LOCUS       NM_009910               1609 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus C-X-C motif chemokine receptor 3 (Cxcr3), mRNA.
ACCESSION   NM_009910
VERSION     NM_009910.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1609)
  AUTHORS   Ball,A.G., Morgaenko,K., Anbaei,P., Ewald,S.E. and Pompano,R.R.
  TITLE     Poly I:C vaccination drives transient CXCL9 expression near B cell
            follicles in the lymph node through type-I and type-II interferon
            signaling
  JOURNAL   Cytokine 183, 156731 (2024)
   PUBMED   39168064
  REMARK    Erratum:[Cytokine. 2024 Nov;183:156752. doi:
            10.1016/j.cyto.2024.156752.. PMID: 39261247]
REFERENCE   2  (bases 1 to 1609)
  AUTHORS   Li,W.J., Li,R.Y., Wang,D.Y., Shen,M. and Liu,H.L.
  TITLE     CXCR3 participates in asymmetric division of mouse oocytes by
            modulating actin dynamics
  JOURNAL   Theriogenology 225, 43-54 (2024)
   PUBMED   38788628
  REMARK    GeneRIF: CXCR3 participates in asymmetric division of mouse oocytes
            by modulating actin dynamics.
REFERENCE   3  (bases 1 to 1609)
  AUTHORS   Liu,F., Sun,X., Deng,S., Wu,Y., Liu,X., Wu,C., Huang,K., Li,Y.,
            Dong,Z., Xiao,W., Li,M., Chen,Z., Ju,Z., Xiao,J., Du,J. and Zeng,H.
  TITLE     Cxcl10 and Cxcr3 regulate self-renewal and differentiation of
            hematopoietic stem cells
  JOURNAL   Stem Cell Res Ther 15 (1), 248 (2024)
   PUBMED   39113086
  REMARK    GeneRIF: Cxcl10 and Cxcr3 regulate self-renewal and differentiation
            of hematopoietic stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1609)
  AUTHORS   Wei,J., Wang,D.F., Cui,C.C., Tan,J.J., Peng,M.Y. and Lu,H.X.
  TITLE     CXCL4/CXCR3 axis regulates cardiac fibrosis by activating
            TGF-beta1/Smad2/3 signaling in mouse viral myocarditis
  JOURNAL   Immun Inflamm Dis 12 (4), e1237 (2024)
   PUBMED   38577984
  REMARK    GeneRIF: CXCL4/CXCR3 axis regulates cardiac fibrosis by activating
            TGF-beta1/Smad2/3 signaling in mouse viral myocarditis.
REFERENCE   5  (bases 1 to 1609)
  AUTHORS   Hancock,W.W., Lu,B., Gao,W., Csizmadia,V., Faia,K., King,J.A.,
            Smiley,S.T., Ling,M., Gerard,N.P. and Gerard,C.
  TITLE     Requirement of the chemokine receptor CXCR3 for acute allograft
            rejection
  JOURNAL   J Exp Med 192 (10), 1515-1520 (2000)
   PUBMED   11085753
REFERENCE   6  (bases 1 to 1609)
  AUTHORS   Wang,X., Li,X., Schmidt,D.B., Foley,J.J., Barone,F.C., Ames,R.S.
            and Sarau,H.M.
  TITLE     Identification and molecular characterization of rat CXCR3:
            receptor expression and interferon-inducible protein-10 binding are
            increased in focal stroke
  JOURNAL   Mol Pharmacol 57 (6), 1190-1198 (2000)
   PUBMED   10825390
REFERENCE   7  (bases 1 to 1609)
  AUTHORS   Mahalingam,S. and Karupiah,G.
  TITLE     Chemokines and chemokine receptors in infectious diseases
  JOURNAL   Immunol Cell Biol 77 (6), 469-475 (1999)
   PUBMED   10571666
  REMARK    Review article
REFERENCE   8  (bases 1 to 1609)
  AUTHORS   Lu,B., Humbles,A., Bota,D., Gerard,C., Moser,B., Soler,D.,
            Luster,A.D. and Gerard,N.P.
  TITLE     Structure and function of the murine chemokine receptor CXCR3
  JOURNAL   Eur J Immunol 29 (11), 3804-3812 (1999)
   PUBMED   10556837
REFERENCE   9  (bases 1 to 1609)
  AUTHORS   Tamaru,M., Tominaga,Y., Yatsunami,K. and Narumi,S.
  TITLE     Cloning of the murine interferon-inducible protein 10 (IP-10)
            receptor and its specific expression in lymphoid organs
  JOURNAL   Biochem Biophys Res Commun 251 (1), 41-48 (1998)
   PUBMED   9790904
REFERENCE   10 (bases 1 to 1609)
  AUTHORS   Soto,H., Wang,W., Strieter,R.M., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Hedrick,J. and Zlotnik,A.
  TITLE     The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8205-8210 (1998)
   PUBMED   9653165
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL805980.28.
            
            On May 7, 2015 this sequence version replaced NM_009910.2.
            
            Summary: This gene encodes a transmembrane protein that functions
            as a receptor for C-X-R chemokines. Signalling through this protein
            regulates a variety of biological processes, including
            inflammation, immunity, and would healing. This protein also plays
            a role in tumor growth and metastasis. [provided by RefSeq, May
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB003174.1, BC096626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AL805980.28        61557-61657         c
            102-1609            AL805980.28        59045-60552         c
FEATURES             Location/Qualifiers
     source          1..1609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 44.58 cM"
     gene            1..1609
                     /gene="Cxcr3"
                     /gene_synonym="Cd183; Cmkar3"
                     /note="C-X-C motif chemokine receptor 3"
                     /db_xref="GeneID:12766"
                     /db_xref="MGI:MGI:1277207"
     exon            1..101
                     /gene="Cxcr3"
                     /gene_synonym="Cd183; Cmkar3"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1193
                     /gene="Cxcr3"
                     /gene_synonym="Cd183; Cmkar3"
                     /note="IP-10 receptor; interferon-inducible protein 10
                     receptor; chemokine (C-X-C motif) receptor 3"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 3"
                     /protein_id="NP_034040.1"
                     /db_xref="CCDS:CCDS30319.1"
                     /db_xref="GeneID:12766"
                     /db_xref="MGI:MGI:1277207"
                     /translation="MYLEVSERQVLDASDFAFLLENSTSPYDYGENESDFSDSPPCPQ
                     DFSLNFDRTFLPALYSLLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLV
                     LTLPLWAVDAAVQWVFGPGLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATQIYR
                     RDPRVRVALTCIVVWGLCLLFALPDFIYLSANYDQRLNATHCQYNFPQVGRTALRVLQ
                     LVAGFLLPLLVMAYCYAHILAVLLVSRGQRRFRAMRLVVVVVAAFAVCWTPYHLVVLV
                     DILMDVGVLARNCGRESHVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFREQMWMLFTR
                     LGRSDQRGPQRQPSSSRRESSWSETTEASYLGL"
     exon            102..1609
                     /gene="Cxcr3"
                     /gene_synonym="Cd183; Cmkar3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1590..1595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcr3"
                     /gene_synonym="Cd183; Cmkar3"
                     /note="hexamer: AATAAA"
     polyA_site      1609
                     /gene="Cxcr3"
                     /gene_synonym="Cd183; Cmkar3"
                     /note="major polyA site"
ORIGIN      
        1 gcaagttccc aaccacaagt gccaaaggca gagaagcagg cagcacgaga cctgacccca
       61 gcagccacag ccggagcacc agccaagcca tgtaccttga ggttagtgaa cgtcaagtgc
      121 tagatgcctc ggactttgcc tttcttctgg aaaacagcac ctctccctac gattatgggg
      181 aaaacgagag cgacttctct gactccccgc cctgcccaca ggatttcagc ctgaactttg
      241 acagaacctt cctgccagcc ctctacagcc tcctcttctt gctggggctg ctaggcaatg
      301 gggcggtggc tgctgtgcta ctgagtcagc gcactgccct gagcagcacg gacaccttcc
      361 tgctccacct ggctgtagcc gatgttctgc tggtgttaac tcttccattg tgggcagtgg
      421 atgctgctgt ccagtgggtt ttcggccctg gcctctgcaa agtggcaggc gccttgttca
      481 acatcaactt ctatgcaggg gccttcctgc tggcttgtat aagcttcgac agatatctga
      541 gcatagtgca cgccacccag atctaccgca gggacccccg ggtacgtgta gccctcacct
      601 gcatagttgt atggggtctc tgtctgctct ttgccctccc agatttcatc tacctatcag
      661 ccaactacga tcagcgcctc aatgccaccc attgccagta caacttccca caggtgggtc
      721 gcactgctct gcgtgtactg cagctagtgg ctggtttcct gctgcccctt ctggtcatgg
      781 cctactgcta tgcccatatc ctagctgttc tgctggtctc cagaggccag aggcgttttc
      841 gagctatgag gctagtggta gtggtggtgg cagcctttgc tgtctgctgg accccctatc
      901 acctggtggt gctagtggat atcctcatgg atgtgggagt tttggcccgc aactgtggtc
      961 gagaaagcca cgtggatgtg gccaagtcag tcacctcggg catggggtac atgcactgct
     1021 gcctcaatcc gctgctctat gcctttgtgg gagtgaagtt cagagagcaa atgtggatgt
     1081 tgttcacgcg cctgggccgc tctgaccaga gagggcccca gcggcagccg tcatcttcac
     1141 ggagagaatc atcctggtct gagacaactg aggcctccta cctgggcttg taattctgga
     1201 ctggaactgt agcctgcgca gcccaagtcc taacacactc caagtgcttg tcctccttgt
     1261 agttgggcta gctcgaactt acccgtaact ttgctgccag gatgcactga cagctcagca
     1321 tatatccagg tctcctgaga atcaatctca gcaacaagga caacaccatt actgtgcctt
     1381 agctgccatg ccctatcttg ctgttttaga actagctgcc tggagcccca ccgccctact
     1441 aaattagcaa gtagaactca gccatccctg tgtgagaaga gggagaggca aatagcacag
     1501 agggccaggc gttgtcagca ctgaatgtgc ccatctcagt atctcaatat ttgcccaatt
     1561 ttatttctag aaacctcact taaactttca ataaacaagg taatgagga
//
