LOCUS       NM_009993               1892 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus cytochrome P450, family 1, subfamily a, polypeptide 2
            (Cyp1a2), mRNA.
ACCESSION   NM_009993
VERSION     NM_009993.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1892)
  AUTHORS   Stading,R., Swanson,L., Xia,G., Jiang,W., Wang,L., Couroucli,X.,
            Lingappan,K. and Moorthy,B.
  TITLE     Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs)
            augments neonatal hyperoxic lung injury: Role of cytochrome P450
            (CYP)1A1, 1A2, and 1B1
  JOURNAL   Free Radic Biol Med 211, 35-46 (2024)
   PUBMED   38081439
REFERENCE   2  (bases 1 to 1892)
  AUTHORS   Feltner,M., Hare,P.M., Good,A., Foster,E.G., Clough,K., Perry,J.,
            Honaker,A., Kyntchev,A., Kowalski,M. and Curran,C.P.
  TITLE     Differential Susceptibility to Benzo[a]pyrene Exposure during
            Gestation and Lactation in Mice with Genetic Variations in the Aryl
            Hydrocarbon Receptor and Cyp1 Genes
  JOURNAL   Toxics 11 (9), 778 (2023)
   PUBMED   37755789
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1892)
  AUTHORS   Rong,R., Wei,Y., Li,L., Wang,T., Zhu,H., Xiao,G. and Wang,Y.
  TITLE     Image-based quantification of histological features as a function
            of spatial location using the Tissue Positioning System
  JOURNAL   EBioMedicine 94, 104698 (2023)
   PUBMED   37453365
REFERENCE   4  (bases 1 to 1892)
  AUTHORS   Kawasaki,Y., Nemoto,N. and Sakuma,T.
  TITLE     Constitutive androstane receptor-responsive elements for mouse
            Cyp1a2 transcriptional activation induced by constitutive
            androstane receptor ligands
  JOURNAL   Drug Metab Pharmacokinet 48, 100485 (2023)
   PUBMED   36740553
  REMARK    GeneRIF: Constitutive androstane receptor-responsive elements for
            mouse Cyp1a2 transcriptional activation induced by constitutive
            androstane receptor ligands.
REFERENCE   5  (bases 1 to 1892)
  AUTHORS   He,Y., Cen,H., Guo,L., Zhang,T., Yang,Y., Dong,D. and Wu,B.
  TITLE     Circadian oscillator NPAS2 regulates diurnal expression and
            activity of CYP1A2 in mouse liver
  JOURNAL   Biochem Pharmacol 206, 115345 (2022)
   PUBMED   36379250
  REMARK    GeneRIF: Circadian oscillator NPAS2 regulates diurnal expression
            and activity of CYP1A2 in mouse liver.
REFERENCE   6  (bases 1 to 1892)
  AUTHORS   Nemoto,N. and Sakurai,J.
  TITLE     Differences in regulation of gene expression between Cyp1a-1 and
            Cyp1a-2 in adult mouse hepatocytes in primary culture
  JOURNAL   Carcinogenesis 13 (12), 2249-2254 (1992)
   PUBMED   1335375
REFERENCE   7  (bases 1 to 1892)
  AUTHORS   Degawa,M., Kobayashi,K., Miura,S., Arai,H., Esumi,H., Sugimura,T.
            and Hashimoto,Y.
  TITLE     Species difference among experimental rodents in induction of
            P450IA family enzymes by
            2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
  JOURNAL   Jpn J Cancer Res 83 (10), 1047-1051 (1992)
   PUBMED   1452456
REFERENCE   8  (bases 1 to 1892)
  AUTHORS   Okino,S.T., Pendurthi,U.R. and Tukey,R.H.
  TITLE     Phorbol esters inhibit the dioxin receptor-mediated transcriptional
            activation of the mouse Cyp1a-1 and Cyp1a-2 genes by
            2,3,7,8-tetrachlorodibenzo-p-dioxin
  JOURNAL   J Biol Chem 267 (10), 6991-6998 (1992)
   PUBMED   1313028
REFERENCE   9  (bases 1 to 1892)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
REFERENCE   10 (bases 1 to 1892)
  AUTHORS   Montagutelli,X., Serikawa,T. and Guenet,J.L.
  TITLE     PCR-analyzed microsatellites: data concerning laboratory and
            wild-derived mouse inbred strains
  JOURNAL   Mamm Genome 1 (4), 255-259 (1991)
   PUBMED   1794054
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X00479.1.
            
            On Apr 5, 2007 this sequence version replaced NM_009993.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X00479.1, BC054827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1892              X00479.1           2-1893
FEATURES             Location/Qualifiers
     source          1..1892
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.3 cM"
     gene            1..1892
                     /gene="Cyp1a2"
                     /gene_synonym="CP12; CYPIA2; P450-3"
                     /note="cytochrome P450, family 1, subfamily a, polypeptide
                     2"
                     /db_xref="GeneID:13077"
                     /db_xref="MGI:MGI:88589"
     exon            1..51
                     /gene="Cyp1a2"
                     /gene_synonym="CP12; CYPIA2; P450-3"
                     /inference="alignment:Splign:2.1.0"
     exon            52..887
                     /gene="Cyp1a2"
                     /gene_synonym="CP12; CYPIA2; P450-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1601
                     /gene="Cyp1a2"
                     /gene_synonym="CP12; CYPIA2; P450-3"
                     /EC_number="1.14.14.1"
                     /EC_number="4.2.1.152"
                     /note="cytochrome P450 family 1 subfamily a polypeptide 1;
                     cytochrome P450-P2; cytochrome P450-P3; cytochrome P450,
                     1a2, aromatic compound inducible; cholesterol
                     25-hydroxylase; hydroperoxy icosatetraenoate dehydratase"
                     /codon_start=1
                     /product="cytochrome P450 1A2"
                     /protein_id="NP_034123.1"
                     /db_xref="CCDS:CCDS23229.1"
                     /db_xref="GeneID:13077"
                     /db_xref="MGI:MGI:88589"
                     /translation="MAFSQYISLAPELLLATAIFCLVFWMVRASRTQVPKGLKNPPGP
                     WGLPFIGHMLTVGKNPHLSLTRLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVRQGD
                     DFKGRPDLYSFTLITNGKSMTFNPDSGPVWAARRRLAQDALKSFSIASDPTSASSCYL
                     EEHVSKEANHLVSKLQKAMAEVGHFEPVSQVVESVANVIGAMCFGKNFPRKSEEMLNI
                     VNNSKDFVENVTSGNAVDFFPVLRYLPNPALKRFKTFNDNFVLFLQKTVQEHYQDFNK
                     NSIQDITSALFKHSENYKDNGGLIPEEKIVNIVNDIFGAGFDTVTTAITWSILLLVTW
                     PNVQRKIHEELDTVVGRDRQPRLSDRPQLPYLEAFILEIYRYTSFVPFTIPHSTTRDT
                     SLNGFHIPKERCIYINQWQVNHDEKQWKDPFVFRPERFLTNNNSAIDKTQSEKVMLFG
                     LGKRRCIGEIPAKWEVFLFLAILLQHLEFSVPPGVKVDLTPNYGLTMKPGTCEHVQAW
                     PRFSK"
     exon            888..1005
                     /gene="Cyp1a2"
                     /gene_synonym="CP12; CYPIA2; P450-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1095
                     /gene="Cyp1a2"
                     /gene_synonym="CP12; CYPIA2; P450-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1219
                     /gene="Cyp1a2"
                     /gene_synonym="CP12; CYPIA2; P450-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1306
                     /gene="Cyp1a2"
                     /gene_synonym="CP12; CYPIA2; P450-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1892
                     /gene="Cyp1a2"
                     /gene_synonym="CP12; CYPIA2; P450-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1873..1878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp1a2"
                     /gene_synonym="CP12; CYPIA2; P450-3"
                     /note="hexamer: TATAAA"
     polyA_site      1892
                     /gene="Cyp1a2"
                     /gene_synonym="CP12; CYPIA2; P450-3"
                     /note="major polyA site"
ORIGIN      
        1 gtcctggact gactcccaca actctgccag tctccagccc ctgcccttca gtggtacaga
       61 tggcgttctc ccagtacatc tccttagccc cagagctgct actggccact gccatcttct
      121 gtttagtgtt ctggatggtc agagcctcaa ggacccaggt tcccaaaggc ctgaagaatc
      181 cacccggacc ctggggcttg cccttcattg ggcacatgct gactgtgggg aagaacccac
      241 acctgtcact gacacggctg agtcagcagt atggggacgt gctgcagatc cgcatcggct
      301 ccactcctgt ggtggtgctg agcggcctga acaccatcaa gcaggccctg gtgaggcagg
      361 gagatgactt caagggccga ccagacctct acagcttcac acttatcact aacggcaaga
      421 gcatgacttt caacccagac tctggacccg tgtgggctgc ccgccggcgc ctggcccagg
      481 atgccctgaa gagcttctcc atagcctcgg acccgacgtc agcatcctct tgctatttgg
      541 aggagcacgt gagcaaggag gctaaccatc tcgtcagcaa gcttcagaag gcgatggcag
      601 aggttggcca cttcgaacca gtcagccagg tggtggaatc ggtggctaac gtcattggtg
      661 ccatgtgctt tgggaagaac ttcccccgga agagcgagga gatgctgaac atcgtgaata
      721 acagcaagga ctttgtggag aatgtcacct cagggaatgc agtggacttc ttcccggtcc
      781 tgcgctacct gcccaacccg gccctcaaga ggtttaagac cttcaatgat aacttcgtgc
      841 tgtttctgca gaaaactgtc caggagcact accaagactt caacaagaac agtatccaag
      901 acatcacaag tgccctgttc aagcacagcg agaactacaa agacaatggc ggtctcatcc
      961 ccgaggagaa gattgtcaac attgtcaatg acatctttgg agctggcttt gacacagtca
     1021 ccacagccat cacctggagc attttgctac ttgtgacatg gcctaacgtg cagaggaaga
     1081 tccatgagga gctggacacg gtggttggca gggatcggca accacggctt tctgaccgtc
     1141 cccagctgcc atatctagag gccttcatcc tggagatcta ccgatacaca tcctttgtcc
     1201 ccttcaccat cccccacagc acaacgaggg acacctcact gaatggcttc cacattccca
     1261 aggagcgctg tatctacata aaccagtggc aggtcaacca tgatgagaag cagtggaaag
     1321 acccctttgt gttccgccca gagcggtttc ttaccaataa caactcggcc atcgacaaga
     1381 cccagagcga gaaggtgatg ctcttcggct tgggaaagcg ccggtgcatt ggggagatcc
     1441 cggccaagtg ggaagtcttc ctcttcttag ccatcctgct gcagcatctg gagtttagtg
     1501 tgccaccggg tgtgaaggtg gacctgacac ccaactatgg gttgaccatg aagcccggga
     1561 cctgtgaaca cgtccaggca tggccacgct tttccaagtg aagattgtcg aggcatcggt
     1621 ggggccgtca cccttgtttc ttttcctttt ttaaaaaaaa aaaaaaaaca gctttttttt
     1681 ttttgagaga tacaattctt tccccattta attcatctcc aagcaatttt acaatagtgt
     1741 ctatcatgtt caccccataa cccatactca ttaggactta tgatttaaga ttcctcctac
     1801 cctgtcttgc ttgccgcacc tcatgctaat ctagtttttg actcaataga tttgcctact
     1861 ctggctgtct catataaatc gaatgaatta tg
//
