LOCUS       NM_026134               1969 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus cylicin, basic protein of sperm head cytoskeleton 1
            (Cylc1), mRNA.
ACCESSION   NM_026134 NM_001081460 XM_006528264 XM_909141 XM_987751 XM_991148
VERSION     NM_026134.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1969)
  AUTHORS   Jin,H.J., Fan,Y., Yang,X., Dong,Y., Zhang,X.Z., Geng,X.Y., Yan,Z.,
            Wu,L., Ma,M., Li,B., Lyu,Q., Pan,Y., Liu,M., Kuang,Y. and Chen,S.R.
  TITLE     Disruption in CYLC1 leads to acrosome detachment, sperm head
            deformity, and male in/subfertility in humans and mice
  JOURNAL   Elife 13, 95054 (2024)
   PUBMED   38573307
  REMARK    GeneRIF: Disruption in CYLC1 leads to acrosome detachment, sperm
            head deformity, and male in/subfertility in humans and mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1969)
  AUTHORS   Schneider,S., Kovacevic,A., Mayer,M., Dicke,A.K., Arevalo,L.,
            Koser,S.A., Hansen,J.N., Young,S., Brenker,C., Kliesch,S.,
            Wachten,D., Kirfel,G., Strunker,T., Tuttelmann,F. and Schorle,H.
  TITLE     Cylicins are a structural component of the sperm calyx being
            indispensable for male fertility in mice and human
  JOURNAL   Elife 12, 86100 (2023)
   PUBMED   38013430
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            LO016976.2.
            
            On or before Feb 20, 2019 this sequence version replaced
            XM_006528264.1, NM_026134.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                LO016976.2         3955-4011
            58-111              LO016976.2         6881-6934
            112-152             LO016976.2         12717-12757
            153-268             LO016976.2         14425-14540
            269-1936            LO016976.2         15880-17547
            1937-1969           LO016976.2         19523-19555
FEATURES             Location/Qualifiers
     source          1..1969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 48.2 cM"
     gene            1..1969
                     /gene="Cylc1"
                     /gene_synonym="4930401M13Rik"
                     /note="cylicin, basic protein of sperm head cytoskeleton
                     1"
                     /db_xref="GeneID:67407"
                     /db_xref="MGI:MGI:1914657"
     exon            1..57
                     /gene="Cylc1"
                     /gene_synonym="4930401M13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1969
                     /gene="Cylc1"
                     /gene_synonym="4930401M13Rik"
                     /note="cylicin I"
                     /codon_start=1
                     /product="cylicin-1"
                     /protein_id="NP_080410.3"
                     /db_xref="CCDS:CCDS41103.2"
                     /db_xref="GeneID:67407"
                     /db_xref="MGI:MGI:1914657"
                     /translation="MSLSKLDSEKLTIEDVQTSSSSCRREINTTTYDDYILSIQTSEK
                     QNQEHFVLTFPKTPMPDKKKRSGPSELEVAVPIQVKRKIEKDQKPTHVWINQFLRDIF
                     LKSSFSRPFITQAPFKYLYNPQNHYTMAESRKSKNDERRKTLKIKFRGKISSCVVNLE
                     PMRTITNGEPEILGNTEKNPSKSSHKIKLPKTSNSTSETNLEYNNSKKTLEMSLRNGN
                     KNSMNFVLKGNAATCCKDNPNTDSKKSVEEFSDDISECINSSNMDLMLRLNEFRAEFT
                     DLDVWSTNCSQNNAKKPLKTGGKKERDSDIDSGGSKDAKKEGKKKGKRESRKKRNTES
                     SDAESGDSKDGKKKSKHDKKNEIKKKKDTDSTGSGSGASMVSKKGKTEKKSTGKKSTG
                     STGSESVDSKSTNKVKKQVKKGVMKKAVSTDSESDASSKKSKKDEKKENKGRKKKPIK
                     DTESTDADSESEGDSTGKKNEKKDKKITKKGEKKDAKKNTASSESESDLGVNKKKTKI
                     KEIVSFSDSTSDSYSKAGRRKNVRRSDSESEDSSGFRVLKSTDDSEASSTDSKTGMPG
                     MRRGFRSLSKKTTFNERGKRSVTGRIPSSRERLPFPPCEPFRASPKPVHVCKCKESPS
                     PKARYAPLPGVEWIHKLL"
     exon            58..111
                     /gene="Cylc1"
                     /gene_synonym="4930401M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            112..152
                     /gene="Cylc1"
                     /gene_synonym="4930401M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            153..268
                     /gene="Cylc1"
                     /gene_synonym="4930401M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            269..1936
                     /gene="Cylc1"
                     /gene_synonym="4930401M13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..1969
                     /gene="Cylc1"
                     /gene_synonym="4930401M13Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atacaaatgc tgaagtcctg gcagaagaca ggcaaaggaa atgtctcttt caaaactgga
       61 cagtgaaaaa ttgactattg aagatgttca aacttcaagt tcttcctgtc gacgagaaat
      121 aaataccaca acatatgatg attacattct gagcattcaa actagcgaaa aacagaatca
      181 agaacatttt gttttgacat ttcccaaaac acctatgcca gataaaaaga agagatcagg
      241 accttcagaa ttagaagttg cagttcctat acaagtgaaa aggaaaattg agaaagatca
      301 gaaaccaact cacgtatgga taaaccagtt tttaagagac attttcttaa agtcatcctt
      361 ttctcggccg tttattacac aagctccatt caaatatctt tataatcctc aaaaccatta
      421 tacaatggca gaaagtagaa agtccaaaaa tgatgaaaga agaaaaactt tgaagataaa
      481 gttcagggga aaaataagct catgtgtagt aaatctggag cccatgagaa caataaccaa
      541 tggggaacct gaaatactag gcaatacaga aaaaaatcca tcaaaatcat cacataaaat
      601 taaattgcct aagacgtcaa attctacatc agaaacaaat ctagaataca acaattcaaa
      661 gaaaaccttg gaaatgagtt tgagaaatgg caacaaaaat tcaatgaact ttgttctgaa
      721 ggggaatgca gccacatgtt gcaaggacaa tcccaataca gactctaaga agagtgttga
      781 agaattttct gatgacatat cagagtgtat aaacagctca aatatggatt taatgttgcg
      841 tctaaatgag ttcagagctg aattcacaga tttggatgta tggtcaacaa attgctcaca
      901 gaacaatgca aagaagcctt taaagacggg aggaaagaag gaaagggact cagatattga
      961 ttctggaggc tcaaaagatg caaagaaaga gggaaagaaa aaaggcaaga gagaatccag
     1021 gaaaaagagg aatacagaat cgagtgatgc tgaatctggt gactccaagg atggaaagaa
     1081 aaaatcaaaa cacgataaaa aaaatgaaat taagaaaaag aaggatacag actctactgg
     1141 tagtggatct ggggcgtcca tggtttcaaa gaaaggtaag acggaaaaga agagtacagg
     1201 aaaaaagagt acaggatcta ctggtagtga atctgtagat tcaaagagta caaataaagt
     1261 aaagaaacaa gtaaaaaaag gtgtcatgaa gaaagcagtc tctactgatt ctgaatcaga
     1321 tgcatcatca aagaagagca agaaagatga aaagaaggaa aataaaggga gaaagaagaa
     1381 gcctattaag gatacagagt ctactgatgc tgattctgaa tctgaaggtg actcaacagg
     1441 taaaaagaat gaaaagaagg ataagaaaat tacaaagaaa ggagaaaaga aggatgcaaa
     1501 gaagaataca gcatcctctg aaagtgagtc tgatttggga gtaaacaaaa agaaaactaa
     1561 aataaaggaa atagtgagtt tcagtgattc aacatctgat tcatattcta aggcaggcag
     1621 aagaaaaaat gtaaggcgct cagattccga atctgaagat tcgtcagggt tcagagtttt
     1681 aaagtcaact gatgattcag aggcctcatc cacagactcc aagacgggaa tgccaggaat
     1741 gagaagagga ttcagatcat tatccaaaaa gactactttc aatgaaaggg ggaaaagaag
     1801 tgtgaccggt agaatccctt catcaagaga aagactacct ttccctcctt gtgagccttt
     1861 tagagcatca cctaagcctg tgcatgtctg taagtgcaag gaatctccat ctccaaaagc
     1921 aagatatgct cctttgcctg gagtggagtg gattcataaa ctgctctaa
//
