LOCUS       NM_007551               2659 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus C-X-C motif chemokine receptor 5 (Cxcr5), mRNA.
ACCESSION   NM_007551 XM_991331
VERSION     NM_007551.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2659)
  AUTHORS   Luo,B., Zeng,X. and Luo,L.
  TITLE     Intrauterine adhesions repair with menstrual blood-derived
            mesenchymal stem cells via CXCL13-CXCR5 signal axis and its
            mechanism
  JOURNAL   Stem Cell Res Ther 15 (1), 380 (2024)
   PUBMED   39456064
  REMARK    GeneRIF: Intrauterine adhesions repair with menstrual blood-derived
            mesenchymal stem cells via CXCL13-CXCR5 signal axis and its
            mechanism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2659)
  AUTHORS   Chang,Y., Bach,L., Hasiuk,M., Wen,L., Elmzzahi,T., Tsui,C.,
            Gutierrez-Melo,N., Steffen,T., Utzschneider,D.T., Raj,T.,
            Jost,P.J., Heink,S., Cheng,J., Burton,O.T., Zeitrag,J.,
            Alterauge,D., Dahlstrom,F., Becker,J.C., Kastl,M., Symeonidis,K.,
            van Uelft,M., Becker,M., Reschke,S., Krebs,S., Blum,H.,
            Abdullah,Z., Paeschke,K., Ohnmacht,C., Neumann,C., Liston,A.,
            Meissner,F., Korn,T., Hasenauer,J., Heissmeyer,V., Beyer,M.,
            Kallies,A., Jeker,L.T. and Baumjohann,D.
  TITLE     TGF-beta specifies TFH versus TH17 cell fates in murine CD4+ T
            cells through c-Maf
  JOURNAL   Sci Immunol 9 (93), eadd4818 (2024)
   PUBMED   38427718
  REMARK    Erratum:[Sci Immunol. 2024 May 31;9(95):eadp3365. doi:
            10.1126/sciimmunol.adq3365.. PMID: 38820142]
REFERENCE   3  (bases 1 to 2659)
  AUTHORS   Herbst,C.H., Bouteau,A., Menyko,E.J., Qin,Z., Gyenge,E., Su,Q.,
            Cooper,V., Mabbott,N.A. and Igyarto,B.Z.
  TITLE     Dendritic cells overcome Cre/Lox induced gene deficiency by
            siphoning cytosolic material from surrounding cells
  JOURNAL   iScience 27 (3), 109119 (2024)
   PUBMED   38384841
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2659)
  AUTHORS   Zhang,Z., Zhang,H., Antonic-Baker,A., Kwan,P., Yan,Y. and Ma,Y.
  TITLE     CXCR5 Regulates Neuronal Polarity Development and Migration in the
            Embryonic Stage via F-Actin Homeostasis and Results in
            Epilepsy-Related Behavior
  JOURNAL   Neurosci Bull 39 (11), 1605-1622 (2023)
   PUBMED   37460877
  REMARK    GeneRIF: CXCR5 Regulates Neuronal Polarity Development and
            Migration in the Embryonic Stage via F-Actin Homeostasis and
            Results in Epilepsy-Related Behavior.
REFERENCE   5  (bases 1 to 2659)
  AUTHORS   Diupotex,M., Zamora-Chimal,J., Gajon,J.A., Bonifaz,L.C. and
            Becker,I.
  TITLE     CXCR5 and TIM-3 expressions define distinct exhausted T cell
            subsets in experimental cutaneous infection with Leishmania
            mexicana
  JOURNAL   Front Immunol 14, 1231836 (2023)
   PUBMED   37691941
  REMARK    GeneRIF: CXCR5 and TIM-3 expressions define distinct exhausted T
            cell subsets in experimental cutaneous infection with Leishmania
            mexicana.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2659)
  AUTHORS   Gunn,M.D., Ngo,V.N., Ansel,K.M., Ekland,E.H., Cyster,J.G. and
            Williams,L.T.
  TITLE     A B-cell-homing chemokine made in lymphoid follicles activates
            Burkitt's lymphoma receptor-1
  JOURNAL   Nature 391 (6669), 799-803 (1998)
   PUBMED   9486651
REFERENCE   7  (bases 1 to 2659)
  AUTHORS   Forster,R., Mattis,A.E., Kremmer,E., Wolf,E., Brem,G. and Lipp,M.
  TITLE     A putative chemokine receptor, BLR1, directs B cell migration to
            defined lymphoid organs and specific anatomic compartments of the
            spleen
  JOURNAL   Cell 87 (6), 1037-1047 (1996)
   PUBMED   8978608
REFERENCE   8  (bases 1 to 2659)
  AUTHORS   Forster,R., Wolf,I., Kaiser,E. and Lipp,M.
  TITLE     Selective expression of the murine homologue of the
            G-protein-coupled receptor BLR1 in B cell differentiation, B cell
            neoplasia and defined areas of the cerebellum
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 40 (3), 381-387 (1994)
   PUBMED   7920182
REFERENCE   9  (bases 1 to 2659)
  AUTHORS   Wilkie,T.M., Chen,Y., Gilbert,D.J., Moore,K.J., Yu,L., Simon,M.I.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Identification, chromosomal location, and genome organization of
            mammalian G-protein-coupled receptors
  JOURNAL   Genomics 18 (2), 175-184 (1993)
   PUBMED   8288218
REFERENCE   10 (bases 1 to 2659)
  AUTHORS   Kaiser,E., Forster,R., Wolf,I., Ebensperger,C., Kuehl,W.M. and
            Lipp,M.
  TITLE     The G protein-coupled receptor BLR1 is involved in murine B cell
            differentiation and is also expressed in neuronal tissues
  JOURNAL   Eur J Immunol 23 (10), 2532-2539 (1993)
   PUBMED   8405054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125129.5 and BC064059.1.
            
            On Jan 16, 2019 this sequence version replaced NM_007551.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064059.1, AK156087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC125129.5         50620-50642
            24-317              BC064059.1         1-294
            318-318             AC125129.5         62957-62957
            319-1949            BC064059.1         296-1926
            1950-1950           AC125129.5         64589-64589
            1951-2072           BC064059.1         1928-2049
            2073-2073           AC125129.5         64712-64712
            2074-2659           BC064059.1         2051-2636
FEATURES             Location/Qualifiers
     source          1..2659
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..2659
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; CXC-R5; CXCR-5; Gpcr6; MDR15"
                     /note="C-X-C motif chemokine receptor 5"
                     /db_xref="GeneID:12145"
                     /db_xref="MGI:MGI:103567"
     exon            1..123
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; CXC-R5; CXCR-5; Gpcr6; MDR15"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1191
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; CXC-R5; CXCR-5; Gpcr6; MDR15"
                     /note="burkitt lymphoma receptor 1 homolog; chemochine
                     (C-X-C motif) receptor 5; chemokine (C-X-C motif) receptor
                     5"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 5"
                     /protein_id="NP_031577.2"
                     /db_xref="CCDS:CCDS23115.1"
                     /db_xref="GeneID:12145"
                     /db_xref="MGI:MGI:103567"
                     /translation="MNYPLTLDMGSITYNMDDLYKELAFYSNSTEIPLQDSNFCSTVE
                     GPLLTSFKAVFMPVAYSLIFLLGMMGNILVLVILERHRHTRSSTETFLFHLAVADLLL
                     VFILPFAVAEGSVGWVLGTFLCKTVIALHKINFYCSSLLLACIAVDRYLAIVHAVHAY
                     RRRRLLSIHITCTAIWLAGFLFALPELLFAKVGQPHNNDSLPQCTFSQENEAETRAWF
                     TSRFLYHIGGFLLPMLVMGWCYVGVVHRLLQAQRRPQRQKAVRVAILVTSIFFLCWSP
                     YHIVIFLDTLERLKAVNSSCELSGYLSVAITLCEFLGLAHCCLNPMLYTFAGVKFRSD
                     LSRLLTKLGCAGPASLCQLFPNWRKSSLSESENATSLTTF"
     exon            124..2638
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; CXC-R5; CXCR-5; Gpcr6; MDR15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2502..2507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; CXC-R5; CXCR-5; Gpcr6; MDR15"
                     /note="hexamer: AATAAA"
     polyA_site      2523
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; CXC-R5; CXCR-5; Gpcr6; MDR15"
ORIGIN      
        1 ataggcacca gcacaaacct tctcgacatc agacagtgac cagcctggtg acgcagagct
       61 gcagctatga actacccact aaccctggac atgggctcca tcacatacaa tatggatgac
      121 ctgtacaagg aactggcctt ctacagtaac agcacggaga ttcccctaca ggacagtaac
      181 ttctgctcta cagtcgaggg acccttactg acgtccttta aggcggtatt catgcctgtg
      241 gcctacagcc tcatcttcct cctgggtatg atgggaaaca tcctggtgct ggtaatcctg
      301 gagaggcacc ggcacacgcg gagctcaacc gagaccttcc tgttccacct cgcagtagcc
      361 gaccttctct tagtcttcat cctgcctttt gcagtggctg agggctctgt gggttgggtc
      421 ctagggacct tcctctgcaa aactgtgatc gctctgcaca agatcaattt ctactgcagc
      481 agcctgctgc tggcctgtat agctgtagac cggtacctag ccatcgtcca tgctgttcac
      541 gcctaccgcc gccgtcgact cctctccatc cacatcacct gcacggccat ttggctggcc
      601 ggcttcctgt tcgccttacc ggaactcctc tttgccaagg ttggccaacc tcataacaac
      661 gactccttac cacagtgcac cttctcccag gaaaacgaag cggaaactag agcctggttc
      721 acctcccgtt tcctctacca catcgggggc ttcctactac cgatgcttgt gatgggatgg
      781 tgttacgtgg gcgtggtcca caggctactg caggcccagc ggcgccctca gcggcagaag
      841 gcggtcaggg tggccatttt agtgacaagc attttcttcc tctgctggtc gccctaccac
      901 attgtcatct tcctagatac actggagagg ctgaaggctg tgaatagcag ctgcgagctg
      961 agtggctatc tctctgtggc catcaccttg tgtgaattcc tgggcctggc acactgctgt
     1021 ctcaatccca tgctctacac cttcgctggc gtaaagttcc gcagtgacct ctctcggctt
     1081 ctgaccaagc tgggctgtgc tggcccggcc tccctttgcc aacttttccc caactggcgc
     1141 aagagtagtc tctctgagtc agagaatgct acttccctca ccaccttcta gatcccggaa
     1201 gtctcggggc ccctgtctgt ttctgttttc cttgggagga taaagtggtg gcggaaccca
     1261 tccaactcga gcttgggcca gtgtccccag atgggaaagc tagataaact ctctcaaact
     1321 ttcccaaagg ggaaagcagc ccaaaggcaa agcaagctat atccaggcca cctgtatcac
     1381 cttagatgaa gagaactcca tacacctccc atcctaacca gctaaagcta agctcagctt
     1441 tatttcttcc tggccatagg gacaaccacc tctgctgtgg cccacagtct catcttcctc
     1501 ctgattatga gcccagactc tcctcccaga atgtattcca tcatcttaaa gactactggc
     1561 tgccacagct acccaccact cctataccac agaggaatag ccagctggcg gcggcagact
     1621 atggccttaa tgtgcctgtc tcataaatac agacttcatg ccagaccttc aaccgtgcct
     1681 ttctcttaac caagcagaaa gctgaaaccg atctacttta ggtagctgtc tggttccaac
     1741 ctaaccagca ttgggtcagc cccatgttac tggatcttgg attacagact gagggcaagt
     1801 tccagaaggt tctggaagct agccagtatc ctaagaagag taaagggcaa gccagcagga
     1861 aagaggccca gtggaaaagt ggaaagacac cttttccagg ctctaaggaa gaacaagtaa
     1921 aaatcaaacc cagctgtctt ctccacccat tgtaccaaag cttacagact ggtggggaaa
     1981 tgagatccag ggccctcgtg gattctacgc accaatgggg aaggaagcca acttgcctgg
     2041 ggaaagcaag atagcaaagt ggtcctagcc tcaagagagg ggacacctag ctaagagaat
     2101 gacgacagag gttcctgtct tcattaggca gaggcaatat aagaagccaa cctgggcagg
     2161 caagtcctca aaccccagga aggcagtacc ctgcccctgg gagggtacca ctcacatgga
     2221 accagaggaa gctgctccat gcatacatag gggaagttag caggcaattc tgagctcggc
     2281 ttcctcccag ccaccgatct gggggcgtgg gggtaggaag cagagttgcc tagtaccact
     2341 caagccaacc gtacaagctc cctgggggat cccactgggg aaaccaatgc tatagcttca
     2401 gagactgtat cctcattgca gaaccgtgaa gacacctggg gacccccttt tctgctccca
     2461 gcatccaaca accagctggg aagaggcaaa ccgggcacag aaataaaaat gcaagagatg
     2521 gcatttttga attttctctt tttaataaaa aggcacctat aaaacaggtc aatacaggca
     2581 gagacccccg gaacaagcct aaaaagtgtt tcaaaataaa aacaggaaga tgtcttcaaa
     2641 aaaaaaaaaa aaaaaaaaa
//
