LOCUS       NM_007809               1841 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus cytochrome P450, family 17, subfamily a, polypeptide 1
            (Cyp17a1), mRNA.
ACCESSION   NM_007809
VERSION     NM_007809.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1841)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   2  (bases 1 to 1841)
  AUTHORS   Migale,R., Neumann,M., Mitter,R., Rafiee,M.R., Wood,S., Olsen,J.
            and Lovell-Badge,R.
  TITLE     FOXL2 interaction with different binding partners regulates the
            dynamics of ovarian development
  JOURNAL   Sci Adv 10 (12), eadl0788 (2024)
   PUBMED   38517962
REFERENCE   3  (bases 1 to 1841)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1841)
  AUTHORS   Lettieri,A., Oleari,R., van den Munkhof,M.H., van Battum,E.Y.,
            Verhagen,M.G., Tacconi,C., Spreafico,M., Paganoni,A.J.J.,
            Azzarelli,R., Andre',V., Amoruso,F., Palazzolo,L., Eberini,I.,
            Dunkel,L., Howard,S.R., Fantin,A., Pasterkamp,R.J. and Cariboni,A.
  TITLE     SEMA6A drives GnRH neuron-dependent puberty onset by tuning median
            eminence vascular permeability
  JOURNAL   Nat Commun 14 (1), 8097 (2023)
   PUBMED   38062045
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1841)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1841)
  AUTHORS   Fan,Y.S., Sasi,R., Lee,C., Winter,J.S., Waterman,M.R. and Lin,C.C.
  TITLE     Localization of the human CYP17 gene (cytochrome P450(17 alpha)) to
            10q24.3 by fluorescence in situ hybridization and simultaneous
            chromosome banding
  JOURNAL   Genomics 14 (4), 1110-1111 (1992)
   PUBMED   1478654
REFERENCE   7  (bases 1 to 1841)
  AUTHORS   Youngblood,G.L. and Payne,A.H.
  TITLE     Isolation and characterization of the mouse P450 17
            alpha-hydroxylase/C17-20-lyase gene (Cyp17): transcriptional
            regulation of the gene by cyclic adenosine 3',5'-monophosphate in
            MA-10 Leydig cells
  JOURNAL   Mol Endocrinol 6 (6), 927-934 (1992)
   PUBMED   1323057
REFERENCE   8  (bases 1 to 1841)
  AUTHORS   Youngblood,G.L., Sartorius,C., Taylor,B.A. and Payne,A.H.
  TITLE     Isolation, characterization, and chromosomal mapping of mouse P450
            17 alpha-hydroxylase/C17-20 lyase
  JOURNAL   Genomics 10 (1), 270-275 (1991)
   PUBMED   1840559
REFERENCE   9  (bases 1 to 1841)
  AUTHORS   Perkins,L.M. and Payne,A.H.
  TITLE     Quantification of P450scc, P450(17) alpha, and iron sulfur protein
            reductase in Leydig cells and adrenals of inbred strains of mice
  JOURNAL   Endocrinology 123 (6), 2675-2682 (1988)
   PUBMED   2848682
REFERENCE   10 (bases 1 to 1841)
  AUTHORS   Malaska,T. and Payne,A.H.
  TITLE     Luteinizing hormone and cyclic AMP-mediated induction of microsomal
            cytochrome P-450 enzymes in cultured mouse Leydig cells
  JOURNAL   J Biol Chem 259 (19), 11654-11657 (1984)
   PUBMED   6090441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD552634.1, M64863.1 and AK134376.1.
            
            On Nov 22, 2007 this sequence version replaced NM_007809.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132830.1, BC064793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-515               CD552634.1         1-515
            516-1452            M64863.1           389-1325
            1453-1841           AK134376.1         1347-1735
FEATURES             Location/Qualifiers
     source          1..1841
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.97 cM"
     gene            1..1841
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17; p450c17"
                     /note="cytochrome P450, family 17, subfamily a,
                     polypeptide 1"
                     /db_xref="GeneID:13074"
                     /db_xref="MGI:MGI:88586"
     exon            1..454
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17; p450c17"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1681
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17; p450c17"
                     /EC_number="1.14.14.19"
                     /EC_number="1.14.14.32"
                     /note="cytochrome P450, 17a1; CYPXVII; cytochrome P450c17;
                     cytochrome P450-C17; cytochrome P450 17A1; steroid
                     17-alpha hydroxylase; 17-alpha-hydroxyprogesterone
                     aldolase; steroid 17-alpha-monooxygenase"
                     /codon_start=1
                     /product="steroid 17-alpha-hydroxylase/17,20 lyase"
                     /protein_id="NP_031835.3"
                     /db_xref="CCDS:CCDS29882.1"
                     /db_xref="GeneID:13074"
                     /db_xref="MGI:MGI:88586"
                     /translation="MWELVGLLLLILAYFFWPKSKTPNAKFPRSLPFLPLVGSLPFLP
                     RRGHMHANFFKLQEKYGPIYSLRLGTTTAVIVGHYQLAREVLVKKGKEFSGRPQMVTL
                     GLLSDQGKGVAFADSSSSWQLHRKLVFSTFSLFRDDQKLEKMICQEANSLCDLILTYD
                     GESRDLSTLIFKSVINIICTICFNISFENKDPILTTIQTFTEGIVDVLGHSDLVDIFP
                     WLKIFPNKNLEMIKEHTKIREKTLVEMFEKCKEKFNSESLSSLTDILIQAKMNAENNN
                     TGEGQDPSVFSDKHILVTVGDIFGAGIETTSSVLNWILAFLVHNPEVKRKIQKEIDQY
                     VGFSRTPSFNDRTHLLMLEATIREVLRIRPVAPLLIPHKANIDSSIGEFAIPKDTHVI
                     INLWALHHDKNEWDQPDRFMPERFLDPTGSHLITPTPSYLPFGAGPRSCIGEALARQE
                     LFIFMALLLQRFDFDVSDDKQLPCLVGDPKVVFLIDPFKVKITVRQAWKDAQVEVST"
     exon            455..590
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17; p450c17"
                     /inference="alignment:Splign:2.1.0"
     exon            591..820
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17; p450c17"
                     /inference="alignment:Splign:2.1.0"
     exon            821..907
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17; p450c17"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1123
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17; p450c17"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1293
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17; p450c17"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1397
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17; p450c17"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1841
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17; p450c17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1807..1812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17; p450c17"
                     /note="hexamer: ATTAAA"
     polyA_site      1828
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17; p450c17"
                     /note="major polyA site"
ORIGIN      
        1 caggcttgga gacactccag gataaacttc tgcaggccaa gagataacac gtcttcaagg
       61 tgacaatcag aaacgccttt taaaagttct ccttctctgc tgaaattgct gtagcttctc
      121 cactccacag ctggccatct gcctacacct ggctgccatg tgggaacttg tgggtctctt
      181 gctgctcatc ctggcctatt tcttttggcc caagtcaaag acacctaatg ccaagttccc
      241 caggagcctt ccattcctgc ccctggtggg tagtctaccg tttctcccca gacgtggtca
      301 tatgcatgcc aacttcttca agctgcagga aaagtatggt cccatctatt ctcttcgcct
      361 gggtaccaca actgcagtga ttgtcggtca ctatcagctg gccagagaag tgctcgtgaa
      421 gaaggggaaa gaattctctg gtcggcccca gatggtgact ctaggcctct tgtcggacca
      481 aggaaaaggc gtcgcctttg cggatagtag tagctcctgg cagctgcacc ggaagctggt
      541 attcagcacc ttttccctgt tcagggatga ccagaaactg gagaagatga tatgtcagga
      601 agccaactca ctgtgtgact tgatacttac atacgacggg gagtcccgag atctgtctac
      661 gctcatcttc aagtcagtaa tcaatatcat ctgtaccatc tgcttcaaca tctcttttga
      721 gaacaaggat ccgatactga ctaccataca gacctttaca gagggtattg tggatgtcct
      781 gggccacagc gatctggtgg acatattccc gtggttgaag atttttccca ataaaaactt
      841 ggaaatgata aaggaacaca ctaaaattcg agaaaaaaca ctggttgaaa tgtttgaaaa
      901 atgcaaggag aaattcaata gtgaatctct ctccagcctg acagacattc tgatacaagc
      961 caagatgaat gcagaaaata ataacactgg ggaaggccag gacccaagtg tgttctcaga
     1021 taagcatatc cttgtcacgg tgggagacat ctttggggca ggcatagaga caactagctc
     1081 tgtgctgaac tggatcctgg ctttcctggt gcacaatcct gaggtgaaga ggaagatcca
     1141 aaaggagatt gaccagtatg taggcttcag tcgaacaccg tctttcaatg accggactca
     1201 cctcctcatg ctggaggcca ctatccgaga agtgcttcgt atcaggccgg tggccccctt
     1261 gctcatccca cacaaggcta acattgactc cagcattgga gagtttgcca tcccgaagga
     1321 cacacatgtg atcatcaatc tctgggcact gcatcacgat aaaaatgaat gggaccagcc
     1381 agatcggttt atgcctgagc gcttcttaga tccaacagga agccatctca ttacacccac
     1441 acccagttat ttgcccttcg gagctggtcc ccgatcgtgc attggagagg ctctggcccg
     1501 gcaggagctc tttatcttca tggccttgct gctgcagagg tttgactttg atgtgtcaga
     1561 tgacaaacag ctgccctgtc tggtgggtga ccccaaggtg gtctttctga tcgacccttt
     1621 caaagtgaaa atcacagtgc gacaagcatg gaaggatgca caggttgagg ttagcaccta
     1681 gaggccgaat ctaacgtccc ggatcccatg ccttgacacc cacagcccaa tcttagaggt
     1741 gcctccaaca atcctcctca ctcctatccc gttttctact tggcagcaat gaagggtgag
     1801 acacatatta aaggttttcc aataaacatc tctgagctgt c
//
