LOCUS       NM_001004367            5619 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CXXC finger 4 (Cxxc4), mRNA.
ACCESSION   NM_001004367 XM_131233
VERSION     NM_001004367.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5619)
  AUTHORS   Pappas,M.P., Kawakami,H., Corcoran,D., Chen,K.Q., Scott,E.P.,
            Wong,J., Gearhart,M.D., Nishinakamura,R., Nakagawa,Y. and
            Kawakami,Y.
  TITLE     Sall4 regulates posterior trunk mesoderm development by promoting
            mesodermal gene expression and repressing neural genes in the
            mesoderm
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38345319
REFERENCE   2  (bases 1 to 5619)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5619)
  AUTHORS   Abou-Jaoude,A., Huang,C.Y., Flores,J.C., Ravichandran,M., Lei,R.,
            Chrysanthou,S. and Dawlaty,M.M.
  TITLE     Idax and Rinf facilitate expression of Tet enzymes to promote
            neural and suppress trophectodermal programs during differentiation
            of embryonic stem cells
  JOURNAL   Stem Cell Res 61, 102770 (2022)
   PUBMED   35390758
  REMARK    GeneRIF: Idax and Rinf facilitate expression of Tet enzymes to
            promote neural and suppress trophectodermal programs during
            differentiation of embryonic stem cells.
REFERENCE   4  (bases 1 to 5619)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5619)
  AUTHORS   Guan,B., Zhan,Z., Wang,L., Wang,L. and Liu,L.
  TITLE     CXXC4 mediates glucose-induced beta-cell proliferation
  JOURNAL   Acta Diabetol 57 (9), 1101-1109 (2020)
   PUBMED   32280999
  REMARK    GeneRIF: CXXC4 mediates glucose-induced beta-cell proliferation.
REFERENCE   6  (bases 1 to 5619)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (bases 1 to 5619)
  AUTHORS   Liu,N., Wang,M., Deng,W., Schmidt,C.S., Qin,W., Leonhardt,H. and
            Spada,F.
  TITLE     Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC
            zinc finger modules
  JOURNAL   PLoS One 8 (5), e62755 (2013)
   PUBMED   23690950
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5619)
  AUTHORS   Ko,M., An,J., Bandukwala,H.S., Chavez,L., Aijo,T., Pastor,W.A.,
            Segal,M.F., Li,H., Koh,K.P., Lahdesmaki,H., Hogan,P.G., Aravind,L.
            and Rao,A.
  TITLE     Modulation of TET2 expression and 5-methylcytosine oxidation by the
            CXXC domain protein IDAX
  JOURNAL   Nature 497 (7447), 122-126 (2013)
   PUBMED   23563267
  REMARK    GeneRIF: IDAX depletion prevents TET2 downregulation in
            differentiating mouse embryonic stem cells
REFERENCE   9  (bases 1 to 5619)
  AUTHORS   Mori,A.D., Zhu,Y., Vahora,I., Nieman,B., Koshiba-Takeuchi,K.,
            Davidson,L., Pizard,A., Seidman,J.G., Seidman,C.E., Chen,X.J.,
            Henkelman,R.M. and Bruneau,B.G.
  TITLE     Tbx5-dependent rheostatic control of cardiac gene expression and
            morphogenesis
  JOURNAL   Dev Biol 297 (2), 566-586 (2006)
   PUBMED   16870172
  REMARK    Erratum:[Dev Biol. 2007 Sep 15;309(2):386]
REFERENCE   10 (bases 1 to 5619)
  AUTHORS   Hino,S., Kishida,S., Michiue,T., Fukui,A., Sakamoto,I., Takada,S.,
            Asashima,M. and Kikuchi,A.
  TITLE     Inhibition of the Wnt signaling pathway by Idax, a novel
            Dvl-binding protein
  JOURNAL   Mol Cell Biol 21 (1), 330-342 (2001)
   PUBMED   11113207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164408.4.
            
            On Dec 28, 2011 this sequence version replaced NM_001004367.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.912011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AC164408.4         41660-41851
            193-268             AC164408.4         41977-42052
            269-1581            AC164408.4         44568-45880
            1582-5619           AC164408.4         63218-67255
FEATURES             Location/Qualifiers
     source          1..5619
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 62.12 cM"
     gene            1..5619
                     /gene="Cxxc4"
                     /gene_synonym="9330210J02Rik; C030003J12Rik; Idax"
                     /note="CXXC finger 4"
                     /db_xref="GeneID:319478"
                     /db_xref="MGI:MGI:2442112"
     exon            1..192
                     /gene="Cxxc4"
                     /gene_synonym="9330210J02Rik; C030003J12Rik; Idax"
                     /inference="alignment:Splign:2.1.0"
     exon            193..268
                     /gene="Cxxc4"
                     /gene_synonym="9330210J02Rik; C030003J12Rik; Idax"
                     /inference="alignment:Splign:2.1.0"
     exon            269..1581
                     /gene="Cxxc4"
                     /gene_synonym="9330210J02Rik; C030003J12Rik; Idax"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..1626
                     /gene="Cxxc4"
                     /gene_synonym="9330210J02Rik; C030003J12Rik; Idax"
                     /note="inhibition of the Dvl and axin complex protein"
                     /codon_start=1
                     /product="CXXC-type zinc finger protein 4"
                     /protein_id="NP_001004367.2"
                     /db_xref="CCDS:CCDS17851.2"
                     /db_xref="GeneID:319478"
                     /db_xref="MGI:MGI:2442112"
                     /translation="MNTNVCVEPGPSPEAPGLPKESHLPEGALNSLVDYNSEMERYRS
                     FATSFYKTNGGAFPQAAKIARITTPIFPSSAAAAAAAARIGMSPWNCDNAATAAATAM
                     LWGSGGGGGGGGGGGGGGGAGRKSSSAAASSSASSSAILPAAGGGGGGGGGGSGGGGG
                     GGGGGRTSMHHRNDSQRLGKAGCPPEPSLQMANTNFLSTLSPEHCRPLAGECMNKLKC
                     GAAEAEIMNLPERVGTFSAIPALGGISLPPGVIVMTALHSPAAASAAVTDSAFQIANL
                     ADCPQNHSSSSSSSSGGAGGANPAKKKRKRCGVCVPCKRLINCGVCSSCRNRKTGHQI
                     CKFRKCEELKKKPGTSLERTPVPSAEAFRWFF"
     exon            1582..5619
                     /gene="Cxxc4"
                     /gene_synonym="9330210J02Rik; C030003J12Rik; Idax"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2182..2187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxxc4"
                     /gene_synonym="9330210J02Rik; C030003J12Rik; Idax"
                     /note="hexamer: AATAAA"
     polyA_site      2202
                     /gene="Cxxc4"
                     /gene_synonym="9330210J02Rik; C030003J12Rik; Idax"
                     /note="major polyA site"
ORIGIN      
        1 acagcgactg gagacggacc gggagcaacg cgccgggaag agcagagacc accgacaaca
       61 gccccgcgct ctcccacaca cgctcacact cggcgctttc ctctccaccc ccacctcctc
      121 ctccttccac cccctccact aacaccatct cctcctcctc tctacaacaa gaaaaaaaaa
      181 agccatttac agggggtgat gtgcaactaa ttaaaggcag actggcagcg tctgtaaatt
      241 ctaaggctcc ccaaataaaa agagactgtt gtaacagttg gaggataatg caaaggaaga
      301 cgctgcttgg gaagtcaccg tctgtggaca tgcgccccag agaggactag agcagccctc
      361 gccttgctct ccccacccgg atcccacttt cctgcacggc ccggcccgta ccccgacccc
      421 accatcaccc gcttcccttc cccccacctc tccccctttc ccacccaggt gtcggaccag
      481 gcggtcccca cttccaccct gcaccccttc ttccccccct gcaccatgaa caccaatgtc
      541 tgcgtggagc ccgggccgag cccggaggcc ccgggcttgc ccaaggaaag ccacctgccc
      601 gagggggccc tgaacagcct tgtggattac aactcggaga tggagcgtta ccgctccttt
      661 gccacctcct tctacaagac caacgggggc gccttcccgc aggcagccaa gatcgcgcgc
      721 atcaccaccc ccatcttccc cagcagcgcc gccgccgccg cggccgccgc gcgcatcggc
      781 atgtccccgt ggaactgcga caacgcggcc accgccgccg ccaccgcgat gctctggggc
      841 agcgggggcg gcggcggagg cggtgggggc gggggtgggg gcggcggggc cggcaggaaa
      901 tcctcctcgg ccgccgcctc ctcctccgcc tcctcctcgg cgatcctccc cgccgccggc
      961 ggtggcggtg gcggcggcgg cggtggcagc ggcggaggcg gcggcggcgg cggcggcggc
     1021 aggaccagca tgcaccaccg gaacgactcc cagcggctgg ggaaggctgg ctgtccgcca
     1081 gagccgtcgt tgcaaatggc aaatactaat ttcctctcca ccttatcccc cgaacactgc
     1141 agacctttgg cgggggaatg catgaacaag ctcaaatgcg gcgctgctga agcagagata
     1201 atgaatctcc ccgagcgggt ggggactttt tccgctatcc cggctttagg gggcatctca
     1261 ttacctccag gggtcatcgt catgacagcc cttcactccc ccgcagcagc ctcagcagcc
     1321 gtcacagaca gtgcgtttca aattgccaat ctggcagact gcccgcagaa tcattcctcc
     1381 tcctcctcgt cctcctcggg gggagctggc ggagccaacc cggccaagaa gaagaggaaa
     1441 aggtgtgggg tctgcgtgcc ctgcaagagg ctcatcaact gtggcgtctg cagcagttgc
     1501 aggaaccgca aaacgggaca ccagatctgc aaatttagaa aatgtgaaga gctaaagaaa
     1561 aaacctggca cttcgctaga gagaacacct gttcccagcg ctgaagcgtt ccgatggttc
     1621 ttttaaagct gtagtgtatc ttattttcaa ggcatttggg aatgaagggc aaactaatgt
     1681 cttgttttaa gaaaccgctt agtccaccat tgaagaaatt atccagaaat tattttcatt
     1741 ttatgtatag ggatttcttc aaaaaaaatc aaaaaacaaa aaacaagagg aaaagaaaac
     1801 accaacagca acaacaaaaa aaagacacat aaaattaaca gggaagtttg gggaattggc
     1861 cagtttattt actttcaata cactgattct tcctttgatg tatttagctc tactagtgaa
     1921 gttgttgtct attttgaaag tggctgtaaa aaaaaataat aataataagt ttgggtaacc
     1981 cccgactgta aaatcatgta tctttgcaaa gtacatatct atacttcatt ttcaaatata
     2041 tgtgtttcag tactgtaaac tgtacagata gcagcttgta ttttgtgtgt ttagacacaa
     2101 ggagacaatc atgtctgagc atctatggag attaacagtt tgtacacaac actatggttc
     2161 tgcaagttaa aaatctggag caataaattt tagctttaaa tattttttgg ccagttgttt
     2221 ttagaagcag aaacaacacc ggcgggtggt tttcatgcat ctttgtgtag aggcttgttg
     2281 gctggtttgt caagactaaa agataatgcc gcatccagca atgaccttcg gttgtgttga
     2341 tataagaggg aaagctacaa tgaaggttgc aattaatctt ttgagcactg tattagagta
     2401 gtggttatgc acttgcattg cttacaaacg agctgtacag aggggatacc cccggatatt
     2461 tagtgtagtt gacatgtttg ggttgcactg taaggggagt acgctgaata gttggaaaat
     2521 gcagattcag ttctatcttt tttaattttt tttaattgaa aatgtgtttt ctaggctaac
     2581 cttatcagat catagaaaga caaattcatg cctgacacca cttttttccc ctaggcatac
     2641 acaggttgtt taagcttttt tattctttga ttattatttt gctttgggga agggtaagaa
     2701 aaacaaaaac cagagagtat tcaaaatgtt tgaattctgt gtatgacgct ggatgggtag
     2761 gtttaaaaca atgctcaaat gcattgaagc ctactttaag gcatgactgg gcttattttc
     2821 aagttcaaaa taatcaagca cattggttaa aagggaggct tttttttttt gtttctttat
     2881 cttcctttcc ttagtctctc agttggacca ctattcttcc ccagtctctc atggaacacc
     2941 cactgcttcc ctcccctttc ttaccactgg aagctttctt ttcactgaag caaggccaca
     3001 gtgtgaggaa tttcataaaa acaagacagc ccatccccca ctcccacctc agaatgcttt
     3061 atagaaccag ggctgcctca ccctgtacga gttggtttgc ctagaacagt cttgcttctc
     3121 aaaggatgcc catcccaata agacaactag cctaaaagaa tcagtttcag gaataaaaca
     3181 tagtttagga aagacacaaa gaataacaaa gttgccgcgt cacttacctc tttgttcttt
     3241 atgaccacca gacaggttag ccagctgaat caaaaggaaa gcaacaggag agatcgataa
     3301 gtcagccaag actttagagt ctaaagggct tcaaaagctg acaggggaat attttaaaaa
     3361 tttcatttta gatttgaatg gaaagaggga tgacattttt ttttttctaa aggcaggtca
     3421 aatactacgc catcattggt catctggatg agagtatagt aggtttgtag gacgcaagtg
     3481 taaggcacca gtgggacgaa tgtgcctggc tagcatacca gtgcttagtc tgcagtatgg
     3541 tcaagcagcg tttgtgagga aaatgtatta tgtattacac ctgcctatgc ttaaaaagag
     3601 ggatgaactc atcaaaaggt aaaatgtgct gtgtattact tttgagatag cattctcctc
     3661 cgtgtgaatt ccctagactg tttgaagcta taatttctgt ttctgctgta ggaccaatga
     3721 gagttctatg atttctttat ttctttattg tcccactgtc tgtctgcctg tctgtctgtc
     3781 tctttacaat ttttacttta ttattttatt ttattcttat tttggacaat ttgttagtga
     3841 actatgagca cgtgaaaatt tattttcaca cttgaatggg acgcttccct tgcttatgtt
     3901 aagaaaaaaa atgattataa atgaaaccaa tttcctttca gactgtatta ggcacacaat
     3961 aaggacctca tagcaatgta tggaaagtca aaaactcaag gtggtattgc atatcttgat
     4021 atatttttct gtttgtttgt ttgtttgttt tttggctttt gttctaagac aatgaatttg
     4081 tgtattgtaa atgtgttgtt tcacatggct gtccatttat ttttaagtag aggaatctgt
     4141 ttgttaccat gatgaacagt gtggcctttt ttctttaatt tttttttttg cattttcatt
     4201 attaacacta attgctctta tgccacacac ttcttatgtt tcctcttaaa ctcagtttac
     4261 aaaatgtagg gtacagatag agttctcact ggtgatggtg aagaaatgag ccttctacat
     4321 tacctctagt tttctttctc aagtttatct acataccaac agcctgtagc cttagggcag
     4381 tgaagggatg cctgtgtatt ttctttattt caaaaatgta aatgaaacat aacttttaac
     4441 agcggctcac tgtgtgtctc attttccata ccaaggaaat ttagaagtta gcaatcagat
     4501 tgtaggtcgt atatatacaa cttaaaactg acatgccaga ccagatgttg ctcaagctgc
     4561 tggagaagtc cacgtacaca agagtccagt cttcacggat gccattccct ggcagcattt
     4621 gaggggagta caggagaaca tgtgggccgt tggcacatag tgtgttttgc agatgctcca
     4681 tctagctatt ccttagcaca ccagaagaat attataatgc agagctctgt ctttattgac
     4741 tttcagacta aagtgacttt ctgttggact cctcttctcc tcatacaaac acagaggccc
     4801 actcacaaag tagtactgac tccatccaga ttacatgaat agtaaatatc ttcccctaat
     4861 gtatgggtat gcaaaaacgt ctcctgtttt gtttaacccc aaaccttcca tttcatacta
     4921 agcaatcaca gggagtgaga gacaatgggc ttgttatgaa ttaacattaa gtaatcatga
     4981 aaggaatgga atgttccatc ctttgtcaga agccctggtg tggatgttgt tcaattagtg
     5041 ctaaagcata gaaagactag ctgattgtat cagtaatcaa agaaagaaaa tagagacaca
     5101 gttaaatgaa ggcacgagtc agggtcaaat atgttgagca gaaagctgta gtgggtcttt
     5161 gatcatggtg agattcacag cgatatcaaa cagttggttc tcatgtaaca gctaaatgtt
     5221 tcagattttg ttttttatta aatttgacat ttcacactga gatctgtatt cctagcgagt
     5281 agaacacagc tcctgtgttc agagggattc cgttccacaa ttgacaaata gatatttcag
     5341 gacatgggcc accaagtgta ctccgttccc agtgtcctcc cgttctgaac tgtgcagtta
     5401 tcggttacat tttctaatag atatttgtgt aaaagtgtat gtaagcttgt gcagttattt
     5461 taaaaagcag ttttggaaaa cagtgtattt attaaagaaa aaatcactta tggggcatgt
     5521 acaaaactgt aaaaaaaatt aaaaatcact tcaatttgcc cagtaaagtt gtttttgtga
     5581 gatttctgtg ttgttaaata aaggacttta gtactcaaa
//
