LOCUS       NM_133687               2320 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus CXXC finger 5 (Cxxc5), transcript variant 1, mRNA.
ACCESSION   NM_133687
VERSION     NM_133687.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2320)
  AUTHORS   Ma,L., Wang,H., Huang,X., Huang,H., Peng,Y., Liu,H., Wang,X. and
            Cao,Z.
  TITLE     CXXC5 mitigates P. gingivalis-inhibited cementogenesis by
            influencing mitochondrial biogenesis
  JOURNAL   Cell Commun Signal 22 (1), 4 (2024)
   PUBMED   38167023
  REMARK    GeneRIF: CXXC5 mitigates P. gingivalis-inhibited cementogenesis by
            influencing mitochondrial biogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2320)
  AUTHORS   Galazo,M.J., Sweetser,D.A. and Macklis,J.D.
  TITLE     Tle4 controls both developmental acquisition and early post-natal
            maturation of corticothalamic projection neuron identity
  JOURNAL   Cell Rep 42 (8), 112957 (2023)
   PUBMED   37561632
REFERENCE   3  (bases 1 to 2320)
  AUTHORS   Kim,E., Seo,S.H., Hwang,Y., Ryu,Y.C., Kim,H., Lee,K.M., Lee,J.W.,
            Park,K.H. and Choi,K.Y.
  TITLE     Inhibiting the cytosolic function of CXXC5 accelerates diabetic
            wound healing by enhancing angiogenesis and skin repair
  JOURNAL   Exp Mol Med 55 (8), 1770-1782 (2023)
   PUBMED   37524876
  REMARK    GeneRIF: Inhibiting the cytosolic function of CXXC5 accelerates
            diabetic wound healing by enhancing angiogenesis and skin repair.
REFERENCE   4  (bases 1 to 2320)
  AUTHORS   Yoon,M., Kim,H., Shin,H., Lee,H., Kang,M.J., Park,S.H., Han,G.,
            Kim,Y. and Choi,K.Y.
  TITLE     Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes
            by restoring Wnt/beta-catenin signaling pathway
  JOURNAL   Pharmacol Res 194, 106836 (2023)
   PUBMED   37355147
  REMARK    GeneRIF: Inhibition of CXXC5 function rescues Alzheimer's disease
            phenotypes by restoring Wnt/beta-catenin signaling pathway.
REFERENCE   5  (bases 1 to 2320)
  AUTHORS   Ryu,Y.C., Park,J., Kim,Y.R., Choi,S., Kim,G.U., Kim,E., Hwang,Y.,
            Kim,H., Han,G., Lee,S.H. and Choi,K.Y.
  TITLE     CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2
  JOURNAL   Cells 12 (4), 555 (2023)
   PUBMED   36831222
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2320)
  AUTHORS   Kim,M.Y., Kim,H.Y., Hong,J., Kim,D., Lee,H., Cheong,E., Lee,Y.,
            Roth,J., Kim,D.G., Min do,S. and Choi,K.Y.
  TITLE     CXXC5 plays a role as a transcription activator for myelin genes on
            oligodendrocyte differentiation
  JOURNAL   Glia 64 (3), 350-362 (2016)
   PUBMED   26462610
  REMARK    GeneRIF: The finding of this study indicate that the regulation of
            myelin genes expression by CXXC5 is important for forming myelin
            structure involved with axonal electrical signal transfer in the
            corpus callosum.
REFERENCE   7  (bases 1 to 2320)
  AUTHORS   Lee,S.H., Kim,M.Y., Kim,H.Y., Lee,Y.M., Kim,H., Nam,K.A., Roh,M.R.,
            Min do,S., Chung,K.Y. and Choi,K.Y.
  TITLE     The Dishevelled-binding protein CXXC5 negatively regulates
            cutaneous wound healing
  JOURNAL   J Exp Med 212 (7), 1061-1080 (2015)
   PUBMED   26056233
  REMARK    GeneRIF: The Dishevelled-binding protein CXXC5 negatively regulates
            cutaneous wound healing.
REFERENCE   8  (bases 1 to 2320)
  AUTHORS   Kim,H.Y., Yoon,J.Y., Yun,J.H., Cho,K.W., Lee,S.H., Rhee,Y.M.,
            Jung,H.S., Lim,H.J., Lee,H., Choi,J., Heo,J.N., Lee,W., No,K.T.,
            Min,D. and Choi,K.Y.
  TITLE     CXXC5 is a negative-feedback regulator of the Wnt/beta-catenin
            pathway involved in osteoblast differentiation
  JOURNAL   Cell Death Differ 22 (6), 912-920 (2015)
   PUBMED   25633194
REFERENCE   9  (bases 1 to 2320)
  AUTHORS   Kim,H.Y., Yang,D.H., Shin,S.W., Kim,M.Y., Yoon,J.H., Kim,S.,
            Park,H.C., Kang,D.W., Min,D., Hur,M.W. and Choi,K.Y.
  TITLE     CXXC5 is a transcriptional activator of Flk-1 and mediates bone
            morphogenic protein-induced endothelial cell differentiation and
            vessel formation
  JOURNAL   FASEB J 28 (2), 615-626 (2014)
   PUBMED   24136587
  REMARK    GeneRIF: CXXC5 is a transcriptional activator for Flk-1, mediating
            BMP signaling for differentiation and migration of endothelial cell
            and vessel formation.
REFERENCE   10 (bases 1 to 2320)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY705532.1, BC089314.1 and AI843749.1.
            
            On Oct 28, 2017 this sequence version replaced NM_133687.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089314.1, AK005364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY705532.1         2-31
            31-2302             BC089314.1         1-2272
            2303-2320           AI843749.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.26 cM"
     gene            1..2320
                     /gene="Cxxc5"
                     /gene_synonym="4930415K17Rik"
                     /note="CXXC finger 5"
                     /db_xref="GeneID:67393"
                     /db_xref="MGI:MGI:1914643"
     exon            1..199
                     /gene="Cxxc5"
                     /gene_synonym="4930415K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            200..1263
                     /gene="Cxxc5"
                     /gene_synonym="4930415K17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1308
                     /gene="Cxxc5"
                     /gene_synonym="4930415K17Rik"
                     /codon_start=1
                     /product="CXXC-type zinc finger protein 5"
                     /protein_id="NP_598448.1"
                     /db_xref="CCDS:CCDS29150.1"
                     /db_xref="GeneID:67393"
                     /db_xref="MGI:MGI:1914643"
                     /translation="MSSLGGGSQDAGGSSSSSNTNSSSGSGQKAGGTDKSTAVAATTA
                     PTSVADDAPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGSSGGGGSMMGVESADKA
                     AAAAASLLANGHDLAAAMAVDKSNPTSKHKSGAVASLLSKAERATELAAEGQLTLQQF
                     AQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIM
                     TPAGVFLAESALHMAGLAEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSC
                     RNRKTGHQICKFRKCEELKKKPSAALEKVMLPSGAAFRWFQ"
     exon            1264..2307
                     /gene="Cxxc5"
                     /gene_synonym="4930415K17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2273..2278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxxc5"
                     /gene_synonym="4930415K17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2305
                     /gene="Cxxc5"
                     /gene_synonym="4930415K17Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaggcggcg gagcctgagc tgggatgtag aggcggcggc gagatcaggc gtccgagcag
       61 agccagaaga ggagagcctc atccccgaca gcccagcccc gcgtcccagc ctgcgcctag
      121 caatgcgcac cgcctgctga gtccgggcgc cgcacgccga gtccttcgcc cgccgcgccg
      181 cgaggcgctg cgctccggga gtaaagacat ttccacgtgg acacctgatc atgtgcctac
      241 cctgactgag gctccccagg catctctatt gtgggcagcc gtgctacacg ctcaactctg
      301 agcccccaac agtttgcagg ctcccagccc cggggtctgg gcctcggccc caccatgtcg
      361 agcctcggcg gtggctccca ggacgccggt ggcagtagca gcagcagtaa caccaatagc
      421 agcagtggca gtggccaaaa ggcaggagga acagacaaaa gtaccgcggt ggccgccacc
      481 acggcgccga cctccgtggc agacgatgcc ccaccccctg agcgtcggaa caagagcggt
      541 atcatcagtg aacccctcaa caagagcctg cggcgctccc gaccactctc tcactactct
      601 tcctttggta gcagtggtgg cggcggaagc atgatggggg tggagtctgc tgacaaggca
      661 gcggcagccg cagcctccct attggccaat ggtcatgacc tggctgcggc catggcagtg
      721 gacaaaagca accctacctc aaagcacaaa agtggtgctg tggccagcct gctgagcaag
      781 gcagagaggg ccacagagct ggcagctgag ggacagctga cgctgcagca gtttgcacag
      841 tccacagaga tgctaaagcg cgtggtgcag gaacacctgc cactgatgag tgaggccggt
      901 gccggcctgc ctgacatgga ggctgtggcc ggcgccgaag ccctcaatgg ccagtccgac
      961 ttcccctatc tgggcgcttt ccccatcaat ccaggcctct tcatcatgac cccagctggc
     1021 gtgttcctgg ctgagagtgc actgcacatg gctggcctgg ccgagtaccc catgcaggga
     1081 gagctggctt ccgccatcag ctcaggcaag aagaagcgga aacgctgcgg catgtgtgcg
     1141 ccctgccggc ggcgcatcaa ctgtgagcag tgcagcagtt gtaggaaccg aaagactggc
     1201 catcagattt gcaaattcag aaagtgtgaa gaactcaaaa agaagccttc cgctgctctg
     1261 gagaaggtga tgcttccgtc gggagccgcc ttccggtggt ttcagtgatt tcagtgacgg
     1321 ccgggaaccc aaagctgccc tctccgtgca atgtcactgc ccgcgtggtc tccggcaagg
     1381 gattcgggcg aagacaaacg gatgcacccg tctttagaac caaaaatatt ctctcacaga
     1441 tttcattcct gtttttatat atatatattt tttgttgtcg ttttaacatc tccacgtccc
     1501 tagtataaaa agaaaaagaa aagaaaaaaa attttaactg ctttttcaga agaacatcaa
     1561 caacaacaag agaggtaaag acgaatctat aaagtaccga gacttcctgg gcaaagaatg
     1621 gacaatcagt ctccttcctg tgtcaatgtc aatgtcaatg ttgtctgtgc gggagatgct
     1681 gtttttgtgt agagaatgta aattttctgt aaccttttgc aatctagtta ctaataagca
     1741 ctactgtaat ttagcacagt tttaactcca ctctcatttt aaacttcctt tgattctttc
     1801 caaccatgaa atagtgcata gtttgcctgg agaatccatt cacgtttata aaggaatagg
     1861 tggtggcacc gtgtagaagc ccctctgtat ccatccatgt gtgcagaggg gccagagccc
     1921 actgggactg ggagttcctg acccaggccc gaccatgttg caccccatcg tcccctgatt
     1981 gggattcccc ctaccccaac agtgatggat tttggagaga tgaaaattct attcatttgt
     2041 tgatccactg agatctggag agcccacatc tcagtatttc tgatcctggc tacttccctt
     2101 agagaaaata agccctcttt tctcagcctt gctcgcagca gcagaagaaa gggcttctct
     2161 gcgtggtccc ctgctggtag gggtgggtgc ccagggggcc ccctgcccgt ggccagctcc
     2221 ctgctgagga acatgctgtt tgtattgttt taggagacca ggctgttttg tgaataaaac
     2281 tgaatgcatg tttgtgtcat gataacaaaa aaaaaaaaaa
//
