LOCUS       NM_001024926            2393 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus cytochrome b5 domain containing 2 (Cyb5d2), mRNA.
ACCESSION   NM_001024926 XM_109819
VERSION     NM_001024926.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2393)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2393)
  AUTHORS   Ogawa,Y., Sasanuma,Y., Shitara,S., Koshizuka,A., Okada,R.,
            Sakuraba,H. and Oishi,K.
  TITLE     Abnormal organization during neurodevelopment in a mouse model of
            Sandhoff disease
  JOURNAL   Neurosci Res 155, 12-19 (2020)
   PUBMED   31340161
REFERENCE   3  (bases 1 to 2393)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2393)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2393)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2393)
  AUTHORS   Kimura,I., Nakayama,Y., Konishi,M., Kobayashi,T., Mori,M., Ito,M.,
            Hirasawa,A., Tsujimoto,G., Ohta,M., Itoh,N. and Fujimoto,M.
  TITLE     Neuferricin, a novel extracellular heme-binding protein, promotes
            neurogenesis
  JOURNAL   J Neurochem 112 (5), 1156-1167 (2010)
   PUBMED   19968755
  REMARK    GeneRIF: This study identified neuferricin, a novel extracellular
            heme-binding protein with cytochrome b5-like heme/steroid-binding
            domain, which is the fourth member of the MAPR family in mammals.
            Neuferricin was abundantly expressed in the developing brain
REFERENCE   7  (bases 1 to 2393)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ151047.1, CJ150252.1, BC086682.1, AK034043.1, CJ284318.1,
            BX632403.1 and CD776759.1.
            
            On Feb 13, 2008 this sequence version replaced NM_001024926.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086682.1, SRR7345562.3354037.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CJ151047.1         1-15
            16-304              CJ150252.1         1-289
            305-1871            BC086682.1         271-1837
            1872-2073           AK034043.1         1570-1771
            2074-2184           CJ284318.1         87-197
            2185-2357           BX632403.1         22-194              c
            2358-2393           CD776759.1         1-36                c
FEATURES             Location/Qualifiers
     source          1..2393
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 44.51 cM"
     gene            1..2393
                     /gene="Cyb5d2"
                     /gene_synonym="9330151E16Rik; Gm2"
                     /note="cytochrome b5 domain containing 2"
                     /db_xref="GeneID:192986"
                     /db_xref="MGI:MGI:2684848"
     exon            1..327
                     /gene="Cyb5d2"
                     /gene_synonym="9330151E16Rik; Gm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..869
                     /gene="Cyb5d2"
                     /gene_synonym="9330151E16Rik; Gm2"
                     /note="cytochrome b5 domain-containing protein 2;
                     neuferricin"
                     /codon_start=1
                     /product="neuferricin precursor"
                     /protein_id="NP_001020097.2"
                     /db_xref="CCDS:CCDS24990.2"
                     /db_xref="GeneID:192986"
                     /db_xref="MGI:MGI:2684848"
                     /translation="MLRICGLGVVLSLAVAAVAVMAVWLMDWWGPRPGIRLFLPEELA
                     RYRGGPGDPGLYLALLGRVYDVSSGRRHYEPGAHYSGFAGRDASRAFVTGDYSEAGLV
                     DDINGLSSSEILTLHNWLSFYEKNYVFVGRLVGRFYRKDGLPTSELTQVEAMVTKGME
                     ANEQEQREKQKFPPCNSEWSSAKGSRLWCSQKSGGVHRDWIGVPRKLYKPGAKEPHCV
                     CVRTTGPPSDQQDNPRHSNHGDLDNPNLEEYTGCPPLATTCSFPL"
     exon            328..468
                     /gene="Cyb5d2"
                     /gene_synonym="9330151E16Rik; Gm2"
                     /inference="alignment:Splign:2.1.0"
     exon            469..655
                     /gene="Cyb5d2"
                     /gene_synonym="9330151E16Rik; Gm2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..2376
                     /gene="Cyb5d2"
                     /gene_synonym="9330151E16Rik; Gm2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2336..2341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyb5d2"
                     /gene_synonym="9330151E16Rik; Gm2"
                     /note="hexamer: AATAAA"
     polyA_site      2376
                     /gene="Cyb5d2"
                     /gene_synonym="9330151E16Rik; Gm2"
                     /note="major polyA site"
ORIGIN      
        1 ggccggcgtc tctgctgtct tagtggtggc ttaagaggtg gctacctccg aagcgtgtct
       61 ggtgtgttgc tgtatagatg ctgaggatat gcgggcttgg tgtggtgctg agcctggccg
      121 tggcggcggt ggctgtcatg gccgtgtggt tgatggactg gtggggtccc cgccctggta
      181 ttcgcctctt ccttcccgag gagctagccc gctatcgcgg cggcccaggg gacccgggcc
      241 tgtacttggc actgctcggc cgcgtctacg acgtgtcctc tggcaggagg cactacgagc
      301 ctggggcgca ctatagcggc ttcgcaggcc gggatgcatc cagagcattt gtgacaggag
      361 actattctga agccggtctt gtggatgata taaatggctt gtcctcctct gagatactga
      421 cgctgcacaa ctggctttca ttctacgaga aaaattatgt atttgtcgga agactggttg
      481 gaaggttcta cagaaaggat gggttaccca cttcagaact aacccaggta gaagccatgg
      541 tgactaaagg catggaggca aatgaacagg aacaaagaga aaagcagaag ttcccaccat
      601 gcaattccga gtggagctct gctaagggca gcaggctctg gtgctcccaa aagagtggag
      661 gtgtgcacag agactggatt ggtgtcccca ggaagttgta taagccaggg gccaaggagc
      721 cccattgtgt gtgtgtgaga acaactggcc ctcctagtga ccagcaagac aaccctagac
      781 actcaaatca tggggacttg gacaacccca acttggaaga atacacaggc tgcccaccac
      841 tggctaccac atgttccttc ccactctaag atggtgtcct gtatgtggct gacacatgga
      901 gaaccttcca gatctacaga aagccctcga tcttgtgccc tagcatggct cctggcctga
      961 aataggagtg tcaaggactc caaccacact ctgcaaatgt gggtcacaat tctactggct
     1021 gagacaagag cctgatagcc tatctcatat ggtcagcttg ttctgacagt gtttggaacc
     1081 tctgtcctct ctcatcttcc ttcagagcct gcagacatta atgaacaaag tgaaatcaac
     1141 atagaattga tcagataagg agtctgagag ctccagaagg gacttgccgt agacttggtg
     1201 ttgcctgaat cagagcttgc actctgccca tcatgccagt cctgctggta cttggagcag
     1261 gactgtggtt ctcagtggaa aatcagacat ttcccaagaa gattttgcac cttagtaaaa
     1321 tgaaggtaac tgttctaagt cacagggtaa ttgactgagc tcttaacttc tgacatttgt
     1381 gacatttcta aaacctctac tccagggcaa actgactcca tgagaactgg gatggtccag
     1441 tgagatgaga taataaacta gagtagcaga ttctggggct tgacttacac agatggagca
     1501 caccataatc cccctgccct ggtgtgcatc aaacagcttt ctttactcat attgctagtg
     1561 aaaagttgtc cctctatgac tgccacacgc tgtaagaggc ttcgctgcag gtttctcacc
     1621 cccgctgcag aattccgttc tctgctgcac agccgcagct cttctcatct ctttctggtt
     1681 cttgttttcg ttttccagaa agggtctcat tatgtagctc tagctatcct ggaagtcacc
     1741 aggtagacgg agctgacctg gaactcacag aaatccacct gcctctgcct cccgagtatt
     1801 gggattaaag acatgcacca ctatgtccta ctaattttac ctatcttgat ctctgctact
     1861 taaaaaaaaa attacttgac tttatgaggc aggatctcat gtttccaggt cagccttgaa
     1921 ctcagtatgt aagcatgtgc tcccatgccc agtttagtca gtaggagggg ttgaatgaac
     1981 cggagccaca tacatgctag gcaagcactt taccaactga gctatatccc taggtccttg
     2041 agcttcattg ctcttgactt tttttttttt ttttcgtttt tttgagacag ggtttctctg
     2101 tgtagctctg gctgtcctgg aactcactct gtagaccagg ctggcctaga actcagaaat
     2161 ccacctgtct ctgcctccca agtgctagga ttaaaggcgt gtgccaccac gcccagcgct
     2221 cttgactttt tgaccatgat gtcctgcaag atcctcataa agccctcact tgctgcactg
     2281 gtcccatccc ttaggggttc cttctgaggt agcatctcca atcaaaaagc ttgataataa
     2341 agatgtctgt gagttctgca ggcactgtaa ctcccaaaaa aaaaaaaaaa aaa
//
