LOCUS       NM_009994               5161 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus cytochrome P450, family 1, subfamily b, polypeptide 1
            (Cyp1b1), transcript variant 1, mRNA.
ACCESSION   NM_009994
VERSION     NM_009994.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5161)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 5161)
  AUTHORS   Tung,H.C., Kim,J.W., Zhu,J., Li,S., Yan,J., Liu,Q., Koo,I.,
            Koshkin,S.A., Hao,F., Zhong,G., Xu,M., Wang,Z., Wang,J., Huang,Y.,
            Xi,Y., Cai,X., Xu,P., Ren,S., Higashiyama,T., Gonzalez,F.J., Li,S.,
            Isoherranen,N., Yang,D., Ma,X., Patterson,A.D. and Xie,W.
  TITLE     Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic
            stellate cell activation and liver fibrosis by accumulating
            trehalose
  JOURNAL   Sci Transl Med 16 (766), eadk8446 (2024)
   PUBMED   39321267
  REMARK    GeneRIF: Inhibition of heme-thiolate monooxygenase CYP1B1 prevents
            hepatic stellate cell activation and liver fibrosis by accumulating
            trehalose.
REFERENCE   3  (bases 1 to 5161)
  AUTHORS   Wu,J., Li,Y., Tian,S., Na,S., Wei,H., Wu,Y., Yang,Y., Shen,Z.,
            Ding,J., Bao,S., Liu,S., Li,L., Feng,R., Zhu,Y., He,C. and Yue,J.
  TITLE     CYP1B1 affects the integrity of the blood-brain barrier and
            oxidative stress in the striatum: An investigation of
            manganese-induced neurotoxicity
  JOURNAL   CNS Neurosci Ther 30 (3), e14633 (2024)
   PUBMED   38429921
  REMARK    GeneRIF: CYP1B1 affects the integrity of the blood-brain barrier
            and oxidative stress in the striatum: An investigation of
            manganese-induced neurotoxicity.
REFERENCE   4  (bases 1 to 5161)
  AUTHORS   Stading,R., Swanson,L., Xia,G., Jiang,W., Wang,L., Couroucli,X.,
            Lingappan,K. and Moorthy,B.
  TITLE     Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs)
            augments neonatal hyperoxic lung injury: Role of cytochrome P450
            (CYP)1A1, 1A2, and 1B1
  JOURNAL   Free Radic Biol Med 211, 35-46 (2024)
   PUBMED   38081439
REFERENCE   5  (bases 1 to 5161)
  AUTHORS   Larsen,M.C., Rondelli,C.M., Almeldin,A., Song,Y.S., N'Jai,A.,
            Alexander,D.L., Forsberg,E.C., Sheibani,N. and Jefcoate,C.R.
  TITLE     AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor
            Cells: The Enrichment of Multiple Olfactory Receptors as Potential
            Microbiome Sensors
  JOURNAL   Int J Mol Sci 24 (23), 16884 (2023)
   PUBMED   38069208
  REMARK    GeneRIF: AhR and CYP1B1 Control Oxygen Effects on Bone Marrow
            Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as
            Potential Microbiome Sensors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5161)
  AUTHORS   Bhattacharyya,K.K., Brake,P.B., Eltom,S.E., Otto,S.A. and
            Jefcoate,C.R.
  TITLE     Identification of a rat adrenal cytochrome P450 active in
            polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a
            unique tissue-specific pattern of hormonal and aryl hydrocarbon
            receptor-linked regulation
  JOURNAL   J Biol Chem 270 (19), 11595-11602 (1995)
   PUBMED   7744798
REFERENCE   7  (bases 1 to 5161)
  AUTHORS   Shen,Z., Liu,J., Wells,R.L. and Elkind,M.M.
  TITLE     cDNA cloning, sequence analysis, and induction by aryl hydrocarbons
            of a murine cytochrome P450 gene, Cyp1b1
  JOURNAL   DNA Cell Biol 13 (7), 763-769 (1994)
   PUBMED   7772257
REFERENCE   8  (bases 1 to 5161)
  AUTHORS   Savas,U., Bhattacharyya,K.K., Christou,M., Alexander,D.L. and
            Jefcoate,C.R.
  TITLE     Mouse cytochrome P-450EF, representative of a new 1B subfamily of
            cytochrome P-450s. Cloning, sequence determination, and tissue
            expression
  JOURNAL   J Biol Chem 269 (21), 14905-14911 (1994)
   PUBMED   8195121
REFERENCE   9  (bases 1 to 5161)
  AUTHORS   Shen,Z., Wells,R.L., Liu,J. and Elkind,M.M.
  TITLE     Identification of a cytochrome P450 gene by reverse
            transcription--PCR using degenerate primers containing inosine
  JOURNAL   Proc Natl Acad Sci U S A 90 (24), 11483-11487 (1993)
   PUBMED   7505439
REFERENCE   10 (bases 1 to 5161)
  AUTHORS   Pottenger,L.H., Christou,M. and Jefcoate,C.R.
  TITLE     Purification and immunological characterization of a novel
            cytochrome P450 from C3H/10T1/2 cells
  JOURNAL   Arch Biochem Biophys 286 (2), 488-497 (1991)
   PUBMED   1910294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ059150.1, AK137461.1 and AC132612.3.
            
            On Jul 13, 2018 this sequence version replaced NM_009994.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U03283.1, BC050063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               CJ059150.1         2-102
            102-3318            AK137461.1         1-3217
            3319-5161           AC132612.3         182186-184028       c
FEATURES             Location/Qualifiers
     source          1..5161
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 50.3 cM"
     gene            1..5161
                     /gene="Cyp1b1"
                     /gene_synonym="CP1B; CYPIB1; P4501b1"
                     /note="cytochrome P450, family 1, subfamily b, polypeptide
                     1"
                     /db_xref="GeneID:13078"
                     /db_xref="MGI:MGI:88590"
     exon            1..375
                     /gene="Cyp1b1"
                     /gene_synonym="CP1B; CYPIB1; P4501b1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..1419
                     /gene="Cyp1b1"
                     /gene_synonym="CP1B; CYPIB1; P4501b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..2008
                     /gene="Cyp1b1"
                     /gene_synonym="CP1B; CYPIB1; P4501b1"
                     /EC_number="1.14.14.1"
                     /EC_number="4.2.1.152"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytochrome P450 1B1; cytochrome P450EF; cytochrome
                     P450CMEF; cytochrome P450, 1b1, benz[a]anthracene
                     inducible; hydroperoxy icosatetraenoate dehydratase"
                     /codon_start=1
                     /product="cytochrome P450 1B1 isoform 1"
                     /protein_id="NP_034124.1"
                     /db_xref="CCDS:CCDS28986.1"
                     /db_xref="GeneID:13078"
                     /db_xref="MGI:MGI:88590"
                     /translation="MATSLSADSPQQLSSLSTQQTTLLLLFSVLAAVHLGQWLLRQWQ
                     RKPWSSPPGPFPWPLIGNAAAVGQASHLYFARLARRYGDVFQIRLGSCPVVVLNGESA
                     IHQALVQQGSIFADRPPFASFRVVSGGRSLAFGHYSEHWKTQRRSAYSTMRAFSTRHP
                     RSRGLLEGHALAEARELVAVLVRRCAGGAFLDPTQPVIVAVANVMSAVCFGCRYNHDD
                     AEFLELLSHNEEFGRTVGAGSLVDVLPWLQLFPNPVRTTFRKFEQLNRNFSNFVLDKF
                     LRHRESLVPGAAPRDMTDAFILSAEKKASGAPGDDSSGLDLEDVPATITDIFGASQDT
                     LSTALLWLLILFTRYPDVQARVQAELDQVVGRDRLPCMSDQPNLPYVMAFLYESMRFS
                     SFLPVTIPHATTANTFVLGYYIPKNTVVFVNQWSVNHDPAKWPNPEDFDPARFLDKDG
                     FINKALASSVMIFSVGKRRCIGEELSKMLLFLFISILAHQCNFKANQNESSNMSFSYG
                     LTIKPKSFRIHVSLRESMELLDNAVKKLQTEEGCK"
     exon            1420..5161
                     /gene="Cyp1b1"
                     /gene_synonym="CP1B; CYPIB1; P4501b1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5132..5137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp1b1"
                     /gene_synonym="CP1B; CYPIB1; P4501b1"
                     /note="hexamer: AATAAA"
     polyA_site      5156
                     /gene="Cyp1b1"
                     /gene_synonym="CP1B; CYPIB1; P4501b1"
                     /note="major polyA site"
ORIGIN      
        1 atcgcctctg gggtgcgttg cagacacctc tgcgacgcca gcttgaaaac tgccagcggg
       61 ctgggattta actccacttt atcaactccc acccccgacc cttctcaact gcaaccccaa
      121 ctccgtgaga aagccctgac tttgcggggt cccaggtgca aacttgagac acttttgtcc
      181 ctgtcctcca tcctaatcta agtttaggct ctgattgagt caagagtagg tgctaaagca
      241 gcgggcctca ggtgtctagg tctcggggtc cctggggact ctcaggttga agccttgcca
      301 gaatctgggc agaggctcca gagcttctcc cagatcccgc tgctctacac cgctggaaac
      361 cacgcttcat cgcagcatgg ccaccagcct tagtgcagac agtccacagc agctgagctc
      421 gctgtctacc cagcagacca ctcttctgct actcttctcc gtcctggccg ccgtgcactt
      481 aggccagtgg ctgctgcgac agtggcaacg gaaaccgtgg tcctcgcccc caggtccctt
      541 tccttggcca ctgatcggaa acgcggcggc tgttggccag gcgtcgcact tgtacttcgc
      601 tcgccttgca aggcgctatg gcgacgtttt ccagatccgt ctgggcagct gtcccgtggt
      661 ggtgctgaat ggagagagtg ccatccacca ggccctggtg cagcagggca gcatcttcgc
      721 ggaccggccg cccttcgcct ctttccgtgt ggtgtctggt ggccgcagtc tggcgttcgg
      781 tcactactct gagcactgga agacgcagcg acgctcggcc tatagcacga tgcgtgcttt
      841 ctccacgcgc cacccgcgca gtcgcggtct tctcgagggc cacgcgctgg cagaggctcg
      901 agaattggtg gcagtgctgg tgcggcgctg tgcgggcggc gccttcctcg atccaacgca
      961 gccggtcatt gtggcggtgg ccaacgtcat gagcgctgtg tgcttcggct gtcggtacaa
     1021 ccacgacgat gcggagttcc tagagctgct cagccacaat gaggagttcg ggcgcacagt
     1081 gggtgcgggc agcctggtgg atgtgctgcc ctggctgcag ctatttccca acccggtgcg
     1141 caccaccttc cgcaagttcg agcagctcaa ccgcaacttc agcaacttcg ttctggacaa
     1201 gttcctgagg caccgcgaaa gcctggtgcc cggggctgct cctcgagaca tgacggacgc
     1261 cttcatcctc tctgccgaaa agaaagcgtc tggggcccct ggcgacgatt cctccgggct
     1321 ggacttggag gatgtgcctg ccactattac ggacatcttc ggagccagcc aggacaccct
     1381 ttccaccgcg ctgctgtggc tgctcatcct ctttaccaga tacccggatg ttcaggcccg
     1441 cgtgcaggct gagttggacc aggttgtggg gagggaccgc ctgccctgca tgagtgacca
     1501 gcccaacctg ccatatgtca tggcttttct ttatgaatca atgcgattct ccagcttttt
     1561 gcctgtcacc attccacacg ccaccaccgc caacaccttt gttttaggtt actacatccc
     1621 caagaatacg gtcgtttttg ttaaccagtg gtctgtgaat catgacccag ccaagtggcc
     1681 taacccagag gactttgatc cagcccgctt cctggacaag gacggcttca ttaacaaggc
     1741 gctagccagc agtgtgatga tattctcagt gggcaaacgg aggtgcatcg gtgaggaact
     1801 gtctaagatg cttctgtttc tcttcatctc catcctcgct catcagtgca atttcaaggc
     1861 taaccaaaat gagtcctcaa acatgagttt cagttatggc ctgaccatta agcccaagtc
     1921 gtttagaatc catgtgtctc tcagagagtc gatggaactc ctggataatg ctgttaaaaa
     1981 gctgcaaact gaggaaggct gcaagtgaga ggccggaggg agctggaatg tttaaggaat
     2041 acctatctca ttaactgggg aggaaataga ttttttcccc cagcttcatt tttggcctca
     2101 gctctcagca gtgaatggaa accaagtggt ctgaaggtgg ggcatgctca ccaattcatg
     2161 gctcctcttg gacctgtgct ggagttcctg gaagtatttt ggaattgaag agcaaaaggg
     2221 cccaaggaat ttggagcctg ttgttttttg ggtttttcag ctaaacacat gcacacatat
     2281 caacatgtat gcacaactat ctaagaaagt atttcagtaa ttctgccttt ttgggtagat
     2341 ttgtgaggga acttctatgt gcagaaattg accccatagg aaactgcagt aagcaaaggc
     2401 ttaggatata cccaagattc aaagacatgt gatttcagtg taaaatgtaa agaccagaag
     2461 tcctcctacc aagagacagc ttgcttggaa aaatgcttca actcctttat agccctggat
     2521 gaggctttct gcctgcctgt tgatgggcct cccactttag aatggaccat aaagtcagtt
     2581 gtcccctaag aatttatggc tgatttaaca actgcagtag gttttagaga ttagcgaatt
     2641 taaaggtaaa ttgtttaggt ggtaaaaaat gtttataagt taaagccgaa cctcatttgg
     2701 gtgctcagat gaagtattcc agttataagg gagaaaaaga tttgctgggc tagcttacgg
     2761 tttcaagttt gggattgtaa tgaactggtt tcagtaataa gtctgataaa ctaaaaaagg
     2821 aacccagtgt tcccaaatag tattcaatgc atataaaaat ttacctaact gctcataaac
     2881 atcatatgaa tattaactat tcaatcagga aaacacttga ataatatatt tcttatgtca
     2941 tattgcaaac caaaaagtat aatcagttga gtgaaatttg cccaattcca ggaaacgagc
     3001 ctgactaaat caatccgttt tgacatcagg gaactgagta acagaacagt cttttcttat
     3061 ttatagttca tacaagggac aaatctcaaa actaaaccag cgaaatatgt tctgatctgg
     3121 taattgtagt tacaacatgg atggttcttt tggaattgac cccattaata tgttaagctt
     3181 acaaattctt ggtttgcttc gatttttaaa ttagtttaaa atccatcttg attatttcgt
     3241 tccagttgaa gctagagaaa atgtgatcat tatctcgcag aaggtgagaa acctaacctt
     3301 tgcctaagaa caaatgccaa atgtaaaaat aaataaatga taagtaaata aaggccatga
     3361 atgttctggg tgttcattag agaccatatg ataggaggct cactacaacc agtaattggt
     3421 agtttctttt tccgagttct tactattgtt gttgtagttg ttttttaagt tgagtattaa
     3481 agtctgtgtg tcttttgttt ttgtttttaa agtcagaatc tgaagattgt cttgggaggt
     3541 tgtttaacaa ctgcttcttg agacagcaga gatgcctaaa atcagtttct tttatttagg
     3601 atggcacacc acgatgagca gccacttcct ggaagctgag agaggttaga aatacatgta
     3661 ttccgattat gtaaacaatc cgaaagccct ttgagaagcg ttggatgggt ggaaaagtgg
     3721 ggacagggcc cgtggggggt ttcccatttc tgttttcatt tcgattagcc tgaacaaaag
     3781 aagccctcag cactcagaga gcttactgct ggctctgttt cattaggctt cttggaattt
     3841 tcctatcaaa attacaaagg aaggggagtg cgatagtctc tgtgtgcaga ggctgcaaga
     3901 cagagaaagc atgaggagaa gagagaagtc tagatggtcc ccattcactc caaattagtt
     3961 tcctgaagta taaaatttga ggcatgaatg tttagacaaa aggagttttg agtggcaggc
     4021 tttaccttca agtgtctctt aagagtggct ggagccctgg ccctttcctc ctatctcccc
     4081 catctatttt gtggttgcaa gttgaattat aaaaaattac aatgtaaacc ttatttaaat
     4141 ttctccacaa cagaacccct tgaatgtgat acgcaggttg tgtcagtatt ttaaaggcct
     4201 taatttcaac aaaaattaac tctatgcaat aatttttaag tttttcagac attttaaaag
     4261 catgcgcctt agtaaggctg ggacggtgat ttgagcttcc atggcccttt tactatgaga
     4321 aatttacaat agtgaaagtc ttcatgtatc agtctggact ccttattaaa ccaaccagac
     4381 ccggatgttt tgtgaatgta ggggtcattt tcatctgatg ctttcagcaa aggagaaagt
     4441 agagggggct actttgttta ttatatttag aacctagtga aaggaagaag ggtacaagcc
     4501 aggaaagagt aataattgtc atatttggaa gctcgaatag attacaggct tagtcagaaa
     4561 gcctgctttt gtttctgcca cagagggact tcttttgctg ctcaccatgt tcctcagagt
     4621 atctacttca gatcagtgcg gcaaaagcat gtctcattaa atgcctcatc tgtacagtat
     4681 agcttggact gtgtcagaac gttgcttttc cccccaaaac aaaaacagat gcctcaggtg
     4741 tgtttgatgg attaatcaca agaattcatg ccccagaact tagccttgac ctgtgaaata
     4801 ttagcacact cttatgcatt cccaccaggg ctgtactaca ttaagcagat agatcaccat
     4861 gtatgctaat tagtatgctt ttcgctgtga cacaattgta tggtaaaagg tgtatgttac
     4921 caggtgataa taacccagga ataactcccc atttagctgc ttcttgtgtt attgtacttt
     4981 gtcatatatg ttcttaacat gtatatagct gatacagtgc acacagatcc tccgtacaca
     5041 gaattaacta acatgtagct tctacctttg atataccaaa atttaaaatg ttctgtcttc
     5101 attatctctc atgaaacatt gttacctaaa caataaaacc caatgtcata atcctatgaa
     5161 a
//
