LOCUS       NM_001177713            4700 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus cytochrome P450, family 26, subfamily b, polypeptide 1
            (Cyp26b1), transcript variant 2, mRNA.
ACCESSION   NM_001177713
VERSION     NM_001177713.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4700)
  AUTHORS   Schott,M., Leon-Perinan,D., Splendiani,E., Strenger,L., Licha,J.R.,
            Pentimalli,T.M., Schallenberg,S., Alles,J., Samut Tagliaferro,S.,
            Boltengagen,A., Ehrig,S., Abbiati,S., Dommerich,S., Pagani,M.,
            Ferretti,E., Macino,G., Karaiskos,N. and Rajewsky,N.
  TITLE     Open-ST: High-resolution spatial transcriptomics in 3D
  JOURNAL   Cell 187 (15), 3953-3972 (2024)
   PUBMED   38917789
REFERENCE   2  (bases 1 to 4700)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
REFERENCE   3  (bases 1 to 4700)
  AUTHORS   Yan,F., Suzuki,A., Iwaya,C., Pei,G., Chen,X., Yoshioka,H., Yu,M.,
            Simon,L.M., Iwata,J. and Zhao,Z.
  TITLE     Single-cell multiomics decodes regulatory programs for mouse
            secondary palate development
  JOURNAL   Nat Commun 15 (1), 821 (2024)
   PUBMED   38280850
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4700)
  AUTHORS   Souali-Crespo,S., Condrea,D., Vernet,N., Feret,B., Klopfenstein,M.,
            Grandgirard,E., Alunni,V., Cerciat,M., Jung,M., Mayere,C., Nef,S.,
            Mark,M., Chalmel,F. and Ghyselinck,N.B.
  TITLE     Loss of NR5A1 in mouse Sertoli cells after sex determination
            changes cellular identity and induces cell death by anoikis
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38078651
REFERENCE   5  (bases 1 to 4700)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4700)
  AUTHORS   Zhang,J., Smith,D., Yamamoto,M., Ma,L. and McCaffery,P.
  TITLE     The meninges is a source of retinoic acid for the late-developing
            hindbrain
  JOURNAL   J Neurosci 23 (20), 7610-7620 (2003)
   PUBMED   12930800
REFERENCE   7  (bases 1 to 4700)
  AUTHORS   Tahayato,A., Dolle,P. and Petkovich,M.
  TITLE     Cyp26C1 encodes a novel retinoic acid-metabolizing enzyme expressed
            in the hindbrain, inner ear, first branchial arch and tooth buds
            during murine development
  JOURNAL   Gene Expr Patterns 3 (4), 449-454 (2003)
   PUBMED   12915310
REFERENCE   8  (bases 1 to 4700)
  AUTHORS   Menke,D.B. and Page,D.C.
  TITLE     Sexually dimorphic gene expression in the developing mouse gonad
  JOURNAL   Gene Expr Patterns 2 (3-4), 359-367 (2002)
   PUBMED   12617826
REFERENCE   9  (bases 1 to 4700)
  AUTHORS   Abu-Abed,S., MacLean,G., Fraulob,V., Chambon,P., Petkovich,M. and
            Dolle,P.
  TITLE     Differential expression of the retinoic acid-metabolizing enzymes
            CYP26A1 and CYP26B1 during murine organogenesis
  JOURNAL   Mech Dev 110 (1-2), 173-177 (2002)
   PUBMED   11744378
  REMARK    GeneRIF: Differential expression of the retinoic acid-metabolizing
            enzymes CYP26A1 and CYP26B1 during murine organogenesis.
REFERENCE   10 (bases 1 to 4700)
  AUTHORS   MacLean,G., Abu-Abed,S., Dolle,P., Tahayato,A., Chambon,P. and
            Petkovich,M.
  TITLE     Cloning of a novel retinoic-acid metabolizing cytochrome P450,
            Cyp26B1, and comparative expression analysis with Cyp26A1 during
            early murine development
  JOURNAL   Mech Dev 107 (1-2), 195-201 (2001)
   PUBMED   11520679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC059246.1 and AC153606.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059246.1, SRR7652917.182365.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4182              BC059246.1         1-4182
            4183-4700           AC153606.3         148882-149399       c
FEATURES             Location/Qualifiers
     source          1..4700
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 36.45 cM"
     gene            1..4700
                     /gene="Cyp26b1"
                     /gene_synonym="CP26; P450RAI-2"
                     /note="cytochrome P450, family 26, subfamily b,
                     polypeptide 1"
                     /db_xref="GeneID:232174"
                     /db_xref="MGI:MGI:2176159"
     exon            1..120
                     /gene="Cyp26b1"
                     /gene_synonym="CP26; P450RAI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            121..512
                     /gene="Cyp26b1"
                     /gene_synonym="CP26; P450RAI-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1847
                     /gene="Cyp26b1"
                     /gene_synonym="CP26; P450RAI-2"
                     /note="retinoic acid hydroxylase; cytochrome P450, 26,
                     retinoic acid B1; cytochrome P450RAI-2; cytochrome P450
                     retinoic acid-inactivating 2"
                     /codon_start=1
                     /product="cytochrome P450 26B1"
                     /protein_id="NP_001171184.1"
                     /db_xref="CCDS:CCDS20289.1"
                     /db_xref="GeneID:232174"
                     /db_xref="MGI:MGI:2176159"
                     /translation="MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKS
                     CKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENV
                     RKILLGEHQLVSTEWPRSARVLLGPNTVANSIGDIHRNKRKVFSKIFSHEALESYLPK
                     IQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSIPEEDLGHLFEVYQQFV
                     ENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKE
                     HGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHG
                     GGCPCEGTLRLDTLSSLRYLDCVIKEVMRLFTPVSGGYRTVLQTFELDGFQIPKGWSV
                     MYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLF
                     LKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAML
                     SATV"
     exon            513..737
                     /gene="Cyp26b1"
                     /gene_synonym="CP26; P450RAI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1013
                     /gene="Cyp26b1"
                     /gene_synonym="CP26; P450RAI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1169
                     /gene="Cyp26b1"
                     /gene_synonym="CP26; P450RAI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1454
                     /gene="Cyp26b1"
                     /gene_synonym="CP26; P450RAI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..4700
                     /gene="Cyp26b1"
                     /gene_synonym="CP26; P450RAI-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4672..4677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp26b1"
                     /gene_synonym="CP26; P450RAI-2"
                     /note="hexamer: AATAAA"
     polyA_site      4690
                     /gene="Cyp26b1"
                     /gene_synonym="CP26; P450RAI-2"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcgaca gtgtccctgc cagccacagc cagcctgggg cactgcccat accccatcgc
       61 catcgggcgg gctcttcctt tggacacagc tgccagttgc gccccttcca ccttctatcg
      121 gcaatctttt tcctctctct cttcgatcac ctcgcagcct ccagcccctt cccctcggcc
      181 ccatctcctg ggtttctccg aggggtgcca ggaccccctg ccgcagcctc ccctcccccg
      241 tcactctggt ccggccctcc cctcccccat cgcggaccgc acagccaatc ccccaagcgg
      301 ctgccaacat gctgtttgaa ggcttggagt tggtgtcggc gctggccacc ctcgccgcgt
      361 gcctggtgtc cgtgacgctg ctgctggcgg tgtcgcagca gctgtggcag ctgcgctggg
      421 ctgccacccg cgacaagagc tgcaagctgc ccatccccaa gggctccatg ggattcccgc
      481 tcatcggaga gactggtcac tggttgctac agggttccgg cttccagtcg tcgcgccggg
      541 agaagtatgg caacgttttc aagacacact tactggggcg gccgctgatt cgtgtgaccg
      601 gtgcggagaa tgtgcgcaag atcctactgg gcgaacacca gctagtgagc accgagtggc
      661 cgcggagcgc acgcgtactg ctgggtccca acacggtggc caattccatt ggcgacatcc
      721 accgcaacaa gcgcaaggtc ttctccaaga tcttcagcca tgaggcactt gagagctacc
      781 tgcccaagat ccaactggtg atccaggata cacttcgagc ctggagcagc cagcctgagg
      841 ccatcaatgt atatcaggag gcccagcgac ttaccttccg aatggccgtg cgtgtgctgc
      901 taggcttcag catccctgag gaggacctgg gccacctctt tgaggtatac cagcagtttg
      961 tggagaatgt cttctctctg ccagtggacc tgcccttcag tggctaccgg aggggcatcc
     1021 aagctcggca gatccttcag aagggcctag agaaggctat ccgtgagaag ctgcagtgta
     1081 cccagggcaa agactactcg gacgccctgg acattctcat tgagagcagc aaggaacatg
     1141 gcaaggagat gaccatgcag gagctgaagg atggaaccct ggagttgatc ttcgcagcct
     1201 acgccacgac ggccagtgca agcacatcct tgatcatgca actgctaaaa caccctgctg
     1261 tgctggagaa gctgagggag gaactgcggg cccagggcct gctgcatggc ggtggctgcc
     1321 cctgtgaggg taccctgcgc ctggacacgc tcagcagcct gcgctacctg gactgtgtca
     1381 tcaaggaggt catgagactc ttcacgcccg tctcaggcgg ctaccgcact gtgctgcaga
     1441 ccttcgaact ggatggtttc cagatcccca agggctggag tgtcatgtat agcatccgag
     1501 acactcacga cacagcgccc gtgttcaagg acgtgaatgt gtttgacccg gaccgcttca
     1561 gtcaggcacg cagtgaggat aaggatggcc gcttccatta cctcccgttt ggcggtggcg
     1621 tgcggacctg cctgggcaag cacttggcca agctgttcct gaaggtgctg gcagtggagc
     1681 tggccagcac tagccgcttc gagctggcca cccggacctt ccctcgcatc actctggtcc
     1741 ccgtcttgca ccccgtggat ggcctcagtg tcaagttctt tggtctggac tccaaccaga
     1801 atgagattct gccggagaca gaggccatgt tgagtgctac ggtgtagcct cactctggtc
     1861 tcagcccagc ccaacagcag gggtggggga cagagataga aacctgtggg gtggggaggg
     1921 gctgggtggg aggccagcag cccccctatg ttgttctctg gcctcttccc tggcagaacc
     1981 tcccccaaag acaaaagggc cccgccccct cctgactccc tctctcttgg atctccactg
     2041 ccacctagct tagctcctgg gacagagcca ggactgtatg cccatgacag tgttagcgcc
     2101 ggccggttga gctgcagtat atgcttatga catctgaatc cttccttccc ttgccccctt
     2161 gtctttttgt tggtgagtgg tcaggtggct ctgaaggcag aagggaggaa aagagggggc
     2221 cccttggagc actctttgac accccccccc ccacgtccct ctttctgtca ctgatcaaat
     2281 ggtgaccaga acagtgttct ggagattctc gcctaagcca accgaggcag ggcagcggct
     2341 gccaccagcc ttgaggggcc cataccagcc taaccagttt ggacattgga aattacctat
     2401 cgctgctatt tgtcctctct tctgaccttg ggggtacagg agcctatagg cttaatcctc
     2461 agcatcttcc ttggtggccc tggacaggga caccggcatg cctcccccat gggaccaact
     2521 gagccgggtg gcttctggct atagctgggc tccccgctac ctacccttgc ccctgtccca
     2581 tatttattca ctgaccttgg ccagactgag gtctggagca ccctccccca acacctacac
     2641 accgccattg ccaccacacg cacacacctg ccagcctctg tcctttccag ggcttcagtg
     2701 aggcaagaag acagtgtgtc tggtctaacc cagttctttg gtagagggtt aacagccctg
     2761 ctgggctcta ggcaaaagat gtagtttaac ctcagagtca gacaccctgc atctctgcca
     2821 ggtgtactta gcacctcctc ccaggctgtc aaagccctgg gcatgtgggt ctaggggcca
     2881 ccacttcctg ttcactcact gcctgtccca gtgccagcca ctcccctggt gaggatgaat
     2941 aaggatacgg gttcttctga agggacttct gtcttccctt ccttagctct ctgccccttt
     3001 gctcttggaa gagtccccca ccccataacc actcccaccc catgccactg tctgctaagc
     3061 ccagcccagg gtttggggta gagaagaaag cagagaggta aggtggaaag agagtcctct
     3121 ctctgagctg cttcaggccc tgtggggtct ggagaagctg caggggaggc tgtagctaga
     3181 aagcaatgga gaaggagagg aggaagatga gggcgattga ggtcagggca taagtgattt
     3241 gtcagaagtg gttcagttgc agaaaggcca gtgggggtgt ggaagatgac tgggtggaag
     3301 acgagggatt cctgcctctg gcattttgag ggttggccat gtgggacctt cctgggaagg
     3361 gtttggggtt ctggtgtgtc tctaggcaat tttgtctgtt ttcagattcc ccttcatttt
     3421 ccgtccatgg cttttgcctg ttactaaggt agtggctctt tttctccaga aaacagaggc
     3481 acagaatgac agtccatatc gatctgaccc tggatggcca ctgtcatgag ggtcagccac
     3541 atctcaccag ccacacagaa catcctatga gccacatttc ttgatgtttc actggtctgc
     3601 attttttttt tctgacagaa ccagaacaaa ctacagcatt agaatcccag caaaattatt
     3661 gtggagtcaa acatagctgt cagccctcag ctccctttcc ctgttctaaa acaggccaga
     3721 ctgtgtaaag actcagcaaa gtttatgaaa aaggtgcatg ctgcccatac cccacagacc
     3781 agtgcccggg aggctcatct tcctgcacgc taaccctgcc tgcctgcagc catctgcttc
     3841 agactgacga tgtggcatgt gactctggtc ctggtgaggg atgggcactg gggggcccct
     3901 ccaggcgtca gaggccttca ttttcagggg gccggccgag gaagtgtgaa ggaaaagctg
     3961 aaggggatcc ctgtgggggt gggaggaaga aaagatggtc tgcccggatg ggtctcagag
     4021 gtaacaggaa aagagacctc gcctcagcac ctgcggtgtg atacccgtct cacctctgta
     4081 gatgtgtctg ttccgtgttc gtgtgtctcg ttgtggtagc attaatgggt gatgtagtct
     4141 cacattccta actattgtaa cttgacattt aaaaaaaaaa aacaaacccc acaaaaattc
     4201 ctgccacggg cttgcagatt gaagcacttt caaagttagg cgctggcgtg tgcatcctgg
     4261 gcagccattt tgatgcggcc cagatttcta ttattttata cacaaaactt tttttttcat
     4321 aaatgttata attttgtgtc tgtctttata aactattata agtactattt ttgttataat
     4381 tcaaaataga tatttagtat aaagtttttg ctgttaaata tttgttattt agtaaaatat
     4441 gaattgttct ttattgtaaa catggttcaa aatattaata tgcttttatc acagttgttt
     4501 taatattgag aaagcacttg tgtgtctcgt tttggtatga gctggtgctg tgtgtgtgtt
     4561 ttggctgtcg tgtggttttg atgtgtatat aatattccgt gttgcatatt acaacaatga
     4621 atgccatgca ttttgtgaaa tactcaatgt ggctctttta ttggcttccg taataaactg
     4681 tggggactca cccttgtctc
//
