LOCUS       NP_031835                507 aa            linear   ROD 03-JUN-2025
DEFINITION  steroid 17-alpha-hydroxylase/17,20 lyase [Mus musculus].
ACCESSION   NP_031835
VERSION     NP_031835.3
DBSOURCE    REFSEQ: accession NM_007809.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 507)
  AUTHORS   Estermann,M.A., Grimm,S.A., Kitakule,A.S., Rodriguez,K.F.,
            Brown,P.R., McClelland,K., Amato,C.M. and Yao,H.H.
  TITLE     NR2F2 regulation of interstitial cell fate in the embryonic mouse
            testis and its impact on differences of sex development
  JOURNAL   Nat Commun 16 (1), 3987 (2025)
   PUBMED   40295478
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 507)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   3  (residues 1 to 507)
  AUTHORS   Migale,R., Neumann,M., Mitter,R., Rafiee,M.R., Wood,S., Olsen,J.
            and Lovell-Badge,R.
  TITLE     FOXL2 interaction with different binding partners regulates the
            dynamics of ovarian development
  JOURNAL   Sci Adv 10 (12), eadl0788 (2024)
   PUBMED   38517962
REFERENCE   4  (residues 1 to 507)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 507)
  AUTHORS   Lettieri,A., Oleari,R., van den Munkhof,M.H., van Battum,E.Y.,
            Verhagen,M.G., Tacconi,C., Spreafico,M., Paganoni,A.J.J.,
            Azzarelli,R., Andre',V., Amoruso,F., Palazzolo,L., Eberini,I.,
            Dunkel,L., Howard,S.R., Fantin,A., Pasterkamp,R.J. and Cariboni,A.
  TITLE     SEMA6A drives GnRH neuron-dependent puberty onset by tuning median
            eminence vascular permeability
  JOURNAL   Nat Commun 14 (1), 8097 (2023)
   PUBMED   38062045
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 507)
  AUTHORS   Fan,Y.S., Sasi,R., Lee,C., Winter,J.S., Waterman,M.R. and Lin,C.C.
  TITLE     Localization of the human CYP17 gene (cytochrome P450(17 alpha)) to
            10q24.3 by fluorescence in situ hybridization and simultaneous
            chromosome banding
  JOURNAL   Genomics 14 (4), 1110-1111 (1992)
   PUBMED   1478654
REFERENCE   7  (residues 1 to 507)
  AUTHORS   Youngblood,G.L. and Payne,A.H.
  TITLE     Isolation and characterization of the mouse P450 17
            alpha-hydroxylase/C17-20-lyase gene (Cyp17): transcriptional
            regulation of the gene by cyclic adenosine 3',5'-monophosphate in
            MA-10 Leydig cells
  JOURNAL   Mol Endocrinol 6 (6), 927-934 (1992)
   PUBMED   1323057
REFERENCE   8  (residues 1 to 507)
  AUTHORS   Youngblood,G.L., Sartorius,C., Taylor,B.A. and Payne,A.H.
  TITLE     Isolation, characterization, and chromosomal mapping of mouse P450
            17 alpha-hydroxylase/C17-20 lyase
  JOURNAL   Genomics 10 (1), 270-275 (1991)
   PUBMED   1840559
REFERENCE   9  (residues 1 to 507)
  AUTHORS   Perkins,L.M. and Payne,A.H.
  TITLE     Quantification of P450scc, P450(17) alpha, and iron sulfur protein
            reductase in Leydig cells and adrenals of inbred strains of mice
  JOURNAL   Endocrinology 123 (6), 2675-2682 (1988)
   PUBMED   2848682
REFERENCE   10 (residues 1 to 507)
  AUTHORS   Malaska,T. and Payne,A.H.
  TITLE     Luteinizing hormone and cyclic AMP-mediated induction of microsomal
            cytochrome P-450 enzymes in cultured mouse Leydig cells
  JOURNAL   J Biol Chem 259 (19), 11654-11657 (1984)
   PUBMED   6090441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD552634.1, M64863.1 and AK134376.1.
            
            On Nov 22, 2007 this sequence version replaced NP_031835.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132830.1, BC064793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.97 cM"
     Protein         1..507
                     /product="steroid 17-alpha-hydroxylase/17,20 lyase"
                     /EC_number="1.14.14.19"
                     /EC_number="1.14.14.32"
                     /note="cytochrome P450, 17a1; CYPXVII; cytochrome P450c17;
                     cytochrome P450-C17; cytochrome P450 17A1; steroid
                     17-alpha hydroxylase; 17-alpha-hydroxyprogesterone
                     aldolase; steroid 17-alpha-monooxygenase"
                     /calculated_mol_wt=57507
     Region          60..490
                     /region_name="CYP17A1"
                     /note="cytochrome P450 family 17, subfamily A, polypeptide
                     1; cd20673"
                     /db_xref="CDD:410766"
     Site            order(86,96,112..113,121,125,297..298,301..302,305..306,
                     309,365,369,372,433..435,439..443,447)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:410766"
     Site            order(105,113..114,200..201,204..205,208,238,296..297,
                     300..301,304..305,365..366,370,441,481..482)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:410766"
     CDS             1..507
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17; p450c17"
                     /coded_by="NM_007809.3:158..1681"
                     /db_xref="CCDS:CCDS29882.1"
                     /db_xref="GeneID:13074"
                     /db_xref="MGI:MGI:88586"
ORIGIN      
        1 mwelvgllll ilayffwpks ktpnakfprs lpflplvgsl pflprrghmh anffklqeky
       61 gpiyslrlgt ttavivghyq larevlvkkg kefsgrpqmv tlgllsdqgk gvafadssss
      121 wqlhrklvfs tfslfrddqk lekmicqean slcdliltyd gesrdlstli fksviniict
      181 icfnisfenk dpilttiqtf tegivdvlgh sdlvdifpwl kifpnknlem ikehtkirek
      241 tlvemfekck ekfnseslss ltdiliqakm naennntgeg qdpsvfsdkh ilvtvgdifg
      301 agiettssvl nwilaflvhn pevkrkiqke idqyvgfsrt psfndrthll mleatirevl
      361 rirpvaplli phkanidssi gefaipkdth viinlwalhh dknewdqpdr fmperfldpt
      421 gshlitptps ylpfgagprs cigealarqe lfifmalllq rfdfdvsddk qlpclvgdpk
      481 vvflidpfkv kitvrqawkd aqvevst
//
