LOCUS       NM_007805               2827 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cytochrome b-561 (Cyb561), transcript variant 2, mRNA.
ACCESSION   NM_007805
VERSION     NM_007805.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2827)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2827)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2827)
  AUTHORS   van den Berg,M.P., Almomani,R., Biaggioni,I., van Faassen,M., van
            der Harst,P., Sillje,H.H.W., Mateo Leach,I., Hemmelder,M.H.,
            Navis,G., Luijckx,G.J., de Brouwer,A.P.M., Venselaar,H.,
            Verbeek,M.M., van der Zwaag,P.A., Jongbloed,J.D.H., van
            Tintelen,J.P., Wevers,R.A. and Kema,I.P.
  TITLE     Mutations in CYB561 Causing a Novel Orthostatic Hypotension
            Syndrome
  JOURNAL   Circ Res 122 (6), 846-854 (2018)
   PUBMED   29343526
REFERENCE   4  (bases 1 to 2827)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   5  (bases 1 to 2827)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2827)
  AUTHORS   Berczi,A., Su,D., Lakshminarasimhan,M., Vargas,A. and Asard,H.
  TITLE     Heterologous expression and site-directed mutagenesis of an
            ascorbate-reducible cytochrome b561
  JOURNAL   Arch Biochem Biophys 443 (1-2), 82-92 (2005)
   PUBMED   16256064
REFERENCE   7  (bases 1 to 2827)
  AUTHORS   Vargas,J.D., Herpers,B., McKie,A.T., Gledhill,S., McDonnell,J., van
            den Heuvel,M., Davies,K.E. and Ponting,C.P.
  TITLE     Stromal cell-derived receptor 2 and cytochrome b561 are functional
            ferric reductases
  JOURNAL   Biochim Biophys Acta 1651 (1-2), 116-123 (2003)
   PUBMED   14499595
  REMARK    GeneRIF: Data show that four members of the b561 family of
            predicted ferric reductases:  mouse cytochrome b561, human duodenal
            cytochrome b, and mouse stromal cell-derived receptor 2, have
            ferric reductase activity.
REFERENCE   8  (bases 1 to 2827)
  AUTHORS   Srivastava,M., Pollard,H.B. and Fleming,P.J.
  TITLE     Mouse cytochrome b561: cDNA cloning and expression in rat brain,
            mouse embryos, and human glioma cell lines
  JOURNAL   DNA Cell Biol 17 (9), 771-777 (1998)
   PUBMED   9778036
REFERENCE   9  (bases 1 to 2827)
  AUTHORS   Srivastava,M.
  TITLE     Xenopus cytochrome b561: molecular confirmation of a general five
            transmembrane structure and developmental regulation at the
            gastrula stage
  JOURNAL   DNA Cell Biol 15 (12), 1075-1080 (1996)
   PUBMED   8985121
REFERENCE   10 (bases 1 to 2827)
  AUTHORS   Kozak,C.A., Buckler,C.E. and Srivastava,M.
  TITLE     Genetic mapping of the gene encoding cytochrome b561 to mouse
            chromosome 11
  JOURNAL   Mamm Genome 6 (8), 559 (1995)
   PUBMED   8589532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596246.10, AK014395.2, AK028780.1 and AW985556.1.
            
            [WARNING] On Jun 10, 2024 this sequence was replaced by
            NM_007805.6.
            
            On Sep 30, 2017 this sequence version replaced NM_007805.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 both encode the same
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006732.1, AK169711.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               AL596246.10        104398-104737       c
            341-1256            AK014395.2         2-917
            1257-2812           AK028780.1         791-2346
            2813-2827           AW985556.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..2827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.81 cM"
     gene            1..2827
                     /gene="Cyb561"
                     /note="cytochrome b-561"
                     /db_xref="GeneID:13056"
                     /db_xref="MGI:MGI:103253"
     exon            1..377
                     /gene="Cyb561"
                     /inference="alignment:Splign:2.1.0"
     exon            378..589
                     /gene="Cyb561"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..1143
                     /gene="Cyb561"
                     /note="cytochrome b561; CGCytb; chromaffin granule Cyt
                     b561"
                     /codon_start=1
                     /product="transmembrane ascorbate-dependent reductase
                     CYB561"
                     /protein_id="NP_031831.2"
                     /db_xref="CCDS:CCDS25542.1"
                     /db_xref="GeneID:13056"
                     /db_xref="MGI:MGI:103253"
                     /translation="MEHSSASVPAALPYYVAFSQLLGLTVVAVTGAWLGLYRGGIAWE
                     SSLQFNVHPLCMVIGMIFLQGDALLVYRVFRREAKRTTKILHGLLHVFAFIIALVGLV
                     AVFDYHKKKGYADLYSLHSWCGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHI
                     FFGATIFLFSVGTALLGLKEALLFKLGSKYSTFEPEGVLANVLGLLLVCFGVVVLYIL
                     AQADWKRPSQAEEQALSMDFKTLTEGDSPSPQ"
     exon            590..688
                     /gene="Cyb561"
                     /inference="alignment:Splign:2.1.0"
     exon            689..792
                     /gene="Cyb561"
                     /inference="alignment:Splign:2.1.0"
     exon            793..950
                     /gene="Cyb561"
                     /inference="alignment:Splign:2.1.0"
     exon            951..2816
                     /gene="Cyb561"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2797..2802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyb561"
                     /note="hexamer: AATAAA"
     polyA_site      2815
                     /gene="Cyb561"
                     /note="major polyA site"
ORIGIN      
        1 ccaggcctga cacctagcgg cctcctgggt ttgggcgtgg agagtagcga gcgagaagct
       61 agagaccggg aacccgggcg ccgaacccgc gccgctaacc ttccccgcac gccggtcccg
      121 agccagtccg gagccagtcc cgaagctgct ggagttcggg tcctgagtgc gggtcggtgt
      181 agccgaggtg ccctaccgag tgccggcgcc tggcgggact tccggcgcag gtgaccgtcg
      241 cctcctcgcg cgcgctaccg cttccccgcc gccgccccgt ctccatggcg acgccgtcgc
      301 gccgaggctc gtggaacctg ccgagcgtcc ggggcgcggc gcgtggacgc gcgcaggcct
      361 ggcggcggcg ggacaagctg gggtctcaga atggagcaca gttctgcgtc tgtccctgct
      421 gcactgccgt actatgtggc cttctcccag ctgctgggcc tcactgtagt ggctgtgact
      481 ggtgcgtggc tgggtctgta ccgaggtggc attgcctggg aaagctccct gcagtttaat
      541 gtgcacccgc tctgcatggt cataggcatg atcttccttc aaggagatgc tctgctggtg
      601 taccgtgtct tcagaagaga agccaaacgc acgaccaaga tcttgcatgg gctgctgcac
      661 gtcttcgcct tcatcatcgc cctggtgggg ttggtggctg tgttcgacta ccacaagaag
      721 aagggctatg cagacctgta cagcttgcac agctggtgtg ggatcttagt ctttgttctg
      781 tactttgtgc agtggctcgt gggtttcagc ttcttcctgt tccctggagc ttcattctct
      841 ctgcggagcc gctaccgccc tcagcacatt ttctttggtg ccaccatctt cctcttctct
      901 gtgggcacag ccctactggg cctgaaggag gccctgctgt ttaaattggg gtccaagtac
      961 agcacgtttg aacctgaggg ggtgctggcc aacgtgctag gcttgctgct ggtctgtttt
     1021 ggggtggttg tgctctacat cttggctcag gctgactgga agcggccttc ccaggctgaa
     1081 gagcaagccc tctccatgga cttcaagaca ctcacggagg gagacagccc cagtccccag
     1141 tgatcgccct ccttgtcctc ttggctctgt gggtttccag atatcttttt gctcttccct
     1201 gcagacactg agtctcttag gtccaggagt gtgagtgtgg ggctgtgttg ttagtttagt
     1261 ggggttccag gctttggagt tgttctcagt ctcccttcct ccccttcctc tctgcagctt
     1321 ttgatacatc ctgtgagccc tgagtaggct ctgtctgcct gtacccgctg ttgtccgttc
     1381 acgtgcagaa agcttggtta ggggatctgg ggtcaagcct ggccctgatc cctattggag
     1441 ctagacaata gctccgccct ccatgcagca gatggctgct gggcctgggc ctgagggact
     1501 ggcatggaga agtcagaccg ctgctttgtg tattcaaccc aggagttcca gcagcttggg
     1561 aagcatgtgt ccttggcagt agagcaagtg atattatgtg taaaatatgc tggtgttcag
     1621 aggaaggctc cccagaaagg ttgactctgg ctcccaaagg agccttggcg tgtgggttgg
     1681 ctacagtctt taggcctttc tgttctttta aaatccctga tcattaaata ggcttttcgt
     1741 ggggaagggg attagtgatc aaaactcagg taaatacctg ccctggtgga ggagggcagg
     1801 ctgcttgctc acagtgaggg ctgccctggc agagtacctc ccttcagcag gggctaagcc
     1861 ctagcttcct tctgcgggcc agcctgggca gactctgaga gtgggaggcc acacctccgg
     1921 agtttttgga agagggctgc tgtttgcctt gttctccagg ggggctgctg gggtaccctg
     1981 gcttggggtg ccctgtcttg gttgaagcag ccctgaggga tcatggtcct cccagccctg
     2041 ggtccatcat cgctggacag taggactgaa gtggaagaga ggaacgggat tggtctcctg
     2101 cacttagctt caacccccta ctgcctgttg cgttgttagc tgagtcactg tttggcttga
     2161 gtctagagat attgggatta gagcactgat cttgtattct ctggcttggc acatgctctc
     2221 ttcttgtttt ccttctctcg ggttttaagc ctcacagttt gtgacacaca tggttaactt
     2281 agtgaggaaa tgaatggttt ctgaacctgg cagttcttta agtcactagg ctggttttct
     2341 ctgtcagatt tctaataact gcgtgggccc tgcttctggt gaggtctctt cccccagctg
     2401 tggtgtagct ctctccctga tgctccctca ccttccctcc cgtctctcca cttgctagga
     2461 tggtgaggtt tgcctccagt tccaactgta tatgctgtaa ggctagggaa tcttaggagt
     2521 tctgtcgtcg gttggcacac ttgtacagtc aagtgtttac atctgggcga ctcggcctta
     2581 gacaaactca cgagtaccat ttcgagtctc ccttgccaga ctacacagag aattagaagt
     2641 taggtctgca atgagagtct gtaaactagt ctttttgcca aagtgtatga tacatgacta
     2701 aggaccaaag aaagccccca agcagatgtc tgtggtttct tctgtctctt ctgtctcctg
     2761 tgacgtacag tgtgttgttg gtgcaacaga ggaatcaata aatgtctaca gctgacaaaa
     2821 aaaaaaa
//
