LOCUS       NM_007806                764 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus cytochrome b-245, alpha polypeptide (Cyba), transcript
            variant 1, mRNA.
ACCESSION   NM_007806
VERSION     NM_007806.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 764)
  AUTHORS   Saldova,R., Thomsson,K.A., Wilkinson,H., Chatterjee,M., Singh,A.K.,
            Karlsson,N.G. and Knaus,U.G.
  TITLE     Characterization of intestinal O-glycome in reactive oxygen species
            deficiency
  JOURNAL   PLoS One 19 (3), e0297292 (2024)
   PUBMED   38483964
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 764)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 764)
  AUTHORS   Petzold,T., Zhang,Z., Ballesteros,I., Saleh,I., Polzin,A.,
            Thienel,M., Liu,L., Ul Ain,Q., Ehreiser,V., Weber,C., Kilani,B.,
            Mertsch,P., Gotschke,J., Cremer,S., Fu,W., Lorenz,M.,
            Ishikawa-Ankerhold,H., Raatz,E., El-Nemr,S., Gorlach,A.,
            Marhuenda,E., Stark,K., Pircher,J., Stegner,D., Gieger,C.,
            Schmidt-Supprian,M., Gaertner,F., Almendros,I., Kelm,M., Schulz,C.,
            Hidalgo,A. and Massberg,S.
  TITLE     Neutrophil 'plucking' on megakaryocytes drives platelet production
            and boosts cardiovascular disease
  JOURNAL   Immunity 55 (12), 2285-2299 (2022)
   PUBMED   36272416
REFERENCE   4  (bases 1 to 764)
  AUTHORS   Johnson,J.L., Ramadass,M., Rahman,F., Meneses-Salas,E.,
            Zgajnar,N.R., Carvalho Gontijo,R., Zhang,J., Kiosses,W.B.,
            Zhu,Y.P., Hedrick,C.C., Perego,M., Gunton,J.E., Pestonjamasp,K.,
            Napolitano,G. and Catz,S.D.
  TITLE     The atypical small GTPase GEM/Kir is a negative regulator of the
            NADPH oxidase and NETs production through macroautophagy
  JOURNAL   J Leukoc Biol 110 (4), 629-649 (2021)
   PUBMED   34085299
  REMARK    GeneRIF: The atypical small GTPase GEM/Kir is a negative regulator
            of the NADPH oxidase and NETs production through macroautophagy.
REFERENCE   5  (bases 1 to 764)
  AUTHORS   Prieto-Bermejo,R., Romo-Gonzalez,M., Perez-Fernandez,A.,
            Garcia-Macias,M.C., Sanchez-Bernal,C., Garcia-Tunon,I.,
            Sanchez-Yague,J., Sanchez-Martin,M. and Hernandez-Hernandez,A.
  TITLE     Granuloma Formation in a Cyba-Deficient Model of Chronic
            Granulomatous Disease Is Associated with Myeloid Hyperplasia and
            the Exhaustion of B-Cell Lineage
  JOURNAL   Int J Mol Sci 22 (16), 8701 (2021)
   PUBMED   34445407
  REMARK    GeneRIF: Granuloma Formation in a Cyba-Deficient Model of Chronic
            Granulomatous Disease Is Associated with Myeloid Hyperplasia and
            the Exhaustion of B-Cell Lineage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 764)
  AUTHORS   Taille,C., El-Benna,J., Lanone,S., Dang,M.C., Ogier-Denis,E.,
            Aubier,M. and Boczkowski,J.
  TITLE     Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by
            down-regulating cytochrome b558 expression via the reduction of
            heme availability
  JOURNAL   J Biol Chem 279 (27), 28681-28688 (2004)
   PUBMED   15123630
  REMARK    GeneRIF: cytochrome b558 expression is downregulated via the
            reduction of heme availability after NADPH oxidase is inhibited by
            HO-1
REFERENCE   7  (bases 1 to 764)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 764)
  AUTHORS   Baehner,R.L., Millar-Groff,S. and Bringas,P.
  TITLE     Developmental expression of NADPH phagocytic oxidase components in
            mouse embryos
  JOURNAL   Pediatr Res 46 (2), 152-157 (1999)
   PUBMED   10447107
REFERENCE   9  (bases 1 to 764)
  AUTHORS   Takenaka,M., Imai,E., Kaneko,T., Ito,T., Moriyama,T., Yamauchi,A.,
            Hori,M., Kawamoto,S. and Okubo,K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   10 (bases 1 to 764)
  AUTHORS   Sumimoto,H., Nozaki,M., Sasaki,H., Takeshige,K., Sakaki,Y. and
            Minakami,S.
  TITLE     Complementary DNA for the mouse homolog of the small subunit of
            human cytochrome b558
  JOURNAL   Biochem Biophys Res Commun 165 (2), 902-906 (1989)
   PUBMED   2597164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY005999.1, AK152414.1 and CF738398.1.
            
            On Nov 22, 2007 this sequence version replaced NM_007806.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF738398.1, AK152414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY005999.1         4-13
            11-712              AK152414.1         2-703
            713-754             AK152414.1         705-746
            755-764             CF738398.1         737-746
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 71.04 cM"
     gene            1..764
                     /gene="Cyba"
                     /gene_synonym="b558; nmf333; p22-phox; p22phox"
                     /note="cytochrome b-245, alpha polypeptide"
                     /db_xref="GeneID:13057"
                     /db_xref="MGI:MGI:1316658"
     exon            1..131
                     /gene="Cyba"
                     /gene_synonym="b558; nmf333; p22-phox; p22phox"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..652
                     /gene="Cyba"
                     /gene_synonym="b558; nmf333; p22-phox; p22phox"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytochrome b-245 light chain; p22 phagocyte B-cytochrome;
                     cytochrome b(558) alpha chain; cytochrome b558 subunit
                     alpha; neutrophil cytochrome b 22 kDa polypeptide;
                     superoxide-generating NADPH oxidase light chain subunit;
                     cytochrome beta-558; p22 phox"
                     /codon_start=1
                     /product="cytochrome b-245 light chain isoform 1"
                     /protein_id="NP_031832.2"
                     /db_xref="CCDS:CCDS22737.1"
                     /db_xref="GeneID:13057"
                     /db_xref="MGI:MGI:1316658"
                     /translation="MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIA
                     AGVLICLLEYPRGKRKKGSTMERCGQKYLTSVVKLFGPLTRNYYVRAALHFLLSVPAG
                     FLLATILGTVCLAIASVIYLLAAIRGEQWTPIEPKPKERPQVGGTIKQPPTNPPPRPP
                     AEVRKKPSEGEEEAASAGGPQVNPMPVTDEVV"
     exon            132..201
                     /gene="Cyba"
                     /gene_synonym="b558; nmf333; p22-phox; p22phox"
                     /inference="alignment:Splign:2.1.0"
     exon            202..276
                     /gene="Cyba"
                     /gene_synonym="b558; nmf333; p22-phox; p22phox"
                     /inference="alignment:Splign:2.1.0"
     exon            277..360
                     /gene="Cyba"
                     /gene_synonym="b558; nmf333; p22-phox; p22phox"
                     /inference="alignment:Splign:2.1.0"
     exon            361..442
                     /gene="Cyba"
                     /gene_synonym="b558; nmf333; p22-phox; p22phox"
                     /inference="alignment:Splign:2.1.0"
     exon            443..759
                     /gene="Cyba"
                     /gene_synonym="b558; nmf333; p22-phox; p22phox"
                     /inference="alignment:Splign:2.1.0"
     regulatory      732..737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyba"
                     /gene_synonym="b558; nmf333; p22-phox; p22phox"
                     /note="hexamer: AATAAA"
     polyA_site      755
                     /gene="Cyba"
                     /gene_synonym="b558; nmf333; p22-phox; p22phox"
                     /note="major polyA site"
ORIGIN      
        1 gccgatcagt gaggacttgc gaagtgggct gcagagttgg accgggctgc tgcgtgtgcg
       61 cagggtcctc gtcatggggc agatcgagtg ggccatgtgg gccaacgaac aggcgctggc
      121 gtctggcctg attctcatca ctgggggcat cgtggctact gctggacgtt tcacacagtg
      181 gtatttcggc gcctactcta tcgctgcagg tgtgctcatc tgtctgctgg agtatccccg
      241 gggaaagagg aaaaaggggt ccaccatgga gcgatgtgga cagaagtacc tgacctctgt
      301 ggtgaagctt ttcgggcccc tcaccaggaa ttactacgtc cgggctgccc tccacttcct
      361 gttgtcggtg cctgcaggct tcctcctggc caccatcctg gggaccgtct gcttggccat
      421 tgccagtgtg atctatctgc tggcagccat ccgaggtgag cagtggactc ccattgagcc
      481 taaacccaag gagcggccac aggttggagg caccatcaag caaccaccta ccaacccccc
      541 accccggcca cccgcagagg tccgaaagaa gccgagtgag ggtgaagagg aggcagcctc
      601 agctggagga ccccaggtta acccaatgcc agtgacagat gaggtcgtgt gaccttcagt
      661 ggctgtctac agctcctgct tgagtttctg tggagttgtc cccccccccc cagggtggtg
      721 ttgctcactg taataaacat gattaatagc tggtacggaa aaaa
//
