LOCUS       NM_007811               1781 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus cytochrome P450, family 26, subfamily a, polypeptide 1
            (Cyp26a1), mRNA.
ACCESSION   NM_007811
VERSION     NM_007811.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1781)
  AUTHORS   Matsuoka,R., Kitajima,K., Nii,T., Zou,Z., Tanaka,K., Joo,K.,
            Ohkawa,Y., Ohga,S. and Meno,C.
  TITLE     Hyperglycaemia induces diet-dependent defects of the left-right
            axis by lowering intracellular pH
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167550 (2025)
   PUBMED   39442590
REFERENCE   2  (bases 1 to 1781)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1781)
  AUTHORS   Pappas,M.P., Kawakami,H., Corcoran,D., Chen,K.Q., Scott,E.P.,
            Wong,J., Gearhart,M.D., Nishinakamura,R., Nakagawa,Y. and
            Kawakami,Y.
  TITLE     Sall4 regulates posterior trunk mesoderm development by promoting
            mesodermal gene expression and repressing neural genes in the
            mesoderm
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38345319
REFERENCE   4  (bases 1 to 1781)
  AUTHORS   Yoo,H.S., Cockrum,M.A. and Napoli,J.L.
  TITLE     Cyp26a1 supports postnatal retinoic acid homeostasis and
            glucoregulatory control
  JOURNAL   J Biol Chem 299 (5), 104669 (2023)
   PUBMED   37011860
  REMARK    GeneRIF: Cyp26a1 supports postnatal retinoic acid homeostasis and
            glucoregulatory control.
REFERENCE   5  (bases 1 to 1781)
  AUTHORS   Li,B., Brusman,L., Dahlka,J. and Niswander,L.A.
  TITLE     TMEM132A ensures mouse caudal neural tube closure and regulates
            integrin-based mesodermal migration
  JOURNAL   Development 149 (17) (2022)
   PUBMED   35950911
REFERENCE   6  (bases 1 to 1781)
  AUTHORS   Iulianella,A., Beckett,B., Petkovich,M. and Lohnes,D.
  TITLE     A molecular basis for retinoic acid-induced axial truncation
  JOURNAL   Dev Biol 205 (1), 33-48 (1999)
   PUBMED   9882496
REFERENCE   7  (bases 1 to 1781)
  AUTHORS   White,J.A., Beckett,B., Scherer,S.W., Herbrick,J.A. and
            Petkovich,M.
  TITLE     P450RAI (CYP26A1) maps to human chromosome 10q23-q24 and mouse
            chromosome 19C2-3
  JOURNAL   Genomics 48 (2), 270-272 (1998)
   PUBMED   9521883
REFERENCE   8  (bases 1 to 1781)
  AUTHORS   Abu-Abed,S.S., Beckett,B.R., Chiba,H., Chithalen,J.V., Jones,G.,
            Metzger,D., Chambon,P. and Petkovich,M.
  TITLE     Mouse P450RAI (CYP26) expression and retinoic acid-inducible
            retinoic acid metabolism in F9 cells are regulated by retinoic acid
            receptor gamma and retinoid X receptor alpha
  JOURNAL   J Biol Chem 273 (4), 2409-2415 (1998)
   PUBMED   9442090
REFERENCE   9  (bases 1 to 1781)
  AUTHORS   Ray,W.J., Bain,G., Yao,M. and Gottlieb,D.I.
  TITLE     CYP26, a novel mammalian cytochrome P450, is induced by retinoic
            acid and defines a new family
  JOURNAL   J Biol Chem 272 (30), 18702-18708 (1997)
   PUBMED   9228041
REFERENCE   10 (bases 1 to 1781)
  AUTHORS   Fujii,H., Sato,T., Kaneko,S., Gotoh,O., Fujii-Kuriyama,Y.,
            Osawa,K., Kato,S. and Hamada,H.
  TITLE     Metabolic inactivation of retinoic acid by a novel P450
            differentially expressed in developing mouse embryos
  JOURNAL   EMBO J 16 (14), 4163-4173 (1997)
   PUBMED   9250660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK626921.1, CB574526.1, AA239785.1 and CJ217321.1.
            
            On Apr 8, 2008 this sequence version replaced NM_007811.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y12657.1, AF115769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-618               CK626921.1         1-618
            619-1098            CB574526.1         193-672
            1099-1545           AA239785.1         28-474
            1546-1781           CJ217321.1         163-398
FEATURES             Location/Qualifiers
     source          1..1781
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 32.36 cM"
     gene            1..1781
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26; P450RA; P450RAI; RAH"
                     /note="cytochrome P450, family 26, subfamily a,
                     polypeptide 1"
                     /db_xref="GeneID:13082"
                     /db_xref="MGI:MGI:1096359"
     exon            1..291
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26; P450RA; P450RAI; RAH"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1596
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26; P450RA; P450RAI; RAH"
                     /note="cytochrome P450, 26, retinoic acid A1; cytochrome
                     P450RAI; retinoic acid 4-hydroxylase; retinoic
                     acid-metabolizing cytochrome; retinoic acid hydrolase"
                     /codon_start=1
                     /product="cytochrome P450 26A1"
                     /protein_id="NP_031837.2"
                     /db_xref="CCDS:CCDS29780.1"
                     /db_xref="GeneID:13082"
                     /db_xref="MGI:MGI:1096359"
                     /translation="MGLPALLASALCTFVLPLLLFLAALKLWDLYCVSSRDRSCALPL
                     PPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILL
                     GEHRLVSVHWPASVRTILGAGCLSNLHDSSHKQRKKVIMQAFSREALQCYVPVIAEEV
                     SSCLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPGPAGGGEDEQQLVEAFEEMT
                     RNLFSLPIDVPFSGLYRGVKARNLIHARIEENIRAKIRRLQATEPDGGCKDALQLLIE
                     HSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEIKSKG
                     LLCKSNQDNKLDMETLEQLKYTGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGW
                     NVIYSICDTHDVADIFTNKEEFNPDRFIVPHPEDASRFSFIPFGGGLRSCVGKEFAKI
                     LLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFQGDI"
     exon            292..516
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26; P450RA; P450RAI; RAH"
                     /inference="alignment:Splign:2.1.0"
     exon            517..807
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26; P450RA; P450RAI; RAH"
                     /inference="alignment:Splign:2.1.0"
     exon            808..966
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26; P450RA; P450RAI; RAH"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1101
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26; P450RA; P450RAI; RAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1254
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26; P450RA; P450RAI; RAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1781
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26; P450RA; P450RAI; RAH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1760..1765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26; P450RA; P450RAI; RAH"
                     /note="hexamer: AATAAA"
     polyA_site      1781
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26; P450RA; P450RAI; RAH"
                     /note="major polyA site"
ORIGIN      
        1 ggtaacgtgg gcagtaacct gggcggcctt ataaagaggg cgcgcggcgg ggttcggagc
       61 tagggcggcg gcggcaggtg gcgcgggagg ctgaagcgtg ccatggggct cccggcgctg
      121 ctggccagtg cgctctgcac cttcgtgctg ccgctgctgc tcttcctggc ggcgctcaag
      181 ctctgggacc tgtactgtgt gagcagccgc gatcgcagct gcgccctccc cttgcccccc
      241 ggtaccatgg gcttcccatt ctttggggaa acattgcaga tggtgcttca gcggaggaag
      301 tttctgcaga tgaagcgcag gaaatacggc ttcatctaca agacgcatct gtttgggcgg
      361 cccacggtgc gggtgatggg cgcggataat gtgcggcgca tcttgctggg agagcaccgg
      421 ttggtgtcgg tgcactggcc cgcgtcggtg cgcaccatcc tgggcgctgg ctgcctctcc
      481 aacctgcacg attcctcgca caagcagcga aagaaggtga ttatgcaggc cttcagccgc
      541 gaggcactcc agtgctacgt gcccgtgatc gctgaggaag tcagcagttg tctggagcag
      601 tggctaagct gcggcgagcg cggcctcctg gtctaccccg aggtgaagcg cctcatgttc
      661 cgcatcgcca tgcgcatcct gctgggctgc gagccgggtc cagcgggcgg cggggaggac
      721 gagcagcagc tcgtggaggc tttcgaggag atgacccgca atctcttctc tcttcccatt
      781 gacgtgccct ttagcggcct gtaccggggc gtgaaggcgc ggaaccttat acacgcgcgc
      841 atcgaggaga acattcgcgc caagatccgc cggcttcagg ctacagagcc ggatgggggt
      901 tgcaaggacg cgctgcagct cctgattgag cactcgtggg agaggggaga gaggctggat
      961 atgcaggcac taaaacaatc gtcaacagag ctcctctttg gtggtcatga aactacagcc
     1021 agtgctgcga cgtcactgat cacttaccta ggactctacc cacatgtcct ccagaaagtt
     1081 cgagaagaga taaagagcaa gggcttactt tgcaagagca atcaagacaa caagttagac
     1141 atggaaactt tggaacagct taaatacact gggtgtgtca ttaaggagac cctgcgattg
     1201 aatcctccgg ttccaggagg gtttcgggtt gctctgaaga cttttgagct gaatggatac
     1261 cagatcccca agggctggaa tgttatttac agtatctgtg acacccacga tgtggcagat
     1321 atcttcacta acaaggagga atttaatccc gaccgcttta tagtgcctca tccagaggat
     1381 gcttcccggt tcagcttcat tccatttgga ggaggccttc ggagctgtgt aggcaaagag
     1441 tttgcaaaaa ttcttcttaa gatatttaca gtggagctgg ctaggcactg tgattggcag
     1501 cttctaaatg gacctcctac aatgaagaca agccccactg tgtaccctgt ggacaatctc
     1561 cctgcaagat ttacccactt ccagggagat atctgatagc tatttcaatt cttggactta
     1621 tttgaagtgt atattgtttt ttttaaaata gtgtcatgtt gactttattt aatttctaaa
     1681 tgtatagtat gatatttatg tgtctctact acagtcccgt ggtcttaaat attaaaataa
     1741 tgaatttgta tgatttccca ataaagtaaa attaaaaagt g
//
