LOCUS       NM_030712               1893 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus C-X-C motif chemokine receptor 6 (Cxcr6), mRNA.
ACCESSION   NM_030712
VERSION     NM_030712.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1893)
  AUTHORS   Tooley,K., Jerby,L., Escobar,G., Krovi,S.H., Mangani,D.,
            Dandekar,G., Cheng,H., Madi,A., Goldschmidt,E., Lambden,C.,
            Krishnan,R.K., Rozenblatt-Rosen,O., Regev,A. and Anderson,A.C.
  TITLE     Pan-cancer mapping of single CD8+ T cell profiles reveals a
            TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor
            immunity
  JOURNAL   Cell Rep Med 5 (7), 101640 (2024)
   PUBMED   38959885
  REMARK    GeneRIF: Pan-cancer mapping of single CD8[+] T cell profiles
            reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and
            anti-tumor immunity.
REFERENCE   2  (bases 1 to 1893)
  AUTHORS   Liang,Z., Tang,Z., Zhu,C., Li,F., Chen,S., Han,X., Zheng,R., Hu,X.,
            Lin,R., Pei,Q., Yin,C., Wang,J., Tang,C., Cao,N., Zhao,J., Wang,R.,
            Li,X., Luo,N., Wen,Q., Yu,J., Li,J., Xia,X., Zheng,X., Wang,X.,
            Huang,N., Zhong,Z., Mo,C., Chen,P., Wang,Y., Fan,J., Guo,Y.,
            Zhong,H., Liu,J., Peng,Z., Mao,H., Shi,G.P., Bonventre,J.V.,
            Chen,W. and Zhou,Y.
  TITLE     Intestinal CXCR6+ ILC3s migrate to the kidney and exacerbate renal
            fibrosis via IL-23 receptor signaling enhanced by PD-1 expression
  JOURNAL   Immunity 57 (6), 1306-1323 (2024)
   PUBMED   38815582
REFERENCE   3  (bases 1 to 1893)
  AUTHORS   Zou,D., Yin,Z., Yi,S.G., Wang,G., Guo,Y., Xiao,X., Li,S., Zhang,X.,
            Gonzalez,N.M., Minze,L.J., Wang,L., Wong,S.T.C., Osama Gaber,A.,
            Ghobrial,R.M., Li,X.C. and Chen,W.
  TITLE     CD4+ T cell immunity is dependent on an intrinsic stem-like program
  JOURNAL   Nat Immunol 25 (1), 66-76 (2024)
   PUBMED   38168955
REFERENCE   4  (bases 1 to 1893)
  AUTHORS   Munoz-Ruiz,M., Llorian,M., D'Antuono,R., Pavlova,A.,
            Mavrigiannaki,A.M., McKenzie,D., Garcia-Cassani,B., Iannitto,M.L.,
            Wu,Y., Dart,R., Davies,D., Jamal-Hanjani,M., Jandke,A.,
            Ushakov,D.S. and Hayday,A.C.
  TITLE     IFN-gamma-dependent interactions between tissue-intrinsic
            gammadelta T cells and tissue-infiltrating CD8 T cells limit
            allergic contact dermatitis
  JOURNAL   J Allergy Clin Immunol 152 (6), 1520-1540 (2023)
   PUBMED   37562754
REFERENCE   5  (bases 1 to 1893)
  AUTHORS   Su,W., Saravia,J., Risch,I., Rankin,S., Guy,C., Chapman,N.M.,
            Shi,H., Sun,Y., Kc,A., Li,W., Huang,H., Lim,S.A., Hu,H., Wang,Y.,
            Liu,D., Jiao,Y., Chen,P.C., Soliman,H., Yan,K.K., Zhang,J.,
            Vogel,P., Liu,X., Serrano,G.E., Beach,T.G., Yu,J., Peng,J. and
            Chi,H.
  TITLE     CXCR6 orchestrates brain CD8+ T cell residency and limits mouse
            Alzheimer's disease pathology
  JOURNAL   Nat Immunol 24 (10), 1735-1747 (2023)
   PUBMED   37679549
  REMARK    GeneRIF: CXCR6 orchestrates brain CD8[+] T cell residency and
            limits mouse Alzheimer's disease pathology.
REFERENCE   6  (bases 1 to 1893)
  AUTHORS   Johnston,B., Kim,C.H., Soler,D., Emoto,M. and Butcher,E.C.
  TITLE     Differential chemokine responses and homing patterns of murine TCR
            alpha beta NKT cell subsets
  JOURNAL   J Immunol 171 (6), 2960-2969 (2003)
   PUBMED   12960320
REFERENCE   7  (bases 1 to 1893)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   8  (bases 1 to 1893)
  AUTHORS   Kiss,H., Darai,E., Kiss,C., Kost-Alimova,M., Klein,G.,
            Dumanski,J.P. and Imreh,S.
  TITLE     Comparative human/murine sequence analysis of the common eliminated
            region 1 from human 3p21.3
  JOURNAL   Mamm Genome 13 (11), 646-655 (2002)
   PUBMED   12461651
REFERENCE   9  (bases 1 to 1893)
  AUTHORS   Matloubian,M., David,A., Engel,S., Ryan,J.E. and Cyster,J.G.
  TITLE     A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo
  JOURNAL   Nat Immunol 1 (4), 298-304 (2000)
   PUBMED   11017100
REFERENCE   10 (bases 1 to 1893)
  AUTHORS   Unutmaz,D., Xiang,W., Sunshine,M.J., Campbell,J., Butcher,E. and
            Littman,D.R.
  TITLE     The primate lentiviral receptor Bonzo/STRL33 is coordinately
            regulated with CCR5 and its expression pattern is conserved between
            human and mouse
  JOURNAL   J Immunol 165 (6), 3284-3292 (2000)
   PUBMED   10975845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF305709.1, AF301018.1, BQ562712.1 and AK137703.1.
            
            On Sep 14, 2007 this sequence version replaced NM_030712.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB660928.1, AK153914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-693               AF305709.1         4-696
            694-1241            AF301018.1         697-1244
            1242-1460           AF305709.1         1245-1463
            1461-1480           AF305709.1         1465-1484
            1481-1610           AF305709.1         1486-1615
            1611-1791           BQ562712.1         104-284             c
            1792-1893           AK137703.1         1771-1872
FEATURES             Location/Qualifiers
     source          1..1893
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 74.57 cM"
     gene            1..1893
                     /gene="Cxcr6"
                     /gene_synonym="BONZO; STRL33"
                     /note="C-X-C motif chemokine receptor 6"
                     /db_xref="GeneID:80901"
                     /db_xref="MGI:MGI:1934582"
     exon            1..69
                     /gene="Cxcr6"
                     /gene_synonym="BONZO; STRL33"
                     /inference="alignment:Splign:2.1.0"
     exon            70..1893
                     /gene="Cxcr6"
                     /gene_synonym="BONZO; STRL33"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1130
                     /gene="Cxcr6"
                     /gene_synonym="BONZO; STRL33"
                     /note="CXC-R6; CXCR-6; chemokine (C-X-C motif) receptor 6"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 6"
                     /protein_id="NP_109637.3"
                     /db_xref="CCDS:CCDS23664.1"
                     /db_xref="GeneID:80901"
                     /db_xref="MGI:MGI:1934582"
                     /translation="MDDGHQESALYDGHYEGDFWLFNNSSDNSQENKRFLKFKEVFLP
                     CVYLVVFVFGLLGNSLVLIIYIFYQKLRTLTDVFLLNLPLADLVFVCTLPFWAYAGTY
                     EWVFGTVMCKTLRGMYTMNFYVSMLTLTCITVDRFIVVVQATKAFNRQAKWKIWGQVI
                     CLLIWVVSLLVSLPQIIYGHVQDIDKLICQYHSEEISTMVLVIQMTLGFFLPLLTMIL
                     CYSGIIKTLLHARNFQKHKSLKIIFLVVAVFLLTQTPFNLAMLIQSTSWEYYTITSFK
                     YAIVVTEAIAYFRACLNPVLYAFVGLKFRKNVWKLMKDIGCLSHLGVSSQWKSSEDSS
                     KTCSASHNVETTSMFQL"
     regulatory      1874..1879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcr6"
                     /gene_synonym="BONZO; STRL33"
                     /note="hexamer: AATAAA"
     polyA_site      1893
                     /gene="Cxcr6"
                     /gene_synonym="BONZO; STRL33"
                     /note="major polyA site"
ORIGIN      
        1 agagaaccag aggcagacct ttagtgagca cacttcactc tggaacaaag ctactgggct
       61 tctcttctga tgccatggat gatgggcatc aagagtcagc tctgtacgat gggcactacg
      121 agggagattt ctggctcttc aacaattcca gtgataacag ccaggagaac aaacgcttcc
      181 taaagttcaa ggaggtcttt ttgccctgtg tgtacctggt agtgtttgtc tttggactgc
      241 taggaaactc cctggttctg attatataca ttttctacca gaagctgagg actctgacag
      301 atgtgtttct gctgaacttg cccctggctg acctggtgtt tgtctgtact ctgccctttt
      361 gggcctatgc aggcacctat gagtgggtct ttggcacagt catgtgcaaa actcttcgag
      421 gcatgtatac aatgaacttc tacgtgtcca tgctcactct cacctgcatc acagtggatc
      481 gtttcattgt agtggtccag gctaccaagg ccttcaaccg gcaggctaag tggaagatct
      541 ggggccaagt catttgcttg ctcatttggg tggtctccct gttggtttct ttgccacaga
      601 tcatctatgg ccatgttcaa gatattgaca agcttatctg tcagtaccac agtgaggaga
      661 tatccactat ggttcttgtt atacagatga ctctggggtt cttcctgcca ttgctcacta
      721 tgattctgtg ctactcaggc attatcaaga ccttgcttca tgctcgaaac ttccagaagc
      781 acaaatctct aaagatcatc ttccttgtag tggctgtgtt cctgctgacc cagacaccct
      841 tcaaccttgc catgttaatc caaagtacaa gctgggagta ctataccata accagcttta
      901 agtatgccat cgtagtgaca gaggctatag catactttcg ggcttgcctt aaccctgtac
      961 tttatgcctt tgttggctta aagttccgga agaacgtctg gaaacttatg aaggatatcg
     1021 gctgcctctc tcacctggga gtctcaagtc aatggaagtc ttctgaggac agttccaaga
     1081 cttgttctgc ctcccacaat gtagagacca ccagtatgtt ccaattgtag taggccttgc
     1141 cacacttaga gaagttaata acagaattct aggagcatgg ctgtatcatt tggatgcaac
     1201 aagaaaagct ttgcttatag catgtggagt atcatggaga agtcactgaa caccatggct
     1261 ggtacacaaa acttctcaga tataaatata ccctattctt aatatctaag cctaatgctc
     1321 aaaggagaat gagtatcttg agattttgaa gcactttctc tctttcatcc tcaagaatgc
     1381 tgaaatcaag gtcatgacgg ttaactctag agatctcaag ttctcttttt accaagtttg
     1441 ggcctaaaag ttgaagagct gcatcaacaa agatgttgct ggcagataat gttcagggct
     1501 cttgagttca gaagattctt cagtgggcaa gcagttgaga attgaaaagg ctccatacaa
     1561 atgctgcttg aatgagacca ggttctgact catccagggg tctgtctgac ttttgtatgg
     1621 gtggatgctt atgttttact ggaattgtct tgtaaagtgc agcaatatgg gactgaaaac
     1681 aggccagaat aaataagctg aatttcagtg gtccatgtaa tgctagaaaa atgtataaaa
     1741 cagagcttaa gactttaaca aatacaagag gactctggtg gctttgctca tctaaaaaaa
     1801 aaaaatgaaa gaaattgtga cacatactat gtacacacaa atatatcaag cattttgagt
     1861 ttcatggcta agaaataaaa ccttttaaat gtt
//
