LOCUS       NM_201351               3357 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cytochrome b561 family, member A3 (Cyb561a3),
            transcript variant 1, mRNA.
ACCESSION   NM_201351 XM_129187
VERSION     NM_201351.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3357)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3357)
  AUTHORS   Zhang,D.L., Su,D., Berczi,A., Vargas,A. and Asard,H.
  TITLE     An ascorbate-reducible cytochrome b561 is localized in macrophage
            lysosomes
  JOURNAL   Biochim Biophys Acta 1760 (12), 1903-1913 (2006)
   PUBMED   16996694
REFERENCE   3  (bases 1 to 3357)
  AUTHORS   Su,D. and Asard,H.
  TITLE     Three mammalian cytochromes b561 are ascorbate-dependent
            ferrireductases
  JOURNAL   FEBS J 273 (16), 3722-3734 (2006)
   PUBMED   16911521
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125093.4, AK139533.1, AK168841.1 and BY387699.1.
            
            On Aug 15, 2013 this sequence version replaced NM_201351.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168841.1, BC065078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC125093.4         34649-34663         c
            16-2576             AK139533.1         4-2564
            2577-3353           AK168841.1         2281-3057
            3354-3357           BY387699.1         429-432
FEATURES             Location/Qualifiers
     source          1..3357
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.6 cM"
     gene            1..3357
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
                     /note="cytochrome b561 family, member A3"
                     /db_xref="GeneID:225912"
                     /db_xref="MGI:MGI:2686925"
     exon            1..927
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1020
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1120
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1319
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
                     /inference="alignment:Splign:2.1.0"
     CDS             1136..1864
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
                     /EC_number="7.2.1.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytochrome b ascorbate-dependent protein 3; lysosomal
                     cytochrome b; lysosomal membrane ascorbate-dependent
                     ferrireductase CYB561A3"
                     /codon_start=1
                     /product="lysosomal membrane ascorbate-dependent
                     ferrireductase CYB561A3 isoform 1"
                     /protein_id="NP_958739.1"
                     /db_xref="CCDS:CCDS29582.1"
                     /db_xref="GeneID:225912"
                     /db_xref="MGI:MGI:2686925"
                     /translation="MASGWFYLSCMVLGSLGSMCILFTAYWMQYWRGGFAWDGTVLMF
                     NWHPVLMVAGMVVLYGAASLVYRLPSSWVGPRLPWKVLHAALHLLAFTCTVVGLIAVF
                     RFHNHSRIAHLYSLHSWLGITTVVLFACQWFLGFAVFLLPWASQWLRSLLKPLHVFFG
                     ACILSLSITSVISGINEKLFFVLKNATKPYSSLPGEAVFANSTGLLVVAFGLLVLYVL
                     LASSWKRPDPGALTDRQPLLHDRE"
     exon            1320..1528
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1683
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1840
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..3357
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3124..3129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
                     /note="hexamer: ATTAAA"
     polyA_site      3146
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
                     /note="major polyA site"
     regulatory      3329..3334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
                     /note="hexamer: AATAAA"
     polyA_site      3349
                     /gene="Cyb561a3"
                     /gene_synonym="2310004G04Rik; Cybasc3; Lcytb"
ORIGIN      
        1 agattgctaa ttgcccgcca tgttagggtc tttgctttct caggctctcc ctgtgaccgg
       61 ttcttctatc ttgcctcgct gagggccgac cctagcgtga ggttgttaac cccagcattt
      121 cacctgtctc tggacggggt ctgtggttag agacaaggct gataggacgc agcgctccta
      181 ggaatcggac cgctcaggaa cgcgcccctt agcttgcaaa ccccatttcc cagacgcccc
      241 agctcacccc cggaagtggc cgagcctata aaaatctcac ttagcgccct ctgtagcgga
      301 tgccgtggtc tgcagacttg ctggaaagtc agttctccga ggttcaagag gagcctaggg
      361 agtggcagct ctcgctgacc ggcgggtccc agagacctgc ccccaaggtg tcccactgtg
      421 tggctaaggg tgggatagaa cccgggctgg gagagccggg ttatgggttc cagtggtggt
      481 tccgccgctt ccttgcttcg ctctgtctta cctcggcgtt cagcctattt ttcctcgtaa
      541 gaattggaca cttttccgtg ccccttccat accgcaggtg gtgttcgtag aggctctcac
      601 gcttttcaaa aggcgtctca tctaagactt gctagaacca acctgactaa aggagtcacc
      661 gtcatacccc ccttgcacct ggagtaaatc tgactgtccg aaggacgaag gaccggtctg
      721 tgagcacttg tgctaaggtg gactttattc acactcctga gtggaatatt atttgtcact
      781 cactcctgag tcctgccgtt tggaggggct gcctttggaa atgagttctg ggaactgaac
      841 acaggaactg ggtgcctgta ccaggcttgc catttgcctg accgagttac tcttctttgg
      901 atcccggcgc tgcagtactt ttgaattgtt cctgtgaagg ccagaagtag gtatttggtc
      961 ccttggagct gtgagctgat gtaggtgctg ggaactcagc tgtggtgtgc tgcaagacca
     1021 aggacgagtc ttgcagtgtt aagtgttttc ctcagggtgc tcagacggtg aaaatcagag
     1081 atcaggccac ctttctgtga gccttcagct gagtctaaag gtgttattga tcagaatggc
     1141 ttcaggatgg ttttacctgt cctgcatggt gctgggatcg ctgggatcga tgtgcatcct
     1201 cttcactgcc tactggatgc agtactggcg cggtggcttt gcctgggatg gcacggtgct
     1261 catgtttaac tggcacccag tgctcatggt tgccggcatg gtggtgctct atggagctgc
     1321 ctcactggtg taccgcctgc cttcatcgtg ggtggggccc aggctgccct ggaaagttct
     1381 ccatgcagca ctgcacctgc tggccttcac ctgcactgtg gtggggctga ttgccgtctt
     1441 tcggtttcac aaccactcga gaatcgcaca cctctactcc ctgcacagct ggctgggtat
     1501 caccactgta gtcctcttcg cctgccagtg gttcctgggc tttgctgtct tcctcctgcc
     1561 ctgggcatcc cagtggctgc gaagcctcct gaaacctctg catgtattct ttggagcctg
     1621 catcctttcc ctgtccatca catctgttat ttccggcatc aatgagaagc ttttctttgt
     1681 tttgaaaaat gccaccaagc cctactccag cctgcctggt gaggctgtct ttgccaacag
     1741 cacagggctc ttggtggtgg cttttggctt gctggttctc tatgttcttc tggcttcatc
     1801 atggaagcgt ccagatccag gagctctgac tgatagacag cccctgttgc atgacaggga
     1861 atgaagcggg caggggctcc tgggaacggt cagcgatgcg gtctctgctc cctcagaagt
     1921 tctgctgtac tggggctcct ggctggtttc agcaacagac ttctcttggg ccagagaccc
     1981 aaccttgcta ctccagttgc aggctctcgc tgtccagcca ctagctgttc ctctgctttt
     2041 cttgtggctt tggcttattg ccgttttttt ctggtcctcc attggcacaa agaccttctt
     2101 gccttggtca cacatgtctc ttctgctggt ctgcagattt tgggctgctt tccttaccac
     2161 tcctagggat gtgggagaag ccaaagctgg ggttcaaatg cagtctacac gtgtaaaata
     2221 caaagtctgc tctctgtggg agcatttgtc ttagttaggt atgcttcccc ctctgctctg
     2281 tcctggatgt gtatttgggt gggcagttgc attgaggggt cattcatggg acagtggcag
     2341 ccggagaagc ctctgctgta aagtcaggtg cccagtactc tgctcttttc actttgatgt
     2401 gctgtattgt gtggattgtg accttgtgat tccccctctt ctagctgctg ctccagctgc
     2461 ttcctggatc ccgccctttc cctgtgactt acatgcctgt tcccctcagg tagcatgacg
     2521 agccgttaaa cagttctccc aagaacacat gtcctgtccc tagagtccct cccagtgatg
     2581 agtctgaggt ttctttggcc ttcctttctg tccctttgtg ggtatgggct ttcctgcctc
     2641 ctctagttat gctctcccct gacagggccc cagcccacta tgaaattgaa accagcatta
     2701 tgaagcaatt tgctgggagc cattcactgc tgctgccttc agagatgttc cttattgagt
     2761 agtgggtgct tctgttcccc aaaaggtcac tcagctaccc tctatgctat accagaatgt
     2821 gagctttgct cttctgaata gaaactgggt agagagggag gagtcttgcc ccactccttt
     2881 gtgttagccc tgccaggtcc ctcaacaggc aggcaggcag gcaagcaggc agacaggcag
     2941 gcagagttgg gttcctgaac tctctgcaga cagtggccag gctgccagac gttgggagga
     3001 gggctggcat ggatttgctg actaaatgga agcctgaaca catagcgatg actcttggca
     3061 cccacatgaa catcttcctg gttcactcat gagtgggtat tttacttcat gaatcttatt
     3121 tttattaaat atgtttttaa acatcagagg tctcttttgt tcagactgtt ttttaaaaat
     3181 aattttaggg gctggagaga tggctcagta atgaagagca ctggctgttc ttccagaggt
     3241 cctgagttca attcccagca accacatggt ggctcacaac catctgtaat gggatctgat
     3301 gccctcttct acgtccatac tttaaataaa taaatctttt aaaaaataat tttaaac
//
