LOCUS       NM_009911               1821 bp    mRNA    linear   ROD 17-APR-2023
DEFINITION  Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript
            variant 1, mRNA.
ACCESSION   NM_009911 XM_001478244
VERSION     NM_009911.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1821)
  AUTHORS   Anginot A, Nguyen J, Abou Nader Z, Rondeau V, Bonaud A, Kalogeraki
            M, Boutin A, Lemos JP, Bisio V, Koenen J, Hanna Doumit Sakr L,
            Picart A, Coudert A, Provot S, Dulphy N, Aurrand-Lions M, Mancini
            SJC, Lazennec G, McDermott DH, Guidez F, Blin-Wakkach C, Murphy PM,
            Cohen-Solal M, Espeli M, Rouleau M and Balabanian K.
  TITLE     WHIM Syndrome-linked CXCR4 mutations drive osteoporosis
  JOURNAL   Nat Commun 14 (1), 2058 (2023)
   PUBMED   37045841
  REMARK    GeneRIF: WHIM Syndrome-linked CXCR4 mutations drive osteoporosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1821)
  AUTHORS   Gonzalez-Meljem JM, Ivins S, Andoniadou CL, Le Tissier P, Scambler
            P and Martinez-Barbera JP.
  TITLE     An expression and function analysis of the CXCR4/SDF-1 signalling
            axis during pituitary gland development
  JOURNAL   PLoS One 18 (2), e0280001 (2023)
   PUBMED   36800350
  REMARK    GeneRIF: An expression and function analysis of the CXCR4/SDF-1
            signalling axis during pituitary gland development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1821)
  AUTHORS   Zhang J, Yang Z, Yan X, Duan J, Ruan B, Zhang X, Wen T, Zhang P,
            Liang L and Han H.
  TITLE     RNA-binding protein SPEN controls hepatocyte maturation via
            regulating Hnf4alpha expression during liver development
  JOURNAL   Biochem Biophys Res Commun 642, 128-136 (2023)
   PUBMED   36577249
REFERENCE   4  (bases 1 to 1821)
  AUTHORS   Xu J, Fu L, Deng J, Zhang J, Zou Y, Liao L, Ma X, Li Z, Xu Y, Xu Y,
            Xu S, Liu J, Wang X, Ma X and Guo J.
  TITLE     miR-301a Deficiency Attenuates the Macrophage Migration and
            Phagocytosis through YY1/CXCR4 Pathway
  JOURNAL   Cells 11 (24), 3952 (2022)
   PUBMED   36552718
  REMARK    GeneRIF: miR-301a Deficiency Attenuates the Macrophage Migration
            and Phagocytosis through YY1/CXCR4 Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1821)
  AUTHORS   D'Amato G, Phansalkar R, Naftaly JA, Fan X, Amir ZA, Rios Coronado
            PE, Cowley DO, Quinn KE, Sharma B, Caron KM, Vigilante A and
            Red-Horse K.
  TITLE     Endocardium-to-coronary artery differentiation during heart
            development and regeneration involves sequential roles of Bmp2 and
            Cxcl12/Cxcr4
  JOURNAL   Dev Cell 57 (22), 2517-2532 (2022)
   PUBMED   36347256
  REMARK    GeneRIF: Endocardium-to-coronary artery differentiation during
            heart development and regeneration involves sequential roles of
            Bmp2 and Cxcl12/Cxcr4.
REFERENCE   6  (bases 1 to 1821)
  AUTHORS   Tanabe S, Heesen M, Yoshizawa I, Berman MA, Luo Y, Bleul CC,
            Springer TA, Okuda K, Gerard N and Dorf ME.
  TITLE     Functional expression of the CXC-chemokine receptor-4/fusin on
            mouse microglial cells and astrocytes
  JOURNAL   J Immunol 159 (2), 905-911 (1997)
   PUBMED   9218610
REFERENCE   7  (bases 1 to 1821)
  AUTHORS   Heesen M, Berman MA, Hopken UE, Gerard NP and Dorf ME.
  TITLE     Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal
            cell-derived factor-1alpha is a ligand for both CXC chemokine
            receptor-4 isoforms
  JOURNAL   J Immunol 158 (8), 3561-3564 (1997)
   PUBMED   9103415
REFERENCE   8  (bases 1 to 1821)
  AUTHORS   Heesen M, Berman MA, Benson JD, Gerard C and Dorf ME.
  TITLE     Cloning of the mouse fusin gene, homologue to a human HIV-1
            co-factor
  JOURNAL   J Immunol 157 (12), 5455-5460 (1996)
   PUBMED   8955194
REFERENCE   9  (bases 1 to 1821)
  AUTHORS   Nagasawa T, Nakajima T, Tachibana K, Iizasa H, Bleul CC, Yoshie O,
            Matsushima K, Yoshida N, Springer TA and Kishimoto T.
  TITLE     Molecular cloning and characterization of a murine pre-B-cell
            growth-stimulating factor/stromal cell-derived factor 1 receptor, a
            murine homolog of the human immunodeficiency virus 1 entry
            coreceptor fusin
  JOURNAL   Proc Natl Acad Sci U S A 93 (25), 14726-14729 (1996)
   PUBMED   8962122
REFERENCE   10 (bases 1 to 1821)
  AUTHORS   Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S,
            Kitamura Y, Yoshida N, Kikutani H and Kishimoto T.
  TITLE     Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in
            mice lacking the CXC chemokine PBSF/SDF-1
  JOURNAL   Nature 382 (6592), 635-638 (1996)
   PUBMED   8757135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB872868.1, AB000803.1 and BF662224.1.
            
            [WARNING] On Apr 25, 2023 this sequence was replaced by
            NM_009911.4.
            
            On or before Aug 8, 2008 this sequence version replaced
            XM_001478244.1, NM_009911.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000803.1, U59760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BB872868.1         2-20
            20-1285             AB000803.1         1-1266
            1286-1578           BF662224.1         6-298
            1579-1821           AB000803.1         1559-1801
FEATURES             Location/Qualifiers
     source          1..1821
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.43 cM"
     gene            1..1821
                     /gene="Cxcr4"
                     /gene_synonym="b2b220Clo; CD184; Cmkar4; CXC-R4; CXCR-4;
                     LESTR; PB-CKR; PBSF/SDF-1; Sdf1r"
                     /note="chemokine (C-X-C motif) receptor 4"
                     /db_xref="GeneID:12767"
                     /db_xref="MGI:MGI:109563"
     exon            1..111
                     /gene="Cxcr4"
                     /gene_synonym="b2b220Clo; CD184; Cmkar4; CXC-R4; CXCR-4;
                     LESTR; PB-CKR; PBSF/SDF-1; Sdf1r"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1170
                     /gene="Cxcr4"
                     /gene_synonym="b2b220Clo; CD184; Cmkar4; CXC-R4; CXCR-4;
                     LESTR; PB-CKR; PBSF/SDF-1; Sdf1r"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fusin; C-X-C chemokine receptor type 4; chemokine receptor
                     4; SDF-1 receptor; pre-B-cell-derived chemokine receptor;
                     stromal cell-derived factor 1 receptor; leukocyte-derived
                     seven transmembrane domain receptor; chemokine (C-X-C)
                     receptor 4; leukocyte-expressed
                     seven-transmembrane-domain"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 4 isoform 1"
                     /protein_id="NP_034041.2"
                     /db_xref="CCDS:CCDS15254.1"
                     /db_xref="GeneID:12767"
                     /db_xref="MGI:MGI:109563"
                     /translation="MEPISVSIYTSDNYSEEVGSGDYDSNKEPCFRDENVHFNRIFLP
                     TIYFIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMA
                     DWYFGKFLCKAVHIIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKAVYV
                     GVWIPALLLTIPDFIFADVSQGDISQGDDRYICDRLYPDSLWMVVFQFQHIMVGLVLP
                     GIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYVGISIDSFILLGV
                     IKQGCDFESIVHKWISITEALAFFHCCLNPILYAFLGAKFKSSAQHALNSMSRGSSLK
                     ILSKGKRGGHSSVSTESESSSFHSS"
     exon            112..1814
                     /gene="Cxcr4"
                     /gene_synonym="b2b220Clo; CD184; Cmkar4; CXC-R4; CXCR-4;
                     LESTR; PB-CKR; PBSF/SDF-1; Sdf1r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aattttgttg cctggtgcag caggtagcag tgaaacctct gaggcgtttg gtgctccggt
       61 aaccaccacg gctgtagagc gagtgttgcc atggaaccga tcagtgtgag tatatacact
      121 tctgataact actctgaaga agtgggttct ggagactatg actccaacaa ggaaccctgc
      181 ttccgggatg aaaacgtcca tttcaatagg atcttcctgc ccaccatcta cttcatcatc
      241 ttcttgactg gcatagtcgg caatggattg gtgatcctgg tcatgggtta ccagaagaag
      301 ctaaggagca tgacggacaa gtaccggctg cacctgtcag tggctgacct cctctttgtc
      361 atcacactcc ccttctgggc agttgatgcc atggctgact ggtactttgg gaaatttttg
      421 tgtaaggctg tccatatcat ctacactgtc aacctctaca gcagcgttct catcctggcc
      481 ttcatcagcc tggaccggta cctcgctatt gtccacgcca ccaacagtca gaggccaagg
      541 aaactgctgg ctgaaaaggc agtctatgtg ggcgtctgga tcccagccct cctcctgact
      601 atacctgact tcatctttgc cgacgtcagc cagggggaca tcagtcaggg ggatgacagg
      661 tacatctgtg accgccttta ccccgatagc ctgtggatgg tggtgtttca attccagcat
      721 ataatggtgg gtctcgtcct gcccggcatc gtcatcctct cctgttactg catcatcatc
      781 tctaagctgt cacactccaa gggccaccag aagcgcaagg ccctcaagac gacagtcatc
      841 ctcatcctag ctttctttgc ctgctggctg ccatattatg tggggatcag catcgactcc
      901 ttcatccttt tgggggtcat caagcaagga tgtgacttcg agagcatcgt gcacaagtgg
      961 atctccatca cagaggccct cgccttcttc cactgttgcc tgaaccccat cctctatgcc
     1021 ttcctcgggg ccaagttcaa aagctctgcc cagcatgcac tcaactccat gagcagaggc
     1081 tccagcctca agatcctttc caaaggaaag cggggtggac actcttccgt ctccacggag
     1141 tcagaatcct ccagttttca ctccagctaa cacttatgca aagacatata taatatatat
     1201 atatatatat atgataaaga acttttttat gttacacatt ttccagatat aagagactga
     1261 ccagtcttgt acagtttttt ttttttattg actgttggga gtttatgttc ctctagtttt
     1321 tgtgaggttt gacttaattt atataaatac ttttttttgt ttgtttgttt catgtgaatg
     1381 agtgtctagg caggacctgt ggccaagttc ttagtagctg tttatctgtg tgtaggactg
     1441 tagaactgta gaggaagaaa ctgaacattc cagaatgtgt ggtaaattga ataaagctag
     1501 ccgtgatcct cagctgttgc tgcataatct cttcattccg aggagcaccc cacccccacc
     1561 cccaccccca ccccattctt aaattgtttg gttatgctgt gtgatggttt gtttggtttt
     1621 tttttttgtt gtttttgttt ttgttttttt tctgtaaaag atggcactta aaaccaaagc
     1681 ctgaaatggt ggtagaaatg ctgggggttt ttttgtttgt ttgttttttc agttttcaag
     1741 agtagattga tttcactccc tacaaatgta cagtcttgta ttacattgtt aataaaagtc
     1801 aatgataaac ttaaaaaaaa a
//
