LOCUS       NP_034126                514 aa            linear   ROD 14-JAN-2025
DEFINITION  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor
            [Mus musculus].
ACCESSION   NP_034126
VERSION     NP_034126.1
DBSOURCE    REFSEQ: accession NM_009996.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 514)
  AUTHORS   Meyer,M.B., Lee,S.M., Towne,J.M., Cichanski,S.R., Kaufmann,M.,
            Jones,G. and Pike,J.W.
  TITLE     In Vivo Contribution of Cyp24a1 Promoter Vitamin D Response
            Elements
  JOURNAL   Endocrinology 165 (11) (2024)
   PUBMED   39363152
  REMARK    GeneRIF: In Vivo Contribution of Cyp24a1 Promoter Vitamin D
            Response Elements.
REFERENCE   2  (residues 1 to 514)
  AUTHORS   Tam,P.L.F., Cheung,M.F., Chan,L.Y. and Leung,D.
  TITLE     Cell-type differential targeting of SETDB1 prevents aberrant CTCF
            binding, chromatin looping, and cis-regulatory interactions
  JOURNAL   Nat Commun 15 (1), 15 (2024)
   PUBMED   38167730
  REMARK    GeneRIF: Cell-type differential targeting of SETDB1 prevents
            aberrant CTCF binding, chromatin looping, and cis-regulatory
            interactions.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 514)
  AUTHORS   Verma,A., Vincent-Chong,V.K., DeJong,H., Hershberger,P.A. and
            Seshadri,M.
  TITLE     Impact of dietary vitamin D on initiation and progression of oral
            cancer
  JOURNAL   J Steroid Biochem Mol Biol 199, 105603 (2020)
   PUBMED   31981799
  REMARK    GeneRIF: Impact of dietary vitamin D on initiation and progression
            of oral cancer.
REFERENCE   4  (residues 1 to 514)
  AUTHORS   Meyer,M.B., Lee,S.M., Carlson,A.H., Benkusky,N.A., Kaufmann,M.,
            Jones,G. and Pike,J.W.
  TITLE     A chromatin-based mechanism controls differential regulation of the
            cytochrome P450 gene Cyp24a1 in renal and non-renal tissues
  JOURNAL   J Biol Chem 294 (39), 14467-14481 (2019)
   PUBMED   31439663
REFERENCE   5  (residues 1 to 514)
  AUTHORS   Singh,A., Verma,A., Sallin,M.A., Lang,F., Sen,R. and Sen,J.M.
  TITLE     Noncoding variations in Cyp24a1 gene are associated with
            Klotho-mediated aging phenotypes in different strains of mice
  JOURNAL   Aging Cell 18 (3), e12949 (2019)
   PUBMED   30920112
  REMARK    GeneRIF: Decreased expression of Cyp24a1 in susceptible strains was
            associated with genetic alterations in noncoding regions of Cyp24a1
            gene, which were strongly reminiscent of super-enhancers that
            regulate gene expression.
REFERENCE   6  (residues 1 to 514)
  AUTHORS   Akeno,N., Saikatsu,S., Kawane,T. and Horiuchi,N.
  TITLE     Mouse vitamin D-24-hydroxylase: molecular cloning, tissue
            distribution, and transcriptional regulation by
            1alpha,25-dihydroxyvitamin D3
  JOURNAL   Endocrinology 138 (6), 2233-2240 (1997)
   PUBMED   9165006
REFERENCE   7  (residues 1 to 514)
  AUTHORS   Roy,S. and Tenenhouse,H.S.
  TITLE     Transcriptional regulation and renal localization of
            1,25-dihydroxyvitamin D3-24-hydroxylase gene expression: effects of
            the Hyp mutation and 1,25-dihydroxyvitamin D3
  JOURNAL   Endocrinology 137 (7), 2938-2946 (1996)
   PUBMED   8770917
REFERENCE   8  (residues 1 to 514)
  AUTHORS   Itoh,S., Yoshimura,T., Iemura,O., Yamada,E., Tsujikawa,K.,
            Kohama,Y. and Mimura,T.
  TITLE     Molecular cloning of 25-hydroxyvitamin D-3 24-hydroxylase (Cyp-24)
            from mouse kidney: its inducibility by vitamin D-3
  JOURNAL   Biochim Biophys Acta 1264 (1), 26-28 (1995)
   PUBMED   7578252
REFERENCE   9  (residues 1 to 514)
  AUTHORS   Williamson,C.M., Dutton,E.R., Abbott,C.M., Beechey,C.V., Ball,S.T.
            and Peters,J.
  TITLE     Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1,
            Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal
            imprinting region of mouse chromosome 2 are not monoallelically
            expressed
  JOURNAL   Genet Res 65 (2), 83-93 (1995)
   PUBMED   7781998
REFERENCE   10 (residues 1 to 514)
  AUTHORS   Malas,S., Peters,J. and Abbott,C.
  TITLE     The genes for endothelin 3, vitamin D 24-hydroxylase, and
            melanocortin 3 receptor map to distal mouse chromosome 2, in the
            region of conserved synteny with human chromosome 20
  JOURNAL   Mamm Genome 5 (9), 577-579 (1994)
   PUBMED   8000144
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK159852.1.
            
            Summary: The protein encoded by this gene localizes to the
            mitochondrion, where it degrades calcitriol to calcitetrol. This
            gene is upregulated by binding of calcitriol to the upstream
            regulatory region and to a downstream enhancer region, thereby
            allowing calcitriol to autoregulate its concentration in the cell.
            The encoded protein may also play a role in calcium homeostasis.
            [provided by RefSeq, Aug 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159109.1, AK159852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 91.91 cM"
     Protein         1..514
                     /product="1,25-dihydroxyvitamin D(3) 24-hydroxylase,
                     mitochondrial precursor"
                     /EC_number="1.14.15.16"
                     /note="cytochrome P450, 24a1; 1,25-dihydroxyvitamin D(3)
                     24-hydroxylase, mitochondrial; cytochrome P450 24A1;
                     cytochrome P450-CC24; vitamin D(3) 24-hydroxylase;
                     25-hydroxyvitamin D-24-hydroxylase"
                     /calculated_mol_wt=59322
     Region          90..508
                     /region_name="CYP24A1"
                     /note="cytochrome P450 family 24, subfamily A, polypeptide
                     1, also called vitamin D(3) 24-hydroxylase; cd20645"
                     /db_xref="CDD:410738"
     Site            order(101,104,128..132,134,148,204..205,208,243,246..247,
                     249..251,253..254,325,329,391,393..394,497,499..500)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:410738"
     Site            order(128,147,155,159,323,326..327,330..331,334,391,394,
                     396,454..457,460..464)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:410738"
     CDS             1..514
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; CP24; Cyp24"
                     /coded_by="NM_009996.4:372..1916"
                     /note="cytochrome P450, family 24, subfamily a,
                     polypeptide 1 (MGD|MGI:88593 GB|NM_009996, evidence:
                     BLASTN, 99%, match=3296); putative"
                     /db_xref="CCDS:CCDS17122.1"
                     /db_xref="GeneID:13081"
                     /db_xref="MGI:MGI:88593"
ORIGIN      
        1 mscpidkrrp liaflrrlrd lgqpprsvts kahvkrapke vplcplmtdg etrnvtslpg
       61 ptnwpllgsl leifwkgglk kqhdtlaeyh kkygqifrmk lgsfdsvhlg spsllealyr
      121 tesahpqrle ikpwkayrdh rneayglmil egqewqrvrs afqkklmkpv eimkldkkin
      181 evladfmgqi delrdergri qdlyselnkw sfesiclvly ekrfgllqkd teeealtfia
      241 aiktmmstfg kmmvtpvelh krlntkvwqa htlawdtifk svkpcidhrl erysqqpgad
      301 flcdiyqqdh lskkelyaav telqlaavet tanslmwily nlsrnpqvqq rllreiqsvl
      361 pdnqtpraed vrnmpylkac lkesmrltps vpfttrtldk ptvlgeytlp kgtvltlntq
      421 vlgssednfe dadkfrperw lekekkinpf ahlpfgvgkr mcigrrlael qlhlalcwii
      481 qkynivatds epvemlhlgi lvpsrelpia fcpr
//
