LOCUS       NM_001033229            2398 bp    mRNA    linear   ROD 31-OCT-2023
DEFINITION  Mus musculus cytochrome P450, family 11, subfamily b, polypeptide 1
            (Cyp11b1), mRNA.
ACCESSION   NM_001033229 XM_356312 XM_889243
VERSION     NM_001033229.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2398)
  AUTHORS   Whiley PAF, Luu MCM, O'Donnell L, Handelsman DJ and Loveland KL.
  TITLE     Testis exposure to unopposed/elevated activin A in utero affects
            somatic and germ cells and alters steroid levels mimicking
            phthalate exposure
  JOURNAL   Front Endocrinol (Lausanne) 14, 1234712 (2023)
   PUBMED   37727456
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2398)
  AUTHORS   Ahmed A, Reinhold C, Breunig E, Phan TS, Dietrich L, Kostadinova F,
            Urwyler C, Merk VM, Noti M, Toja da Silva I, Bode K, Nahle F,
            Plazzo AP, Koerner J, Stuber R, Menche C, Karamitopoulou E, Farin
            HF, Gollob KJ and Brunner T.
  TITLE     Immune escape of colorectal tumours via local
            LRH-1/Cyp11b1-mediated synthesis of immunosuppressive
            glucocorticoids
  JOURNAL   Mol Oncol 17 (8), 1545-1566 (2023)
   PUBMED   36861295
  REMARK    GeneRIF: Immune escape of colorectal tumours via local
            LRH-1/Cyp11b1-mediated synthesis of immunosuppressive
            glucocorticoids.
REFERENCE   3  (bases 1 to 2398)
  AUTHORS   Yadav VK, Berger JM, Singh P, Nagarajan P and Karsenty G.
  TITLE     Embryonic osteocalcin signaling determines lifelong adrenal
            steroidogenesis and homeostasis in the mouse
  JOURNAL   J Clin Invest 132 (4) (2022)
   PUBMED   34905510
REFERENCE   4  (bases 1 to 2398)
  AUTHORS   Menard A, Abou Nader N, Levasseur A, St-Jean G, Le Roy MLG,
            Boerboom D, Benoit-Biancamano MO and Boyer A.
  TITLE     Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal
            Cortex Development and Alters Adrenocortical Cell Fate
  JOURNAL   Endocrinology 161 (5) (2020)
   PUBMED   32243503
REFERENCE   5  (bases 1 to 2398)
  AUTHORS   Taves MD, Mittelstadt PR, Presman DM, Hager GL and Ashwell JD.
  TITLE     Single-Cell Resolution and Quantitation of Targeted Glucocorticoid
            Delivery in the Thymus
  JOURNAL   Cell Rep 26 (13), 3629-3642 (2019)
   PUBMED   30917317
REFERENCE   6  (bases 1 to 2398)
  AUTHORS   Keeney DS, Jenkins CM and Waterman MR.
  TITLE     Developmentally regulated expression of adrenal 17
            alpha-hydroxylase cytochrome P450 in the mouse embryo
  JOURNAL   Endocrinology 136 (11), 4872-4879 (1995)
   PUBMED   7588219
REFERENCE   7  (bases 1 to 2398)
  AUTHORS   Bhaumik M, Seldin MF and Stanley P.
  TITLE     Cloning and chromosomal mapping of the mouse Mgat3 gene encoding
            N-acetylglucosaminyltransferase III
  JOURNAL   Gene 164 (2), 295-300 (1995)
   PUBMED   7590346
REFERENCE   8  (bases 1 to 2398)
  AUTHORS   Domalik LJ, Chaplin DD, Kirkman MS, Wu RC, Liu WW, Howard TA,
            Seldin MF and Parker KL.
  TITLE     Different isozymes of mouse 11 beta-hydroxylase produce
            mineralocorticoids and glucocorticoids
  JOURNAL   Mol Endocrinol 5 (12), 1853-1861 (1991)
   PUBMED   1686470
REFERENCE   9  (bases 1 to 2398)
  AUTHORS   Bogerd AM, Franklin A, Rice DA, Schimmer BP and Parker KL.
  TITLE     Identification and characterization of two upstream elements that
            regulate adrenocortical expression of steroid 11 beta-hydroxylase
  JOURNAL   Mol Endocrinol 4 (6), 845-850 (1990)
   PUBMED   2233742
REFERENCE   10 (bases 1 to 2398)
  AUTHORS   Wong M, Rice DA, Parker KL and Schimmer BP.
  TITLE     The roles of cAMP and cAMP-dependent protein kinase in the
            expression of cholesterol side chain cleavage and steroid 11
            beta-hydroxylase genes in mouse adrenocortical tumor cells
  JOURNAL   J Biol Chem 264 (22), 12867-12871 (1989)
   PUBMED   2546938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139671.10, AK168839.1 and AK142439.1.
            
            [WARNING] On Apr 12, 2024 this sequence was replaced by
            NM_001033229.4.
            
            On Nov 25, 2009 this sequence version replaced NM_001033229.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139248.1, AK142439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC139671.10        120714-120737       c
            25-1829             AK168839.1         2-1806
            1830-2395           AK142439.1         1807-2372
            2396-2398           AC139671.10        113986-113988       c
FEATURES             Location/Qualifiers
     source          1..2398
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.29 cM"
     gene            1..2398
                     /gene="Cyp11b1"
                     /gene_synonym="CPN1; Cyp11b; Cyp11b-1; FHI"
                     /note="cytochrome P450, family 11, subfamily b,
                     polypeptide 1"
                     /db_xref="GeneID:110115"
                     /db_xref="MGI:MGI:88583"
     exon            1..276
                     /gene="Cyp11b1"
                     /gene_synonym="CPN1; Cyp11b; Cyp11b-1; FHI"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1537
                     /gene="Cyp11b1"
                     /gene_synonym="CPN1; Cyp11b; Cyp11b-1; FHI"
                     /EC_number="1.14.15.4"
                     /note="steroid-11-beta-hydroxylase"
                     /codon_start=1
                     /product="cytochrome P450, family 11, subfamily b,
                     polypeptide 1"
                     /protein_id="NP_001028401.2"
                     /db_xref="CCDS:CCDS27535.1"
                     /db_xref="GeneID:110115"
                     /db_xref="MGI:MGI:88583"
                     /translation="MTMALRVTTDVWLARPWQCLHRTRALGTTATLAPKTLQPFEAIP
                     QYSRNKWLKMIQILREQGQENLHLEMHQVFRELGPIFRHSVGKTQIVFVTLPEDVEKL
                     YQVESTHPCRMPLESWIVHRELRGLGRGVFLLNGPEWYFNRLQLNPNVLSPKAVQKFV
                     PLVDGIARDFVDNLKKKMLESVHGSFSMDFQSSVFNYTIEASHFVLFGERLGLIGRDL
                     SPDSLKFLHTLHSMFKTTTQLLYLPRSLTRWTSTRVWKENLESWDFISEYVTKCIKNV
                     YRELAEGRPQSWSVTAELVAERTLSMDAIQANSMELIAGSTDTTSTPLVMTFFELARN
                     PDVQQALRQESLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGTFLERILSSDLV
                     LQNYHVPAGTVLNVNLYSMGRNPAVFPRPERYMPQRWLERKRSFKHLAFGFGVRQCLG
                     RRLAEAEMMLLLHHVLKSFHVETQEKEDVRMAYRFVLMPSSSPLLTFRPVN"
     exon            277..432
                     /gene="Cyp11b1"
                     /gene_synonym="CPN1; Cyp11b; Cyp11b-1; FHI"
                     /inference="alignment:Splign:2.1.0"
     exon            433..632
                     /gene="Cyp11b1"
                     /gene_synonym="CPN1; Cyp11b; Cyp11b-1; FHI"
                     /inference="alignment:Splign:2.1.0"
     exon            633..836
                     /gene="Cyp11b1"
                     /gene_synonym="CPN1; Cyp11b; Cyp11b-1; FHI"
                     /inference="alignment:Splign:2.1.0"
     exon            837..988
                     /gene="Cyp11b1"
                     /gene_synonym="CPN1; Cyp11b; Cyp11b-1; FHI"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1155
                     /gene="Cyp11b1"
                     /gene_synonym="CPN1; Cyp11b; Cyp11b-1; FHI"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1234
                     /gene="Cyp11b1"
                     /gene_synonym="CPN1; Cyp11b; Cyp11b-1; FHI"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1423
                     /gene="Cyp11b1"
                     /gene_synonym="CPN1; Cyp11b; Cyp11b-1; FHI"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..2398
                     /gene="Cyp11b1"
                     /gene_synonym="CPN1; Cyp11b; Cyp11b-1; FHI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccacggac taaacacagg aagagaggaa gatgacaatg gctctcaggg tgacaacaga
       61 tgtgtggctg gcaagaccct ggcagtgcct gcacaggaca agggcactgg gcaccacggc
      121 aacactggcc ccaaagaccc tgcagccctt tgaagccata ccacagtact ccaggaacaa
      181 gtggctgaag atgatacaga tcctgaggga gcagggccaa gaaaacctac acctggagat
      241 gcatcaggtc ttccgggagc tggggcccat tttcaggcac agtgtaggga aaacacagat
      301 tgtgtttgtg acgttgccgg aggatgttga gaagctgtac caggtagaga gtacgcaccc
      361 ttgccgcatg cccttggaat cctggatagt ccatagagaa ctccgtggcc tgggacgtgg
      421 tgtgttcttg ctaaatgggc cagaatggta cttcaaccga ctgcagctga acccaaatgt
      481 tctgtcacca aaagccgttc aaaaatttgt ccccttggtg gatgggatag caagggactt
      541 tgtggataac ctgaagaaga aaatgctgga aagtgtccat ggtagcttct ctatggactt
      601 tcagtccagt gtgttcaact ataccataga agctagccac tttgttcttt ttggggagcg
      661 gctgggcctc attggccgtg atctgagccc tgacagcctg aagttcctcc acaccctgca
      721 ctccatgttc aaaaccacca cacagctctt gtacttgccc aggagcctga cccgatggac
      781 aagcaccagg gtgtggaaag aaaacttaga gtcctgggat ttcatctctg aatatgtcac
      841 caaatgtatc aagaatgtgt atcgagagct ggcagagggt cgtccacagt cctggagtgt
      901 cacagcagag ctggtagctg agagaactct gtcaatggat gccatccagg ctaactcaat
      961 ggaactcatt gctggaagca ctgacacgac atcaaccccc ttggtaatga ctttctttga
     1021 gctggctcgg aacccagatg ttcagcaggc cctgaggcag gagagcctgg cagctgaggc
     1081 cagcatcgct gcaaatcctc agaaggccat gtcagacctg cccttgctga gggctgccct
     1141 taaagagacc ttgaggctct atcctgttgg tacttttctg gagagaattc taagctcaga
     1201 cttggtgctt cagaactacc atgtccctgc tgggacagtc ctcaatgtga atctgtattc
     1261 catgggccgg aaccctgcag tgttcccaag gcctgaacgc tatatgcctc agcgctggct
     1321 ggagaggaaa aggagtttca agcacctggc ctttggcttt ggggtgcgcc agtgcctggg
     1381 gaggcgcctg gcagaggcag agatgatgct cctgcttcac catgtgctga aatccttcca
     1441 cgtggagaca caagagaaag aggatgtgcg gatggcctac cgcttcgttt tgatgcccag
     1501 ctccagtcct ctcctcactt tcaggcctgt caactagtca cacagccttt ttcttttggt
     1561 gtcccaagat gtcaatagct tcctgttctg atgacacatt gccctctctt ctcttcctta
     1621 gagtgctatg cctgtggcca tgctcagcct cttgtctagt atctgacaga ttgtgattcg
     1681 gggtcagaga atggctctgg agaattgctg tcccctaact gtcacctccc agtctcctcc
     1741 cgtggtcatc caagtgagcc catcttctga ctttctgtct ggttcccatc atccttgtca
     1801 cactctttct gtcccttcta aaatatcttt gtttgaatgt tgtacaaggg gaacccacca
     1861 tcagtaagga catctcatgt cagcagtgaa agcctatgac cactcatgac acattgtcat
     1921 gcgtgaggga agacagaact aatgtgtatg ttgcacacct cagatgccat gtggtccagc
     1981 ttagacctca cacacacagt aaatgctcag tgatcattct ccagtccaga ctatgtgccg
     2041 atccagggga tgctgtgaag agctaagggg ctcaggtgtg gcaggacaag ctgtagactt
     2101 gtggtaacat atgggtcaga aattgtttag tgcgtttcat aatggtttct gtccacatct
     2161 tctctggtca acagatgaac acatatcata agtcagattc acttgggggc atttggaaaa
     2221 tcactgtgca atgcttttca gttctcatgt tttggactac atgtactact ggccaaatca
     2281 cagtgtacca tacagggagg gcatgtccct tgggttacag tcatccctag gcacactctg
     2341 tttgcctcat tgtttcttac ctaccctaat aaaatataaa ctgcatctct tacataca
//
