LOCUS       NM_007808               3154 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus cytochrome c, somatic (Cycs), mRNA.
ACCESSION   NM_007808 XM_359023
VERSION     NM_007808.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3154)
  AUTHORS   Olarewaju,O., Hu,Y., Tsay,H.C., Yuan,Q., Eimterbaumer,S., Xie,Y.,
            Qin,R., Ott,M., Sharma,A.D. and Balakrishnan,A.
  TITLE     MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in
            hepatocellular carcinoma
  JOURNAL   Cell Death Dis 15 (6), 456 (2024)
   PUBMED   38937450
  REMARK    GeneRIF: MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3154)
  AUTHORS   Chin,T.C., Wilbanks,S.M. and Ledgerwood,E.C.
  TITLE     Altered conformational dynamics contribute to species-specific
            effects of cytochrome c mutations on caspase activation
  JOURNAL   J Biol Inorg Chem 29 (2), 169-176 (2024)
   PUBMED   38472487
  REMARK    GeneRIF: Altered conformational dynamics contribute to
            species-specific effects of cytochrome c mutations on caspase
            activation.
REFERENCE   3  (bases 1 to 3154)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   4  (bases 1 to 3154)
  AUTHORS   Li,C., Lai,H., Cai,X., Liu,Y., Hong,L., Huang,X. and Shao,L.
  TITLE     Thioredoxin Reductase 2 Synergizes with Cytochrome c, Somatic to
            Alleviate Doxorubicin-Induced Oxidative Stress in Cardiomyocytes
            and Mouse Myocardium
  JOURNAL   Int Heart J 64 (1), 60-70 (2023)
   PUBMED   36725079
  REMARK    GeneRIF: Thioredoxin Reductase 2 Synergizes with Cytochrome c,
            Somatic to Alleviate Doxorubicin-Induced Oxidative Stress in
            Cardiomyocytes and Mouse Myocardium.
REFERENCE   5  (bases 1 to 3154)
  AUTHORS   Sato,K., Suzuki-Utsunomiya,K., Mitsui,S., Ono,S., Shimakura,K.,
            Otomo,A. and Hadano,S.
  TITLE     Central nervous system specific high molecular weight ALS2/alsin
            homophilic complex is enriched in mouse brain synaptosomes
  JOURNAL   Biochem Biophys Res Commun 638, 168-175 (2023)
   PUBMED   36459881
REFERENCE   6  (bases 1 to 3154)
  AUTHORS   Hake,L.E., Alcivar,A.A. and Hecht,N.B.
  TITLE     Changes in mRNA length accompany translational regulation of the
            somatic and testis-specific cytochrome c genes during
            spermatogenesis in the mouse
  JOURNAL   Development 110 (1), 249-257 (1990)
   PUBMED   1964409
REFERENCE   7  (bases 1 to 3154)
  AUTHORS   Virbasius,J.V. and Scarpulla,R.C.
  TITLE     Structure and expression of rodent genes encoding the
            testis-specific cytochrome c. Differences in gene structure and
            evolution between somatic and testicular variants
  JOURNAL   J Biol Chem 263 (14), 6791-6796 (1988)
   PUBMED   2834389
REFERENCE   8  (bases 1 to 3154)
  AUTHORS   Limbach,K.J. and Wu,R.
  TITLE     Characterization of a mouse somatic cytochrome c gene and three
            cytochrome c pseudogenes
  JOURNAL   Nucleic Acids Res 13 (2), 617-630 (1985)
   PUBMED   2987801
REFERENCE   9  (bases 1 to 3154)
  AUTHORS   Carlson,S.S., Mross,G.A., Wilson,A.C., Mead,R.T., Wolin,L.D.,
            Bowers,S.F., Foley,N.T., Muijsers,A.O. and Margoliash,E.
  TITLE     Primary structure of mouse, rat, and guinea pig cytochrome c
  JOURNAL   Biochemistry 16 (7), 1437-1442 (1977)
   PUBMED   191069
REFERENCE   10 (bases 1 to 3154)
  AUTHORS   Hennig,B.
  TITLE     Change of cytochrome c structure during development of the mouse
  JOURNAL   Eur J Biochem 55 (1), 167-183 (1975)
   PUBMED   240690
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153386.3, BY311395.1 and AK143887.1.
            
            On May 29, 2018 this sequence version replaced NM_007808.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143887.1, BC034363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC153386.3         49933-49963
            32-95               BY311395.1         2-65
            96-3154             AK143887.1         2-3060
FEATURES             Location/Qualifiers
     source          1..3154
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 24.32 cM"
     gene            1..3154
                     /gene="Cycs"
                     /note="cytochrome c, somatic"
                     /db_xref="GeneID:13063"
                     /db_xref="MGI:MGI:88578"
     exon            1..154
                     /gene="Cycs"
                     /inference="alignment:Splign:2.1.0"
     exon            155..331
                     /gene="Cycs"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..480
                     /gene="Cycs"
                     /codon_start=1
                     /product="cytochrome c, somatic"
                     /protein_id="NP_031834.1"
                     /db_xref="CCDS:CCDS20131.1"
                     /db_xref="GeneID:13063"
                     /db_xref="MGI:MGI:88578"
                     /translation="MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQA
                     AGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKA
                     TNE"
     exon            332..3154
                     /gene="Cycs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1263..1268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cycs"
                     /note="hexamer: ATTAAA"
     polyA_site      1285
                     /gene="Cycs"
                     /note="major polyA site"
     regulatory      1456..1461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cycs"
                     /note="hexamer: TATAAA"
     polyA_site      1480
                     /gene="Cycs"
     regulatory      1651..1656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cycs"
                     /note="hexamer: AAGAAA"
     polyA_site      1674
                     /gene="Cycs"
     regulatory      2457..2462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cycs"
                     /note="hexamer: AGTAAA"
     polyA_site      2483
                     /gene="Cycs"
ORIGIN      
        1 agacggcgct accgcacgtc gggccgcgga cgggcggaac aagtgtggtt gcaccgacac
       61 cggtacatag gcgcgggccg gcgtgtcctt gggctagagc gcgggacgtc tgtcttcgag
      121 tccgaacgtt cgtggtgttg accagcccgg aacgaattaa aaatgggtga tgttgaaaaa
      181 ggcaagaaga tttttgttca gaagtgtgcc cagtgccaca ctgtggaaaa gggaggcaag
      241 cataagactg gaccaaatct ccacggtctg ttcgggcgga agacaggcca ggctgctgga
      301 ttctcttaca cagatgccaa caagaacaaa ggcatcacct ggggagagga taccctgatg
      361 gagtatttgg agaatcccaa aaagtacatc cctggaacaa aaatgatctt cgctggaatt
      421 aagaagaagg gagaaagggc agacctaata gcttatctta aaaaggctac taatgagtaa
      481 ttccactgcc ttatttatta caaaacaaat gtctcatggc ttttaatgta caccataatt
      541 taattcacac accaaattca gatcatgaat ggctagcaat gtttttgttg gacagtcctg
      601 atttaagtaa aactgacttg tcataaagtg ggtacggtct ttattaaagc aacagttcca
      661 gttgtataca tgctaccacg gctctccctt tctcaagata agattggact taattagcaa
      721 tgttttactt tccataaata ggggcatgtc acctcaaacc tactaaatgg ttttatactt
      781 agatttatat aactgggcat atgaatatgc ttaaacactg ggaaaattct atcactgtct
      841 cagaaacaag aagactcaaa tgtgtttcag tttgtgttca ctggcctctt tcaggtcatg
      901 gctaaccacc aggaggcaac tgtctattct tgacagtgca gttttaatta gaattcccta
      961 catcaaggat gttgcctttt actattgaaa ggcatttact gtggtttatg tatgatatca
     1021 aataaagagt atttaacact tctttatagt tgatctgcaa attaaaatgc ttttagaaac
     1081 aagcaagtta ggccttttaa attctctatt ttctaagact aagttgtaaa tcagaattgt
     1141 ccttaaatac ccactcagaa acacacataa ctggaattcg attaggaatg gcactctttg
     1201 ctaacttact agatggaaag atggaaataa aggaaatagt ttgtatcagc agaaagaaga
     1261 taattaaaac aaccacagat cgtgatcctt tgattgtgct ttgtttaatg acagttaaca
     1321 tatctttagt tgtttaaatg ttccctggta taaagccatg gtctagtgaa ggtactaggt
     1381 gctcttacct tgatatctcg ggcaactccg actacagcca cgctttaccc ttcgttcttt
     1441 ggccagaatg agatctataa aggtgaataa ttatgtatta gctgagtggt cctaaatttt
     1501 atagagaatg gcagggaaat gagtgatagt ggtgtctttg tgggggtgaa aaggctggag
     1561 aaagacctca tcgtgacttc agacgtgtag aagatgatta actgggcctc aggtcagagg
     1621 cagcactttg tgacaaatct tactttatac aagaaattga ggacaatctg gaaacaagtt
     1681 tggaaagttt tctgtaattt ggagttttgg gctgatgggt aggaattttt tttttgttgt
     1741 tttggaccta ttttgtatgt atgggtgttt tctctgcatg tatatctgtg cactacactt
     1801 gaaggccaac ccagggtgtt ggattccttg ggactggtgt tacagcggga tctgcagtgg
     1861 gcgcagtcca ggctgagtcc tctggaagaa cagccagtgc tcttgagtcc tctccagccc
     1921 tgataagctt tttactttgt aggtccttca gagatagctt tgtaataaca cttgatgagt
     1981 cccaagtttt tgtaacaact ttccagggca cattttaact aatgtgtaaa gaaataaagc
     2041 cctggaattg ccgggtggtg ttggcataca cctttaatcc cagcacttgg gaggcagagg
     2101 caggtggatt tctgagttca aggccagcct ggtctataga gtgagttcca ggacagcctg
     2161 ggctacacag agaaaccctg tctcaaaaaa acaaaaaata aaaataaagc cctggacttg
     2221 ttttcttata ttctggaaat gatagaaaaa aaaagtcata ataagccgtt gagatgaata
     2281 tatagacatt tggcttaaga ttttataaca ttgggctttc aatataaatt caaaggggcc
     2341 tcgttagtgc agcaggttgt gtgagtccta tagtttataa actcagattc tgtaacccag
     2401 aagtggtgaa gccatgatga cttatttcct gacaggcaac cttttctggg agcccaagta
     2461 aagggtccct actgatgacc aaacttagag ttgttatttc tgtatctata cctaatacat
     2521 catctaaggc ctgtgttaca cagatggaac ctcctgtgtt ctaaggctag actcaagtaa
     2581 gatacccagt gatggagaag gtaaacctgt gagatgcaga aaggggacag tctctgtaca
     2641 ctgattttac aagtcaggaa gtgggaccac tctagctgat ctgcttgctc ttagttgctt
     2701 tgtaggtggc tagttcagtg ataccataaa ggaaaatcag atgaatttct tctcagttcc
     2761 acctgcattc agaatgctta gaaaagctct accccatagt ccttcctgta atggatcttt
     2821 tagacatact tgtccattac cctggtgtgg ctttcaaacc catgaagtac atgtgggttg
     2881 atgaagtagc taatggctgc tgtatttatg gcattgacct agaactagta ccagccagtt
     2941 taagcacttg ccttctgaga atctagaatt aatgcacata aaattctgat gcctttctga
     3001 acactgattt agacaatccc tttgatttta ccatgcttca tctgttgagt ttaagttgtc
     3061 ttttttaggt gggcaggggc accatctgtc ttccgttaca cttacatatt cattttaacc
     3121 actgaagatt gctaaataaa ggacatgtcg gagt
//
