LOCUS       NM_028868               2537 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus CXXC finger protein 1 (Cxxc1), transcript variant 1,
            mRNA.
ACCESSION   NM_028868
VERSION     NM_028868.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2537)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   2  (bases 1 to 2537)
  AUTHORS   Shen,X., Gao,X., Luo,Y., Xu,Q., Fan,Y., Hong,S., Huang,Z., Liu,X.,
            Wang,Q., Chen,Z., Wang,D., Lu,L., Wu,C., Liang,H. and Wang,L.
  TITLE     Cxxc finger protein 1 maintains homeostasis and function of
            intestinal group 3 innate lymphoid cells with aging
  JOURNAL   Nat Aging 3 (8), 965-981 (2023)
   PUBMED   37429951
REFERENCE   3  (bases 1 to 2537)
  AUTHORS   Yang,S.C., Park,M., Hong,K.H., La,H., Park,C., Wang,P., Li,G.,
            Chen,Q., Choi,Y., DeMayo,F.J., Lydon,J.P., Skalnik,D.G., Lim,H.J.,
            Hong,S.H., Park,S.H., Kim,Y.S., Kim,H.R. and Song,H.
  TITLE     CFP1 governs uterine epigenetic landscapes to intervene in
            progesterone responses for uterine physiology and suppression of
            endometriosis
  JOURNAL   Nat Commun 14 (1), 3220 (2023)
   PUBMED   37270588
  REMARK    GeneRIF: CFP1 governs uterine epigenetic landscapes to intervene in
            progesterone responses for uterine physiology and suppression of
            endometriosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2537)
  AUTHORS   Ki,B.S., Shim,S.H., Park,C., Yoo,H., La,H., Lee,O.H., Kwon,Y.,
            Skalnik,D.G., Okada,Y., Yoon,H.G., Kim,J.H., Hong,K. and Choi,Y.
  TITLE     Epigenetic regulator Cfp1 safeguards male meiotic progression by
            regulating meiotic gene expression
  JOURNAL   Exp Mol Med 54 (8), 1098-1108 (2022)
   PUBMED   35918532
REFERENCE   5  (bases 1 to 2537)
  AUTHORS   Wu,Y.W., Li,S., Zheng,W., Li,Y.C., Chen,L., Zhou,Y., Deng,Z.Q.,
            Lin,G., Fan,H.Y. and Sha,Q.Q.
  TITLE     Dynamic mRNA degradome analyses indicate a role of histone H3K4
            trimethylation in association with meiosis-coupled mRNA decay in
            oocyte aging
  JOURNAL   Nat Commun 13 (1), 3191 (2022)
   PUBMED   35680896
  REMARK    Erratum:[Nat Commun. 2022 Jun 15;13(1):3441. doi:
            10.1038/s41467-022-31224-4.. PMID: 35705535]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2537)
  AUTHORS   Carlone,D.L., Lee,J.H., Young,S.R., Dobrota,E., Butler,J.S.,
            Ruiz,J. and Skalnik,D.G.
  TITLE     Reduced genomic cytosine methylation and defective cellular
            differentiation in embryonic stem cells lacking CpG binding protein
  JOURNAL   Mol Cell Biol 25 (12), 4881-4891 (2005)
   PUBMED   15923607
  REMARK    GeneRIF: findings show that CGBP is essential for normal epigenetic
            modification of the genome by cytosine methylation and for cellular
            differentiation, consistent with the requirement for CGBP during
            early mammalian development
REFERENCE   7  (bases 1 to 2537)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2537)
  AUTHORS   Lee,J.H. and Skalnik,D.G.
  TITLE     CpG-binding protein is a nuclear matrix- and euchromatin-associated
            protein localized to nuclear speckles containing human trithorax.
            Identification of nuclear matrix targeting signals
  JOURNAL   J Biol Chem 277 (44), 42259-42267 (2002)
   PUBMED   12200428
REFERENCE   9  (bases 1 to 2537)
  AUTHORS   Carlone,D.L., Hart,S.R., Ladd,P.D. and Skalnik,D.G.
  TITLE     Cloning and characterization of the gene encoding the mouse
            homologue of CpG binding protein
  JOURNAL   Gene 295 (1), 71-77 (2002)
   PUBMED   12242013
REFERENCE   10 (bases 1 to 2537)
  AUTHORS   Carlone,D.L. and Skalnik,D.G.
  TITLE     CpG binding protein is crucial for early embryonic development
  JOURNAL   Mol Cell Biol 21 (22), 7601-7606 (2001)
   PUBMED   11604496
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133186.4.
            
            On Apr 30, 2007 this sequence version replaced NM_028868.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010337.1, AK146688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AC133186.4         166323-166593
            272-390             AC133186.4         167278-167396
            391-491             AC133186.4         167500-167600
            492-727             AC133186.4         167872-168107
            728-919             AC133186.4         168197-168388
            920-946             AC133186.4         168740-168766
            947-1192            AC133186.4         168843-169088
            1193-1300           AC133186.4         169242-169349
            1301-1485           AC133186.4         169494-169678
            1486-1693           AC133186.4         169949-170156
            1694-1804           AC133186.4         170232-170342
            1805-1854           AC133186.4         170468-170517
            1855-1951           AC133186.4         170620-170716
            1952-2104           AC133186.4         170939-171091
            2105-2537           AC133186.4         171170-171602
FEATURES             Location/Qualifiers
     source          1..2537
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 50.7 cM"
     gene            1..2537
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /note="CXXC finger protein 1"
                     /db_xref="GeneID:74322"
                     /db_xref="MGI:MGI:1921572"
     exon            1..271
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..2251
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /note="isoform 1 is encoded by transcript variant 1; CpG
                     binding protein; cpG-binding protein; CXXC-type zinc
                     finger protein 1; PHD finger and CXXC domain-containing
                     protein 1; CXXC finger 1 (PHD domain)"
                     /codon_start=1
                     /product="CXXC-type zinc finger protein 1 isoform 1"
                     /protein_id="NP_083144.1"
                     /db_xref="CCDS:CCDS50320.1"
                     /db_xref="GeneID:74322"
                     /db_xref="MGI:MGI:1921572"
                     /translation="MEGDGSDLEPPDAGDDSKSENGENAPIYCICRKPDINCFMIGCD
                     NCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKCRERDGSERAGSEP
                     RDEGGGRKRPASDPELQRRAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHHQQQQ
                     QQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARE
                     SYKYFPSSLSPVTPSEALPRPRRPPPTQQQPQQSQKLGRIREDEGTVLSSVVKEPPEA
                     TATPEPLSDEDLALDPDLYQDFCAGAFDDHGLPWMSDAEESPFLDPALRKRAVKVKHV
                     KRREKKSEKKKEERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRAAQPGS
                     KYCSDDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQE
                     MERRFHELEAIILRAKQQAVREDEENNENDSDDTDLQIFCVSCGHPINPRVALRHMER
                     CYAKYESQTSFGSMYPTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKVPADE
                     VCGCPLVRDVFELTGDFCRLPKRQCNRHYCWEKLRRAEVDLERVRVWYKLDELFEQER
                     NVRTAMTNRAGLLALMLHQTIQHDPLTTDLRSSADR"
     exon            272..390
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     exon            391..491
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     exon            492..727
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     exon            728..919
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     exon            920..946
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1192
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1300
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1485
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1693
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1804
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1854
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1951
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2104
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2537
                     /gene="Cxxc1"
                     /gene_synonym="2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp;
                     PHF18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtcttac ggactcgatg gtcaagatgg cggcgacaga gagaccttcg cggctctagg
       61 tgggagacct atttgtttgc cgctaaagcc gtcgcgccgg gcgtgaggag ttaaagagtg
      121 cggggccgcg gaggcgggac cagtggcgga agtagttgcg ggcgcctttg cgggcgcctt
      181 tgctcccgcc gcggacgctg ccggggagct cgttcggctt cgcgggttgt tgcacggggt
      241 ccagagcggg cgctctgtga gcggagatat ggaaggagat ggctcagacc tggaacctcc
      301 ggatgccggg gacgacagca agtctgagaa tggggagaac gctcccatct actgcatctg
      361 tcgcaaaccg gacatcaatt gcttcatgat tggatgtgac aactgcaacg agtggttcca
      421 tggagactgc atccggatca ctgagaagat ggccaaggcc atccgggaat ggtactgtcg
      481 ggagtgccga gagaaggacc cgaagctgga gattcgttac cgccacaaaa agtgccggga
      541 gagggatggc agtgagcggg ccggcagtga gccccgggat gagggaggag ggcgcaagag
      601 gccggcttca gatccagagc tgcagcgccg ggcagggtca gggacagggg ttggggccat
      661 gcttgctcgg ggctctgctt ccccccacaa atcttctcca cagcccttgg tggccacacc
      721 tagccagcac caccaccaac agcagcagca gcagcagcag caaatcaaac gatcagctcg
      781 gatgtgtggt gagtgcgagg cctgccgacg cactgaggac tgtggccact gtgacttctg
      841 ccgtgacatg aagaagtttg ggggccccaa caagatccgg cagaagtgcc ggcttcgtca
      901 gtgtcagctg cgggcacggg aatcgtacaa gtacttccct tcctcgctct cgccggtgac
      961 accctcagag gccctgccaa ggccccgccg gccaccaccc actcaacagc agccacagca
     1021 gtcccagaag ctggggcgta ttcgtgaaga tgaggggaca gtgttgtcat cagtggttaa
     1081 ggagccacca gaggctacag caacacctga gccactttca gatgaggacc tagcactgga
     1141 ccccgatctg taccaggact tctgtgctgg ggcctttgat gatcacggcc taccctggat
     1201 gagcgatgca gaagagtccc cgttcctgga tcctgcactg aggaagcggg cggtgaaggt
     1261 gaagcacgtg aagcgccggg agaagaagtc cgagaagaag aaggaggaga ggtacaaacg
     1321 gcatcgacag aagcagaaac ataaagacaa atggaaacac ccagagaggg ctgatgccaa
     1381 ggaccctgca tctctcccgc agtgcctggg gcctggctgt gtgcgggctg cccagcctgg
     1441 gtccaagtat tgttcagatg actgtggcat gaagctggca gccaaccgaa tctatgagat
     1501 cctcccccag cgcatccagc agtggcagca aagcccctgc atcgctgaag agcacggcaa
     1561 gaagctactt gagcggatcc gccgtgagca gcagagcgcc cgcacccgcc ttcaggaaat
     1621 ggagcgcaga ttccacgagc ttgaggccat cattcttcgc gctaagcagc aagctgtgcg
     1681 agaggatgag gagaacaacg agaacgacag tgatgacaca gatctgcaga tcttctgcgt
     1741 ctcctgcggg catcccatca acccacgagt tgccttgcgt cacatggaac gttgctatgc
     1801 taagtatgag agccagacgt cttttgggtc catgtacccc acacgcatcg agggggctac
     1861 ccgactcttc tgtgatgtct acaatcctca gagcaagaca tattgtaagc ggctccaggt
     1921 gctgtgtcct gagcactccc gggaccccaa agtgccagct gatgaggtct gtgggtgtcc
     1981 acttgtacgt gatgtctttg agctcacagg tgacttctgc cgcctgccca agcgccagtg
     2041 taatcgccat tattgctggg agaagcttcg gcgtgcagaa gtggacttgg agcgcgtgcg
     2101 ggtgtggtac aagctggacg agctctttga gcaggaacgt aatgtacgca cagccatgac
     2161 caacagagca gggctacttg ccctgatgct tcaccaaacg atccaacacg atccactcac
     2221 taccgacctt cgctctagtg ccgaccgctg acttcaccag cccagagcct ctcggccctg
     2281 cattcagtta ggggagaggc cctgcattgc cagctgtccg ttcctccatt catctgtttc
     2341 ttctgctgcc cttagtttga tcctcaccat ccacgttttg gcttccgttt gcccttatca
     2401 aagggtctct gctttccctt tgtcaccgtc tgtctcctct ttccatagtc agggctgggg
     2461 tgagactcaa acttactcat ccttgcctat acccaccccc caaaaacagg ttttattaat
     2521 aaaaaatgtg aagaacc
//
