LOCUS       NM_178241               3230 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus C-X-C motif chemokine receptor 1 (Cxcr1), mRNA.
ACCESSION   NM_178241
VERSION     NM_178241.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3230)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3230)
  AUTHORS   Zhuang,W., Zhou,J., Zhong,L., Lv,J., Zhong,X., Liu,G., Xie,L.,
            Wang,C., Saimaier,K., Han,S., Shi,C., Hua,Q., Zhang,R., Xie,X. and
            Du,C.
  TITLE     CXCR1 drives the pathogenesis of EAE and ARDS via boosting
            dendritic cells-dependent inflammation
  JOURNAL   Cell Death Dis 14 (9), 608 (2023)
   PUBMED   37709757
  REMARK    GeneRIF: CXCR1 drives the pathogenesis of EAE and ARDS via boosting
            dendritic cells-dependent inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3230)
  AUTHORS   Dutta,P. and Bishayi,B.
  TITLE     IL-10 in combination with IL-12 and TNF-alpha attenuates
            CXCL8/CXCR1 axis in peritoneal macrophages of mice infected with
            Staphylococcus aureus through the TNFR1-IL-1R-NF-kappaB pathway
  JOURNAL   Int Immunopharmacol 120, 110297 (2023)
   PUBMED   37207443
  REMARK    GeneRIF: IL-10 in combination with IL-12 and TNF-alpha attenuates
            CXCL8/CXCR1 axis in peritoneal macrophages of mice infected with
            Staphylococcus aureus through the TNFR1-IL-1R-NF-kappaB pathway.
REFERENCE   4  (bases 1 to 3230)
  AUTHORS   Xiao,G., Liu,J., Wang,H., He,S., Liu,J., Fan,G., Lyu,M. and Zhu,Y.
  TITLE     CXCR1 and its downstream NF-kappaB inflammation signaling pathway
            as a key target of Guanxinning injection for myocardial
            ischemia/reperfusion injury
  JOURNAL   Front Immunol 13, 1007341 (2022)
   PUBMED   36325326
  REMARK    GeneRIF: CXCR1 and its downstream NF-kappaB inflammation signaling
            pathway as a key target of Guanxinning injection for myocardial
            ischemia/reperfusion injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3230)
  AUTHORS   Le,A., Wu,Y., Liu,W., Wu,C., Hu,P., Zou,J. and Kuang,L.
  TITLE     MiR-144-induced KLF2 inhibition and NF-kappaB/CXCR1 activation
            promote neutrophil extracellular trap-induced transfusion-related
            acute lung injury
  JOURNAL   J Cell Mol Med 25 (14), 6511-6523 (2021)
   PUBMED   34120407
  REMARK    GeneRIF: MiR-144-induced KLF2 inhibition and NF-kappaB/CXCR1
            activation promote neutrophil extracellular trap-induced
            transfusion-related acute lung injury.
REFERENCE   6  (bases 1 to 3230)
  AUTHORS   Zheng,L., Njauw,C.N. and Martins-Green,M.
  TITLE     A hCXCR1 transgenic mouse model containing a conditional
            color-switching system for imaging of hCXCL8/IL-8 functions in vivo
  JOURNAL   J Leukoc Biol 82 (5), 1247-1256 (2007)
   PUBMED   17704296
REFERENCE   7  (bases 1 to 3230)
  AUTHORS   Fan,X., Patera,A.C., Pong-Kennedy,A., Deno,G., Gonsiorek,W.,
            Manfra,D.J., Vassileva,G., Zeng,M., Jackson,C., Sullivan,L.,
            Sharif-Rodriguez,W., Opdenakker,G., Van Damme,J., Hedrick,J.A.,
            Lundell,D., Lira,S.A. and Hipkin,R.W.
  TITLE     Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and
            interleukin-8/CXCL8
  JOURNAL   J Biol Chem 282 (16), 11658-11666 (2007)
   PUBMED   17197447
  REMARK    GeneRIF: CXCR1 is a functional receptor for GCP-2/CXCL6 and
            interleukin-8/CXCL8 in mouse
REFERENCE   8  (bases 1 to 3230)
  AUTHORS   Moepps,B., Nuesseler,E., Braun,M. and Gierschik,P.
  TITLE     A homolog of the human chemokine receptor CXCR1 is expressed in the
            mouse
  JOURNAL   Mol Immunol 43 (7), 897-914 (2006)
   PUBMED   16084593
  REMARK    GeneRIF: The gene encoding mCXCR1-like was mapped to mouse
            chromosome 1 and its genomic organization was determined to be very
            similar to the organization of the gene encoding hCXCR1.
REFERENCE   9  (bases 1 to 3230)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   10 (bases 1 to 3230)
  AUTHORS   Fu,W., Zhang,Y., Zhang,J. and Chen,W.F.
  TITLE     Cloning and characterization of mouse homolog of the CXC chemokine
            receptor CXCR1
  JOURNAL   Cytokine 31 (1), 9-17 (2005)
   PUBMED   15967374
  REMARK    GeneRIF: mCXCR1 may mediate the recruitment of neutrophils to the
            inflammation site under certain infections
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113473.20.
            
            On Oct 12, 2022 this sequence version replaced NM_178241.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.699177.1, AY390263.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC113473.20        103810-103872       c
            64-3230             AC113473.20        98921-102087        c
FEATURES             Location/Qualifiers
     source          1..3230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.44 cM"
     gene            1..3230
                     /gene="Cxcr1"
                     /gene_synonym="Il8ra"
                     /note="C-X-C motif chemokine receptor 1"
                     /db_xref="GeneID:227288"
                     /db_xref="MGI:MGI:2448715"
     exon            1..63
                     /gene="Cxcr1"
                     /gene_synonym="Il8ra"
                     /inference="alignment:Splign:2.1.0"
     exon            64..3230
                     /gene="Cxcr1"
                     /gene_synonym="Il8ra"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1127
                     /gene="Cxcr1"
                     /gene_synonym="Il8ra"
                     /note="interleukin 8 receptor, alpha; CXC chemokine
                     receptor 1; high affinity interleukin-8 receptor A;
                     chemokine (C-X-C motif) receptor 1"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 1"
                     /protein_id="NP_839972.1"
                     /db_xref="CCDS:CCDS15041.1"
                     /db_xref="GeneID:227288"
                     /db_xref="MGI:MGI:2448715"
                     /translation="MAEAEYFIWTNPEGDFEKEFGNITGMLPTGDYFIPCKRVPITNR
                     QALVVFYALVSLLSLLGNSLVMLVILYRRRTRSVMDVYVLNLAIADLLFSLTLPFLAV
                     SKLKGWIFGTPLCKMVSLLKEFNFFSGILLLACISVDRYLAIVHATRTLARKRYLVKF
                     VCVGIWGLSLILSLPFAIFRQAYKPFRSGTVCYEVLGEATTDFRMTLRGLSHIFGFLL
                     PLLTMLVCYGLTLRMLFKTHMRQKHRAMGVIFAVVLVFLLCCLPYNLVLLSDTLLGAH
                     LIEDTCERRNDIDQALYITEILGFSHSCLNPIIYAFVGQNFRHEFLKILANHGLVRKE
                     VLTHRRVAFHTSLTAIY"
     regulatory      1123..1128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcr1"
                     /gene_synonym="Il8ra"
                     /note="hexamer: ATTAAA"
     polyA_site      1148
                     /gene="Cxcr1"
                     /gene_synonym="Il8ra"
                     /note="major polyA site"
ORIGIN      
        1 attctgtttc ctgagctgca ggctcctccc gcacacaagg aacggaccca gctggtgcct
       61 cagatcaaac aatggccgag gctgaatatt tcatctggac taatcctgag ggtgactttg
      121 agaaagaatt tggaaatatc acgggaatgc tgcccactgg agattatttc atcccctgta
      181 agagagttcc aataaccaac aggcaggctt tagttgtctt ttatgcactg gtgtcccttc
      241 tgagcttgct gggaaactcg ctggtgatgc tggttatctt atacaggcga aggacccgat
      301 ccgtcatgga tgtctacgtg ctgaacctag ccatcgccga cctactcttt tcattgaccc
      361 tgcccttctt ggctgtctcc aaattgaagg gctggatttt tggcacaccc ctgtgcaaga
      421 tggtctcact cctgaaggaa ttcaacttct tcagtggtat cctgctgctg gcctgcatca
      481 gtgtggaccg atacctggcc atcgtccatg ccacccgtac gctggcccga aagcgctact
      541 tggttaaatt cgtgtgcgtg ggcatctggg gtctatcttt gattctgtct ctgccttttg
      601 ctatcttccg ccaggcatat aaaccattcc gttctggtac agtctgctat gaagtcctgg
      661 gtgaagccac aacagatttt cggatgacct tgcggggtct gtcccacata tttggcttcc
      721 tcctgccgct gctcactatg ctggtctgct acgggctcac actgcgcatg ctctttaaga
      781 cccacatgag gcagaaacac cgggccatgg gggtgatctt tgctgttgtg ttggtcttct
      841 tgctctgttg tctgccctac aatctggttc tgctctcaga cactctctta ggagcccact
      901 tgattgaaga tacttgcgaa cgccgcaatg acattgacca ggccctgtat attactgaga
      961 tcctgggctt ttctcatagt tgtcttaacc ctatcatcta tgccttcgtt ggccaaaatt
     1021 ttcgccatga attcctcaag atccttgcta accatggcct ggttcgcaag gaggttttga
     1081 cacaccgccg tgttgccttt catacgtctc tcaccgctat ttattaaacc tctgagaatt
     1141 accggaaagt gatcgcttgc cctcaaagag aaggataact attgtgccaa tgtgctgtgt
     1201 gagtgtgtgc gtgtgttgtg tgtatgtgtg tatgtgtggt atatgtgtgt gtgtgtgtgt
     1261 gtatgtatgg tgtatgtatg tatgtatgta tgtatgtata tatggtgtgt gtgtgtgttt
     1321 tgtgtgtgta tatgtatgta tgcgtggtat atgtgtgtgt ggtgtgtgtc agtgtatgtg
     1381 tagtgtatat gtgtgtgtgt atatatgtat gtgtggtata tgtgtgtgtg tgctgtgtgt
     1441 gtatgtgtat gtgtgtgtgt atatatgtat atgtatgcat gtatgcatgt atggtgtatg
     1501 tgttttgtgt gtgtatatgt atgtatgcat ggtatatgtg tgtgtgtggt gtgtgtgagt
     1561 gtatgtgtag tatgagtatg tgtgtatggt aagtgtactt atttatgttg ctgtatctgt
     1621 gtgtgtggtg tgtatgtatg tatgtgtagt atatgcatgt gtctgtatgt actgtgtatg
     1681 tctgtctgta tatagtgtgt gtgtgtgtgt gtgtgtgtgt gtactatggc tatgggcaga
     1741 tactatctgc tttggggagg gaggagacaa gatcaggaga agttagtaac tactgggccc
     1801 acaccagctt tccgaggagg tgctgatggc cctccaagaa ctttatactt ccatgaggaa
     1861 taacgcttca ccatttctat tgaacatata catctttgac ttgtgatctg ggtaattatc
     1921 atggtcacac ctgtagccta acccaccatt agaacaaaga actgggactt gcatctaaca
     1981 ttagccctca tgggctggat tctctctttg gaacaccacc cagactgctc agcacactcc
     2041 agcaggctgt ctgggagctt tctgtcctgt gatctgagct catgagattg tttttccatc
     2101 ttgaggaatg ttgcaatgcc cgctgaggac atcggtcagg tgctatggaa gcgtcaagcc
     2161 accaggcagc cttgtgatgg agctgaagag tttcttccct ttaggtgtca tgagtggacg
     2221 gagggtattt gggaagccag gcctagtgca tgagaatccc ctttaccccg tgaccggtgt
     2281 caccaagggt gatgtgtgtg tgttgggtgc cagctgagcc aaggatggag caagaccagc
     2341 agatgtaact tttgccctct tggcacttcc agtttgacat ggagcaacgg gcaactttat
     2401 aaacccaagt atgctgtcaa tcatctgggc aggcagatgt ttccaataca acttctgtcc
     2461 catgtctgtc catgggggtg ccaaaatgaa aggtgtgtgt ggagtagctg gtgttcctgc
     2521 agcagaacag gagtagccct ccctcctcat aaactgggtg tgggctagtg gctttactgg
     2581 aacaatctct gcaggcatgg cctcaggcag gctctcactc catgctcacc actgtctctc
     2641 acgggtcaag aggtcccctt tgtacctcat atgcgaacat gtgtgacttc agccttatac
     2701 cgatgtatag ccattgtccc cctgggggga cctggcttgt ctcctttaca ttgtattaag
     2761 ttacttccta accaccccca acccctgcca aatgactttg ggaaattacg tttgggaatg
     2821 gagagaatgc ttggtggtta agataacttg ctgctctttc agaggatttg attcccagca
     2881 tccacctggt ggatcacaat catctgtaac ttaggttcca gagggatcca atgccctctt
     2941 ctgacttctg cagccggtaa acatgcacac aatatgtaga catatgttca agcaaagcaa
     3001 ccacacacat ataatttaca aatctaaaat tattttttca aagggctgaa gagatggctc
     3061 agaggttaag ggcattgtct gctcttccag aggtcctgag ttcaatcccc agcaaccaca
     3121 tggtggctca caaacatctg tagtgggctc tgatgccctc ttttggtgtg tctgaagaca
     3181 gctacagtgt acttatatac acaaaataaa taaatctttt aaaaaattgc
//
