagccagtg gccacagagt
      361 gcgcatattc tactagggtc acacacacta cttggcgcgg ttggtgagcc ccatcggcaa
      421 cggcgtaagg tcctggcgcg cgtgttcagc cgctcctctc tggagcaatt cgtgccacgg
      481 ttgcaggggg cgctgcggcg agaggtgcgc tcctggtgcg ccgcccaacg accggtggct
      541 gtttaccagg cggccaaagc actcaccttc cgcatggccg cgcgcatcct gctgggtctg
      601 cagctggacg aagcgcgatg caccgagctg gcccatacct ttgaacagct ggtggagaac
      661 ctcttctcac tgcccttgga cgtaccgttc agcggcctgc gcaagggcat ccgggccagg
      721 gaccagttgt atgagcacct ggatgaggcc gtcgctgaga agcttcagga gaaacagaca
      781 gcagagccag gtgatgccct gctcttgatt attaacagcg ctagggagct gggccacgag
      841 ccctcagtgc aagagctgaa ggagttggct gtagagctcc tcttcgcggc ctttttcacc
      901 acagccagcg ccagcacatc cctcatcctg ctgcttctgc agcacccagc agccatcacc
      961 aaaatccagc aggagctgtc agcgcagggc ctggggcgcg cgtgcacttg cacacccaga
     1021 gcctcaggat cgccaccgga ctgcggttgt gagccggacc ttagcctggc catgctgggc
     1081 cgtttgcgct acgtcgactg cgtagtcaag gaggtgctgc gcctcctacc gccggtgtcc
     1141 gggggctacc gcactgcgct gcgcaccttt gaactggacg gttaccagat ccccaaaggc
     1201 tggagcgtga tgtatagcat ccgagacacg catgagacag ccgcagtgta ccgtagcccg
     1261 cccgagggct tcgatccgga gcgctttggc gtggagagtg gagacgcgcg gggctccggt
     1321 ggccgctttc attacatccc gttcggcggc ggcgcgcgca gctgcctggg gcaggagcta
     1381 gcgcaggcgg tgctgcaact gctcgcagtc gagctggtgc gcaccgcgcg ctgggagctg
     1441 gccacacctg ccttccccgt aatgcagacg gtgcccatcg tgcacccggt ggacgggctg
     1501 ctgctctttt tccaccctct tccgacttcg ggtgcgggag atgggttacc cttctga
//
