LOCUS       NM_009909               3043 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus C-X-C motif chemokine receptor 2 (Cxcr2), mRNA.
ACCESSION   NM_009909 XM_984949
VERSION     NM_009909.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3043)
  AUTHORS   Balog,B.M., Niemi,J.P., Disabato,T., Hashim,F. and Zigmond,R.E.
  TITLE     CXCR2 mediated trafficking of neutrophils and neutrophil
            extracellular traps are required for myelin clearance after a
            peripheral nerve injury
  JOURNAL   Exp Neurol 382, 114985 (2024)
   PUBMED   39368532
REFERENCE   2  (bases 1 to 3043)
  AUTHORS   Masui,H., Kawada,K., Itatani,Y., Hirai,H., Nakanishi,Y., Kiyasu,Y.,
            Hanada,K., Okamoto,M., Hirata,W., Nishikawa,Y., Sugimoto,N.,
            Tamura,T., Sakai,Y. and Obama,K.
  TITLE     Synergistic antitumor activity by dual blockade of CCR1 and CXCR2
            expressed on myeloid cells within the tumor microenvironment
  JOURNAL   Br J Cancer 131 (1), 63-76 (2024)
   PUBMED   38750114
  REMARK    GeneRIF: Synergistic antitumor activity by dual blockade of CCR1
            and CXCR2 expressed on myeloid cells within the tumor
            microenvironment.
REFERENCE   3  (bases 1 to 3043)
  AUTHORS   Yan,D., Wei,G., Ai,Z., Song,S., Zhang,L., Dong,N., Dou,X. and
            Shan,A.
  TITLE     CXCR2, as a key regulatory gene of HDP-PG-1, maintains intestinal
            mucosal homeostasis
  JOURNAL   Int J Biol Macromol 269 (Pt 2), 132025 (2024)
   PUBMED   38704076
  REMARK    GeneRIF: CXCR2, as a key regulatory gene of HDP-PG-1, maintains
            intestinal mucosal homeostasis.
REFERENCE   4  (bases 1 to 3043)
  AUTHORS   Yin,C., Liu,B., Dong,Z., Shi,S., Peng,C., Pan,Y., Bi,X., Nie,H.,
            Zhang,Y., Tai,Y., Hu,Q., Wang,X., Shao,X., An,H., Fang,J., Wang,C.
            and Liu,B.
  TITLE     CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint
            pain and inflammation in experimental gouty arthritis
  JOURNAL   Nat Commun 15 (1), 3263 (2024)
   PUBMED   38627393
  REMARK    GeneRIF: CXCL5 activates CXCR2 in nociceptive sensory neurons to
            drive joint pain and inflammation in experimental gouty arthritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3043)
  AUTHORS   Cui,S., Chen,X., Li,J., Wang,W., Meng,D., Zhu,S. and Shen,S.
  TITLE     Endothelial CXCR2 deficiency attenuates renal inflammation and
            glycocalyx shedding through NF-kappaB signaling in diabetic kidney
            disease
  JOURNAL   Cell Commun Signal 22 (1), 191 (2024)
   PUBMED   38528533
  REMARK    GeneRIF: Endothelial CXCR2 deficiency attenuates renal inflammation
            and glycocalyx shedding through NF-kappaB signaling in diabetic
            kidney disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3043)
  AUTHORS   Shuster,D.E., Kehrli,M.E. Jr. and Ackermann,M.R.
  TITLE     Neutrophilia in mice that lack the murine IL-8 receptor homolog
  JOURNAL   Science 269 (5230), 1590-1591 (1995)
   PUBMED   7667641
REFERENCE   7  (bases 1 to 3043)
  AUTHORS   Lee,J., Cacalano,G., Camerato,T., Toy,K., Moore,M.W. and Wood,W.I.
  TITLE     Chemokine binding and activities mediated by the mouse IL-8
            receptor
  JOURNAL   J Immunol 155 (4), 2158-2164 (1995)
   PUBMED   7636264
REFERENCE   8  (bases 1 to 3043)
  AUTHORS   Heinrich,J.N. and Bravo,R.
  TITLE     The orphan mouse receptor interleukin (IL)-8R beta binds N51.
            Structure-function analysis using N51/IL-8 chimeric molecules
  JOURNAL   J Biol Chem 270 (10), 4987-4989 (1995)
   PUBMED   7890604
REFERENCE   9  (bases 1 to 3043)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     The murine dilute suppressor gene encodes a cell autonomous
            suppressor
  JOURNAL   Genetics 138 (2), 491-497 (1994)
   PUBMED   7828830
REFERENCE   10 (bases 1 to 3043)
  AUTHORS   Suzuki,H., Prado,G.N., Wilkinson,N. and Navarro,J.
  TITLE     The N terminus of interleukin-8 (IL-8) receptor confers high
            affinity binding to human IL-8
  JOURNAL   J Biol Chem 269 (28), 18263-18266 (1994)
   PUBMED   7518426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ056061.1 and AC117757.23.
            
            On or before May 4, 2006 this sequence version replaced
            XM_984949.1, NM_009909.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D17630.1, AK158234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-652               CJ056061.1         2-653
            653-3043            AC117757.23        164943-167333
FEATURES             Location/Qualifiers
     source          1..3043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.41 cM"
     gene            1..3043
                     /gene="Cxcr2"
                     /gene_synonym="CD128; CDw128; Cmkar2; Gpcr16; IL-8rb;
                     IL-8Rh; IL8RA; Il8rb; mIL-8RH"
                     /note="C-X-C motif chemokine receptor 2"
                     /db_xref="GeneID:12765"
                     /db_xref="MGI:MGI:105303"
     exon            1..126
                     /gene="Cxcr2"
                     /gene_synonym="CD128; CDw128; Cmkar2; Gpcr16; IL-8rb;
                     IL-8Rh; IL8RA; Il8rb; mIL-8RH"
                     /inference="alignment:Splign:2.1.0"
     exon            127..3043
                     /gene="Cxcr2"
                     /gene_synonym="CD128; CDw128; Cmkar2; Gpcr16; IL-8rb;
                     IL-8Rh; IL8RA; Il8rb; mIL-8RH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3021..3026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcr2"
                     /gene_synonym="CD128; CDw128; Cmkar2; Gpcr16; IL-8rb;
                     IL-8Rh; IL8RA; Il8rb; mIL-8RH"
                     /note="hexamer: ATTAAA"
     polyA_site      3043
                     /gene="Cxcr2"
                     /gene_synonym="CD128; CDw128; Cmkar2; Gpcr16; IL-8rb;
                     IL-8Rh; IL8RA; Il8rb; mIL-8RH"
                     /note="major polyA site"
ORIGIN      
        1 agtagtttcc tcatcacggc tgcctcactt tcttccagtt caaccagccc tgacagctcc
       61 caagccttga gtcacagaga gttgggagcc actctgctca caaacagcgt cgtagaacta
      121 ctgcaggatt aagtttacct caaagatggg agaattcaag gtggataagt tcaacattga
      181 agatttcttc agtggagatc ttgatatttt caattatagc tctggcatgc cctctattct
      241 gccagatgct gtcccatgcc actcagagaa cctggaaatc aacagttatg ctgtggttgt
      301 aatatacgtc ctggtgactc tgctgagcct tgtggggaac tccttggtga tgctggtcat
      361 cttatacaac cggagcacct gctctgtcac cgatgtctac ctgctgaacc tggccattgc
      421 tgacctgttc tttgccctga ccttgcctgt ctgggctgca tctaaagtaa atggatggac
      481 ttttggctca accctgtgca agatattctc atacgtgaag gaggttacct tctacagcag
      541 tgttctgcta ctagcctgca tcagcatgga ccgctacctg gccattgtac atgccacaag
      601 tacactgatc cagaagagac acttggtcaa gtttgtgtgc atagccatgt ggttactatc
      661 agtaattctg gccctgccca tcttaattct acgaaatcct gttaaggtaa acctttctac
      721 cttagtctgc tatgaggatg taggtaacaa tacatcccgt ttgagggtcg tactgcgtat
      781 cctgcctcag acttttggct tcctcgtgcc gctgctcatc atgctgttct gctacgggtt
      841 cacactgcgc accctcttta aggcccacat ggggcagaag caccgggcca tgcgggtcat
      901 cttcgctgtc gtccttgtct tcctgctctg ctggctgccc tacaacctgg ttctgttcac
      961 agacaccctc atgagaacca agctgatcaa ggagacctgt gagcgccgcg atgacattga
     1021 caaggccttg aatgctacgg agattcttgg cttcctccac agctgcctta accccatcat
     1081 ctatgccttt attggccaga aatttcgcca tggacttctc aagatcatgg ctacttatgg
     1141 ccttgtcagc aaggagttct tagccaagga gggaaggcct tcttttgtta gctcgtcttc
     1201 agcaaacacc tctactaccc tctaaagact gttcacctaa acggtggccc ctcggggttc
     1261 cttcttgtct ttcagcatgg ctcattacca gagactgtgg tatttgaatt gatgcagccc
     1321 ctcctctaca attacaggga gaaagaggtc acgttcttag cagagccccc agagtttaga
     1381 accccctata ttggctgtct gctcccttcc atcttggtat gcctactgat agagttgatc
     1441 catcctaaca ctagacccca aacactcttt tctaagaagc acacgttaca attacagtga
     1501 gatactgcct cctacccatc agaacagtta gcagtaaaag gaagaggtgg aggagagaaa
     1561 atggcaagtg acaatgagga agtagaaaaa gggaactctt caccttacca gtagacgagt
     1621 accagagtcc cctcacacag gaacatagca tagcagtttt ccatttaaaa aaaaattaag
     1681 ggctggtgag atggctcagt gggtaagagc acccgactgc tcttccaaag gtccgaagtt
     1741 caaatcccag caaccacatg gtggctcaca accatctgta acgagatctg atgccctctt
     1801 ctggagtgtc tgaagacagc tacagtgtac ttacatataa taaataaata aatctttaaa
     1861 aaaaaaaatt aaatatagaa ttggcatgta atccagcaag tccatctcta agtagggtac
     1921 ctaaaaaaat tgaaagccag ggttcagaca tttgtatgct gatactcaca acagcattat
     1981 tcatcatgaa aatgatggcc aacagatgaa tgggtaagtt aaacaaggtg tctctacaca
     2041 acaaaagagc gtccacaatg agaagtgcca aaaataatca aatagtgttg actggaggct
     2101 gggtgaggaa gggtggggag ttcgtgtaga agacacagct ccagttaggg atgatgggaa
     2161 agccctgaag gtgggccctg atccctgtgt agtagtgtga atgcactcat taccactgta
     2221 acaaaagtgt taaaatgaaa gctgagtatt gctccctggg agagtgctta tttaacattt
     2281 ctaagaactc aggctcaaat cctagcacct cgacaaacaa acaaacaaac aaacaaaaaa
     2341 gctaaaatgg ttatttttgt tatgtgtgtt ttacctcact ttaccaaaaa tataaaaatc
     2401 taagtctaaa aaatgttcac catcccataa acaaccacca aacccagaca ctaggcagat
     2461 gccaacaaga acctgctgac aggaggctga tatagctgtc tcctgaggag ctctgccagt
     2521 gcctggaaaa tacagaagtg gatgctcaca atcatccatt ggatagagga caaggtccca
     2581 aatgaagaag ctagcgaagg tatccaagga gctaaagggg tctgaagccc cagaggagga
     2641 acatcagtat gaactagcca gtaccccccc agagctcctt ggaactaaac caccaatcaa
     2701 agaaaacaca tggtggaact tgtggctcta gctgtatatg tagcagagga tggcctagtc
     2761 agtcatcaat gggaggagag gcccttggtc ctgtgaaggc tctatgcctc aatatagggg
     2821 aatgccagga ccaggaatgg gagtaggtgg attggggagc agggggagag ggaagggaat
     2881 aggggatatt tggaggggaa actaggaaag gggataacat ttgaaatgta aataaagaaa
     2941 atatctaata aaaaaaatgt tctttaacca ctgaaccaat gcagaactat ctaccttata
     3001 atttcttgta aagtgtgact attaaatgtc gttttaaaaa ata
//
