LOCUS       NM_007807               4750 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus cytochrome b-245, beta polypeptide (Cybb), mRNA.
ACCESSION   NM_007807
VERSION     NM_007807.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4750)
  AUTHORS   Sun,L., Wu,S., Wang,H., Zhang,T., Zhang,M., Bai,X., Zhang,X.,
            Li,B., Zhang,C., Li,Y., Zhou,J. and Li,T.
  TITLE     PDCD6 regulates lactate metabolism to modulate LC3-associated
            phagocytosis and antibacterial defense
  JOURNAL   Nat Commun 15 (1), 10157 (2024)
   PUBMED   39578445
  REMARK    Erratum:[Nat Commun. 2025 Feb 11;16(1):1541. doi:
            10.1038/s41467-025-56837-3.. PMID: 39934130]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4750)
  AUTHORS   Khan,M.Z., Hunt,D.M., Singha,B., Kapoor,Y., Singh,N.K.,
            Prasad,D.V.S., Dharmarajan,S., Sowpati,D.T., de Carvalho,L.P.S. and
            Nandicoori,V.K.
  TITLE     Divergent downstream biosynthetic pathways are supported by
            <sc>L</sc>-cysteine synthases of Mycobacterium tuberculosis
  JOURNAL   Elife 12, 91970 (2024)
   PUBMED   39207917
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4750)
  AUTHORS   Sridhar,A., DeSantiago,J., Chen,H., Pavel,M.A., Ly,O., Owais,A.,
            Barney,M., Jousma,J., Nukala,S.B., Abdelhady,K., Massad,M.,
            Rizkallah,L.E., Ong,S.G., Rehman,J. and Darbar,D.
  TITLE     Modulation of NOX2 causes obesity-mediated atrial fibrillation
  JOURNAL   J Clin Invest 134 (18), e175447 (2024)
   PUBMED   39146015
  REMARK    GeneRIF: Modulation of NOX2 causes obesity-mediated atrial
            fibrillation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4750)
  AUTHORS   Harrison,C.B., Selemidis,S., Guida,E., King,P.T., Sobey,C.G. and
            Drummond,G.R.
  TITLE     NOX2beta: A novel splice variant of NOX2 that regulates NADPH
            oxidase activity in macrophages
  JOURNAL   PLoS One 7 (10), e48326 (2012)
   PUBMED   23118986
  REMARK    GeneRIF: a novel splice variant of NOX2 that regulates NADPH
            oxidase activity in macrophages
REFERENCE   5  (bases 1 to 4750)
  AUTHORS   Lam,G.Y., Huang,J. and Brumell,J.H.
  TITLE     The many roles of NOX2 NADPH oxidase-derived ROS in immunity
  JOURNAL   Semin Immunopathol 32 (4), 415-430 (2010)
   PUBMED   20803017
  REMARK    Review article
REFERENCE   6  (bases 1 to 4750)
  AUTHORS   Heidari,Y., Shah,A.M. and Gove,C.
  TITLE     NOX-2S is a new member of the NOX family of NADPH oxidases
  JOURNAL   Gene 335, 133-140 (2004)
   PUBMED   15194196
REFERENCE   7  (bases 1 to 4750)
  AUTHORS   Bjorgvinsdottir,H., Zhen,L. and Dinauer,M.C.
  TITLE     Cloning of murine gp91phox cDNA and functional expression in a
            human X-linked chronic granulomatous disease cell line
  JOURNAL   Blood 87 (5), 2005-2010 (1996)
   PUBMED   8634451
REFERENCE   8  (bases 1 to 4750)
  AUTHORS   Pollock,J.D., Williams,D.A., Gifford,M.A., Li,L.L., Du,X.,
            Fisherman,J., Orkin,S.H., Doerschuk,C.M. and Dinauer,M.C.
  TITLE     Mouse model of X-linked chronic granulomatous disease, an inherited
            defect in phagocyte superoxide production
  JOURNAL   Nat Genet 9 (2), 202-209 (1995)
   PUBMED   7719350
REFERENCE   9  (bases 1 to 4750)
  AUTHORS   Mullins,L.J., Stephenson,D.A., Grant,S.G. and Chapman,V.M.
  TITLE     Efficient linkage of 10 loci in the proximal region of the mouse X
            chromosome
  JOURNAL   Genomics 7 (1), 19-30 (1990)
   PUBMED   2110546
REFERENCE   10 (bases 1 to 4750)
  AUTHORS   Brockdorff,N., Fisher,E.M., Orkin,S.H., Lyon,M.F. and Brown,S.D.
  TITLE     Localization of the human X-linked gene for chronic granulomatous
            disease to the mouse X chromosome: implications for X-chromosome
            evolution
  JOURNAL   Cytogenet Cell Genet 48 (2), 124-125 (1988)
   PUBMED   3197451
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY194282.1, AK152257.1 and
            AL671864.6.
            
            On May 31, 2013 this sequence version replaced NM_007807.4.
            
            Summary: This gene encodes the heavy chain component of a
            heterodimeric transmembrane ion transporter composed of both a
            heavy and a light chain. This transporter mediates the transfer of
            electrons from nicotinamide adenine dinucleotide phosphate (NADPH)
            to oxygen to generate superoxide. This reaction is important in the
            innate immune response to pathogens. However, increased activity of
            the encoded protein also leads to the generation of reactive oxygen
            species that result in oxidative stress and can cause tissue
            damage. Conversely, loss of function of the related gene in human
            causes chronic granulomatous disease. Alternative splicing results
            in multiple transcript variants, although the full-length nature of
            some of these variants has not been determined. [provided by
            RefSeq, May 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033570.1, BC042838.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY194282.1         1-30
            31-2880             AK152257.1         2-2851
            2881-4750           AL671864.6         47088-48957         c
FEATURES             Location/Qualifiers
     source          1..4750
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 4.3 cM"
     gene            1..4750
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /note="cytochrome b-245, beta polypeptide"
                     /db_xref="GeneID:13058"
                     /db_xref="MGI:MGI:88574"
     exon            1..119
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1787
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /note="cytochrome b-245 heavy chain; p22 phagocyte
                     B-cytochrome; cytochrome b558 subunit beta; neutrophil
                     cytochrome b 91 kDa polypeptide; heme-binding membrane
                     glycoprotein gp91phox"
                     /codon_start=1
                     /product="NADPH oxidase 2"
                     /protein_id="NP_031833.3"
                     /db_xref="CCDS:CCDS30010.1"
                     /db_xref="GeneID:13058"
                     /db_xref="MGI:MGI:88574"
                     /translation="MGNWAVNEGLSIFVILVWLGLNVFLFINYYKVYDDGPKYNYTRK
                     LLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRIRRQLDRNLTFHK
                     MVAWMIALHTAIHTIAHLFNVEWCVNARVGISDRYSIALSDIGDNENEEYLNFAREKI
                     KNPEGGLYVAVTRLAGITGIVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIG
                     LAIHGAERIVRGQTAESLEEHNLDICADKIEEWGKIKECPVPKFAGNPPMTWKWIVGP
                     MFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSK
                     LEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFG
                     TASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCDNATSLKLKKIYFYWLCRDTHA
                     FEWFADLLQLLETQMQERNNANFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQK
                     TLYGRPNWDNEFKTIASEHPNTTIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFN
                     KENF"
     exon            120..215
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            216..326
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            327..411
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..557
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..748
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            749..878
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            879..971
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1225
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1388
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1535
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1660
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..4750
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4485..4490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /note="hexamer: ATTAAA"
     polyA_site      4509
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /note="major polyA site"
     regulatory      4549..4554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
                     /note="hexamer: ATTAAA"
     polyA_site      4574
                     /gene="Cybb"
                     /gene_synonym="Cgd; CGD91-phox; Cyd; gp91-1; gp91phox;
                     Nox2"
ORIGIN      
        1 tgttttcatt tcctcatcag aagaagaagc acagtagaga agagaggcag aaccaacact
       61 taacctttgc taacatgggg aactgggctg tgaatgaagg actctccatc tttgtcattc
      121 tggtgtggtt ggggctgaat gtcttcctct ttatcaacta ctacaaggtt tatgatgatg
      181 ggcctaagta taattatact cgaaaactcc ttgggtcagc actggctctg gcccgggcac
      241 ctgcagcctg cctgaatttc aactgtatgc tgatcctgct gccagtgtgt cgaaatctgc
      301 tctcctttct caggggttcc agtgcgtgtt gctcgacaag gattcgaaga caactggaca
      361 ggaacctcac tttccataag atggtagctt ggatgatagc actgcacacc gccatccaca
      421 caattgcaca tctcttcaac gttgagtggt gtgtgaatgc cagagtcggg atttctgacc
      481 ggtattcaat agctctctct gacatcggtg acaatgagaa cgaagagtat ctcaattttg
      541 ctagagaaaa aatcaagaac cctgaagggg gcctgtatgt ggccgtgact cggttggctg
      601 ggatcacagg aattgtcatc acactgtgtc tcatattgat tatcacatcc tctaccaaaa
      661 ccattcggag gtcttatttt gaagtgttct ggtatacaca ccatctcttt gtgatcttct
      721 tcatcggcct tgccatccat ggagctgaac gaattgtacg tggacagact gcggagagtt
      781 tggaagagca taatttagat atctgtgcag acaaaatcga agaatgggga aaaataaagg
      841 agtgcccagt accaaagttc gctggaaacc ctcctatgac ttggaaatgg atagtgggtc
      901 ctatgttcct gtacctttgt gagaggttgg ttcggttttg gcgatctcag caaaaggtgg
      961 tcatcaccaa ggtggtcacc caccctttca aaaccattga gcttcagatg aagaagaagg
     1021 gattcaagat ggaggtggga cagtacattt ttgtcaagtg ccccaaggta tccaagttag
     1081 aatggcaccc attcacactg acctctgctc ctgaggaaga cttttttagc atccatatcc
     1141 gtattgtggg agactggacg gaggggctat tcaatgcttg tggctgtgat aagcaggagt
     1201 tccaagatgc ctggaaacta cctaagatag cagttgatgg accctttggt acagccagtg
     1261 aagatgtgtt cagctatgag gtggtgatgt tagtgggagc cgggattgga gtcacgccct
     1321 ttgcctccat tctcaagtct gtctggtaca aatattgtga taatgccacc agtctgaaac
     1381 tcaaaaagat ctacttctac tggctgtgca gggacacgca tgcctttgag tggtttgcag
     1441 acctgctgca gctgctggag acccagatgc aggaaaggaa caatgccaac ttcctcagct
     1501 acaatatcta ccttactggc tgggatgaat ctcaggccaa tcactttgct gtgcaccatg
     1561 atgaggagaa agatgtgatc acaggcctaa aacagaagac tctgtatgga cggcccaact
     1621 gggataacga gttcaagacc attgcaagtg aacaccctaa caccacaata ggcgttttcc
     1681 tgtgtggccc tgaagccttg gctgaaactc tcagtaaaca gagcatctcc aactcagaat
     1741 ccggcccgcg tggagtccac ttcattttca acaaggaaaa cttctaactc cgctctttca
     1801 ccaggaaacc agtgtatgct gccaaatgtc ccagtaatgc tggttggttg taggagagaa
     1861 ggaggaaagg aaatcacaat gacacaggcc ccctaaaagg aattccaaag atccttacta
     1921 gtcatctgtc atattgcatg gaacttcatg gtttcagagc actttttaca tacatagtta
     1981 tgcattgttt cacatttccc tttgacatgc cagaagaggg taaggcaaaa gcattttctg
     2041 ggactctctc taggataaac aataggatct caaatgagtt ccacaccttc cttccaattc
     2101 agaagttgaa accacaccta agccatctga ctctgggtgt ggtcaccttt tcacctttaa
     2161 taccaggttg tctcaagcct cagtttttat actatccacc aacaaaaaag caagtcaaag
     2221 aagagctcat cattcttagc tgttgttttc tctttaacct tagcatcatg ctaaaggaaa
     2281 ctttttaaat agaggagata gtgatgctga tggtgactta atacttccta aatgacagta
     2341 tcggcacaga agtatattcc agttttatca gcacaacagt ttaactgggt cagagattat
     2401 tcctagtaag aaatattaga ctgattggag ttaaagtagc actctacatt taccatggtg
     2461 tttggcagaa ttggtgttca aggtcagttt attgaatgaa tgaatgaatg attgaacaaa
     2521 tagatgcaaa cattcagaac tatatcataa tggaatgtat ggccagagac agaattaccc
     2581 ttctgtttct tttacacacc aaagtatcct gattcccctg ggagtagaga gaaagatatg
     2641 aaccaatagg gagagtcagg ccattctact ggtattcatc caactgtcat ttgaagggag
     2701 gaggcatgaa ttcagagacc tattctccta tgatgatggt ggctaacact tctagttcca
     2761 gtctgtaagc tgaaaaagaa gaacacattt atttactgac agaaatgatc tgctccagcc
     2821 aaactttgaa ctgaattcta agaaatgtat acatgataat acatatcctg cttagaatcc
     2881 atttcttctt tggcttaaat acctatacaa atagatctta tgtgcataga caataacttg
     2941 tttttttttt tttaattgca gcattttcat caccactagt accagcatca ccatcttcct
     3001 aaaatataaa ttttagaaac tgtaatcccc aaataactgg gttaagagta aaatcacatc
     3061 cgatatttta tgggcatcca gaaatgcaag acagagtcta gatgactgct agactagtca
     3121 catgtgaaaa aaaaaaaaaa aaagagaaaa ctactcctct ttctgggaac taaaagcatt
     3181 tctgactgcc cccccccccc caggaataca aagacttata actattcagc tttggtaatg
     3241 aggaaggaag agtagagagc agaggccttg atggagagaa agtggtgaag ccaacaggag
     3301 agaaaggaaa gcaccacact cacaagggaa gtgtcagagg caaagggtct catggtggtt
     3361 aggattcggc ctccattgct acttgatatg tatcacatgt aactaaagga cgcatgcgct
     3421 catcttgttt tgacttcata ttgcattgca tagttttagt tctgatcaca aattttgcta
     3481 ttgtatgaag attttgaagg gactagacga agggagagct cagattctcc ttatgttcct
     3541 gctatgctct tgttcgctta gcatccttag agcactcaag gctggttctg gtaaataagg
     3601 ccttcctaga tgtgcacatg gtaccaggag aattgttgcc ctgggacaaa ggtccagaca
     3661 gaccttcgtg ttgcacccta ggcattaggt cattcattca acatacattt gtttggtata
     3721 attaatgagt caattttaac tatttgtggc aaagtttgat ctcagttaca aggactctga
     3781 aaacaccgtg ttctaacaaa agtggtaatg agtctgtttg ttgctacaag aatccttctc
     3841 cagttttctg gggttttcct tgtctttatt tttcttgcag acaatagatc cagactgcag
     3901 actggcccct ctccctctcc cagccctgcc tccacacctc ctcttcccca gatccattgt
     3961 tcctctgttt cccttcaaaa aaaaaaaaaa gagcagacct cccagagaac acagcataac
     4021 aagatgcaat aagactaggc acaaaccctc atatcaaggc tggatgaggc aacccaggag
     4081 gagaaaaaga atcccataag caggctaggg ttgatatcaa catagttccc aaaatagaga
     4141 tctatcctga gttattctgg ttatgagatg gaaaatgagt gcacatgtgc ttgttgtttg
     4201 agaacttcct tctttttgct cccaagcccc cagctcacag ccaccagctg ccagctgcca
     4261 gcacagctct ttctgtactt agttcttaga atttagtaac agatactgag atctgtcatt
     4321 agcaacaaat ctaaaatgag aaaataaggc tagaaatgat ttttcttatt ttttccccgc
     4381 ttttgcaata tcatgtttat ggaatttgaa tacttgcagc cattgtatat gaacagtctg
     4441 gtgagtggga gaagatgatc tagagataac ttttagaaat aactattaaa gcttgctttg
     4501 atgctgaaat cagtgagctt tccctgtgtc tttgttattg aacttgtcat taaagagtga
     4561 atccaactag caaagatact gtattttatc aagaaggttg ttctaaatat gtcaatcagt
     4621 tacaaccctc cctgtctagg taatgcatgg agacatgagc tcatgttttg gactgaattg
     4681 gctgttgtta tcacggatgt aaagcacatc accgaaggca aatgctaata aacagaaata
     4741 gcaaacattt
//
