LOCUS       NM_011370               6471 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus cytoplasmic FMR1 interacting protein 1 (Cyfip1),
            transcript variant 2, mRNA.
ACCESSION   NM_011370
VERSION     NM_011370.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6471)
  AUTHORS   Balekoglu,N., Michaud,J.F., Sauve,R., Ayinde,K.S., Lin,S., Liu,Y.,
            Kramer,D.A., Zhang,K., Steffen,A., Stradal,T., Angers,S., Chen,B.,
            Yam,P.T. and Charron,F.
  TITLE     The WAVE regulatory complex interacts with Boc and is required for
            Shh-mediated axon guidance
  JOURNAL   iScience 27 (12), 111333 (2024)
   PUBMED   39640588
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6471)
  AUTHORS   Zhang,Y., Kang,H.R., Jun,Y., Kang,H., Bang,G., Ma,R., Ju,S.,
            Yoon,D.E., Kim,Y., Kim,K., Kim,J.Y. and Han,K.
  TITLE     Neurodevelopmental disorder-associated CYFIP2 regulates
            membraneless organelles and eIF2alpha phosphorylation via protein
            interactors and actin cytoskeleton
  JOURNAL   Hum Mol Genet 33 (19), 1671-1687 (2024)
   PUBMED   38981622
REFERENCE   3  (bases 1 to 6471)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6471)
  AUTHORS   Sisario,D., Spindler,M., Ermer,K.J., Grutz,N., Nicolai,L.,
            Gaertner,F., Machesky,L.M. and Bender,M.
  TITLE     Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and
            CYFIP1 in Platelets
  JOURNAL   Cells 13 (4), 299 (2024)
   PUBMED   38391912
  REMARK    GeneRIF: Differential Role of the RAC1-Binding Proteins FAM49b
            (CYRI-B) and CYFIP1 in Platelets.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6471)
  AUTHORS   Busch,S.E., Simmons,D.H., Gama,E., Du,X., Longo,F., Gomez,C.M.,
            Klann,E. and Hansel,C.
  TITLE     Overexpression of the autism candidate gene Cyfip1 pathologically
            enhances olivo-cerebellar signaling in mice
  JOURNAL   Front Cell Neurosci 17, 1219270 (2023)
   PUBMED   37545882
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6471)
  AUTHORS   Chai,J.H., Locke,D.P., Greally,J.M., Knoll,J.H., Ohta,T., Dunai,J.,
            Yavor,A., Eichler,E.E. and Nicholls,R.D.
  TITLE     Identification of four highly conserved genes between breakpoint
            hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes
            deletion region that have undergone evolutionary transposition
            mediated by flanking duplicons
  JOURNAL   Am J Hum Genet 73 (4), 898-925 (2003)
   PUBMED   14508708
  REMARK    GeneRIF: indentification on mouse chromosome 7C
REFERENCE   7  (bases 1 to 6471)
  AUTHORS   Schenck,A., Bardoni,B., Moro,A., Bagni,C. and Mandel,J.L.
  TITLE     A highly conserved protein family interacting with the fragile X
            mental retardation protein (FMRP) and displaying selective
            interactions with FMRP-related proteins FXR1P and FXR2P
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8844-8849 (2001)
   PUBMED   11438699
REFERENCE   8  (bases 1 to 6471)
  AUTHORS   Wu,M., Rinchik,E.M. and Johnson,D.K.
  TITLE     An integrated deletion and physical map encompassing l71Rl, a
            chromosome 7 locus required for peri-implantation survival in the
            mouse
  JOURNAL   Genomics 67 (2), 228-231 (2000)
   PUBMED   10903848
REFERENCE   9  (bases 1 to 6471)
  AUTHORS   Koster,F., Schinke,B., Niemann,S. and Hermans-Borgmeyer,I.
  TITLE     Identification of shyc, a novel gene expressed in the murine
            developing and adult nervous system
  JOURNAL   Neurosci Lett 252 (1), 69-71 (1998)
   PUBMED   9756361
REFERENCE   10 (bases 1 to 6471)
  AUTHORS   Russell,L.B., Montgomery,C.S., Cacheiro,N.L. and Johnson,D.K.
  TITLE     Complementation analyses for 45 mutations encompassing the
            pink-eyed dilution (p) locus of the mouse
  JOURNAL   Genetics 141 (4), 1547-1562 (1995)
   PUBMED   8601493
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102298.14, CB527850.1, AK146613.1, AK028811.1, AK052509.1,
            BB228046.2 and AC144633.3.
            
            On Sep 15, 2009 this sequence version replaced NM_011370.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146613.1, AK220320.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC102298.14        166502-166502
            2-199               CB527850.1         1-198
            200-3949            AK146613.1         3-3752
            3950-4098           AK028811.1         2742-2890
            4099-5437           AK052509.1         1-1339
            5438-5438           BB228046.2         399-399             c
            5439-6440           AK052509.1         1341-2342
            6441-6471           AC144633.3         15136-15166         c
FEATURES             Location/Qualifiers
     source          1..6471
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 33.42 cM"
     gene            1..6471
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /note="cytoplasmic FMR1 interacting protein 1"
                     /db_xref="GeneID:20430"
                     /db_xref="MGI:MGI:1338801"
     exon            1..237
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..355
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..4000
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /note="isoform a is encoded by transcript variant 2;
                     specifically Rac1-associated protein 1"
                     /codon_start=1
                     /product="cytoplasmic FMR1-interacting protein 1 isoform
                     a"
                     /protein_id="NP_035500.2"
                     /db_xref="CCDS:CCDS21315.1"
                     /db_xref="GeneID:20430"
                     /db_xref="MGI:MGI:1338801"
                     /translation="MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNT
                     NFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQP
                     NRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLIT
                     LGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHN
                     KITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDG
                     SVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTC
                     ASSSSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFD
                     LALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDNAEEYERATRYNYTTEEKFA
                     LVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQ
                     SVLQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTML
                     ESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFR
                     EFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTKF
                     NKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHL
                     PPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSVVEL
                     DGLLEINRMTHKLLSRYLTLDSFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYC
                     YNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHF
                     QVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGI
                     LEFFHHQLKDIVEYAELKTVCFQNLREVGNAVLFCLLIEQSLSLEEVCDLLHAAPFQN
                     ILPRIHVKEGERVDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCC
                     GLSMFEVILTRIRTFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHE
                     FTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKM
                     VERIRKFQILNDEIITILDKYLKSGDGESTPVEHVRCFQPPIHQSLASS"
     exon            356..445
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..523
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..625
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..807
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..904
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1033
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1138
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1230
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1348
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1471
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1597
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1764
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1912
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2066
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2223
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2320
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2397
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2506
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2626
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2826
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2914
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3058
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3149
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3280
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3353
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3448
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3687
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..3835
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     exon            3836..6471
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4317..4322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /note="hexamer: AATAAA"
     polyA_site      4336
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
     regulatory      4518..4523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /note="hexamer: AATAAA"
     polyA_site      4538
                     /gene="Cyfip1"
                     /gene_synonym="E030028J09Rik; l(7)1Rl; l71Rl; l7Rl1;
                     mKIAA0068; P140SRA-1; P140sra1; pl-1; Shyc; Sra-1; Sra1"
                     /note="major polyA site"
ORIGIN      
        1 gggagacttg gggagacttg ggggccgacc gggctggcct agaggagccg gacccaaggc
       61 agccagcggg aggagggagg agcgccggga ggaagaggcc gagccgagca gcgccgcccc
      121 ggaggaaggg gaggaggccg ggtgtttcct ggtgcattcc cgacccgccc aagtgactca
      181 ttggggtagg aaagctcccg gggcccgccc tggacaaccg aaggcggcgc agaccaggat
      241 ggctgcccaa gtgacactag aggacgcact gtccaatgtg gacctcctgg aggagctgcc
      301 tctgcctgac cagcagccct gcatcgagcc cccaccgtcc tcgctgctct atcagccaaa
      361 tttcaacacc aactttgaag acagaaatgc atttgtcact ggcattgcaa gatacatcga
      421 acaagcaact gtccactcta gcatgaacga gatgctagag gaaggccaag agtatgctgt
      481 catgctgtac acctggagga gctgctcccg ggccatccct caggtgaagt gcaacgagca
      541 gccgaataga gttgaaattt atgagaaaac cgtggaagtc cttgaacccg aggtcacaaa
      601 actgatgaat tttatgtact ttcagagaaa tgccatcgag cggttctgtg gggaagtgag
      661 acgcctgtgt catgctgaga ggagaaagga ctttgtttct gaagcctact tgatcaccct
      721 gggcaaattt atcaacatgt ttgctgtgtt ggatgagctg aagaacatga agtgcagtgt
      781 gaagaatgac cactctgcat ataagagggc tgctcagttt ttacgtaaaa tggcagatcc
      841 acaatccatc caggagtcac agaatctgtc catgttcctg gccaaccaca acaagattac
      901 acaatctctg cagcagcagc ttgaggtcat ttctggctat gaagagctcc tggcagacat
      961 cgtgaatctg tgtgtggatt actatgagaa caggatgtac ttgacaccca gcgaaaaaca
     1021 catgcttctc aaagtcatgg gatttggcct gtacctgatg gatgggagtg tgagtaacat
     1081 ctacaaacta gatgccaaga aaagaataaa tttatccaaa atcgacaagt atttcaagca
     1141 gctgcaggtg gttccactct ttggagatat gcaaatagaa ctggcaagat acatcaagac
     1201 cagcgcacac tatgaggaga ataagtcccg gtggacctgc gcgtcctcca gcagcagccc
     1261 gcagtacaac atctgtgagc agatgatcca gatccgtgag gaccatatgc gtttcatctc
     1321 cgagctggca cgctacagca atagcgaggt agtcacaggg tctggccggc aggaagccca
     1381 gaagacagat gctgagtacc ggaagctctt cgatctggct ctgcagggcc tgcagcttct
     1441 gtcgcagtgg agcgctcacg tgatggaagt gtattcctgg aaacttgtac atccaacaga
     1501 caagtactcc aacaaggact gccccgacaa cgctgaggag tacgagcgag ccacacgcta
     1561 caactacacc actgaggaga agtttgccct ggtggaggtg attgccatga tcaaaggcct
     1621 gcaggtgctg atgggcagga tggagagtgt gttcaatcac gccatcagac acacggttta
     1681 cgctgcgctt caggacttct cccaggtgac cctcagggaa ccactgcgac aggccatcaa
     1741 gaagaaaaag aacgtaatcc agagtgtcct acaggccatc aggaagactg tgtgtgactg
     1801 ggagactggg catgagccct ttaacgaccc agctctgcgg ggagagaagg accctaagag
     1861 tggctttgac atcaaggtgc cacgccgtgc tgtgggaccc tccagcacgc agctttacat
     1921 ggtgagaact atgctagagt ccctcattgc agacaaaagt ggttccaaga aaaccttgag
     1981 aagtagcctt gaggggccca ccatattgga catagaaaaa tttcatcgag aatcattctt
     2041 ctacactcac ttgataaatt tcagtgaaac actgcagcag tgctgtgacc tttcccagct
     2101 gtggttccga gagttcttcc tggagctgac catgggcagg aggatccagt tccccattga
     2161 gatgtctatg ccctggattc tgactgacca catcctagag accaaggagg catcaatgat
     2221 ggagtacgtc ctctactcct tggacctgta caacgacagt gcccactatg cgctcaccaa
     2281 gttcaacaag cagtttctct atgatgagat tgaggcagag gtgaatctgt gttttgacca
     2341 atttgtttat aaactagcag accagatatt tgcatattac aaggttatgg caggaagttt
     2401 gcttcttgac aaaaggttac ggtcagaatg caaaaatcag ggagccacga tccacctccc
     2461 cccatctaac cgctatgaga cgctgttgaa gcaaaggcac gtgcagctgc tcgggagatc
     2521 cattgatctc aaccgtctga ttacacagcg cgtttcagca gccatgtaca aatctctaga
     2581 actggcaatt ggacggtttg aaagtgaaga tttaacatca gtagtcgagc tagatggact
     2641 cttagaaatc aaccgtatga cacacaagct gttgagcagg tacctcacac tggacagctt
     2701 tgatgccatg ttccgggaag ccaaccacaa cgtgtctgca ccttatggaa gaattaccct
     2761 ccacgtcttc tgggagctaa actatgactt cttgcccaac tactgctata atggctctac
     2821 caaccggttt gttcggacag tattaccatt ttctcaggaa tttcaaagag acaaacagcc
     2881 taacgcacag ccccagtatt tgcatggatc caaggctttg aacctagcct actcaagcat
     2941 ttatggcagc taccggaact ttgtggggcc tccgcacttc caagtcatct gccggctact
     3001 tggctaccag ggcattgcag tagtcatgga agagctgctg aaggttgtca agagcctgct
     3061 gcaaggcaca atcctgcagt acgtgaaaac tctgatggaa gtgatgccca agatctgccg
     3121 gcttccgcga catgagtacg gctctcctgg catcctggag ttcttccacc accagctgaa
     3181 ggacattgtg gagtatgcag agctgaaaac cgtatgcttc cagaacctgc gggaggtggg
     3241 caatgctgtt ctcttctgcc tgcttattga gcaaagcctg tctttagaag aagtctgtga
     3301 cctgttgcat gcagctcctt tccagaatat cttacctcga atccatgtaa aagaggggga
     3361 gagagttgat gccaaaatga aaagactaga atccaagtat gccccactgc accttgtccc
     3421 actgattgaa aggctgggga ccccacagca aattgcaatt gcaagagagg gggacttgct
     3481 aaccaaggag cgtctctgtt gtggtctgtc catgtttgaa gtcatcctga cacggatccg
     3541 gacctttctg gatgatccca tctggcgtgg gcccctaccc agcaatggtg tcatgcacgt
     3601 ggatgagtgt gtggagtttc acagactatg gagtgccatg cagtttgttt actgcattcc
     3661 tgtagggaca cacgagttta cagtggagca gtgttttgga gatgggctcc actgggctgg
     3721 ctgcatgatc attgtacttc ttggacagca gcggcgcttt gctgtgttgg atttctgcta
     3781 tcatcttctc aaagttcaga aacatgatgg caaagatgag atcatcaaaa atgtgccatt
     3841 gaagaagatg gtggagagga tccgcaagtt ccagattctc aacgatgaaa tcatcactat
     3901 cctggacaag tacttgaaat ctggtgatgg cgagagcaca cctgtggagc atgtacgctg
     3961 cttccagcca cccatccacc agtccctagc cagtagctga gggctaagct cacagcatcc
     4021 cagtaactga tggcatgttt gtctttatgt aaactatatt gaaattttta ggggctattt
     4081 tccattatgt ctgaacctac ttttgatctg aaagcttaac tttataaaat ttacttattt
     4141 ttctatacta aaattgtata tgcctttgga attgggaagt ctgagaatac ggttactagt
     4201 tgttgccatt acggtattaa caagtatttt catgccgaat attccagcag ctattataaa
     4261 atgctaaatt cactcatcct gtacgagcat aataccaact aattgtatta aaaaaaaata
     4321 aaaaaacaaa aaaagacctc taccagtttc ttttaaattt aatgactagc tctgtttagg
     4381 gatttttctg atggcctttt aggaactctt ttctaagtca ccgttccctt tgatgccaaa
     4441 atagtgaaat tgtctcctct gttcaagtaa atccaacagt gagtctgatt tgtgagatat
     4501 gacttaacaa ttagagaaat aaaaattaat ggagtctgtt tgcgtttgtt cattggcata
     4561 aacatccctg tacataccca catttcacag gacgtgttca ataggacaag atcatgacat
     4621 ctttcaaaca caaccagaac ttaacattca ggtctgggca gggatgacat gaaagccagt
     4681 gagatgtaag acagcaattg tgttgtccat gaaggacatg aaaggaacac cagaactgcg
     4741 atggtatgtg catctactct ttaaggccaa cagtgtgggg gagggcaggg gtttatgtgg
     4801 gacagttgac tctgcaaaaa ggggaccggg cctggcccta acagctctca gcataccttc
     4861 tccattgctg ggggaactat ctcactatag gacttggaca tgtgaacaac aacaacccaa
     4921 ttttgctgta ctatcagaag catcaaaagg gagagaaatt aactgaaaat ctggtacagc
     4981 gacgtgccac tcacatccca gctacatggg aaactgagga ctgaagatcg atggagccga
     5041 gagttcaagg acagcttaag gaacatagta agagccctgt cttaaaaaag agaaaaacat
     5101 cactgggctg ggaaacccca aagtccaaaa gctttgagct ttattttaca cagaaaataa
     5161 aacacaggta ctatccagct gtactgtaaa cctgagtaac attttaaaca agcctattta
     5221 tcaaaaagtt acctaaaata tttttgttga tatgaatagt cgtaatggca tctgtactga
     5281 ccctatgaag tgtagatttt aaaagttaac aactatatta ccaagtgaca ggccaaataa
     5341 aatgcttgca tacaagattc cgtacgtata aagtgttgta tgtacaacac acattctcaa
     5401 tgaggaaact cttcaccccc aagggaatga acattggctt tttttttatg tgcaaaataa
     5461 gacatacagt acataaaaca gacataaatt atatctgcga gggtaagggg gaagcctatt
     5521 ctgtctgaca tttataagtt atataggaag gctggaactg tagctcagtt ttagaacaat
     5581 tgtgtagaat atactaggtc ctgtgactga aaccaagtat ggcccgaaaa ggacttacat
     5641 agagggagtc agaggaaaag aaggcaagaa tccttaagag tgccaataat aaatagaaca
     5701 aagctacccc cactccaaaa aaaacttttt ttccccccac aaaaccagta ctaagctact
     5761 atacaaccat gggcaggacc aggaaacagc ttcagctctt cctgtcagtg agggatagga
     5821 tggaggggag tggttttttt ttaagctagt acatgacttt gaagtgggcg agtctaaagc
     5881 tggagagtgt tccttacatt ggcctaacct ttttgtacct gcttgtattt tttctataaa
     5941 cattttttca cagtttctat ttaaaaaaaa aaagcaaact ctgaagcaaa ataaatcact
     6001 tggttcaaag agacctattt tacaaacatt ttaaacctaa gcaattagga tcaaaataaa
     6061 gattttgttc caacctgcca ttttatgcaa gcacgagttt ctaaatttaa ggaaactcaa
     6121 gtttctgttg ataaggcaga gttaagggct gaatgacaat ctagcccatt ctgaaccaca
     6181 ctgagaggtc caagagctcc ataagatgac acagagatcc agtcaccatg gaaacagcaa
     6241 gtactaactg atagcacagt gggtttttcc aaaagggggc cagcagatgt gtgcgggaaa
     6301 ccagatgttt gggtgacaaa tcaccacctg agaattattt tcttggaatc acacacacat
     6361 aatttataat caaaaagcct tagtatgatg aggtattgat ggaatgggga tcacaaatgt
     6421 acattttaat gttcatcacc aatggaaaaa ataaaacatt tttataagct t
//
