LOCUS       NM_001136059            2637 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus cytochrome P450, family 1, subfamily a, polypeptide 1
            (Cyp1a1), transcript variant 2, mRNA.
ACCESSION   NM_001136059
VERSION     NM_001136059.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2637)
  AUTHORS   Gu,N., Shen,Y., He,Y., Li,C., Xiong,W., Hu,Y., Qiu,Z., Peng,F.,
            Han,W., Li,C., Long,X., Zhao,R., Zhao,Y. and Shi,B.
  TITLE     Loss of m6A demethylase ALKBH5 alleviates hypoxia-induced pulmonary
            arterial hypertension via inhibiting Cyp1a1 mRNA decay
  JOURNAL   J Mol Cell Cardiol 194, 16-31 (2024)
   PUBMED   38821243
  REMARK    GeneRIF: Loss of m6A demethylase ALKBH5 alleviates hypoxia-induced
            pulmonary arterial hypertension via inhibiting Cyp1a1 mRNA decay.
REFERENCE   2  (bases 1 to 2637)
  AUTHORS   Weighardt,H., Shapiro,M., Mayer,M., Forster,I., Stockinger,B. and
            Diny,N.L.
  TITLE     The AHR repressor limits expression of antimicrobial genes but not
            AHR-dependent genes in intestinal eosinophils
  JOURNAL   J Leukoc Biol 116 (2), 369-378 (2024)
   PUBMED   38701199
REFERENCE   3  (bases 1 to 2637)
  AUTHORS   Stading,R., Swanson,L., Xia,G., Jiang,W., Wang,L., Couroucli,X.,
            Lingappan,K. and Moorthy,B.
  TITLE     Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs)
            augments neonatal hyperoxic lung injury: Role of cytochrome P450
            (CYP)1A1, 1A2, and 1B1
  JOURNAL   Free Radic Biol Med 211, 35-46 (2024)
   PUBMED   38081439
REFERENCE   4  (bases 1 to 2637)
  AUTHORS   Huang,R., Duan,J., Huang,W., Cheng,Y., Zhu,B. and Li,F.
  TITLE     Inhibition of CYP1A1 Alleviates Colchicine-Induced Hepatotoxicity
  JOURNAL   Toxins (Basel) 16 (1), 35 (2024)
   PUBMED   38251251
  REMARK    GeneRIF: Inhibition of CYP1A1 Alleviates Colchicine-Induced
            Hepatotoxicity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2637)
  AUTHORS   Feltner,M., Hare,P.M., Good,A., Foster,E.G., Clough,K., Perry,J.,
            Honaker,A., Kyntchev,A., Kowalski,M. and Curran,C.P.
  TITLE     Differential Susceptibility to Benzo[a]pyrene Exposure during
            Gestation and Lactation in Mice with Genetic Variations in the Aryl
            Hydrocarbon Receptor and Cyp1 Genes
  JOURNAL   Toxics 11 (9), 778 (2023)
   PUBMED   37755789
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2637)
  AUTHORS   Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M. and
            Kamataki,T.
  TITLE     Molecular cloning of monkey liver cytochrome P-450 cDNAs:
            similarity of the primary sequences to human cytochromes P-450
  JOURNAL   Biochim Biophys Acta 1171 (2), 141-146 (1992)
   PUBMED   1282830
REFERENCE   7  (bases 1 to 2637)
  AUTHORS   Nemoto,N. and Sakurai,J.
  TITLE     Differences in regulation of gene expression between Cyp1a-1 and
            Cyp1a-2 in adult mouse hepatocytes in primary culture
  JOURNAL   Carcinogenesis 13 (12), 2249-2254 (1992)
   PUBMED   1335375
REFERENCE   8  (bases 1 to 2637)
  AUTHORS   Merchant,M., Morrison,V., Santostefano,M. and Safe,S.
  TITLE     Mechanism of action of aryl hydrocarbon receptor antagonists:
            inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1
            gene expression
  JOURNAL   Arch Biochem Biophys 298 (2), 389-394 (1992)
   PUBMED   1329656
REFERENCE   9  (bases 1 to 2637)
  AUTHORS   Okino,S.T., Pendurthi,U.R. and Tukey,R.H.
  TITLE     Phorbol esters inhibit the dioxin receptor-mediated transcriptional
            activation of the mouse Cyp1a-1 and Cyp1a-2 genes by
            2,3,7,8-tetrachlorodibenzo-p-dioxin
  JOURNAL   J Biol Chem 267 (10), 6991-6998 (1992)
   PUBMED   1313028
REFERENCE   10 (bases 1 to 2637)
  AUTHORS   Puga,A., Raychaudhuri,B. and Nebert,D.W.
  TITLE     Transcriptional derepression of the murine Cyp1a-1 gene by
            mevinolin
  JOURNAL   FASEB J 6 (2), 777-785 (1992)
   PUBMED   1311272
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Y00071.1 and AW110759.1.
            
            On Apr 5, 2011 this sequence version replaced NM_001136059.1.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            non-coding exon compared to variant 1. Variants 1 and 2 encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00071.1, K02588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2619              Y00071.1           1-2619
            2620-2637           AW110759.1         3-20                c
FEATURES             Location/Qualifiers
     source          1..2637
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.34 cM"
     gene            1..2637
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYPIA1; P450-1"
                     /note="cytochrome P450, family 1, subfamily a, polypeptide
                     1"
                     /db_xref="GeneID:13076"
                     /db_xref="MGI:MGI:88588"
     exon            1..87
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYPIA1; P450-1"
                     /inference="alignment:Splign:2.1.0"
     exon            88..938
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYPIA1; P450-1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1065
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYPIA1; P450-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1155
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYPIA1; P450-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1279
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYPIA1; P450-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1366
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYPIA1; P450-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..2621
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYPIA1; P450-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2602..2607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYPIA1; P450-1"
                     /note="hexamer: AATAAA"
     polyA_site      2621
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYPIA1; P450-1"
                     /note="major polyA site"
ORIGIN      
        1 ctgaaggtgg tagttcttgg agcttccccg atcctcccta gggtcctaga gaacactctt
       61 cacttcagtc cctccttaca gcccaagcag ccacctagat catgccttcc atgtatggac
      121 ttccagcctt cgtgtcagcc acagagctgc tcctggctgt caccgtattc tgccttggat
      181 tctgggtggt cagagccaca agaacctggg ttcccaaagg cctgaagact ccaccagggc
      241 cctggggctt gcccttcatt ggtcacatgc tgactgtggg gaagaaccca catctgtcac
      301 tgacacggct gagtcagcag tatggggacg tgctgcagat ccgcatcggc tccactcctg
      361 tggtggtgct gagcggcctg aacaccatca agcaggccct ggtgaggcag ggagatgact
      421 tcaagggccg gccagacctc tacagcttca cacttatcac taatggcaag agcatgactt
      481 ttaacccaga ctctggaccc gtgtgggctg cccgccggcg cctggcccag aatgccctga
      541 agagcttctc catagcctcg gacccgacgt cagcatcctc ttgctacttg gaggagcacg
      601 tgagcaagga ggctaactat ctcgtcagca aacttcagaa ggtgatggca gaggttggcc
      661 actttgaccc ttacaagtat ttggtcgtgt cagtagccaa tgtcatctgt gccatatgct
      721 ttggccaacg ttatgaccat gatgaccaag agctgctcag catagtcaat ctgagcaatg
      781 agtttgggga ggttactggc tctggatacc cagctgactt cattcctgtc ctccgttacc
      841 tgcctaactc ttccctggat gccttcaagg acttgaatga taagttctac agcttcatga
      901 agaagttaat caaagagcac tacaggacat ttgagaaggg ccacatccgg gacatcacag
      961 acagcctcat tgagcattgt caggacagga agctggacga gaatgccaat gtccagctgt
     1021 cagatgataa ggtcatcacg attgttttgg acctctttgg agctgggttt gacacagtca
     1081 caactgctat ctcgtggagc ctcatgtacc tggtaaccaa ccctagggta cagagaaaga
     1141 tccaggagga actagacaca gtgattggca gagatcggca gccccggctt tctgacagac
     1201 ctcagctgcc ctatctggag gccttcattc tggagacctt ccggcattca tccttcgtcc
     1261 ccttcaccat cccccacagc accacaagag atacaagtct gaatggcttc tatatcccca
     1321 aggggtgctg tgtctttgtg aaccagtggc aggttaacca tgaccgggaa ctgtggggtg
     1381 acccaaacga gttccggcct gaaaggtttc tcacccccag cggcactctg gacaagcgct
     1441 tgagtgagaa ggtcactctc tttggtttgg gcaagcgaaa gtgcatcgga gagaccattg
     1501 gccgatcgga ggtctttctc ttcctggcca tcttgctgca gcaaatagaa tttaaggtgt
     1561 ctccagggga gaaggtggat atgactccta cctatgggct gactttaaaa cacgcccgct
     1621 gtgaacactt ccaagtgcag atgcggtctt ctggtcctca gcatcttcag gcttagactg
     1681 tccaggatgc tcaccagacc aggtggctgt tcctgtgatt caactttagc cagaaacaca
     1741 gatcctggga cattgtgcct gcctcctact ttggacttgt ttctctatat gctgaacaca
     1801 cactgggcac agcagaggcc cacaggaacc tcagatcctt ctcaatttca gcatcaacta
     1861 ggagatctga aagggttagg agatacctgg gcctcagaga actcctgaag agtgctctgg
     1921 gtgctccagt ggctaactgg tttgaaaaat actgcaggtt atagcaggat gtgtctggtt
     1981 actttgacaa gtgggagctg cccagaatgg agggagaaga cagcttaaaa ttctggcaca
     2041 gaggtgctct tgccacctgc tgaggctaaa cagccttccc aaatggttta tgacactgca
     2101 tgtggggggc acctctgttc accctacata gaaacaaaca gggtgctcct gtccttgcat
     2161 gtccatgttt ctcttcagga agggttgaga cttgtgtcta gaaagaccca agaacagagg
     2221 gagagattct ctgggcagta aaaccaggtc tagagtaaag gaatgacttt tgagacagag
     2281 tcttgtgtag cccaggctga ctctgaactt gctaccaaag gaggccttgg actccttttt
     2341 gttgttgttg ttcttactac cttaccaagt gctaggatac agtcatagac tactgcatca
     2401 gctcttggtc tctcttcttt actgtataaa atgtttttct tagaaaatgt ttgtgcataa
     2461 gagctttgta ttatggactg tattttgctt atgcatttgt attagttata ccttaagaga
     2521 tttagataat ttgctagtgt aacaaagaag attctaactc aagtattcag aaatatatat
     2581 agaaaaaccc tacctgaact aaataaaaat attacctgga aaaaaaaaaa aaaaaaa
//
