LOCUS       NM_019779               1847 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus cytochrome P450, family 11, subfamily a, polypeptide 1
            (Cyp11a1), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_019779 XM_976231
VERSION     NM_019779.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1847)
  AUTHORS   Fujiki,J., Maeda,N., Yamaguchi,K., Ohtsuki,Y. and Iwano,H.
  TITLE     DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR
            transcripts in C2C12 myoblasts
  JOURNAL   Mol Cell Endocrinol 593, 112336 (2024)
   PUBMED   39094930
  REMARK    GeneRIF: DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR
            transcripts in C2C12 myoblasts.
REFERENCE   2  (bases 1 to 1847)
  AUTHORS   Yin,H., Zhang,J., Chen,Y., Guo,J., Li,Q., Dinnyes,A., Sun,Q.,
            Liu,X., He,G., Zhu,B., Liu,Y., Xu,P., Xu,W. and Xie,J.
  TITLE     Placenta-specific CYP11A1 overexpression lead to autism-like
            symptom in offspring with altered steroid hormone biosynthesis in
            the placenta-brain axis and rescued by vitamin D intervention
  JOURNAL   Brain Behav Immun 121, 13-25 (2024)
   PUBMED   39025414
  REMARK    GeneRIF: Placenta-specific CYP11A1 overexpression lead to
            autism-like symptom in offspring with altered steroid hormone
            biosynthesis in the placenta-brain axis and rescued by vitamin D
            intervention.
REFERENCE   3  (bases 1 to 1847)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   4  (bases 1 to 1847)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   5  (bases 1 to 1847)
  AUTHORS   Hurtado,A., Mota-Gomez,I., Lao,M., Real,F.M., Jedamzick,J.,
            Burgos,M., Lupianez,D.G., Jimenez,R. and Barrionuevo,F.J.
  TITLE     Complete male-to-female sex reversal in XY mice lacking the
            miR-17~92 cluster
  JOURNAL   Nat Commun 15 (1), 3809 (2024)
   PUBMED   38714644
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1847)
  AUTHORS   Keeney,D.S., Ikeda,Y., Waterman,M.R. and Parker,K.L.
  TITLE     Cholesterol side-chain cleavage cytochrome P450 gene expression in
            the primitive gut of the mouse embryo does not require
            steroidogenic factor 1
  JOURNAL   Mol Endocrinol 9 (8), 1091-1098 (1995)
   PUBMED   7476982
REFERENCE   7  (bases 1 to 1847)
  AUTHORS   Rice,D.A., Kirkman,M.S., Aitken,L.D., Mouw,A.R., Schimmer,B.P. and
            Parker,K.L.
  TITLE     Analysis of the promoter region of the gene encoding mouse
            cholesterol side-chain cleavage enzyme
  JOURNAL   J Biol Chem 265 (20), 11713-11720 (1990)
   PUBMED   2365694
REFERENCE   8  (bases 1 to 1847)
  AUTHORS   Youngblood,G.L., Nesbitt,M.N. and Payne,A.H.
  TITLE     The structural genes encoding P450scc and P450arom are closely
            linked on mouse chromosome 9
  JOURNAL   Endocrinology 125 (5), 2784-2786 (1989)
   PUBMED   2792009
REFERENCE   9  (bases 1 to 1847)
  AUTHORS   Wong,M., Rice,D.A., Parker,K.L. and Schimmer,B.P.
  TITLE     The roles of cAMP and cAMP-dependent protein kinase in the
            expression of cholesterol side chain cleavage and steroid 11
            beta-hydroxylase genes in mouse adrenocortical tumor cells
  JOURNAL   J Biol Chem 264 (22), 12867-12871 (1989)
   PUBMED   2546938
REFERENCE   10 (bases 1 to 1847)
  AUTHORS   Perkins,L.M. and Payne,A.H.
  TITLE     Quantification of P450scc, P450(17) alpha, and iron sulfur protein
            reductase in Leydig cells and adrenals of inbred strains of mice
  JOURNAL   Endocrinology 123 (6), 2675-2682 (1988)
   PUBMED   2848682
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ092722.1, AF195119.1 and AC158996.2.
            
            On Oct 30, 2016 this sequence version replaced NM_019779.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF195119.1, BC068264.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                CJ092722.1         2-66
            66-1839             AF195119.1         1-1774
            1840-1847           AC158996.2         130938-130945       c
FEATURES             Location/Qualifiers
     source          1..1847
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.63 cM"
     gene            1..1847
                     /gene="Cyp11a1"
                     /gene_synonym="cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc;
                     Scc"
                     /note="cytochrome P450, family 11, subfamily a,
                     polypeptide 1"
                     /db_xref="GeneID:13070"
                     /db_xref="MGI:MGI:88582"
     exon            1..347
                     /gene="Cyp11a1"
                     /gene_synonym="cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc;
                     Scc"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1668
                     /gene="Cyp11a1"
                     /gene_synonym="cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc;
                     Scc"
                     /EC_number="1.14.15.6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cholesterol side-chain cleavage enzyme,
                     mitochondrial; cholesterol desmolase; cytochrome P450,
                     11a, cholesterol side-chain cleavage; cytochrome P450
                     side-chain cleavage enzyme; cytochrome P450 11A1;
                     cytochrome P450(scc)"
                     /codon_start=1
                     /product="cholesterol side-chain cleavage enzyme,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_062753.3"
                     /db_xref="CCDS:CCDS40653.1"
                     /db_xref="GeneID:13070"
                     /db_xref="MGI:MGI:88582"
                     /translation="MLAKGLSLRSVLVKGCQPFLSPTWQGPVLSTGKGAGTSTSSPRS
                     FNEIPSPGDNGWLNLYHFWRESGTQKIHYHQMQSFQKYGPIYREKLGTLESVYIVDPK
                     DASILFSCEGPNPERFLVPPWVAYHQYYQRPIGVLFKSSDAWKKDRIVLNQEVMAPGA
                     IKNFVPLLEGVAQDFIKVLHRRIKQQNSGNFSGVISDDLFRFSFESISSVIFGERMGM
                     LEEIVDPEAQRFINAVYQMFHTSVPMLNLPPDFFRLLRTKTWKDHAAAWDVIFNKADE
                     YTQNFYWDLRQKRDFSQYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWN
                     LYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQR
                     YTVNDLVLRNYKIPAKTLVQVASFAMGRDPGFFPNPNKFDPTRWLEKSQNTTHFRYLG
                     FGWGVRQCLGRRIAELEMTILLINLLENFRIEVQNLRDVGTKFSLILMPENPILFNFQ
                     PLKQDLGPAVTRKDNTVN"
     exon            348..503
                     /gene="Cyp11a1"
                     /gene_synonym="cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc;
                     Scc"
                     /inference="alignment:Splign:2.1.0"
     exon            504..703
                     /gene="Cyp11a1"
                     /gene_synonym="cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc;
                     Scc"
                     /inference="alignment:Splign:2.1.0"
     exon            704..907
                     /gene="Cyp11a1"
                     /gene_synonym="cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc;
                     Scc"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1065
                     /gene="Cyp11a1"
                     /gene_synonym="cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc;
                     Scc"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1232
                     /gene="Cyp11a1"
                     /gene_synonym="cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc;
                     Scc"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1311
                     /gene="Cyp11a1"
                     /gene_synonym="cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc;
                     Scc"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1509
                     /gene="Cyp11a1"
                     /gene_synonym="cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc;
                     Scc"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1847
                     /gene="Cyp11a1"
                     /gene_synonym="cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc;
                     Scc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1818..1823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp11a1"
                     /gene_synonym="cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc;
                     Scc"
                     /note="hexamer: AATAAA"
     polyA_site      1837
                     /gene="Cyp11a1"
                     /gene_synonym="cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc;
                     Scc"
                     /note="major polyA site"
ORIGIN      
        1 agccttgagc tggtggttat aagtgtggct ctggaggttt ggggcagaga cactcgtgca
       61 gcaggaagtg gcagtcgtgg ggacagtatg ctggctaaag gactttccct gcgctcagtg
      121 ctggtcaaag gctgccaacc tttcctgagc cctacgtggc agggtccagt gctgagtact
      181 ggaaagggag ctggtacctc tactagcagt cctaggtcct tcaatgagat cccttcccct
      241 ggcgacaatg gttggctaaa cctgtaccac ttctggaggg agagtggcac acagaaaatc
      301 cattaccatc agatgcagag tttccaaaag tatggcccca tttacaggga gaagctgggc
      361 actttggagt cagtttacat cgtggacccc aaggatgcgt cgatactctt ctcatgcgag
      421 ggtcccaacc cggagcggtt ccttgtgccc ccctgggtgg cctatcacca gtattatcag
      481 aggcccattg gggtcctgtt taagagttca gatgcctgga agaaagaccg aatcgtccta
      541 aaccaagagg tgatggcgcc tggagccatc aagaacttcg tgcccctgct ggaaggtgta
      601 gctcaggact tcatcaaagt cttacacaga cgcatcaagc agcaaaattc tggaaatttc
      661 tcaggggtca tcagtgatga cctattccgc ttttcctttg agtccatcag cagtgttata
      721 tttggggagc gcatggggat gctggaggag atcgtggatc ccgaggccca gcggttcatc
      781 aatgctgtct accagatgtt ccacaccagt gtccccatgc tcaacctgcc tccagacttc
      841 tttcgactcc tcagaactaa gacctggaag gaccatgcag ctgcctggga tgtgattttc
      901 aataaagctg atgagtacac ccagaacttc tactgggact taaggcagaa gcgagacttc
      961 agccagtacc ctggtgtcct ttatagcctc ctggggggca acaagctgcc cttcaagaac
     1021 atccaggcca acattaccga gatgctggca ggaggggtgg acacgacctc catgaccctg
     1081 cagtggaacc tttatgagat ggcacacaac ttgaaggtac aggagatgct gcgggctgaa
     1141 gtcctggctg cccggcgcca ggcccaggga gacatggcca agatggtaca gttggttcca
     1201 ctcctcaaag ccagcatcaa ggagacactg agactccacc ccatctccgt gaccttgcag
     1261 aggtacactg tgaatgacct ggtgcttcgt aattacaaga ttccagccaa gactttggta
     1321 caggtggcta gctttgccat gggtcgagat ccgggcttct ttcccaatcc aaacaagttt
     1381 gacccaactc gttggctgga aaaaagccaa aataccaccc acttccggta cttgggcttt
     1441 ggctggggtg ttcggcagtg tctgggccgg cggattgcgg agctggagat gaccatcctc
     1501 cttatcaatc tgctggagaa cttcagaatt gaagttcaaa atctccgtga tgtggggacc
     1561 aagttcagcc tcatcctgat gcctgagaac cccatcctct tcaacttcca gcctctcaag
     1621 caggacctgg gcccagccgt gaccagaaaa gacaacactg tgaactgaag gctggagtca
     1681 catggggagg tggcccatgg ggcatttgag ggtggtatct ctgtatcttc agaaacagca
     1741 ctctgtgatt acctgcccag gttagctggg ctctcctctc cttcatcctc tttccctctt
     1801 tccctaccca gggagttaat aaacacttga acactgagga ccgtttg
//
