LOCUS       NM_007810               2674 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus cytochrome P450, family 19, subfamily a, polypeptide 1
            (Cyp19a1), transcript variant 1, mRNA.
ACCESSION   NM_007810
VERSION     NM_007810.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2674)
  AUTHORS   Luo,X., Zhang,D., Zheng,J., Liu,H., Sun,L., Guo,H., Wang,L. and
            Cui,S.
  TITLE     Casein kinase 1alpha mediates estradiol secretion via CYP19A1
            expression in mouse ovarian granulosa cells
  JOURNAL   BMC Biol 22 (1), 176 (2024)
   PUBMED   39183304
  REMARK    GeneRIF: Casein kinase 1alpha mediates estradiol secretion via
            CYP19A1 expression in mouse ovarian granulosa cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2674)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2674)
  AUTHORS   Rubitschung,K., Sherwood,A., Kapadia,R., Xi,Y., Hajibeigi,A.,
            Rubinow,K.B., Zerwekh,J.E. and Oz,O.K.
  TITLE     Aromatase deficiency in transplanted bone marrow cells improves
            vertebral trabecular bone quantity, connectivity, and
            mineralization and decreases cortical porosity in murine bone
            marrow transplant recipients
  JOURNAL   PLoS One 19 (2), e0296390 (2024)
   PUBMED   38315701
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2674)
  AUTHORS   Zhao,J., He,C., Fan,X., Wang,L., Zhao,L., Liu,H., Shen,W.,
            Jiang,S., Pei,K., Gao,J., Qi,Y., Liu,Y., Zhao,J., Zhang,R., Lu,C.,
            Tong,J. and Huai,J.
  TITLE     Tripeptidyl peptidase II coordinates the homeostasis of calcium and
            lipids in the central nervous system and its depletion causes
            presenile dementia in female mice through calcium/lipid
            dyshomeostasis-induced autophagic degradation of CYP19A1
  JOURNAL   Theranostics 14 (4), 1390-1429 (2024)
   PUBMED   38389851
  REMARK    GeneRIF: Tripeptidyl peptidase II coordinates the homeostasis of
            calcium and lipids in the central nervous system and its depletion
            causes presenile dementia in female mice through calcium/lipid
            dyshomeostasis-induced autophagic degradation of CYP19A1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2674)
  AUTHORS   Jiang,X., Cheng,Y., Zhu,Y., Xu,C., Li,Q., Xing,X., Li,W., Zou,J.,
            Meng,L., Azhar,M., Cao,Y., Tong,X., Qin,W., Zhu,X. and Bao,J.
  TITLE     Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression
            and maturation in mice
  JOURNAL   Nat Commun 14 (1), 3729 (2023)
   PUBMED   37349316
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2674)
  AUTHORS   Wozniak,A., Hutchison,R.E. and Hutchison,J.B.
  TITLE     Localisation of aromatase activity in androgen target areas of the
            mouse brain
  JOURNAL   Neurosci Lett 146 (2), 191-194 (1992)
   PUBMED   1491788
REFERENCE   7  (bases 1 to 2674)
  AUTHORS   Harada,N. and Yamada,K.
  TITLE     Ontogeny of aromatase messenger ribonucleic acid in mouse brain:
            fluorometrical quantitation by polymerase chain reaction
  JOURNAL   Endocrinology 131 (5), 2306-2312 (1992)
   PUBMED   1425429
REFERENCE   8  (bases 1 to 2674)
  AUTHORS   Terashima,M., Toda,K., Kawamoto,T., Kuribayashi,I., Ogawa,Y.,
            Maeda,T. and Shizuta,Y.
  TITLE     Isolation of a full-length cDNA encoding mouse aromatase P450
  JOURNAL   Arch Biochem Biophys 285 (2), 231-237 (1991)
   PUBMED   1897929
REFERENCE   9  (bases 1 to 2674)
  AUTHORS   Morris,V.L., Rao,T.R., Kozak,C.A., Gray,D.A., Lee Chan,E.C.,
            Cornell,T.J., Taylor,C.B., Jones,R.F. and McGrath,C.M.
  TITLE     Characterization of Int-5, a locus associated with early events in
            mammary carcinogenesis
  JOURNAL   Oncogene Res 6 (1), 53-63 (1991)
   PUBMED   1705320
REFERENCE   10 (bases 1 to 2674)
  AUTHORS   Naftolin,F., Ryan,K.J., Davies,I.J., Reddy,V.V., Flores,F.,
            Petro,Z., Kuhn,M., White,R.J., Takaoka,Y. and Wolin,L.
  TITLE     The formation of estrogens by central neuroendocrine tissues
  JOURNAL   Recent Prog Horm Res 31, 295-319 (1975)
   PUBMED   812160
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162180.2 and AC159816.2.
            
            On Jan 13, 2017 this sequence version replaced NM_007810.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3, and 4 encode the same protein.
            Expression of this variant has been found in gonads.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D00659.1, AK143323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-487               AC162180.2         157429-157915
            488-638             AC159816.2         2368-2518
            639-793             AC159816.2         8863-9017
            794-970             AC159816.2         12547-12723
            971-1085            AC159816.2         15756-15870
            1086-1200           AC159816.2         16409-16523
            1201-1363           AC159816.2         17234-17396
            1364-1605           AC159816.2         20451-20692
            1606-2674           AC159816.2         22194-23262
FEATURES             Location/Qualifiers
     source          1..2674
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.49 cM"
     gene            1..2674
                     /gene="Cyp19a1"
                     /gene_synonym="Ar; ArKO; Cyp19; Int-5; Int5; p450arom"
                     /note="cytochrome P450, family 19, subfamily a,
                     polypeptide 1"
                     /db_xref="GeneID:13075"
                     /db_xref="MGI:MGI:88587"
     exon            1..487
                     /gene="Cyp19a1"
                     /gene_synonym="Ar; ArKO; Cyp19; Int-5; Int5; p450arom"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..1854
                     /gene="Cyp19a1"
                     /gene_synonym="Ar; ArKO; Cyp19; Int-5; Int5; p450arom"
                     /EC_number="1.14.14.14"
                     /note="cytochrome P450 19A1; CYPXIX; estrogen synthase;
                     cytochrome P-450AROM; cytochrome P450, 19, aromatase"
                     /codon_start=1
                     /product="aromatase"
                     /protein_id="NP_031836.1"
                     /db_xref="CCDS:CCDS23187.1"
                     /db_xref="GeneID:13075"
                     /db_xref="MGI:MGI:88587"
                     /translation="MFLEMLNPMQYNVTIMVPETVTVSAMPLLLIMGLLLLIWNCESS
                     SSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSS
                     MFHVMKHSHYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTIRPFFMKALTGPGLVRM
                     VEVCVESIKQHLDRLGEVTDTSGYVDVLTLMRHIMLDTSNMLFLGIPLDESAIVKKIQ
                     GYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIAVLVEKKRHKVSTAEKLEDCM
                     DFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILK
                     EIHTVVGDRDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGT
                     NIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRGCAGKYIAMVMMKVV
                     LVTLLRRFQVKTLQKRCIENIPKKNDLSLHPNEDRHLVEIIFSPRNSDKYLQQ"
     exon            488..638
                     /gene="Cyp19a1"
                     /gene_synonym="Ar; ArKO; Cyp19; Int-5; Int5; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            639..793
                     /gene="Cyp19a1"
                     /gene_synonym="Ar; ArKO; Cyp19; Int-5; Int5; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            794..970
                     /gene="Cyp19a1"
                     /gene_synonym="Ar; ArKO; Cyp19; Int-5; Int5; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1085
                     /gene="Cyp19a1"
                     /gene_synonym="Ar; ArKO; Cyp19; Int-5; Int5; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1200
                     /gene="Cyp19a1"
                     /gene_synonym="Ar; ArKO; Cyp19; Int-5; Int5; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1363
                     /gene="Cyp19a1"
                     /gene_synonym="Ar; ArKO; Cyp19; Int-5; Int5; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1605
                     /gene="Cyp19a1"
                     /gene_synonym="Ar; ArKO; Cyp19; Int-5; Int5; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..2674
                     /gene="Cyp19a1"
                     /gene_synonym="Ar; ArKO; Cyp19; Int-5; Int5; p450arom"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2493..2498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp19a1"
                     /gene_synonym="Ar; ArKO; Cyp19; Int-5; Int5; p450arom"
                     /note="hexamer: AATATA"
     polyA_site      2520
                     /gene="Cyp19a1"
                     /gene_synonym="Ar; ArKO; Cyp19; Int-5; Int5; p450arom"
                     /note="major polyA site"
ORIGIN      
        1 acagcattgt gattgttcct ctggaatgaa cttcagagag ttgactctca attgagcacg
       61 tcactctact aactcaaggg cgagatgata aggttctatc agaccaactg ttgaacagaa
      121 cctgagcctc ccaaggtcat ccttgttttg acttgtaacc acaaatttgt cttgtctaag
      181 tgtccaatca ctataaaaca aaatgcccat ctctccaatc cagcaccctt ccaagtgaca
      241 ggagccacag ccaaaccgct gggttacgtt ctaactccac cactgctttc ttcccataga
      301 actttacttt tttttttttc ttctgaggcc aaatagcgca agatgttctt ggaaatgctg
      361 aaccccatgc agtataatgt caccatcatg gtcccggaaa ctgtgactgt cagtgccatg
      421 ccactcctgc tgatcatggg cctccttctc ctgatttgga attgtgagag ctcgtcttca
      481 ataccaggtc ctggctactg tctgggaatt gggcccctca tttcccatgg cagattcttg
      541 tggatgggga ttggaagtgc ctgcaactac tacaataaga tgtatggaga gttcatgaga
      601 gtctggatca gtggagagga gacactcatt atcagcaagt cctcaagcat gttccatgtc
      661 atgaagcaca gtcactacat ctcccgattc ggcagcaagc gtgggctgca gtgcatcggc
      721 atgcatgaga acggcatcat atttaacaac aacccgagcc tttggagaac aattcgccct
      781 ttctttatga aagctctgac gggccctggt cttgttcgaa tggtggaagt ttgtgtggag
      841 tccatcaagc agcatttgga ccggctgggc gaagtcaccg acacctcggg ctacgtggat
      901 gtgttgaccc tcatgagaca catcatgctg gacacctcta acatgctctt cctggggatc
      961 cccctggacg aaagtgctat tgtgaagaaa atccagggtt actttaacgc ctggcaagct
     1021 ctcctcatca aaccaaacat cttctttaag atttcttggc tctacagaaa gtatgaacga
     1081 tccgtcaagg acttgaaaga cgagatagct gttttggtgg aaaagaagag acacaaagtt
     1141 tccacagctg agaaactgga agactgtatg gattttgcaa ctgatttgat tttcgctgag
     1201 agacgtggag acctgacgaa agagaacgtg aatcagtgca tactggagat gctgattgca
     1261 gcccctgaca ccatgtcggt cactctgtac ttcatgttac ttctcgtcgc agagtatcca
     1321 gaggtcgaag cagcaatcct gaaggagatc cacactgttg tgggtgacag agacataaag
     1381 atcgaggata tccaaaattt aaaagtggtg gaaaacttca ttaatgaaag catgcggtac
     1441 cagcctgttg tggacttggt catgcgcaga gctctggagg atgacgtaat tgacggctac
     1501 ccggttaaaa agggaactaa catcattctg aacatcggaa gaatgcacag gctcgagtac
     1561 ttccctaagc ccaatgaatt tacccttgaa aactttgaga agaatgttcc ctacaggtac
     1621 tttcagcctt ttggctttgg gccccgcggc tgtgctggga agtacatcgc catggtgatg
     1681 atgaaagttg tcttggttac acttttgaga cgattccagg tgaagacact gcaaaaaagg
     1741 tgtattgaaa acataccgaa aaagaatgac ctgtccttgc acccaaatga ggacaggcac
     1801 cttgtggaaa taattttctc tccaaggaat tcagacaagt acctccaaca gtgaagaagt
     1861 gtggcctatc tactctgggg cattacttat ccgtaattac atggaaacca tccattttat
     1921 cgagtaggtg gcgtgaacct caccatgaac atttgatggt ctgtagaatt ttatgatcat
     1981 agctcctatg gtttgtcatc aagctgggca tccatccagg gagccaggat gcaaaagaaa
     2041 ggagtctgtg ttggggacca gtgaagaaac tgaagcctta aaggaccaat cctacaatat
     2101 ataccttggg aaagacagac catcagtaaa acacgtctgg tctcctgcta gagttctaca
     2161 gctgttgtca gcacatcgaa atgactctgg cagaagtact taagttatta gaaaggccag
     2221 gtcaacatcc cagcatgtgg gccaggcata aatgaacaac aggactttca tatgtgtgtg
     2281 tgtgtgtgtg tgtgtgtgtg tgcgcgcgcg cgtgcgcgcc cacaagcatg tgccatgtac
     2341 gtatgcaagt ctgtgtgtgt acttgtgcat gcatgaatac atagtgtgtg tgtgtgtgtg
     2401 tgtgtgtgtg tgtgtgtgtg gtagactctt tctacattaa acccagttgc ttacggtgga
     2461 tccacatgta aactgtttgg gggcaaaagt gaaatatagg gtgtcgtttc ttactctcaa
     2521 tttgtgctcc caggagtgta gttagactgt agtaggtata gattcaggta aaacatgcct
     2581 aagtagtatt agcctgagta aaatatagct aggactctat gtgtggtgta gggggaaaaa
     2641 tcacatggtg catttcaaat aaagaagtct tttt
//
