LOCUS       NM_009991               1930 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus cytochrome P450, family 11, subfamily b, polypeptide 2
            (Cyp11b2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_009991
VERSION     NM_009991.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1930)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   2  (bases 1 to 1930)
  AUTHORS   van Rooyen,D., Lerario,A.M., Little,D.W. 3rd, Ullenbruch,M.R.,
            Taylor,M.J., Gomez-Sanchez,C.E., Hammer,G.D. and Rainey,W.E.
  TITLE     Chronic activation of adrenal Gq signaling induces Cyp11b2
            expression in the zona fasciculata and hyperaldosteronism
  JOURNAL   Mol Cell Endocrinol 585, 112176 (2024)
   PUBMED   38341019
  REMARK    GeneRIF: Chronic activation of adrenal Gq signaling induces Cyp11b2
            expression in the zona fasciculata and hyperaldosteronism.
REFERENCE   3  (bases 1 to 1930)
  AUTHORS   Daryadel,A., Tang,C., Xie,Y., Peitzsch,M., Fisi,V., Hantel,C.,
            Loffing-Cueni,D., Breault,D.T., Penton,D., Loffing,J. and
            Beuschlein,F.
  TITLE     Zona Glomerulosa-Derived Klotho Modulates Aldosterone Synthase
            Expression in Young Female Mice
  JOURNAL   Endocrinology 165 (5) (2024)
   PUBMED   38573585
REFERENCE   4  (bases 1 to 1930)
  AUTHORS   Liimatta,J., Curschellas,E., Altinkilic,E.M., Naamneh Elzenaty,R.,
            Augsburger,P., du Toit,T., Voegel,C.D., Breault,D.T., Fluck,C.E.
            and Pignatti,E.
  TITLE     Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis
  JOURNAL   Endocrinology 165 (3) (2024)
   PUBMED   38301271
REFERENCE   5  (bases 1 to 1930)
  AUTHORS   Al-Qusairi,L., Ferdaus,M.Z., Pham,T.D., Li,D., Grimm,P.R.,
            Zapf,A.M., Abood,D.C., Tahaei,E., Delpire,E., Wall,S.M. and
            Welling,P.A.
  TITLE     Dietary anions control potassium excretion: it is more than a
            poorly absorbable anion effect
  JOURNAL   Am J Physiol Renal Physiol 325 (3), F377-F393 (2023)
   PUBMED   37498547
REFERENCE   6  (bases 1 to 1930)
  AUTHORS   Allen,R.G., Carey,C., Parker,J.D., Mortrud,M.T., Mellon,S.H. and
            Low,M.J.
  TITLE     Targeted ablation of pituitary pre-proopiomelanocortin cells by
            herpes simplex virus-1 thymidine kinase differentially regulates
            mRNAs encoding the adrenocorticotropin receptor and aldosterone
            synthase in the mouse adrenal gland
  JOURNAL   Mol Endocrinol 9 (8), 1005-1016 (1995)
   PUBMED   7476975
REFERENCE   7  (bases 1 to 1930)
  AUTHORS   Domalik,L.J., Chaplin,D.D., Kirkman,M.S., Wu,R.C., Liu,W.W.,
            Howard,T.A., Seldin,M.F. and Parker,K.L.
  TITLE     Different isozymes of mouse 11 beta-hydroxylase produce
            mineralocorticoids and glucocorticoids
  JOURNAL   Mol Endocrinol 5 (12), 1853-1861 (1991)
   PUBMED   1686470
REFERENCE   8  (bases 1 to 1930)
  AUTHORS   Bogerd,A.M., Franklin,A., Rice,D.A., Schimmer,B.P. and Parker,K.L.
  TITLE     Identification and characterization of two upstream elements that
            regulate adrenocortical expression of steroid 11 beta-hydroxylase
  JOURNAL   Mol Endocrinol 4 (6), 845-850 (1990)
   PUBMED   2233742
REFERENCE   9  (bases 1 to 1930)
  AUTHORS   Wong,M., Rice,D.A., Parker,K.L. and Schimmer,B.P.
  TITLE     The roles of cAMP and cAMP-dependent protein kinase in the
            expression of cholesterol side chain cleavage and steroid 11
            beta-hydroxylase genes in mouse adrenocortical tumor cells
  JOURNAL   J Biol Chem 264 (22), 12867-12871 (1989)
   PUBMED   2546938
REFERENCE   10 (bases 1 to 1930)
  AUTHORS   Mouw,A.R., Rice,D.A., Meade,J.C., Chua,S.C., White,P.C.,
            Schimmer,B.P. and Parker,K.L.
  TITLE     Structural and functional analysis of the promoter region of the
            gene encoding mouse steroid 11 beta-hydroxylase
  JOURNAL   J Biol Chem 264 (2), 1305-1309 (1989)
   PUBMED   2783417
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139671.10.
            
            On Feb 13, 2019 this sequence version replaced NM_009991.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AC139671.10        135081-135325       c
            246-401             AC139671.10        134524-134679       c
            402-601             AC139671.10        132890-133089       c
            602-805             AC139671.10        132558-132761       c
            806-960             AC139671.10        132133-132287       c
            961-1127            AC139671.10        131100-131266       c
            1128-1206           AC139671.10        130789-130867       c
            1207-1395           AC139671.10        130513-130701       c
            1396-1930           AC139671.10        129712-130246       c
FEATURES             Location/Qualifiers
     source          1..1930
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.29 cM"
     gene            1..1930
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cpn2; Cyp11b; Cyp11b-2"
                     /note="cytochrome P450, family 11, subfamily b,
                     polypeptide 2"
                     /db_xref="GeneID:13072"
                     /db_xref="MGI:MGI:88584"
     exon            1..245
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cpn2; Cyp11b; Cyp11b-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1509
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cpn2; Cyp11b; Cyp11b-2"
                     /EC_number="1.14.15.4"
                     /EC_number="1.14.15.5"
                     /note="cytochrome P450C11; aldosterone synthase;
                     cytochrome P-450C18; cytochrome P-450Aldo; steroid
                     18-hydroxylase; aldosterone-synthesizing enzyme; steroid
                     11-beta-hydroxylase, CYP11B2; corticosterone
                     18-monooxygenase, CYP11B2; steroid-11-beta-hydroxylase"
                     /codon_start=1
                     /product="cytochrome P450 11B2, mitochondrial"
                     /protein_id="NP_034121.4"
                     /db_xref="CCDS:CCDS27536.3"
                     /db_xref="GeneID:13072"
                     /db_xref="MGI:MGI:88584"
                     /translation="MALRVTADVWLARPWQCLHRTRALGTTATLAPKTLQPFEAIPQY
                     SRNKWLKMIQILREQGQENLHLEMHQVFRELGPIFRHSVGKTQIVSVMLPEDAEKLHQ
                     VESMLPRRMHLEPWVAHRELRGLRRGVFLLNGPEWRLNRLRLNRNVLSPKAVQKFVPM
                     VDMVARDFLETLKEKVLQNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLSP
                     GSLKFIHALHSMFKSTSQLLFLPKSLTRWTSTRVWKEHFDAWDVISEYANRCIWKVHQ
                     ELRLGSSQTYSGIVAELISQGSLPLDAIKANSMELTAGSVDTTAIPLVMTLFELARNP
                     DVQKALRQESLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILSSDLVL
                     QNYHVPAGTLVLLYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGR
                     RLAEVEMMLLLHHILKTFQVETLRQEDVQMAYRFVLMPSSSPVLTFRPVS"
     exon            246..401
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cpn2; Cyp11b; Cyp11b-2"
                     /inference="alignment:Splign:2.1.0"
     exon            402..601
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cpn2; Cyp11b; Cyp11b-2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..805
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cpn2; Cyp11b; Cyp11b-2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..960
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cpn2; Cyp11b; Cyp11b-2"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1127
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cpn2; Cyp11b; Cyp11b-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1206
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cpn2; Cyp11b; Cyp11b-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1395
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cpn2; Cyp11b; Cyp11b-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1930
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cpn2; Cyp11b; Cyp11b-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcaatgg ctctcagggt gacagcagat gtgtggctgg caagaccctg gcagtgcctg
       61 cacaggacaa gggcactggg caccacggca acactggccc caaagaccct gcagcccttt
      121 gaagccatac cacagtactc caggaacaag tggctgaaga tgatacagat cctgagggag
      181 cagggccaag aaaacctaca cctggagatg catcaggtct tccgggagct ggggcccatt
      241 ttcaggcaca gtgtagggaa aacacagatc gtatctgtga tgttgccgga ggatgctgag
      301 aagttgcacc aggtggagag tatgctcccc cgtcggatgc acctggagcc ctgggtggcc
      361 cacagagaac tccgtggcct gagacgtggt gtgttcttgc taaatgggcc agaatggcgt
      421 ctcaaccgac tgcggctgaa ccgaaatgtg ctgtcaccaa aagccgttca aaaatttgtc
      481 cccatggtgg acatggtagc aagggacttc ttggagacct tgaaagagaa ggtgcttcaa
      541 aatgctcgtg ggagccttac catggatgtc cagcaaagcc tcttcaacta cactatagaa
      601 gccagcaact ttgctctttt tggggaacgg ctaggcctcc ttggccatga cctgagccct
      661 ggcagcctga agtttatcca tgccctgcat tctatgttca agtccacctc acagctcctg
      721 ttcttaccca agagcttgac tcgctggaca agcactcggg tgtggaaaga acatttcgat
      781 gcctgggatg tcatctctga gtatgccaac agatgtatct ggaaggtgca ccaggagctc
      841 agactcggca gctctcagac ctacagtggc attgtggcgg aactaatatc tcagggatct
      901 ttgcctctcg acgccatcaa agcgaactct atggagctca ccgctgggag cgttgacacg
      961 acagcaatcc ccttggtaat gacccttttt gagctggctc ggaacccaga tgttcagaag
     1021 gccctgaggc aggagagcct ggcagctgag gccagcatcg ctgcaaatcc tcagaaggcc
     1081 atgtcagacc tgcccttgct gagggctgcc cttaaagaga ccttgaggct ctatcctgtt
     1141 ggtggctttt tggagagaat tctaagctca gacttggtgc ttcagaacta ccatgtccct
     1201 gctgggacat tggtcctact ttatctctac tccatgggcc gaaaccctgc agtgttccca
     1261 aggcctgaac gctatatgcc tcagcgctgg ctggagagga aaaggagttt ccagcaccta
     1321 gcctttggct ttggggtgcg ccagtgcctg gggaggcgcc tggcagaggt ggagatgatg
     1381 ctcctgcttc accatatact gaaaaccttc caggtggaga cactgaggca agaggatgtg
     1441 cagatggcct accgctttgt tttgatgccc agctccagcc ctgtcctcac tttccggcct
     1501 gtcagctagt cacttttgca tctggggtcc tagtccggcc accagccttc ctctgtcctg
     1561 acacccaagg tcacacttct ctgccagcag aatttttggt ggggaaggga aggaggtcac
     1621 acagtcatcc ttcaacacct ggacaagatt cacagctgaa gacctccagc atcagggaca
     1681 ggcaaggcca gggaggagat tggaagtatc ttggtggcaa tacgcagtct ctgctgtgta
     1741 gtcctcccca tgttttccaa tggtcactcc aggtgtccat gaacttccaa gggcctcaga
     1801 gtaaagtcag aagtcatttc cttccttatg ttccccatta tttgacatga gccacaaaaa
     1861 tggctcacac acatatgggt ttgtaggggc agcaagctgc ataaatgatg gatagataga
     1921 tgatagatag
//
